The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 1992

The mouse α1(XII) and human α1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6, Suk P. Oh, Reginald W. Taylor, Donald R. Gerecke, Julie M. Rochelle, Michael F. Seldin, and Bjorn R. Olsen

SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast, Marc Potenza, Robert Bowser, Heike Müller, and Peter Novick

Time-frequency representation of electrocorticograms in temporal lobe epilepsy, H P. Zaveri, W J. Williams, L D. Iasemidis, and J C. Sackellares

Submissions from 1991

Differential Regulation Of Nicotinic Acetylcholine Receptor Expression By Human Te671/Rd Cells Following Second Messenger Modulation And Sodium Butyrate Treatments, Merouane Bencherif and Ronald J. Lukas

Differential Sensitivity Of Phosphoinositide Metabolism To Sodium Fluoride And Carbachol Treatments In Pc12 Cells, Merouane Bencherif and Ronald J. Lukas

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Sec15 protein, an essential component of the exocytotic apparatis, is associated with the plasma membrane and with a soluble 19.5S particle, R. Bowser and P. Novick

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Alz‐50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease, Daniel R. Brady and Elliott J. Mufson

Effects Of Chronic Nicotinic Ligand Exposure On Functional Activity Of Nicotinic Acetylcholine Receptors Expressed By Cells Of The Pc12 Rat Pheochromocytoma Or The Te671/Rd Human Clonal Line, Ronald J. Lukas

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Nerve growth factor receptor immunoreactivity in the new world monkey (Cebus apella) and human cerebellum, Elliott J. Mufson, Gerald A. Higgins, and Jeffrey H. Kordower

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Nerve growth factor receptor immunoreactivity within the nucleus basalis (Ch4) in Parkinson's disease: reduced cell numbers and co-localization with cholinergic neurons, Elliott J. Mufson, Lesa N. Presley, and Jeffrey H. Kordower

Submissions from 1990

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Processing of prosomatostatin, Robert Benoit, Frederick Esch, Hugh P.J. Bennett, Nicholas Ling, Mariella Ravazzola, Lelio Orci, and Elliott J. Mufson

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Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease, William C. Benzing, Elliott J. Mufson, Lothar Jennes, and David M. Armstrong

Kinetics of hydrolysis of endocytosed substrates by mammalian cultured cells: Early introduction of lysosomal enzymes into the endocytic pathway, Robert Bowser and Robert F. Murphy

Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains, J R. Connor, S L. Menzies, S M. St Martin, and E J. Mufson

Recurrent Inhibition To And From Motoneurons Innervating The Flexor Digitorum And Flexor Hallacis Longus Muscles Of The Cat, T. H. Hamm

Phase space topography and the Lyapunov exponent of electrocorticograms in partial seizures, L D. Iasemidis, J C. Sackellares, H P. Zaveri, and W J. Williams

Galanin-like immunoreactivity within the primate basal forebrain: differential staining patterns between humans and monkeys, J H. Kordower and E J. Mufson

Heterogeneity Of High-Affinity Nicotinic [3H]Acetylcholine Binding Sites, R. J. Lukas

Interactions Of The Thymic Polypeptide Hormone Thymopoietin With Neuronal Nicotinic α-Bungarotoxin Binding Sites And With Muscle-Type But Not Ganglia-Type Nicotinic Acetylcholine Receptor Ligand-Gated Ion Channels, R. J. Lukas, T. Audhya, G. Goldstein, and L. Lucero

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Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry in the hippocampal formation of the new world monkey (Saimiri sciureus), Elliott J. Mufson, Daniel R. Brady, and Russell G. Carey

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Tracing neuronal connections in postmortem human hippocampal complex with the carbocyanine dye DiI, Elliott J. Mufson, Daniel R. Brady, and Jeffrey H. Kordower

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Demonstrating immune-related antigens in Alzheimer's disease brain tissue, Joseph Rogers and Elliott J. Mufson

