The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2000
Positron emission tomography study of pindolol occupancy of 5-HT(1A) receptors in humans: Preliminary analyses, Diana Martinez, Osama Mawlawi, Dah Ren Hwang, Justine Kent, Norman Simpson, Ramin V. Parsey, Tomoki Hashimoto, Mark Slifstein, Yiyun Huang, Ronald Van Heertum, Anissa Abi-Dargham, Stephen Caltabiano, Andrea Malizia, Hugh Cowley, J. John Mann, and Marc Laruelle
Landsat-4 attitude recovery and other experiences with aging landsat spacecraft, Prafulla K. Misra, Joseph Sedlak, Jim Gregory, Sonny Jones, Ron Smilek, Dave Lorenz, William N. Stewart, and Robert Bowser
Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment, T. W. Mitchell, J. Nissanov, L. Y. Han, E. J. Mufson, J. A. Schneider, E. J. Cochran, D. A. Bennett, V. M.Y. Lee, J. Q. Trojanowski, and S. E. Arnold
Galanin receptor plasticity within the nucleus basalis in early and late Alzheimer's disease: An in vitro autoradiographic analysis, E. J. Mufson, D. C. Deecher, M. Basile, S. Izenwasse, and D. C. Mash
Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's diseases, Elliott J. Mufson, Shuang Y. Ma, Elizabeth J. Cochran, David A. Bennett, Laural A. Beckett, Syed Jaffar, H. Uri Saragovi, and Jeffrey H. Kordower
Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis, S. Paul Oh, Tsugio Seki, Kendrick A. Goss, Takeshi Imamura, Youngsuk Yi, Patricia K. Donahoe, Li Li, Kohei Miyazono, Peter Ten Dijke, Seongjin Kim, and En Li
Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons, Gillian O'Meara, Urania Coumis, Shuang Y. Ma, Jan Kehr, Sally Mahoney, Andrea Bacon, Shelley J. Allen, Fiona Holmes, Ulrika Kahl, Fu H. Wang, Ian R. Kearns, Sven Ove-Ogren, David Dawbarn, Elliott J. Mufson, Ceri Davies, Gerard Dawson, and David Wynick
Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the adult trout and tract-tracing observations on the connections of the nuclei of the isthmus., S E Pérez, J Yáñez, O Marín, R Anadón, A González, and I Rodríguez-Moldes
Model of structural and functional adaptation of small conductance vessels to arterial hypotension, Christopher M. Quick, William L. Young, Edward F. Leonard, Shailendra Joshi, Gao Erzhen, and Tomoki Hashimoto
Molecular mechanisms of calcium-dependent excitotoxicity, Rita Sattler and Michael Tymianski
Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity, Rita Sattler, Zhigang Xiong, Wei Yang Lu, John F. MacDonald, and Michael Tymianski
Reduction in TrkA-immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome, T. J. Sendera, S. Y. Ma, S. Jaffar, P. B. Kozlowski, J. H. Kordower, Y. Mawal, H. U. Saragovi, and E. J. Mufson
Hyperthermic Spreading Depressions In The Immature Rat Hippocampal Slice, Jie Wu and Robert S. Fisher
2-Aminoethoxydiphenyl Borate Modulates Kinetics Of Intracellular Ca 2+ Signals Mediated By Inositol 145-Trisphosphate-Sensitive Ca 2+ Stores In Single Pancreatic Acinar Cells Of Mouse, Jie Wu, Noritaka Kamimura, Teruko Takeo, Sechiko Suga, Makoto Wakui, Takayuki Maruyama, and Katsuhiko Mikoshiba
Increase in spinal canal area after inverse laminoplasty: An anatomical study, Kemal Yücesoy and Neil R. Crawford
Submissions from 1999
The septin CDCrel-1 binds syntaxin and inhibits exocytosis, Crestina L. Beites, Hong Xie, Robert Bowser, and William S. Trimble
Immunocytochemical localization of the dopamine transporter in human brain, Brian J. Ciliax, Genny W. Drash, Julie K. Staley, Sharon Haber, Catherine J. Mobley, Gary W. Miller, Elliott J. Mufson, Deborah C. Mash, and Allan I. Levey
Differential biomechanical effects of injury and wiring at C1-C2, Neil R. Crawford, R. John Hurlbert, Won Gyu Choi, and Curtis A. Dickman
