The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2025
Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations, Nadia Aalling, Petar V. Todorov, Shad Hassan, Dylan M. Belmont-Rausch, Oliver Pugerup Christensen, Claes Ottzen Laurentiussen, Anja M. Jørgensen, Kimberly M. Alonge, Jarrad M. Scarlett, Zaman Mirzadeh, Jenny M. Brown, Michael W. Schwartz, and Tune H. Pers
Splicing-based biomarkers define a robust multigene classifier for relapsing-remitting multiple sclerosis, Federica Airi, Valeria Rimoldi, Elvezia Maria Paraboschi, Valentina Pellicanò, Damiano Verda, Giuseppe Liberatore, Claudia Cantoni, Laura Piccio, Alvino Bisecco, Anita Capalbo, Giulia Cardamone, Eduardo Nobile-Orazio, Giulia Soldà, and Rosanna Asselta
The Complex Role of the Complement C3a Receptor (C3aR) in Cerebral Injury and Recovery Following Ischemic Stroke, Naseem Akhter, Ateeq Lambay, Reema Almotairi, Abdullah Hamadi, Kanchan Bhatia, Saif Ahmad, and Andrew F. Ducruet
Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease, Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, and Stephen D. Ginsberg
Benefits of Maternal Choline Supplementation on Aged Basal Forebrain Cholinergic Neurons (BFCNs) in a Mouse Model of Down Syndrome and Alzheimer's Disease, Melissa J. Alldred, Harshitha Pidikiti, Kyrillos W. Ibrahim, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, and Stephen D. Ginsberg
Distinguishing Early from Late Mild Cognitive Impairment Using Magnetic Resonance Free-Water Diffusion Tensor Imaging, Maurizio Bergamino, Molly M. McElvogue, Ashley M. Stokes, and Alzheimer's Disease Neuroimaging Initiative
Assessment of microstructural changes in white matter hyperintensities in aging and mild cognitive impairment revealed by advanced diffusion MRI, Maurizio Bergamino, Megan R. Nelson, Elizabeth Keeling, and Ashley M. Stokes
Investigating white matter alterations in Parkinson's disease using multi-shell free-water DTI and NODDI: insights into neurodegeneration and levodopa effects, Maurizio Bergamino, Shuyi Zhu, Holly A. Shill, and Ashley M. Stokes
Cardiac Troponin T in Tofersen-Treated SOD1 ALS Patients: Beginning to Resolve the Catch-22 of Identifying Treatment Responsive Biomarkers in ALS Drug Development, James D. Berry and Robert Bowser
Transthyretin abnormalities in amyotrophic lateral sclerosis: High molecular weight species in cerebrospinal fluid and stromal deposits in choroid plexus., Mahlon Collins, Heather Kwapiszeski, Jiyan An, Deyri Garcia, Danielle Peller, Shafeeq Ladha, Robert Bowser, and Nadine Bakkar
Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's disease, Scott E. Counts, John S. Beck, Bryan Maloney, Michael Malek-Ahmadi, Stephen D. Ginsberg, Elliott J. Mufson, and Debomoy K. Lahiri
The α-synuclein seed amplification assay: Interpreting a test of Parkinson's pathology, Alberto J. Espay, Andrew J. Lees, Francisco Cardoso, Steven J. Frucht, Daniel Erskine, Ivette M. Sandoval, Luis Daniel Bernal-Conde, Andrea Sturchio, Alberto Imarisio, Christian Hoffmann, Kora T. Montemagno, Dragomir Milovanovic, Glenda M. Halliday, and Fredric P. Manfredsson
Physics of Protein Aggregation in Normal and Accelerated Brain Aging, Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, and Fredric P. Manfredsson
