The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 1993

Expression Of Ganglia-Type Nicotinic Acetylcholine Receptors And Nicotinic Ligand Binding Sites By Cells Of The Imr-32 Human Neuroblastoma Clonal Line, R. J. Lukas

Characterization Of Nicotinic Acetylcholine Receptors Expressed By Cells Of The Sh-Sy5Y Human Neuroblastoma Clonal Line, Ronald J. Lukas, Sylvia A. Norman, and Linda Lucero

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Colocalization of cholinesterases with β amyloid protein in aged and Alzheimer's brains, M. A. Morán, E. J. Mufson, and P. Gómez-Ramos

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Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome, E. J. Mufson, E. Cochran, W. Benzing, and J. H. Kordower

The cycle of SEC4 function in vesicular transport., P. Novick, P. Brennwald, N. C. Walworth, A. K. Kabcenell, M. Garrett, M. Moya, D. Roberts, H. Müller, B. Govindan, and R. Bowser

Tissue‐specific expression of type XII collagen during mouse embryonic development, Suk Paul Oh, C. May Griffith, Elizabeth D. Hay, and Bjorn R. Olsen

Basic Fibroblast Growth Factor (Bfgf) Regulates Tyrosine Hydroxylase And Proenkephalin Mrna Levels In Adrenal Chromaffin Cells, Elzbieta Puchacz, Ewa K. Stachowiak, Robert Z. Florkiewicz, Ronald J. Lukas, and Michal K. Stachowiak

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Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin, Scot D. Styren, Steven T. DeKosky, Joseph Rogers, and Elliott J. Mufson

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Ascending cholinergic pathways: Functional organization and implications for disease models, Bruce H. Wainer, Teresa L. Steininger, John D. Roback, Melanie A. Burke-Watson, Elliott J. Mufson, and Jeffrey Kordower

Cytogenetic and molecular analysis in Angelman syndrome., J L Zackowski, R D Nicholls, B A Gray, A Bent-Williams, W Gottlieb, P J Harris, M F Waters, D J Driscoll, R T Zori, and C A Williams

Submissions from 1992

Vanadate Amplifies Receptor-Mediated Accumulation Of Inositol Trisphosphates And Inhibits Inositol Tris- And Tetrakis-Phosphatase Activities, Merouane Bencherif and Ronald J. Lukas

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Distribution of neurotensin immunoreactivity within the human amygdaloid complex: A comparison with acetylcholinesterase‐ and Nissl‐stained tissue sections, William C. Benzing, Elliott J. Mufson, Lothar Jennes, Edward G. Stopa, and David M. Armstrong

Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis, R. Bowser, H. Muller, B. Govindan, and P. Novick

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A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains, J. R. Connor, S. L. Menzies, S. M. St. Martin, and E. J. Mufson

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Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease, J. R. Connor, B. S. Snyder, J. L. Beard, R. E. Fine, and E. J. Mufson

A DNA methylation imprint, determined by the sex of the parent, distinguishes the Angelman and Prader-Willi syndromes., D J Driscoll, M F Waters, C A Williams, R T Zori, C C Glenn, K M Avidano, and R D Nicholls

A 5€²-Flanking Region Of The Bovine Tyrosine Hydroxylase Gene Is Involved In Cell-Specific Expression Activation Of Gene Transcription By Phorbol Ester And Transactivation By C-Fos And C-Jun, A. Goc, S. A. Norman, E. Puchacz, E. K. Stachowiak, R. J. Lukas, and M. K. Stachowiak

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Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain, P. Gomez-Ramos, E. J. Mufson, and M. A. Moran

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Galanin immunoreactivity in the primate central nervous system, Jeffrey H. Kordower, Hieu K. Le, and Elliott J. Mufson

NGF receptor (p75)-immunoreactivity within hypoglossal motor neurons following axotomy in monkeys, J H. Kordower, K S. Bankiewicz, and E J. Mufson

Nerve growth factor receptor-immunoreactive neurons within the developing human cortex, J H. Kordower and E J. Mufson

Heterogeneity And Regulation Of Nicotinic Acetylcholine Receptors, Ronald J. Lukas and Merouane Bencherif

Recurrent Collaterals Of Motoneurons Projecting To Distal Muscles In The Cat Hindlimb, M. L. McCurdy and T. M. Hamm