A new technique for determining 3-D joint angles: The tilt/twist method, Neil R. Crawford, Gary T. Yamaguchi, and Curtis A. Dickman
Radiographic grading for knee osteoarthritis. A revised scheme that relates to alignment and deformity., T Derek, V Cooke, B P Kelly, L Harrison, G Mohamed, and B Khan
Antidepressants Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function, John D. Fryer and Ronald J. Lukas
Noncompetitive Functional Inhibition At Diverse Human Nicotinic Acetylcholine Receptor Subtypes By Bupropion Phencyclidine And Ibogaine, John D. Fryer and Ronald J. Lukas
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease, Michelle L. Gilmor, Jeffrey D. Erickson, Hélène Varoqui, Louis B. Hersh, David A. Bennett, Elizabeth J. Cochran, Elliott J. Mufson, and Allan I. Levey
Correlations Between Neurograms And Locomotor Drive Potentials In Motoneurons During Fictive Locomotion: Implications For The Organization Of Locomotor Commands, T. M. Hamm, T. V. Trank, and V. V. Turkin
A biomechanical evaluation of occipitocervical instrumentation: Screw compared with wire fixation, R. John Hurlbert, Neil R. Crawford, Won Gyu Choi, and Curtis A. Dickman
DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation, Kelly L. Jordan-Sciutto, Joanna M. Dragich, and Robert Bowser
Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator, Kelly L. Jordan-Sciutto, Joanna M. Dragich, James L. Rhodes, and Robert Bowser
Increased cyclin G1 immunoreactivity during Alzheimer's disease, K. L. Jordan-Sciutto, K. Morgan, and R. Bowser
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease, Jeffrey H. Kordower, Stephane Palfi, Er Yun Chen, Shuang Y. Ma, Timothy Sendera, Elizabeth J. Cochran, Elliott J. Mufson, Richard Penn, Christopher G. Goetz, and Cynthia D. Comella
International Union Of Pharmacology. Xx. Current Status Of The Nomenclature For Nicotinic Acetylcholine Receptors And Their Subunits, Ronald J. Lukas, Jean Pierre Changeux, Nicolas Le Novère, Edson X. Albuquerque, David J.K. Balfour, Darwin K. Berg, Daniel Bertrand, Vincent A. Chiappinelli, Paul B.S. Clarke, Allan C. Collins, John A. Dani, Sharon R. Grady, Kenneth J. Kellar, Jon M. Lindstrom, Michael J. Marks, Maryka Quik, Palmer W. Taylor, and Susan Wonnacott
Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra, S. Y. Ma, B. J. Ciliax, G. Stebbins, S. Jaffar, J. N. Joyce, E. J. Cochran, J. H. Kordower, D. C. Mash, A. I. Levey, and E. J. Mufson
Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment, E. J. Mufson, E. Y. Chen, E. J. Cochran, L. A. Beckett, D. A. Bennett, and J. H. Kordower
Estrogen receptor immunoreactivity within subregions of the rat forebrain: Neuronal distribution and association with perikarya containing choline acetyltransferase, Elliott J. Mufson, Wei Jun Cai, Syed Jaffar, Er Yun Chen, Glenn Stebbins, Timothy Sendera, and Jeffrey H. Kordower
Distribution and retrograde transport of trophic factors in the central nervous system: Functional implications for the treatment of neurodegenerative diseases, Elliott J. Mufson, Jeffrey S. Kroin, Timothy J. Sendera, and Teresa Sobreviela
Inducible Heterologous Expression Of Human α7-Nicotinic Acetylcholine Receptors In A Native Nicotinic Receptor-Null Human Clonal Line, Jian Hong Peng, Linda Lucero, John Fryer, Jennifer Herl, Sherry S. Leonard, and Ronald J. Lukas
Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein, Rita Sattler, Zhigang Xiong, Wei Yang Lu, Mathias Hafner, John F. MacDonald, and Michael Tymianski
The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice, Jihwan Song, Suk P. Oh, Heinrich Schrewe, Masatoshi Nomura, Hong Lei, Makiko Okano, Thomas Gridley, and En Li
