The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 1993
Characterization Of Nicotinic Acetylcholine Receptors Expressed By Cells Of The Sh-Sy5Y Human Neuroblastoma Clonal Line, Ronald J. Lukas, Sylvia A. Norman, and Linda Lucero
Colocalization of cholinesterases with β amyloid protein in aged and Alzheimer's brains, M. A. Morán, E. J. Mufson, and P. Gómez-Ramos
Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome, E. J. Mufson, E. Cochran, W. Benzing, and J. H. Kordower
The cycle of SEC4 function in vesicular transport., P. Novick, P. Brennwald, N. C. Walworth, A. K. Kabcenell, M. Garrett, M. Moya, D. Roberts, H. Müller, B. Govindan, and R. Bowser
Tissue‐specific expression of type XII collagen during mouse embryonic development, Suk Paul Oh, C. May Griffith, Elizabeth D. Hay, and Bjorn R. Olsen
Basic Fibroblast Growth Factor (Bfgf) Regulates Tyrosine Hydroxylase And Proenkephalin Mrna Levels In Adrenal Chromaffin Cells, Elzbieta Puchacz, Ewa K. Stachowiak, Robert Z. Florkiewicz, Ronald J. Lukas, and Michal K. Stachowiak
Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin, Scot D. Styren, Steven T. DeKosky, Joseph Rogers, and Elliott J. Mufson
Ascending cholinergic pathways: Functional organization and implications for disease models, Bruce H. Wainer, Teresa L. Steininger, John D. Roback, Melanie A. Burke-Watson, Elliott J. Mufson, and Jeffrey Kordower
Cytogenetic and molecular analysis in Angelman syndrome., J L Zackowski, R D Nicholls, B A Gray, A Bent-Williams, W Gottlieb, P J Harris, M F Waters, D J Driscoll, R T Zori, and C A Williams
Submissions from 1992
Vanadate Amplifies Receptor-Mediated Accumulation Of Inositol Trisphosphates And Inhibits Inositol Tris- And Tetrakis-Phosphatase Activities, Merouane Bencherif and Ronald J. Lukas
Distribution of neurotensin immunoreactivity within the human amygdaloid complex: A comparison with acetylcholinesterase‐ and Nissl‐stained tissue sections, William C. Benzing, Elliott J. Mufson, Lothar Jennes, Edward G. Stopa, and David M. Armstrong
Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis, R. Bowser, H. Muller, B. Govindan, and P. Novick
A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains, J. R. Connor, S. L. Menzies, S. M. St. Martin, and E. J. Mufson
Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease, J. R. Connor, B. S. Snyder, J. L. Beard, R. E. Fine, and E. J. Mufson
A DNA methylation imprint, determined by the sex of the parent, distinguishes the Angelman and Prader-Willi syndromes., D J Driscoll, M F Waters, C A Williams, R T Zori, C C Glenn, K M Avidano, and R D Nicholls
A 5€²-Flanking Region Of The Bovine Tyrosine Hydroxylase Gene Is Involved In Cell-Specific Expression Activation Of Gene Transcription By Phorbol Ester And Transactivation By C-Fos And C-Jun, A. Goc, S. A. Norman, E. Puchacz, E. K. Stachowiak, R. J. Lukas, and M. K. Stachowiak
Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain, P. Gomez-Ramos, E. J. Mufson, and M. A. Moran
Galanin immunoreactivity in the primate central nervous system, Jeffrey H. Kordower, Hieu K. Le, and Elliott J. Mufson
NGF receptor (p75)-immunoreactivity within hypoglossal motor neurons following axotomy in monkeys, J H. Kordower, K S. Bankiewicz, and E J. Mufson
Nerve growth factor receptor-immunoreactive neurons within the developing human cortex, J H. Kordower and E J. Mufson
Heterogeneity And Regulation Of Nicotinic Acetylcholine Receptors, Ronald J. Lukas and Merouane Bencherif
Recurrent Collaterals Of Motoneurons Projecting To Distal Muscles In The Cat Hindlimb, M. L. McCurdy and T. M. Hamm
Diagnosis of Alzheimer's disease. Evaluation of senile plaques of the diffuse type, M. A. Morán, J. L. Cebrián, P. Gómez-Ramos, A. Cabello, S. Madero, and E. J. Mufson
Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease, E. J. Mufson and J. H. Kordower
p75 Nerve growth factor receptor immunoreactivity in the human brainstem and spinal cord, Elliott J. Mufson, Thomas Brashers-Krug, and Jeffrey H. Kordower
The mouse α1(XII) and human α1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6, Suk P. Oh, Reginald W. Taylor, Donald R. Gerecke, Julie M. Rochelle, Michael F. Seldin, and Bjorn R. Olsen
SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast, Marc Potenza, Robert Bowser, Heike Müller, and Peter Novick
Time-frequency representation of electrocorticograms in temporal lobe epilepsy, H P. Zaveri, W J. Williams, L D. Iasemidis, and J C. Sackellares
Submissions from 1991
Differential Regulation Of Nicotinic Acetylcholine Receptor Expression By Human Te671/Rd Cells Following Second Messenger Modulation And Sodium Butyrate Treatments, Merouane Bencherif and Ronald J. Lukas
Differential Sensitivity Of Phosphoinositide Metabolism To Sodium Fluoride And Carbachol Treatments In Pc12 Cells, Merouane Bencherif and Ronald J. Lukas
Sec15 protein, an essential component of the exocytotic apparatis, is associated with the plasma membrane and with a soluble 19.5S particle, R. Bowser and P. Novick
Alz‐50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease, Daniel R. Brady and Elliott J. Mufson
Nerve growth factor receptor immunoreactivity in the new world monkey (Cebus apella) and human cerebellum, Elliott J. Mufson, Gerald A. Higgins, and Jeffrey H. Kordower
Nerve growth factor receptor immunoreactivity within the nucleus basalis (Ch4) in Parkinson's disease: reduced cell numbers and co-localization with cholinergic neurons, Elliott J. Mufson, Lesa N. Presley, and Jeffrey H. Kordower
Submissions from 1990
Processing of prosomatostatin, Robert Benoit, Frederick Esch, Hugh P.J. Bennett, Nicholas Ling, Mariella Ravazzola, Lelio Orci, and Elliott J. Mufson
Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease, William C. Benzing, Elliott J. Mufson, Lothar Jennes, and David M. Armstrong
Kinetics of hydrolysis of endocytosed substrates by mammalian cultured cells: Early introduction of lysosomal enzymes into the endocytic pathway, Robert Bowser and Robert F. Murphy
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains, J R. Connor, S L. Menzies, S M. St Martin, and E J. Mufson
Phase space topography and the Lyapunov exponent of electrocorticograms in partial seizures, L D. Iasemidis, J C. Sackellares, H P. Zaveri, and W J. Williams
Galanin-like immunoreactivity within the primate basal forebrain: differential staining patterns between humans and monkeys, J H. Kordower and E J. Mufson
Heterogeneity Of High-Affinity Nicotinic [3H]Acetylcholine Binding Sites, R. J. Lukas
Interactions Of The Thymic Polypeptide Hormone Thymopoietin With Neuronal Nicotinic α-Bungarotoxin Binding Sites And With Muscle-Type But Not Ganglia-Type Nicotinic Acetylcholine Receptor Ligand-Gated Ion Channels, R. J. Lukas, T. Audhya, G. Goldstein, and L. Lucero
Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry in the hippocampal formation of the new world monkey (Saimiri sciureus), Elliott J. Mufson, Daniel R. Brady, and Russell G. Carey
Tracing neuronal connections in postmortem human hippocampal complex with the carbocyanine dye DiI, Elliott J. Mufson, Daniel R. Brady, and Jeffrey H. Kordower
Demonstrating immune-related antigens in Alzheimer's disease brain tissue, Joseph Rogers and Elliott J. Mufson
Epidermal growth factor receptor expression in demented and aged human brain, Scot D. Styren, Elliot J. Mufson, Gisele C. Styren, W. Harold Civin, and Joseph Rogers
Submissions from 1989
The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects, Larry I. Benowitz, William Rodriguez, Peter Paskevich, Elliott J. Mufson, Dale Schenk, and Rachael L. Neve