Diagnosis of Alzheimer's disease. Evaluation of senile plaques of the diffuse type, M. A. Morán, J. L. Cebrián, P. Gómez-Ramos, A. Cabello, S. Madero, and E. J. Mufson

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Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease, E. J. Mufson and J. H. Kordower

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p75 Nerve growth factor receptor immunoreactivity in the human brainstem and spinal cord, Elliott J. Mufson, Thomas Brashers-Krug, and Jeffrey H. Kordower

The mouse α1(XII) and human α1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6, Suk P. Oh, Reginald W. Taylor, Donald R. Gerecke, Julie M. Rochelle, Michael F. Seldin, and Bjorn R. Olsen

SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast, Marc Potenza, Robert Bowser, Heike Müller, and Peter Novick

Time-frequency representation of electrocorticograms in temporal lobe epilepsy, H P. Zaveri, W J. Williams, L D. Iasemidis, and J C. Sackellares

Submissions from 1991

Differential Regulation Of Nicotinic Acetylcholine Receptor Expression By Human Te671/Rd Cells Following Second Messenger Modulation And Sodium Butyrate Treatments, Merouane Bencherif and Ronald J. Lukas

Differential Sensitivity Of Phosphoinositide Metabolism To Sodium Fluoride And Carbachol Treatments In Pc12 Cells, Merouane Bencherif and Ronald J. Lukas

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Sec15 protein, an essential component of the exocytotic apparatis, is associated with the plasma membrane and with a soluble 19.5S particle, R. Bowser and P. Novick

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Alz‐50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease, Daniel R. Brady and Elliott J. Mufson

Effects Of Chronic Nicotinic Ligand Exposure On Functional Activity Of Nicotinic Acetylcholine Receptors Expressed By Cells Of The Pc12 Rat Pheochromocytoma Or The Te671/Rd Human Clonal Line, Ronald J. Lukas

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Nerve growth factor receptor immunoreactivity in the new world monkey (Cebus apella) and human cerebellum, Elliott J. Mufson, Gerald A. Higgins, and Jeffrey H. Kordower

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Nerve growth factor receptor immunoreactivity within the nucleus basalis (Ch4) in Parkinson's disease: reduced cell numbers and co-localization with cholinergic neurons, Elliott J. Mufson, Lesa N. Presley, and Jeffrey H. Kordower

Submissions from 1990

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Processing of prosomatostatin, Robert Benoit, Frederick Esch, Hugh P.J. Bennett, Nicholas Ling, Mariella Ravazzola, Lelio Orci, and Elliott J. Mufson

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Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease, William C. Benzing, Elliott J. Mufson, Lothar Jennes, and David M. Armstrong

Kinetics of hydrolysis of endocytosed substrates by mammalian cultured cells: Early introduction of lysosomal enzymes into the endocytic pathway, Robert Bowser and Robert F. Murphy

Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains, J R. Connor, S L. Menzies, S M. St Martin, and E J. Mufson

Recurrent Inhibition To And From Motoneurons Innervating The Flexor Digitorum And Flexor Hallacis Longus Muscles Of The Cat, T. H. Hamm

Phase space topography and the Lyapunov exponent of electrocorticograms in partial seizures, L D. Iasemidis, J C. Sackellares, H P. Zaveri, and W J. Williams

Galanin-like immunoreactivity within the primate basal forebrain: differential staining patterns between humans and monkeys, J H. Kordower and E J. Mufson

Heterogeneity Of High-Affinity Nicotinic [3H]Acetylcholine Binding Sites, R. J. Lukas

Interactions Of The Thymic Polypeptide Hormone Thymopoietin With Neuronal Nicotinic α-Bungarotoxin Binding Sites And With Muscle-Type But Not Ganglia-Type Nicotinic Acetylcholine Receptor Ligand-Gated Ion Channels, R. J. Lukas, T. Audhya, G. Goldstein, and L. Lucero

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Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry in the hippocampal formation of the new world monkey (Saimiri sciureus), Elliott J. Mufson, Daniel R. Brady, and Russell G. Carey

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Tracing neuronal connections in postmortem human hippocampal complex with the carbocyanine dye DiI, Elliott J. Mufson, Daniel R. Brady, and Jeffrey H. Kordower

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Demonstrating immune-related antigens in Alzheimer's disease brain tissue, Joseph Rogers and Elliott J. Mufson