Honokiol and magnolol increase the number of [3H]muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites, Richard F. Squires, Jinglu Ai, Michael Robin Witt, Pia Kahnberg, Else Saederup, Olov Sterner, and Mogens Nielsen
Dynamic expression and cellular localization of the Drosophila 14-3-3ε during embryonic development, An Chi Tien, Hsin Yin Hsei, and Cheng Ting Chien
Organization Of Recurrent Inhibition And Facilitation In Motoneuron Pools Innervating Dorsiflexors Of The Cat Hindlimb, Tamara V. Trank, Vladimir V. Turkin, and Thomas M. Hamm
Stability of the craniovertebral junction after unilateral occipital condyle resection: A biomechanical study, A. Giancarlo Vishteh, Neil R. Crawford, M. Stephen Melton, Robert F. Spetzler, Volker K.H. Sonntag, and Curtis A. Dickman
Submissions from 1998
Expression of FAC1 in activated microglia during Alzheimer's disease, Robert Bowser and Shannon Reilly
Localization of a novel septin protein, hCDCrel-1, in neurons of human brain, John Caltagarone, James Rhodes, William G. Honer, and Robert Bowser
The spinal lax zone and neutral zone: Measurement techniques and parameter comparisons, Neil R. Crawford, Joseph D. Peles, and Curtis A. Dickman
Characterization and localization of galanin receptors in human entorhinal cortex, D. C. Deecher, D. C. Mash, J. K. Staley, and E. J. Mufson
Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys, Marina E. Emborg, Shuang Y. Ma, Elliott J. Mufson, Allan I. Levey, Michael D. Taylor, W. Douglas Brown, James E. Holden, and Jeffrey H. Kordower
Occlusion of the pilot tube in a Laser-Shield II endotracheal tube caused by methylene blue crystals: A case report, Tomoki Hashimoto and Valerie E. Armstead
Marked increases of aminotransferase levels after cresol ingestion, Tomoki Hashimoto, Hiroki Iida, and Shuji Dohi
Kinematics of the knee joint in deep flexion: a radiographic assessment., M S Hefzy, B P Kelly, and T D Cooke
Red Nucleus Stimulation Inhibits Within The Inferior Olive, K. M. Horn, T. M. Hamm, and A. R. Gibson
Endothelial cell dysfunction in response to intracellular overexpression of amyloid precursor protein, N. Jahroudi, J. Kitney, J. S. Greenberger, and R. Bowser
Alzheimer's disease and brain development: common molecular pathways., K. Jordan-Sciutto and R. Bowser
The presence of FAC1 protein in Hirano bodies, K. Jordan-Sciutto, J. Dragich, D. Walcott, and R. Bowser
Effects Of Chronic Nicotine Treatment On Expression Of Diverse Nicotinic Acetylcholine Receptor Subtypes. I. Dose- And Time-Dependent Effects Of Nicotine Treatment, Lei Ke, Cynthia M. Eisenhour, Merouane Bencherif, and Ronald J. Lukas
Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease, Jeffrey H. Kordower, Thomas B. Freeman, Er Yun Chen, Elliott J. Mufson, Paul R. Sanberg, Robert A. Hauser, Barry Snow, and C. Warren Olanow
Repression of enzymes of the pentose phosphate pathway by glucose in fission yeast, Shwetal Mehta, S. Velmurugan, and Zita Lobo
std1, a gene involved in glucose transport in Schizosaccharomyces pombe, Shwetal V. Mehta, Vandana B. Patil, S. Velmurugan, Zita Lobo, and Pabitra K. Maitra
m2 muscarinic acetylcholine receptor-immunoreactive neurons are not reduced within the nucleus basalis in Alzheimer's disease: relationship with cholinergic and galaninergic perikarya, E J. Mufson, S Jaffar, and A I. Levey
Galanin expression within the basal forebrain in Alzheimer's disease: Comments on therapeutic potential, Elliott J. Mufson, Ulrika Kahl, Robert Bowser, Deborah C. Mash, Jeffrey H. Kordower, and Darlene C. Deecher