Devaluing memories of reward: a case for dopamine, Benjamin R. Fry, Nicolette Russell, Victoria Fex, Bing Mo, Nathan Pence, Joseph A. Beatty, Fredric P. Manfredsson, Brandon A. Toth, Christian R. Burgess, Samuel Gershman, and Alexander W. Johnson
Preoperative Multifidus and Psoas Major Muscle Quality and Patient-Reported Outcomes After Anterolateral Lumbar Interbody Fusion: Predictors for Preoperative Disability and Back Pain Improvement, Juan P. Giraldo, Anna G. Sawa, Gerardo Gomez-Castro, James J. Zhou, Nima Alan, S Harrison Farber, Lea M. Alhilali, Pablo Sanchez-Quinones, Luke K. O'Neill, Brian P. Kelly, Jay D. Turner, and Juan S. Uribe
A unique case of heavy-ion therapy-induced intracranial pseudoaneurysm rupture., Soshi Gotan, Takuma Maeda, Masataka Yoshimura, Hiroki Kurita, and Shinya Kohyama
Calcified cerebral emboli following coil embolization: a case report., Soshi Gotan, Takuma Maeda, Masataka Yoshimura, Hiroki Kurita, and Shinya Kohyama
Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade glioma, Kevin C. Johnson, An-Chi Tien, Jun Jiang, James McNamara, Yu-Wei Chang, Chelsea Montgomery, Anita DeSantis, Leonel Elena-Sanchez, Yoko Fujita, Seongho Kim, Avishay Spitzer, Paul Gabriel, William F. Flynn, Elise T. Courtois, Amy Hong, Jocelyn Harmon, Yoshie Umemura, Artak Tovmasyan, Jing Li, Shwetal Mehta, Roel G. Verhaak, and Nader Sanai
Manganese Porphyrin Reduces Oxidative Stress in Vulnerable Parkin-Null Drosophila Dopaminergic Neurons, Amber N. Juba, Petros P. Keoseyan, Riley P. Hamel, Tigran Margaryan, Michaela L. Barber, Amanda N. Foley, T Bucky Jones, Ines Batinic-Haberle, Artak Tovmasyan, and Lori M. Buhlman
park+/+ and park-/- Drosophila have sexually dimorphic brain redox chemistry, Amber N. Juba, Bobbi Stwalley, Tigran Margaryan, Riley Hamel, Amanda N. Foley, T Bucky Jones, Artak Tovmasyan, and Lori M. Buhlman
Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease, Betul Kara, John S. Beck, Zhen Fu, Stephanie L. Hickey, Nicholas M. Kanaan, Elliott J. Mufson, Stephen D. Ginsberg, and Scott E. Counts
Repeatability and reliability of cerebrovascular reactivity in young adults using multi-echo, multi-contrast MRI, Elizabeth G. Keeling, Maurizio Bergamino, Lauren R. Ott, Molly M. McElvogue, and Ashley M. Stokes
Driving under the influence of opioids in 2024: a narrative review of science and pandemic policy updates, Colin Kirsch, Patrick Wintergalen, Steven P. Cohen, Zaman Mirzadeh, S Harrison Farber, and Brian G. Wilhelmi
Protoporphyrin IX plasma and blood pharmacokinetics and brain tumor distribution determined by a validated LC-MS/MS method, William Knight, Tigran Margaryan, Kamal Shaik, Nader Sanai, and Artak Tovmasyan
Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum, Amanda Labuza, Melissa J. Alldred, Harshitha Pidikiti, Michael H. Malek-Ahmadi, Sang Han Lee, Adriana Heguy, Paul D. Coleman, Souparna Chakrabarty, Gabriela Chiosis, Elliott J. Mufson, and Stephen D. Ginsberg
Mechanistic Modeling of Spatial Heterogeneity of Drug Penetration and Exposure in the Human Central Nervous System and Brain Tumors, Jing Li, Charuka Wickramasinghe, Jun Jiang, Andrew Wu, Yuanyuan Jiang, Artak Tovmasyan, Seongho Kim, and Nader Sanai
