Dynamic expression and cellular localization of the Drosophila 14-3-3ε during embryonic development
Document Type
Article
Abstract
The 14-3-3 protein family is known to interact with various proteins involved in signaling pathways. We report here the expression pattern of the Drosophila 14-3-3 (d14-3-3ε) protein during embryonic development. In syncytial blastoderm when the nuclei divided rapidly, d14-3-3ε localized in the nuclei. During cellularization d14-3-3ε gradually became membrane- bound. During gastrulation, an enhanced staining in the perinuclear region was observed in various tissues. Co-labeling with dp-ERK which recognized the activated form of MAPK suggested that d 14-3-3ε was expressed prior to MAPK activation. During neuronal differentiation, the d14-3-3ε protein remained at a high level in the neuronal cytoplasm.
Keywords
14-3-3, Dp-ERK, Drosophila, Egfr, MAPK, Receptor tyrosine kinase
Publication Date
3-1-1999
Publication Title
Mechanisms of Development
ISSN
09254773
Volume
81
Issue
1-2
First Page
209
Last Page
212
PubMed ID
10330502
Digital Object Identifier (DOI)
10.1016/S0925-4773(98)00238-X
Recommended Citation
Tien, An Chi; Hsei, Hsin Yin; and Chien, Cheng Ting, "Dynamic expression and cellular localization of the Drosophila 14-3-3ε during embryonic development" (1999). Translational Neuroscience. 1997.
https://scholar.barrowneuro.org/neurobiology/1997