Biomechanical comparison of C1-C2 posterior fixations. Cable, graft, and screw combinations, Sait Naderi, Neil R. Crawford, Geun Sung Song, Volker K.H. Sonntag, and Curtis A. Dickman
Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity, Rita Sattler, Milton P. Charlton, Mathias Hafner, and Michael Tymianski
Tyrosine kinase A, galanin and nitric oxide synthase within basal forebrain neurons in the rat, T Sobreviela, S Jaffar, and E J. Mufson
Immunohistochemical Localization Of Nicotinic β2 And α4 Receptor Subunits In Normal Human Brain And Individuals With Lewy Body And Alzheimer'S Disease: Preliminary Observations, D. Larry Sparks, Thomas G. Beach, and Ronald J. Lukas
Organization Of Recurrent Inhibition And Facilitation In Motor Nuclei Innervating Ankle Muscles Of The Cat, Vladimir V. Turkin, Katrina S. Monroe, and Thomas M. Hamm
Targeted intraparenchymal delivery of human NGF by gene transfer to the primate basal forebrain for 3 months does not accelerate β-amyloid plaque deposition, Mark H. Tuszynski, David E. Smith, Jeffrey Roberts, Heather McKay, and Elliott Mufson
Characterization Of Neuroprotection From Excitotoxicity By Moderate And Profound Hypothermia In Cultured Cortical Neurons Unmasks A Temperature- Insensitive Component Of Glutamate Neurotoxicity, Michael Tymianski, Rita Sattler, Joseph M. Zabramski, and Robert F. Spetzler
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300, Tso Pang Yao, Suk P. Oh, Miriam Fuchs, Nai Dong Zhou, Lian Ee Ch'ng, David Newsome, Roderick T. Bronson, En Li, David M. Livingston, and Richard Eckner
Submissions from 1997
The heteroyohimbine mayumbine binds with high affinity to rat brain benzodiazepine receptors in vitro, Jinglu Ai, Kim Dekermendjian, Mogens Nielsen, and Michael Robin Witt
6-Methylflavone, a benzodiazepine receptor ligand with antagonistic properties on rat brain and human recombinant GABA(A) receptors in vitro, Jinglu Ai, Kim Dekermendjian, Xiaomei Wang, Mogens Nielsen, and Michael Robin Witt
Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors, C Bäckman, G M. Rose, R T. Bartus, B J. Hoffer, E J. Mufson, and A C. Granholm
Furanocoumarins with affinity to brain benzodiazepine receptors in vitro, Ola Bergendorff, Kim Dekermendjian, Mogens Nielsen, Rudong Shan, Robin Witt, Jinglu Ai, and Olov Sterner
A confocal microscopic analysis of galaninergic hyperinnervation of cholinergic basal forebrain neurons in Alzheimer's disease, Robert Bowser, Jeffrey H. Kordower, and Elliott J. Mufson
Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain, D. R. Brady and E. J. Mufson
Biomechanical effects of transthoracic microdiscectomy, Guy G. Broc, Neil R. Crawford, Volker K.H. Sonntag, and Curtis A. Dickman
Non-linearity in invasive EEG recordings from patients with temporal lobe epilepsy, M C. Casdagli, L D. Iasemidis, R S. Savit, R L. Gilmore, S N. Roper, and J C. Sackellares
Construction of local vertebral coordinate systems using a digitizing probe: Technical note, Neil R. Crawford and Curtis A. Dickman
Plasticity of galaninergic fibers following neurotoxic damage within the rat basal forebrain: Initial observations, S. De Lacalle, S. Kulkarni, and E. J. Mufson
Comparative mechanical properties of spinal cable and wire fixation systems, Curtis A. Dickman, Stephen M. Papadopoulos, Neil R. Crawford, Anna G.U. Brantley, and Roy L. Gealer
Knee kinematics in-vivo of kneeling in deep flexion examined by bi-planar radiographs., M S Hefzy, B P Kelly, T D Cooke, A M al-Baddah, and L Harrison
The effect of overexpression of amyloid precursor protein in different cell types of vascular tissue, N. Jahroudi, J. Kitnev, J. S. Greenberger, and R. Bowser
