The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 1999
Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment, E. J. Mufson, E. Y. Chen, E. J. Cochran, L. A. Beckett, D. A. Bennett, and J. H. Kordower
Estrogen receptor immunoreactivity within subregions of the rat forebrain: Neuronal distribution and association with perikarya containing choline acetyltransferase, Elliott J. Mufson, Wei Jun Cai, Syed Jaffar, Er Yun Chen, Glenn Stebbins, Timothy Sendera, and Jeffrey H. Kordower
Distribution and retrograde transport of trophic factors in the central nervous system: Functional implications for the treatment of neurodegenerative diseases, Elliott J. Mufson, Jeffrey S. Kroin, Timothy J. Sendera, and Teresa Sobreviela
Inducible Heterologous Expression Of Human α7-Nicotinic Acetylcholine Receptors In A Native Nicotinic Receptor-Null Human Clonal Line, Jian Hong Peng, Linda Lucero, John Fryer, Jennifer Herl, Sherry S. Leonard, and Ronald J. Lukas
Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein, Rita Sattler, Zhigang Xiong, Wei Yang Lu, Mathias Hafner, John F. MacDonald, and Michael Tymianski
The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice, Jihwan Song, Suk P. Oh, Heinrich Schrewe, Masatoshi Nomura, Hong Lei, Makiko Okano, Thomas Gridley, and En Li
Honokiol and magnolol increase the number of [3H]muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites, Richard F. Squires, Jinglu Ai, Michael Robin Witt, Pia Kahnberg, Else Saederup, Olov Sterner, and Mogens Nielsen
Dynamic expression and cellular localization of the Drosophila 14-3-3ε during embryonic development, An Chi Tien, Hsin Yin Hsei, and Cheng Ting Chien
Organization Of Recurrent Inhibition And Facilitation In Motoneuron Pools Innervating Dorsiflexors Of The Cat Hindlimb, Tamara V. Trank, Vladimir V. Turkin, and Thomas M. Hamm
Stability of the craniovertebral junction after unilateral occipital condyle resection: A biomechanical study, A. Giancarlo Vishteh, Neil R. Crawford, M. Stephen Melton, Robert F. Spetzler, Volker K.H. Sonntag, and Curtis A. Dickman
Submissions from 1998
Expression of FAC1 in activated microglia during Alzheimer's disease, Robert Bowser and Shannon Reilly
Localization of a novel septin protein, hCDCrel-1, in neurons of human brain, John Caltagarone, James Rhodes, William G. Honer, and Robert Bowser
The spinal lax zone and neutral zone: Measurement techniques and parameter comparisons, Neil R. Crawford, Joseph D. Peles, and Curtis A. Dickman
Characterization and localization of galanin receptors in human entorhinal cortex, D. C. Deecher, D. C. Mash, J. K. Staley, and E. J. Mufson
Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys, Marina E. Emborg, Shuang Y. Ma, Elliott J. Mufson, Allan I. Levey, Michael D. Taylor, W. Douglas Brown, James E. Holden, and Jeffrey H. Kordower
Occlusion of the pilot tube in a Laser-Shield II endotracheal tube caused by methylene blue crystals: A case report, Tomoki Hashimoto and Valerie E. Armstead
Marked increases of aminotransferase levels after cresol ingestion, Tomoki Hashimoto, Hiroki Iida, and Shuji Dohi
Kinematics of the knee joint in deep flexion: a radiographic assessment., M S Hefzy, B P Kelly, and T D Cooke
Red Nucleus Stimulation Inhibits Within The Inferior Olive, K. M. Horn, T. M. Hamm, and A. R. Gibson
Endothelial cell dysfunction in response to intracellular overexpression of amyloid precursor protein, N. Jahroudi, J. Kitney, J. S. Greenberger, and R. Bowser
Alzheimer's disease and brain development: common molecular pathways., K. Jordan-Sciutto and R. Bowser