The structure of avian type XII collagen. Alpha 1 (XII) chains contain 190-kDa non-triple helical amino-terminal domains and form homotrimeric molecules., B Dublet, S Oh, S P Sugrue, M K Gordon, D R Gerecke, B R Olsen, and M van der Rest
NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease, Gerald A. Higgins and Elliott J. Mufson
Ground release SF6 tracer experiments used to characterize transport and dispersion of atmospheric pollutants during the Southern California air quality study of 1987, Robin Scott Horrell, Michael Deem, Peter Wyckoff, Fred Shair, and Neil Crawford
NGF and Alzheimer's disease: Unfulfilled promise and untapped potential, Jeffrey H. Kordower and Elliott J. Mufson
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients, J H. Kordower, D M. Gash, M Bothwell, L Hersh, and E J. Mufson
Tau in situ hybridization in normal and alzheimer brain: Localization in the somatodendritic compartment, Kenneth S. Kosik, James E. Crandall, Elliott J. Mufson, and Rachael L. Neve
Nicotinic Acetylcholine Receptor Diversity: Agonist Binding And Functional Potency, Ronald J. Lukas
Nerve growth factor receptor expressing human basal forebrain neurons: pathologic alterations in Alzheimer's and Parkinson's disease, E J. Mufson and J H. Kordower
Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons, Elliott J. Mufson, Mark Bothwell, Louis B. Hersh, and Jeffrey H. Kordower
Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain, Elliott J. Mufson, Mark Bothwell, and Jeffrey H. Kordower
Characterization Of Nicotinic Acetylcholine Receptor Channels Of The Te671 Human Medulloblastoma Clonal Line, Robert E. Oswald, Roger L. Papke, and Ronald J. Lukas
On The Function Of Muscle And Reflex Partitioning, Uwe Windhorst, Thomas M. Hamm, and Douglas G. Stuart
Submissions from 1988
Localization of choline acetyltransferase to somata of posterior lateral line efferents in the goldfish, Paul D. Danielson, Steven J. Zottoli, J. Gregory Corrodi, Kenneth J. Rhodes, and Elliott J. Mufson
Association Between Biochemical And Physiological Properties In Single Motor Units, Thomas M. Hamm, Patti M. Nemeth, Lata Solanki, Debra A. Gordon, Robert M. Reinking, and Douglas G. Stuart
Modelling of ECoG in temporal lobe epilepsy, L D. Iasemidis, H P. Zaveri, J C. Sackellares, and W J. Williams
Modulation of type III collagen synthesis in bovine corneal endothelial cells., E P Kay and S Oh
An Isotopic Rubidium Ion Efflux Assay For The Functional Characterization Of Nicotinic Acetylcholine Receptors On Clonal Cell Lines, Ronald J. Lukas and Mary Jane Cullen
Immunohistochemical evidence for a possible somatostatin-containing amygdalostriatal pathway in normal and Alzheimer's disease brain, E. J. Mufson, Robert Benoit, and M. M. Mesulam
Observations on choline acetyltransferase containing structures in the CD-1 mouse brain, Elliott J. Mufson and Miles G. Cunningham
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease, Elliott J. Mufson, Deborah C. Mash, and Louis B. Hersh
Morphological And Biochemical Differentiation Of The Human Medulloblastoma Cell Line Te671, Hal N. Siegel and Ronald J. Lukas
Nicotinic Agonists Regulate α€Bungarotoxin Binding Sites Of Te671 Human Medulloblastoma Cells, Hal N. Siegel and Ronald J. Lukas
Putative cholinergic projections from the nucleus isthmi and the nucleus reticularis mesencephali to the optic tectum in the goldfish (Carassius auratus), Steven J. Zottoli, Kenneth J. Rhodes, J. Gregory Corrodi, and Elliott J. Mufson
Submissions from 1987
Colchicine reverts cell shape but not collagen phenotypes in corneal endothelial cells modulated by polymorphonuclear leukocytes., E P Kay and S Oh
Neural inputs into the temporopolar cortex of the rhesus monkey, M. A. Morán, E. J. Mufson, and M. ‐M Mesulam
Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons, E. J. Mufson, A. D. Kehr, B. H. Wainer, and M. M. Mesulam
Morphologic features of embryonic neocortex grafts in adult rats following frontal cortical ablation, E. J. Mufson, R. Labbe, and D. G. Stein
Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes, Mario Roederer, Robert Bowser, and Robert F. Murphy
Morphological and behavioral characteristics of embryonic brain tissue transplants in adults, brain-damaged subjects, D G. Stein and E J. Mufson
Comparison of acetylcholinesterase and choline acetyltransferase staining patterns in the optic tectum of the goldfish carassius auratus: A histochemical and immunocytochemical analysis, Steven J. Zottoli, Kenneth J. Rhodes, and Elliott J. Mufson
Submissions from 1986
Characterization Of Curaremimetic Neurotoxin Binding Sites On Cellular Membrane Fragments Derived From The Rat Pheochromocytoma Pc 12, Ronald J. Lukas
Characterization Of Curaremimetic Neurotoxin Binding Sites On Membrane Fractions Derived From The Human Medulloblastoma Clonal Line Te671, Ronald J. Lukas
Interactions Of Anti-Nicotinic Acetylcholine Receptor Antibodies At α-Bungarotoxin Binding Sites Across Species And Tissues, Ronald J. Lukas
Interactions Of Antinicotinic Acetylcholine Receptor Antibodies With Rat Brain And Muscle Antigenic Determinants, Ronald J. Lukas
Three-dimensional representation and cortical projection topography of the nucleus basalis (Ch4) in the macaque: concurrent demonstration of choline acetyltransferase and retrograde transport with a stabilized tetramethylbenzidine method for horseradish peroxidase, M. Marsel Mesulam, Elliott J. Mufson, and Bruce H. Wainer
Systematic regional differences in the cholinergic innervation of the primate cerebral cortex: Distribution of enzyme activities and some behavioral implications, M. ‐Marsel Mesulam, Ladislav Volicer, Judith K. Marquis, Elliott J. Mufson, and Robert C. Green
Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry, E. J. Mufson, T. L. Martin, D. C. Mash, B. H. Wainer, and M. M. Mesulam
Choline acetyltransferase immunohistochemical staining in the goldfish (Carassius auratus) brain: Evidence that the Mauthner cell does not contain choline acetyltransferase, Kenneth J. Rhodes, Steven J. Zottoli, and Elliott J. Mufson
Submissions from 1985
Cholinergic and non-cholinergic septohippocampal pathways, B H. Wainer, A I. Levey, D B. Rye, M M. Mesulam, and E J. Mufson
Submissions from 1984
Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons, A. I. Levey, B. H. Wainer, D. B. Rye, E. J. Mufson, and M. M. Mesulam
Detection Of Low-Affinity α-Bungarotoxin Binding Sites In The Rat Central Nervous System, Ronald J. Lukas
Monoclonal Rat Anti-Torpedo Electroplax Nicotinic Acetylcholine Receptor Antibodies: Immunochemical Characterization, Ronald J. Lukas
Properties Of Curaremimetic Neurotoxin Binding Sites In The Rat Central Nervous System, Ronald J. Lukas
The light side of horseradish peroxidase histochemistry., T. L. Martin, E. J. Mufson, and M. M. Mesulam
Neural inputs into the nucleus basalis of the substantia innominata (ch4) in the rhesus monkey, M. Marsel Mesulam and Elliott J. Mufson
Regional variations in cortical cholinergic innervation: Chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain, M. Marsel Mesulam, Anna D. Rosen, and Elliott J. Mufson
Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry, M. M. Mesulam, E. J. Mufson, A. I. Levey, and B. H. Wainer
Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans), E. J. Mufson, P. H. Desan, M. M. Mesulam, B. H. Wainer, and A. I. Levey
Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus, Elliott J. Mufson and M. Marsel Mesulam
Some observations on the course and composition of the cingulum bundle in the rhesus monkey, Elliott J. Mufson and Deepak N. Pandya