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau, Gregory A. Jicha, Robert Bowser, Imrana G. Kazam, and Peter Davies
Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of huntington's disease, Jeffrey H. Kordower, Er Yun Chen, Christian Winkler, Rose Fricker, Vinod Charles, Albee Messing, Elliott J. Mufson, Shou C. Wong, Jeffrey M. Rosenstein, Anders Björklund, Dwaine F. Emerich, Joseph Hammang, and Melissa K. Carpenter
Cellular delivery of NGF does not alter the expression of β-amyloid immunoreactivity in young or aged nonhuman primates, Jeffrey H. Kordower, Elliott J. Mufson, Fox Nathan, Leena Martel, and Dwaine F. Emerich
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease, Allan I. Levey, Craig J. Heilman, James J. Lah, Norman R. Nash, Howard D. Rees, Masakazu Wakai, Suzanne S. Mirra, David B. Rye, David Nochlin, Thomas D. Bird, and Elliott J. Mufson
Connections of the hippocampal formation in humans: II. The endfolial fiber pathway, Chun Lim, Elliott J. Mufson, Jeffrey H. Kordower, Howard W. Blume, Joseph R. Madsen, and Clifford B. Saper
Reduction in p140-trkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease, Elliott J. Mufson, Natalie Lavine, Syed Jaffar, Jeffrey H. Kordower, Rémi Quirion, and H. Uri Saragovi
Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease, Elliott J. Mufson, J. M. Li, T. Sobreviela, and J. H. Kordower
FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord, Xiaojun Mu, Joe E. Springer, and Robert Bowser
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse, Suk P. Oh and En Li
Comparative pull-out strength of tapped and untapped pilot holes for bicortical anterior cervical screws, Juan F. Ronderos, Ronald Jacobowitz, Volker K.H. Sonntag, Neil R. Crawford, and Curtis A. Dickman
Determination of the time course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multiwell plate fluorescence scanner, Rita Sattler, Milton P. Charlton, Mathias Hafner, and Michael Tymianski
Expression of fetal ALZ-50 reactive Clone 1 (FAC1) in dentate gyrus following entorhinal cortex lesion, S. D. Styren, R. Bowser, and S. T. Dekosky
A novel use for a carbodiimide compound for the fixation of fluorescent and non-fluorescent calcium indicators in situ following physiological experiments, M. Tymianski, G. M. Bernstein, K. M. Abdel-Hamid, R. Sattler, A. Velumian, P. L. Carlen, H. Razavi, and O. T. Jones
Preparation, characterization and utility of a novel antibody for resolving the spatial and temporal dynamics of the calcium chelator BAPTA, M. Tymianski, R. Sattler, G. Bernstein, and O. T. Jones
The neuronal system of the saccus vasculosus of trout (Salmo trutta fario and Oncorhynchus mykiss): an immunocytochemical and nerve tracing study., J Yáñez, M Rodríguez, S Pérez, F Adrio, I Rodríguez-Moldes, M J Manso, and R Anadón
Submissions from 1996
Organisation of the cerebellar nucleus of the dogfish, Scyliorhinus canicula L.: a light microscopic, immunocytochemical, and ultrastructural study., R Alvarez-Otero, S E Perez, M A Rodriguez, and R Anadón
Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization, Robert Bowser
Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: Genotype analysis and relationships to neuropathological changes, Luc Buée, Jordi Pérez-Tur, Béatrice Leveugle, Valérie Buée-Scherrer, Elliott J. Mufson, Arthur J. Loerzel, Marie Christine Chartier-Harlin, Daniel P. Perl, André Delacourte, and Patrick R. Hof
Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate, Vinod Charles, Elliott J. Mufson, Phillip M. Friden, Raymond T. Bartus, and Jeffrey H. Kordower
TRK and p75 neurotrophin receptor systems in the developing human brain, E. R.Yun Chen, Elliott J. Mufson, and Jeffrey H. Kordower