The presence of FAC1 protein in Hirano bodies, K. Jordan-Sciutto, J. Dragich, D. Walcott, and R. Bowser
Effects Of Chronic Nicotine Treatment On Expression Of Diverse Nicotinic Acetylcholine Receptor Subtypes. I. Dose- And Time-Dependent Effects Of Nicotine Treatment, Lei Ke, Cynthia M. Eisenhour, Merouane Bencherif, and Ronald J. Lukas
Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease, Jeffrey H. Kordower, Thomas B. Freeman, Er Yun Chen, Elliott J. Mufson, Paul R. Sanberg, Robert A. Hauser, Barry Snow, and C. Warren Olanow
Repression of enzymes of the pentose phosphate pathway by glucose in fission yeast, Shwetal Mehta, S. Velmurugan, and Zita Lobo
std1, a gene involved in glucose transport in Schizosaccharomyces pombe, Shwetal V. Mehta, Vandana B. Patil, S. Velmurugan, Zita Lobo, and Pabitra K. Maitra
m2 muscarinic acetylcholine receptor-immunoreactive neurons are not reduced within the nucleus basalis in Alzheimer's disease: relationship with cholinergic and galaninergic perikarya, E J. Mufson, S Jaffar, and A I. Levey
Galanin expression within the basal forebrain in Alzheimer's disease: Comments on therapeutic potential, Elliott J. Mufson, Ulrika Kahl, Robert Bowser, Deborah C. Mash, Jeffrey H. Kordower, and Darlene C. Deecher
Biomechanical comparison of C1-C2 posterior fixations. Cable, graft, and screw combinations, Sait Naderi, Neil R. Crawford, Geun Sung Song, Volker K.H. Sonntag, and Curtis A. Dickman
Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity, Rita Sattler, Milton P. Charlton, Mathias Hafner, and Michael Tymianski
Tyrosine kinase A, galanin and nitric oxide synthase within basal forebrain neurons in the rat, T Sobreviela, S Jaffar, and E J. Mufson
Immunohistochemical Localization Of Nicotinic β2 And α4 Receptor Subunits In Normal Human Brain And Individuals With Lewy Body And Alzheimer'S Disease: Preliminary Observations, D. Larry Sparks, Thomas G. Beach, and Ronald J. Lukas
Organization Of Recurrent Inhibition And Facilitation In Motor Nuclei Innervating Ankle Muscles Of The Cat, Vladimir V. Turkin, Katrina S. Monroe, and Thomas M. Hamm
Targeted intraparenchymal delivery of human NGF by gene transfer to the primate basal forebrain for 3 months does not accelerate β-amyloid plaque deposition, Mark H. Tuszynski, David E. Smith, Jeffrey Roberts, Heather McKay, and Elliott Mufson
Characterization Of Neuroprotection From Excitotoxicity By Moderate And Profound Hypothermia In Cultured Cortical Neurons Unmasks A Temperature- Insensitive Component Of Glutamate Neurotoxicity, Michael Tymianski, Rita Sattler, Joseph M. Zabramski, and Robert F. Spetzler
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300, Tso Pang Yao, Suk P. Oh, Miriam Fuchs, Nai Dong Zhou, Lian Ee Ch'ng, David Newsome, Roderick T. Bronson, En Li, David M. Livingston, and Richard Eckner
Submissions from 1997
The heteroyohimbine mayumbine binds with high affinity to rat brain benzodiazepine receptors in vitro, Jinglu Ai, Kim Dekermendjian, Mogens Nielsen, and Michael Robin Witt
6-Methylflavone, a benzodiazepine receptor ligand with antagonistic properties on rat brain and human recombinant GABA(A) receptors in vitro, Jinglu Ai, Kim Dekermendjian, Xiaomei Wang, Mogens Nielsen, and Michael Robin Witt
Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors, C Bäckman, G M. Rose, R T. Bartus, B J. Hoffer, E J. Mufson, and A C. Granholm
Furanocoumarins with affinity to brain benzodiazepine receptors in vitro, Ola Bergendorff, Kim Dekermendjian, Mogens Nielsen, Rudong Shan, Robin Witt, Jinglu Ai, and Olov Sterner