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Epidermal growth factor receptor expression in demented and aged human brain, Scot D. Styren, Elliot J. Mufson, Gisele C. Styren, W. Harold Civin, and Joseph Rogers

Submissions from 1989

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The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects, Larry I. Benowitz, William Rodriguez, Peter Paskevich, Elliott J. Mufson, Dale Schenk, and Rachael L. Neve

The structure of avian type XII collagen. Alpha 1 (XII) chains contain 190-kDa non-triple helical amino-terminal domains and form homotrimeric molecules., B Dublet, S Oh, S P Sugrue, M K Gordon, D R Gerecke, B R Olsen, and M van der Rest

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NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease, Gerald A. Higgins and Elliott J. Mufson

Ground release SF6 tracer experiments used to characterize transport and dispersion of atmospheric pollutants during the Southern California air quality study of 1987, Robin Scott Horrell, Michael Deem, Peter Wyckoff, Fred Shair, and Neil Crawford

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NGF and Alzheimer's disease: Unfulfilled promise and untapped potential, Jeffrey H. Kordower and Elliott J. Mufson

Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients, J H. Kordower, D M. Gash, M Bothwell, L Hersh, and E J. Mufson

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Tau in situ hybridization in normal and alzheimer brain: Localization in the somatodendritic compartment, Kenneth S. Kosik, James E. Crandall, Elliott J. Mufson, and Rachael L. Neve

Nicotinic Acetylcholine Receptor Diversity: Agonist Binding And Functional Potency, Ronald J. Lukas

Nerve growth factor receptor expressing human basal forebrain neurons: pathologic alterations in Alzheimer's and Parkinson's disease, E J. Mufson and J H. Kordower

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Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons, Elliott J. Mufson, Mark Bothwell, Louis B. Hersh, and Jeffrey H. Kordower

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Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain, Elliott J. Mufson, Mark Bothwell, and Jeffrey H. Kordower

Characterization Of Nicotinic Acetylcholine Receptor Channels Of The Te671 Human Medulloblastoma Clonal Line, Robert E. Oswald, Roger L. Papke, and Ronald J. Lukas

On The Function Of Muscle And Reflex Partitioning, Uwe Windhorst, Thomas M. Hamm, and Douglas G. Stuart

Submissions from 1988

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Localization of choline acetyltransferase to somata of posterior lateral line efferents in the goldfish, Paul D. Danielson, Steven J. Zottoli, J. Gregory Corrodi, Kenneth J. Rhodes, and Elliott J. Mufson

Association Between Biochemical And Physiological Properties In Single Motor Units, Thomas M. Hamm, Patti M. Nemeth, Lata Solanki, Debra A. Gordon, Robert M. Reinking, and Douglas G. Stuart

Modelling of ECoG in temporal lobe epilepsy, L D. Iasemidis, H P. Zaveri, J C. Sackellares, and W J. Williams

Modulation of type III collagen synthesis in bovine corneal endothelial cells., E P Kay and S Oh

An Isotopic Rubidium Ion Efflux Assay For The Functional Characterization Of Nicotinic Acetylcholine Receptors On Clonal Cell Lines, Ronald J. Lukas and Mary Jane Cullen

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Immunohistochemical evidence for a possible somatostatin-containing amygdalostriatal pathway in normal and Alzheimer's disease brain, E. J. Mufson, Robert Benoit, and M. M. Mesulam

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Observations on choline acetyltransferase containing structures in the CD-1 mouse brain, Elliott J. Mufson and Miles G. Cunningham

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Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease, Elliott J. Mufson, Deborah C. Mash, and Louis B. Hersh

Morphological And Biochemical Differentiation Of The Human Medulloblastoma Cell Line Te671, Hal N. Siegel and Ronald J. Lukas

Nicotinic Agonists Regulate တBungarotoxin Binding Sites Of Te671 Human Medulloblastoma Cells, Hal N. Siegel and Ronald J. Lukas