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Epidermal growth factor receptor expression in demented and aged human brain, Scot D. Styren, Elliot J. Mufson, Gisele C. Styren, W. Harold Civin, and Joseph Rogers

Submissions from 1989

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The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects, Larry I. Benowitz, William Rodriguez, Peter Paskevich, Elliott J. Mufson, Dale Schenk, and Rachael L. Neve

The structure of avian type XII collagen. Alpha 1 (XII) chains contain 190-kDa non-triple helical amino-terminal domains and form homotrimeric molecules., B Dublet, S Oh, S P Sugrue, M K Gordon, D R Gerecke, B R Olsen, and M van der Rest

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NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease, Gerald A. Higgins and Elliott J. Mufson

Ground release SF6 tracer experiments used to characterize transport and dispersion of atmospheric pollutants during the Southern California air quality study of 1987, Robin Scott Horrell, Michael Deem, Peter Wyckoff, Fred Shair, and Neil Crawford

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NGF and Alzheimer's disease: Unfulfilled promise and untapped potential, Jeffrey H. Kordower and Elliott J. Mufson

Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients, J H. Kordower, D M. Gash, M Bothwell, L Hersh, and E J. Mufson

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Tau in situ hybridization in normal and alzheimer brain: Localization in the somatodendritic compartment, Kenneth S. Kosik, James E. Crandall, Elliott J. Mufson, and Rachael L. Neve

Nicotinic Acetylcholine Receptor Diversity: Agonist Binding And Functional Potency, Ronald J. Lukas

Nerve growth factor receptor expressing human basal forebrain neurons: pathologic alterations in Alzheimer's and Parkinson's disease, E J. Mufson and J H. Kordower

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Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons, Elliott J. Mufson, Mark Bothwell, Louis B. Hersh, and Jeffrey H. Kordower

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Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain, Elliott J. Mufson, Mark Bothwell, and Jeffrey H. Kordower

Characterization Of Nicotinic Acetylcholine Receptor Channels Of The Te671 Human Medulloblastoma Clonal Line, Robert E. Oswald, Roger L. Papke, and Ronald J. Lukas

On The Function Of Muscle And Reflex Partitioning, Uwe Windhorst, Thomas M. Hamm, and Douglas G. Stuart

Submissions from 1988

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Localization of choline acetyltransferase to somata of posterior lateral line efferents in the goldfish, Paul D. Danielson, Steven J. Zottoli, J. Gregory Corrodi, Kenneth J. Rhodes, and Elliott J. Mufson

Association Between Biochemical And Physiological Properties In Single Motor Units, Thomas M. Hamm, Patti M. Nemeth, Lata Solanki, Debra A. Gordon, Robert M. Reinking, and Douglas G. Stuart

Modelling of ECoG in temporal lobe epilepsy, L D. Iasemidis, H P. Zaveri, J C. Sackellares, and W J. Williams

Modulation of type III collagen synthesis in bovine corneal endothelial cells., E P Kay and S Oh

An Isotopic Rubidium Ion Efflux Assay For The Functional Characterization Of Nicotinic Acetylcholine Receptors On Clonal Cell Lines, Ronald J. Lukas and Mary Jane Cullen

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Immunohistochemical evidence for a possible somatostatin-containing amygdalostriatal pathway in normal and Alzheimer's disease brain, E. J. Mufson, Robert Benoit, and M. M. Mesulam

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Observations on choline acetyltransferase containing structures in the CD-1 mouse brain, Elliott J. Mufson and Miles G. Cunningham

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Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease, Elliott J. Mufson, Deborah C. Mash, and Louis B. Hersh

Morphological And Biochemical Differentiation Of The Human Medulloblastoma Cell Line Te671, Hal N. Siegel and Ronald J. Lukas

Nicotinic Agonists Regulate တBungarotoxin Binding Sites Of Te671 Human Medulloblastoma Cells, Hal N. Siegel and Ronald J. Lukas

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Putative cholinergic projections from the nucleus isthmi and the nucleus reticularis mesencephali to the optic tectum in the goldfish (Carassius auratus), Steven J. Zottoli, Kenneth J. Rhodes, J. Gregory Corrodi, and Elliott J. Mufson