A confocal microscopic analysis of galaninergic hyperinnervation of cholinergic basal forebrain neurons in Alzheimer's disease, Robert Bowser, Jeffrey H. Kordower, and Elliott J. Mufson
Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain, D. R. Brady and E. J. Mufson
Biomechanical effects of transthoracic microdiscectomy, Guy G. Broc, Neil R. Crawford, Volker K.H. Sonntag, and Curtis A. Dickman
Non-linearity in invasive EEG recordings from patients with temporal lobe epilepsy, M C. Casdagli, L D. Iasemidis, R S. Savit, R L. Gilmore, S N. Roper, and J C. Sackellares
Construction of local vertebral coordinate systems using a digitizing probe: Technical note, Neil R. Crawford and Curtis A. Dickman
Plasticity of galaninergic fibers following neurotoxic damage within the rat basal forebrain: Initial observations, S. De Lacalle, S. Kulkarni, and E. J. Mufson
Comparative mechanical properties of spinal cable and wire fixation systems, Curtis A. Dickman, Stephen M. Papadopoulos, Neil R. Crawford, Anna G.U. Brantley, and Roy L. Gealer
Knee kinematics in-vivo of kneeling in deep flexion examined by bi-planar radiographs., M S Hefzy, B P Kelly, T D Cooke, A M al-Baddah, and L Harrison
The effect of overexpression of amyloid precursor protein in different cell types of vascular tissue, N. Jahroudi, J. Kitnev, J. S. Greenberger, and R. Bowser
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau, Gregory A. Jicha, Robert Bowser, Imrana G. Kazam, and Peter Davies
Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of huntington's disease, Jeffrey H. Kordower, Er Yun Chen, Christian Winkler, Rose Fricker, Vinod Charles, Albee Messing, Elliott J. Mufson, Shou C. Wong, Jeffrey M. Rosenstein, Anders Björklund, Dwaine F. Emerich, Joseph Hammang, and Melissa K. Carpenter
Cellular delivery of NGF does not alter the expression of β-amyloid immunoreactivity in young or aged nonhuman primates, Jeffrey H. Kordower, Elliott J. Mufson, Fox Nathan, Leena Martel, and Dwaine F. Emerich
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease, Allan I. Levey, Craig J. Heilman, James J. Lah, Norman R. Nash, Howard D. Rees, Masakazu Wakai, Suzanne S. Mirra, David B. Rye, David Nochlin, Thomas D. Bird, and Elliott J. Mufson
Connections of the hippocampal formation in humans: II. The endfolial fiber pathway, Chun Lim, Elliott J. Mufson, Jeffrey H. Kordower, Howard W. Blume, Joseph R. Madsen, and Clifford B. Saper
Reduction in p140-trkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease, Elliott J. Mufson, Natalie Lavine, Syed Jaffar, Jeffrey H. Kordower, Rémi Quirion, and H. Uri Saragovi
Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease, Elliott J. Mufson, J. M. Li, T. Sobreviela, and J. H. Kordower
FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord, Xiaojun Mu, Joe E. Springer, and Robert Bowser
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse, Suk P. Oh and En Li
Comparative pull-out strength of tapped and untapped pilot holes for bicortical anterior cervical screws, Juan F. Ronderos, Ronald Jacobowitz, Volker K.H. Sonntag, Neil R. Crawford, and Curtis A. Dickman
Determination of the time course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multiwell plate fluorescence scanner, Rita Sattler, Milton P. Charlton, Mathias Hafner, and Michael Tymianski
Expression of fetal ALZ-50 reactive Clone 1 (FAC1) in dentate gyrus following entorhinal cortex lesion, S. D. Styren, R. Bowser, and S. T. Dekosky