Corrigendum: The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson's disease, Natalie Lipari, Ashley Galfano, Shruti Venkatesh, Han Grezenko, Ivette M. Sandoval, Fredric P. Manfredsson, and Christopher Bishop
Optimization of 3D-printed titanium interbody cage design. Part 2: An in vivo study of spinal fusion in sheep, Jeremy A. Lombardo, Dan Wills, Tian Wang, Matthew Pelletier, S Harrison Farber, Brian P. Kelly, Juan S. Uribe, Jay D. Turner, Frank Vizesi, and William R. Walsh
Histopathological analysis of duragen collagen matrix over time in humans., Takuma Maeda, Kaima Suzuki, Peyton L Nisson, Yoshiki Mochizuki, Reina Mizuno, Akio Teranishi, Yushiro Take, Tomomichi Kayahara, and Hiroki Kurita
Effects of genetic knockdown of the serotonin transporter on established L-DOPA-induced dyskinesia and gene expression in hemiparkinsonian rats, Grace McManus, Ashley Galfano, Carla Budrow, Natalie Lipari, Kuei Y. Tseng, Fredric P. Manfredsson, and Christopher Bishop
Cholinotrophic basal forebrain connectome dysfunction in Down syndrome with and without dementia, Marta Moreno-Rodriguez, Sylvia E. Perez, Muhammad Nadeem, Elizabeth Head, and Elliott J. Mufson
The cholinotrophic system in Down syndrome, Elliott J. Mufson and Sylvia E. Perez
Ventral Midline Hysterectomy, Ovariectomy, and Ovariohysterectomy in Mus Musculus: A Surgical Protocol., Peyton L Nisson, Takuma Maeda, Hiroki Uchikawa, Oscar Cisneros, Michael T Lawton, and Tomoki Hashimoto
U1-70K and U1A and tau pathogenesis in demented and non-demented individuals with Down syndrome, Sylvia E. Perez, Jennifer C. Miguel, Muhammad Nadeem, Michael Malek-Ahmadi, Chadwick M. Hales, Elizabeth Head, and Elliott J. Mufson
Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease, Sylvia E. Perez, Muhammad Nadeem, Bin He, Jennifer C. Miguel, David G. Moreno, Marta Moreno-Rodriguez, Michael Malek-Ahmadi, Chadwick M. Hales, and Elliott J. Mufson
Sexually Dimorphic Responses Reveal Multifaceted Benefits of Glibenclamide in Traumatic Brain Injury, Anupama Rani, Sudhanshu P. Raikwar, Wonsuk Yoo, Saif Ahmad, Vincent A. Vagni, Keri L. Janesko-Feldman, Shaun W. Carlson, Adam Eberle, Margaux Miller, John Helm, Joshua Catapano, Benjamin E. Zusman, Shashvat Desai, Raemier Anne Javelosa, Semeon Afework, Erin Audrey McNally, Gary Kohanbash, Dhivyaa Rajasundaram, Michael F. Waters, Andrew Ducruet, Ashutosh Jadhav, Aditya Kumar, Chia-Ling Phuah, Patrick M. Kochanek, and Ruchira M. Jha
Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study., Mathilde Ripart, Hannah Spitzer, Logan Z J Williams, Lennart Walger, Andrew Chen, Antonio Napolitano, Camilla Rossi-Espagnet, Stephen T. Foldes, Wenhan Hu, Jiajie Mo, Marcus Likeman, Theodor Rüber, Maria Eugenia Caligiuri, Antonio Gambardella, Christopher Guttler, Anna Tietze, Matteo Lenge, Renzo Guerrini, Nathan T Cohen, Irene Wang, Ane Kloster, Lars H Pinborg, Khalid Hamandi, Graeme Jackson, Domenico Tortora, Martin Tisdall, Estefania Conde-Blanco, Jose C Pariente, Carmen Perez-Enriquez, Sofia Gonzalez-Ortiz, Nandini Mullatti, Katy Vecchiato, Yawu Liu, Reetta Kalviainen, Drahoslav Sokol, Jay Shetty, Benjamin Sinclair, Lucy Vivash, Anna Willard, Gavin P Winston, Clarissa Yasuda, Fernando Cendes, Russell T Shinohara, John S Duncan, J Helen Cross, Torsten Baldeweg, Emma C Robinson, Juan Eugenio Iglesias, Sophie Adler, and Konrad Wagstyl