Submissions from 1987

Colchicine reverts cell shape but not collagen phenotypes in corneal endothelial cells modulated by polymorphonuclear leukocytes., E P Kay and S Oh

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Neural inputs into the temporopolar cortex of the rhesus monkey, M. A. Morán, E. J. Mufson, and M. ‐M Mesulam

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Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons, E. J. Mufson, A. D. Kehr, B. H. Wainer, and M. M. Mesulam

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Morphologic features of embryonic neocortex grafts in adult rats following frontal cortical ablation, E. J. Mufson, R. Labbe, and D. G. Stein

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes, Mario Roederer, Robert Bowser, and Robert F. Murphy

Morphological and behavioral characteristics of embryonic brain tissue transplants in adults, brain-damaged subjects, D G. Stein and E J. Mufson

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Comparison of acetylcholinesterase and choline acetyltransferase staining patterns in the optic tectum of the goldfish carassius auratus: A histochemical and immunocytochemical analysis, Steven J. Zottoli, Kenneth J. Rhodes, and Elliott J. Mufson

Submissions from 1986

Characterization Of Curaremimetic Neurotoxin Binding Sites On Cellular Membrane Fragments Derived From The Rat Pheochromocytoma Pc 12, Ronald J. Lukas

Characterization Of Curaremimetic Neurotoxin Binding Sites On Membrane Fractions Derived From The Human Medulloblastoma Clonal Line Te671, Ronald J. Lukas

Interactions Of Anti-Nicotinic Acetylcholine Receptor Antibodies At α-Bungarotoxin Binding Sites Across Species And Tissues, Ronald J. Lukas

Interactions Of Antinicotinic Acetylcholine Receptor Antibodies With Rat Brain And Muscle Antigenic Determinants, Ronald J. Lukas

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Three-dimensional representation and cortical projection topography of the nucleus basalis (Ch4) in the macaque: concurrent demonstration of choline acetyltransferase and retrograde transport with a stabilized tetramethylbenzidine method for horseradish peroxidase, M. Marsel Mesulam, Elliott J. Mufson, and Bruce H. Wainer

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Systematic regional differences in the cholinergic innervation of the primate cerebral cortex: Distribution of enzyme activities and some behavioral implications, M. ‐Marsel Mesulam, Ladislav Volicer, Judith K. Marquis, Elliott J. Mufson, and Robert C. Green

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Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry, E. J. Mufson, T. L. Martin, D. C. Mash, B. H. Wainer, and M. M. Mesulam

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Choline acetyltransferase immunohistochemical staining in the goldfish (Carassius auratus) brain: Evidence that the Mauthner cell does not contain choline acetyltransferase, Kenneth J. Rhodes, Steven J. Zottoli, and Elliott J. Mufson

Submissions from 1985

Cholinergic and non-cholinergic septohippocampal pathways, B H. Wainer, A I. Levey, D B. Rye, M M. Mesulam, and E J. Mufson

Submissions from 1984

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Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons, A. I. Levey, B. H. Wainer, D. B. Rye, E. J. Mufson, and M. M. Mesulam

Detection Of Low-Affinity α-Bungarotoxin Binding Sites In The Rat Central Nervous System, Ronald J. Lukas

Monoclonal Rat Anti-Torpedo Electroplax Nicotinic Acetylcholine Receptor Antibodies: Immunochemical Characterization, Ronald J. Lukas

Properties Of Curaremimetic Neurotoxin Binding Sites In The Rat Central Nervous System, Ronald J. Lukas

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The light side of horseradish peroxidase histochemistry., T. L. Martin, E. J. Mufson, and M. M. Mesulam

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Neural inputs into the nucleus basalis of the substantia innominata (ch4) in the rhesus monkey, M. Marsel Mesulam and Elliott J. Mufson

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Regional variations in cortical cholinergic innervation: Chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain, M. Marsel Mesulam, Anna D. Rosen, and Elliott J. Mufson

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Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry, M. M. Mesulam, E. J. Mufson, A. I. Levey, and B. H. Wainer

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Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans), E. J. Mufson, P. H. Desan, M. M. Mesulam, B. H. Wainer, and A. I. Levey

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Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus, Elliott J. Mufson and M. Marsel Mesulam

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Some observations on the course and composition of the cingulum bundle in the rhesus monkey, Elliott J. Mufson and Deepak N. Pandya