A novel use for a carbodiimide compound for the fixation of fluorescent and non-fluorescent calcium indicators in situ following physiological experiments, M. Tymianski, G. M. Bernstein, K. M. Abdel-Hamid, R. Sattler, A. Velumian, P. L. Carlen, H. Razavi, and O. T. Jones
Preparation, characterization and utility of a novel antibody for resolving the spatial and temporal dynamics of the calcium chelator BAPTA, M. Tymianski, R. Sattler, G. Bernstein, and O. T. Jones
The neuronal system of the saccus vasculosus of trout (Salmo trutta fario and Oncorhynchus mykiss): an immunocytochemical and nerve tracing study., J Yáñez, M Rodríguez, S Pérez, F Adrio, I Rodríguez-Moldes, M J Manso, and R Anadón
Submissions from 1996
Organisation of the cerebellar nucleus of the dogfish, Scyliorhinus canicula L.: a light microscopic, immunocytochemical, and ultrastructural study., R Alvarez-Otero, S E Perez, M A Rodriguez, and R Anadón
Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization, Robert Bowser
Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: Genotype analysis and relationships to neuropathological changes, Luc Buée, Jordi Pérez-Tur, Béatrice Leveugle, Valérie Buée-Scherrer, Elliott J. Mufson, Arthur J. Loerzel, Marie Christine Chartier-Harlin, Daniel P. Perl, André Delacourte, and Patrick R. Hof
Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate, Vinod Charles, Elliott J. Mufson, Phillip M. Friden, Raymond T. Bartus, and Jeffrey H. Kordower
TRK and p75 neurotrophin receptor systems in the developing human brain, E. R.Yun Chen, Elliott J. Mufson, and Jeffrey H. Kordower
Methods for determining spinal flexion/extension, lateral bending, and axial rotation from marker coordinate data: Analysis and refinement, Neil R. Crawford, Gary T. Yamaguchi, and Curtis A. Dickman
Characterisation of the furanocoumarin phellopterin as a rat brain benzodiazepine receptor partial agonist in vitro, Kim Dekermendjian, Jinglu Ai, Mogens Nielsen, Olov Sterner, Rudong Shan, and Michael Robin Witt
Biomechanical characteristics of C1-2 cable fixations, Curtis A. Dickman, Neil R. Crawford, and Christopher G. Paramore
Sensitivity And Specificity Of Paired Capillary Prolactin Measurement In Diagnosis Of Seizures, Tajammul Ehsan, Robert S. Fisher, Donald Johns, Ronald J. Lukas, David Blum, and Jennifer Eskola
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys, A H. Gazzaley, S J. Siegel, J H. Kordower, E J. Mufson, and J H. Morrison
Effects Of Steroid Exposure On Ligand Binding And Functional Activities Of Diverse Nicotinic Acetylcholine Receptor Subtypes, Lei Ke and Ronald J. Lukas
Functional fetal nigral grafts in a patient with Parkinson's disease: Chemoanatomic, ultrastructural, and metabolic studies, Jeffrey H. Kordower, Jeffrey M. Rosenstein, Timothy J. Collier, Melanie A. Burke, Er Yun Chen, Jing Min Li, Leena Martel, Allan E. Levey, Elliott J. Mufson, Thomas B. Freeman, and C. Warren Olanow
Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: Trophic effects upon cholinergic and noncholinergic striatal neurons, J. H. Kordower, E. Y. Chen, E. J. Mufson, S. R. Winn, and D. F. Emerich
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells, Hong Lei, Suk P. Oh, Masaki Okano, Ruth Jüttermann, Kendrick A. Goss, Rudolf Jaenisch, and En Li
Interactions Between Tachykinins And Diverse Human Nicotinic Acetylcholine Receptor Subtypes, Ronald J. Lukas and Cynthia M. Eisenhour
Regulation By Nicotine Of Its Own Receptors, Ronald J. Lukas, Lei Ke, Merouane Bencherif, and Cynthia M. Eisenhour