Impact of multipoint pelvic fixation and multirod distal constructs on proximal junction biomechanics in cadaveric specimens, Robert F. Rudy, Anna G. Sawa, Sarah McBryan, Luke A. Mugge, Katherine Thielen, Temesgen G. Assefa, Derek P. Lindsey, David W. Polly, Juan S. Uribe, Brian P. Kelly, and Jay D. Turner
Gene therapy for Parkinson's disease-Ample room for optimism, Ivette M. Sandoval, Michael F. Salvatore, and Fredric P. Manfredsson
Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study, Natalie Saunders, Claire Magnussen, HyungMo Kang, Mathieu Blais, Harpreet Bhinder, Gerald Pfeffer, Shelagh K. Genuis, Liziane Bouvier, Tanushka Anand, Rida Abou-Haidar, Agessandro Abrahao, Marie-Noëlle Boivin, Robert Bowser, Tania Bubela, Julia Chiappini, Samir Das, Avnit Dhanoa, Nicolas Dupré, Alan Evans, Nicolas Ferry, Yvonne Frater, Angela Genge, Simon J. Graham, Russell Greiner, Yasser Iturria Medina, Wendy S. Johnston, Kelvin E. Jones, Jason Karamchandani, Jasna Kriz, Westerly Luth, and Geneviève Matte
Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia, Monis B. Shamsi, Rima Dada, Reham M. Balahmar, Dimah Zaytuni, Ghadeer Alharbi, Syed N. Imam, Emad Rajih, Muhammad Latif, and Saif Ahmad
Plasma neurofilament analysis in VITALITY-ALS, Tyrell J. Simkins, Stuart Kupfer, Fady I. Malik, Lisa Meng, Stacy A. Rudnicki, Jenny Wei, Jeremy M. Shefner, and Robert Bowser
Suppression of Paclitaxel-Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE-2-PyP (BMX-001), Ivan Spasojevic, Zhiqing Huang, Welida Tamires da Silva, Weina Duan, Li Du, Cathleen Chen, Jie Cao, Shasha Zhang, Hannah Lee, Gaomong Lo, Artak Tovmasyan, Huaxin Sheng, Ines Batinic-Haberle, and Angeles Alvarez Secord
Disease-modifying, multidimensional efficacy of putaminal Ca1.3-shRNA gene therapy in aged parkinsonism male and female macaques, Kathy Steece-Collier, Margaret E. Caulfield, Molly J. Vander Werp, Scott J. Muller, Jennifer A. Stancati, Yaping Chu, Ivette M. Sandoval, Timothy J. Collier, Jeffrey H. Kordower, and Fredric P. Manfredsson
Glucose transporter 1 in vascular smooth muscle cells is dispensable for abdominal aortic aneurysm induced by angiotensin II, Keiichi Torimoto, Hymavathi Reddy Vari, Yuki Nakayama, Hirotoshi Utsunomiya, Masatoshi Takeda, Tomoki Hashimoto, Victor Rizzo, and Satoru Eguchi
Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology, Jhodi M. Webster, Ya-Ting Yang, Aidan T. Miller, Asta Zane, Kasandra Scholz, William J. Stone, Nikhita Mudium, Nicole J. Corbin-Stein, Woong-Jai Won, Anna C. Stoll, Kelsey M. Greathouse, Noelle H. Cooper, Lillian F. Long, Phaedra N. Manuel, Jeremy H. Herskowitz, Talene A. Yacoubian, Daniel J. Tyrrell, Ivette M. Sandoval, Fredric P. Manfredsson, Jeffrey H. Kordower, and Ashley S. Harms
hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation., Ian Weidling, Christina N Preiss, Sarah E Chancellor, Gyan Srivastava, Lauren Gibilisco, Gen Lin, Melanie Shackett Brennan, Janice Lee, Lindsay M Roth, Olga Morozova, Kyong Nyon Nam, Nehal R Patel, Qing Liu, J K Thomas, Peter Reinhardt, Ruven Wilkens, Dagmar E Ehrnhoefer, Andreas Striebinger, Stefan Barghorn, Christina Xanthopoulos, Marie-Theres Weil, Sandra Biesinger, Miroslav Cik, Nandini Romanul, Kiran Yanamandra, Alessandra M Welker, Jessica Wu, Laura Gasparini, Jan Stöhr, Xavier Langlois, and Justine D Manos