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Putative cholinergic projections from the nucleus isthmi and the nucleus reticularis mesencephali to the optic tectum in the goldfish (Carassius auratus), Steven J. Zottoli, Kenneth J. Rhodes, J. Gregory Corrodi, and Elliott J. Mufson

Submissions from 1987

Colchicine reverts cell shape but not collagen phenotypes in corneal endothelial cells modulated by polymorphonuclear leukocytes., E P Kay and S Oh

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Neural inputs into the temporopolar cortex of the rhesus monkey, M. A. Morán, E. J. Mufson, and M. ‐M Mesulam

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Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons, E. J. Mufson, A. D. Kehr, B. H. Wainer, and M. M. Mesulam

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Morphologic features of embryonic neocortex grafts in adult rats following frontal cortical ablation, E. J. Mufson, R. Labbe, and D. G. Stein

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes, Mario Roederer, Robert Bowser, and Robert F. Murphy

Morphological and behavioral characteristics of embryonic brain tissue transplants in adults, brain-damaged subjects, D G. Stein and E J. Mufson

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Comparison of acetylcholinesterase and choline acetyltransferase staining patterns in the optic tectum of the goldfish carassius auratus: A histochemical and immunocytochemical analysis, Steven J. Zottoli, Kenneth J. Rhodes, and Elliott J. Mufson

Submissions from 1986

Characterization Of Curaremimetic Neurotoxin Binding Sites On Cellular Membrane Fragments Derived From The Rat Pheochromocytoma Pc 12, Ronald J. Lukas

Characterization Of Curaremimetic Neurotoxin Binding Sites On Membrane Fractions Derived From The Human Medulloblastoma Clonal Line Te671, Ronald J. Lukas

Interactions Of Anti-Nicotinic Acetylcholine Receptor Antibodies At α-Bungarotoxin Binding Sites Across Species And Tissues, Ronald J. Lukas

Interactions Of Antinicotinic Acetylcholine Receptor Antibodies With Rat Brain And Muscle Antigenic Determinants, Ronald J. Lukas

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Three-dimensional representation and cortical projection topography of the nucleus basalis (Ch4) in the macaque: concurrent demonstration of choline acetyltransferase and retrograde transport with a stabilized tetramethylbenzidine method for horseradish peroxidase, M. Marsel Mesulam, Elliott J. Mufson, and Bruce H. Wainer

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Systematic regional differences in the cholinergic innervation of the primate cerebral cortex: Distribution of enzyme activities and some behavioral implications, M. ‐Marsel Mesulam, Ladislav Volicer, Judith K. Marquis, Elliott J. Mufson, and Robert C. Green

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Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry, E. J. Mufson, T. L. Martin, D. C. Mash, B. H. Wainer, and M. M. Mesulam

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Choline acetyltransferase immunohistochemical staining in the goldfish (Carassius auratus) brain: Evidence that the Mauthner cell does not contain choline acetyltransferase, Kenneth J. Rhodes, Steven J. Zottoli, and Elliott J. Mufson

Submissions from 1985

Cholinergic and non-cholinergic septohippocampal pathways, B H. Wainer, A I. Levey, D B. Rye, M M. Mesulam, and E J. Mufson

Submissions from 1984

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Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons, A. I. Levey, B. H. Wainer, D. B. Rye, E. J. Mufson, and M. M. Mesulam

Detection Of Low-Affinity α-Bungarotoxin Binding Sites In The Rat Central Nervous System, Ronald J. Lukas

Monoclonal Rat Anti-Torpedo Electroplax Nicotinic Acetylcholine Receptor Antibodies: Immunochemical Characterization, Ronald J. Lukas

Properties Of Curaremimetic Neurotoxin Binding Sites In The Rat Central Nervous System, Ronald J. Lukas