Amyloid load and neural elements in Alzheimer's disease and nondemented individuals with high amyloid plaque density, Akihide Mochizuki, John W. Peterson, Elliott J. Mufson, and Bruce D. Trapp
Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: Distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neurons, E. J. Mufson, J. S. Kroin, Y. T. Liu, T. Sobreviela, R. D. Penn, J. A. Miller, and J. H. Kordower
NADPH-diaphorase histochemistry reveals oligodendrocytes in the rainbow trout (teleosts)., S E Perez, F Adrio, M A Rodriguez, I Rodriguez-Moldes, and R Anadon
Similarity Between Rat Brain Nicotinic α-Bungarotoxin Receptors And Stably Expressed α-Bungarotoxin Binding Sites, M. Quik, J. Choremis, J. Komourian, R. J. Lukas, and E. Puchacz
Voltage-sensitive calcium channels mediate calcium entry into cultured mammalian sympathetic neurons following neurite transection, Rita Sattler, Michael Tymianski, Imran Feyaz, Mathias Hafner, and Charles H. Tator
Immunolocalization and redistribution of the FAC1 protein in Alzheimer's disease, Susan Schoonover, Peter Davies, and Robert Bowser
Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo- and limbic cortex in rat: Relationship to BDNF mRNA expressing neurons, Teresa Sobreviela, Maria Pagcatipunan, Jeffrey S. Kroin, and Elliott J. Mufson
Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes., B R Stevens, D K Kakuda, K Yu, M Waters, C B Vo, and M K Raizada
Identification and analysis of the complete cDNA sequence for the human FAC1 gene, Ping Zhu and Robert Bowser
Submissions from 1995
GABAergic neuronal circuits in the cerebellum of the dogfish Scyliorhinus canicula (Elasmobranchs): an immunocytochemical study., R Alvarez-Otero, S E Pérez, M A Rodríguez, F Adrio, and R Anadón
The electric lobes of the electric ray (Torpedo marmorata) are innervated by GABAergic fibres: immunocytochemical evidence for dual innervation of electromotoneurons., R Anadón, S E Pérez, M A Rodríguez, F Adrio, and I Rodríguez-Moldes
Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia, Maria Andersson, Ola Bergendorff, Mogens Nielsen, Olov Sterner, Robin Witt, Jinglu Ai, Aiping Lu, and An Min Wang
The 'Calcium Antagonist' Tmb-8 [345-Trimethoxybenzoic Acid 8- (Diethylamino)Octyl Ester] Is A Potent Non-Competitive Functional Antagonist At Diverse Nicotinic Acetylcholine Receptor Subtypes, M. Bencherif, C. M. Eisenhour, R. J. Prince, P. M. Lippiello, and R. J. Lukas
Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to tau and PHF in Alzheimer's disease, William C. Benzing and Elliott J. Mufson
Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease, William C. Benzing and Elliott J. Mufson
Primary structure of the long and short splice variants of mouse collagen XII and their tissue‐specific expression during embryonic development, Kathrin Böhme, Yefu Li, Paul S. Oh, and Bjorn R. Olsen
FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain, R. Bowser, A. Giambrone, and P. Davies
The Sea Anemone Purine Caissarone: Adenosine Receptor Antagonism, Rol A. Cooper, JC De Freitas, Frank Porreca, Cynthia M. Eisenhour, Ronald Lukas, and Ryan J. Huxtable
An apparatus for applying pure nonconstraining moments to spine segments in vitro, Neil R. Crawford, Anna G.U. Brantley, Curtis A. Dickman, and Edward J. Koeneman
Galanin receptors in human basal forebrain differ from receptors in the hypothalamus: Characterization using [125I]galanin (porcine) and [125I]galantide, D. C. Deecher, O. O. Odusan, and E. J. Mufson