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The light side of horseradish peroxidase histochemistry., T. L. Martin, E. J. Mufson, and M. M. Mesulam

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Neural inputs into the nucleus basalis of the substantia innominata (ch4) in the rhesus monkey, M. Marsel Mesulam and Elliott J. Mufson

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Regional variations in cortical cholinergic innervation: Chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain, M. Marsel Mesulam, Anna D. Rosen, and Elliott J. Mufson

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Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry, M. M. Mesulam, E. J. Mufson, A. I. Levey, and B. H. Wainer

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Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans), E. J. Mufson, P. H. Desan, M. M. Mesulam, B. H. Wainer, and A. I. Levey

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Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus, Elliott J. Mufson and M. Marsel Mesulam

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Some observations on the course and composition of the cingulum bundle in the rhesus monkey, Elliott J. Mufson and Deepak N. Pandya

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Cortical projections arising from the basal forebrain: A study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase, D. B. Rye, B. H. Wainer, M. M. Mesulam, E. J. Mufson, and C. B. Saper

Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase, B H. Wainer, A I. Levey, E J. Mufson, and M M. Mesulam

Submissions from 1983

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Fetal brain transplants: Reduction of cognitive deficits in rats with frontal cortex lesions, Randy Labbe, Arhur Firl, Elliott J. Mufson, and Donald G. Stein

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Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum, A. I. Levey, B. H. Wainer, E. J. Mufson, and M. M. Mesulam

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Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey, M. ‐Marsel Mesulam, Elliott J. Mufson, Allan I. Levey, and Bruce H. Wainer

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Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6), M. M. Mesulam, E. J. Mufson, B. H. Wainer, and A. I. Levey

Submissions from 1982

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Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain, M. ‐Marsel Mesulam and Elliott J. Mufson

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Insula of the old world monkey. III: Efferent cortical output and comments on function, M. ‐Marsel Mesulam and Elliott J. Mufson

Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain, M M. Mesulam and E J. Mufson

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Insula of the old world monkey. II: Afferent cortical input and comments on the claustrum, Elliott J. Mufson and M. ‐Marsel Mesulam

Biomechanical assessment of anchored cervical interbody cages: Comparison of 2-screw and 4-screw designs, Marco T. Reis, Phillip M. Reyes, and Neil R. Crawford

Submissions from 1981

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Insular interconnections with the amygdala in the rhesus monkey, E. J. Mufson, M. M. Mesulam, and D. N. Pandya

Submissions from 1980

Additional factors influencing sensitivity in the tetramethyl benzidine method for horseradish peroxidase neurohistochemistry, M M. Mesulam, E Hegarty, H Barbas, K A. Carson, E C. Gower, A G. Knapp, M B. Moss, and E J. Mufson

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The rapid anterograde transport of horseradish peroxidase, M. M. Mesulam and E. J. Mufson

Pathways disrupted in aphagia and adipsia following diencephalic damage, E J. Mufson

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Fiber degeneration associated with hyperphagia-inducing knife cuts in the hypothalamus, Elliott J. Mufson, Anthony Sclafani, and Paul F. Aravich

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Degeneration in the spinal cord of old rats, Elliott J. Mufson and Donald G. Stein

Submissions from 1979

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Tumor induced brain damage in rats: Implications for behavioral and anatomical studies with aging animals, Donald G. Stein and Elliott J. Mufson

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Spinal cord projections from the medial cerebellar nucleus in tree shrew Tupaia glis, Carolyn B. Ware and Elliott J. Mufson

Submissions from 1976

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Tail pinch-induced arousal and stimulus-bound behavior in rats with lateral hypothalamic lesions: Further evaluation of hypothalamic control of feeding and drinking, Elliott J. Mufson, S. Balagura, and W. Riss

Submissions from 1972

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Weight regulation with palatable food and liquids in rats with lateral hypothalamic lesions, Elliott J. Mufson and Richard S. Wampler