Submissions from 2024
Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON)., Naseem Akhter, Jessica Contreras, Mairaj A Ansari, Andrew F. Ducruet, Md Nasrul Hoda, Abdullah S Ahmad, Laxman D Gangwani, Kanchan Bhatia, and Saif Ahmad
Down Syndrome Biobank Consortium: A perspective., Iban Aldecoa, Isabel Barroeta, Steven L Carroll, Juan Fortea, Anah Gilmore, Stephen D Ginsberg, Samuel J Guzman, Eric D Hamlett, Elizabeth Head, S E Pérez, Huntington Potter, Laura Molina-Porcel, Ruma Raha-Chowdhury, Thomas Wisniewski, William H Yong, Shahid Zaman, Sujay Ghosh, Elliott J Mufson, and Ann-Charlotte Granholm
Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome., Melissa J Alldred, Harshitha Pidikiti, Kyrillos W Ibrahim, Sang Han Lee, Adriana Heguy, Gabriel E Hoffman, Panos Roussos, Thomas Wisniewski, Jerzy Wegiel, Grace E Stutzmann, Elliott J. Mufson, and Stephen D Ginsberg
Exosomes in Vascular/Neurological Disorders and the Road Ahead., Faisal A Alzahrani, Yasir M Riza, Thamir M Eid, Reema Almotairi, Lea Scherschinski, Jessica Contreras, Muhammed Nadeem, Sylvia E Perez, Sudhanshu P Raikwar, Ruchira M Jha, Mark C Preul, Andrew F Ducruet, Michael T Lawton, Kanchan Bhatia, Naseem Akhter, and Saif Ahmad
Exosomes in Vascular/Neurological Disorders and the Road Ahead., Faisal A Alzahrani, Yasir M Riza, Thamir M Eid, Reema Almotairi, Lea Scherschinski, Jessica Contreras, Muhammed Nadeem, Sylvia E Perez, Sudhanshu P Raikwar, Ruchira M Jha, Mark C Preul, Andrew F. Ducruet, Michael T Lawton, Kanchan Bhatia, Naseem Akhter, and Saif Ahmad
"Advanced" Parkinson's disease: A review., Sana Aslam, Fredric P. Manfredsson, Ashley Stokes, and Holly Shill
Altered resting-state functional connectivity and dynamic network properties in cognitive impairment: an independent component and dominant-coactivation pattern analyses study., Maurizio Bergamino, Anna Burke, Marwan N Sabbagh, Richard J Caselli, Leslie C Baxter, and Ashley M. Stokes
EGFRvIII Confers Sensitivity to Saracatinib in a STAT5-Dependent Manner in Glioblastoma., Mylan R Blomquist, Ryan Eghlimi, Angad Beniwal, Dustin Grief, David G Nascari, Landon Inge, Christopher P Sereduk, Serdar Tuncali, Alison Roos, Hannah Inforzato, Ritin Sharma, Patrick Pirrotte, Shwetal Mehta, Shannon P Fortin Ensign, Joseph C Loftus, and Nhan L Tran
ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO., Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, and David C Butler
Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy., Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Md Akkas Ali, Ivette M Sandoval, Fredric P. Manfredsson, Jeffrey H Kordower, Daniel J Tyrrell, and Ashley S Harms
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy., Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H Kordower, and Ashley S Harms
A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation., John E Downey, Hunter R Schone, Stephen T. Foldes, Charles Greenspon, Fang Liu, Ceci Verbaarschot, Daniel Biro, David Satzer, Chan Hong Moon, Brian A Coffman, Vahab Youssofzadeh, Daryl Fields, Taylor G Hobbs, Elizaveta Okorokova, Elizabeth C Tyler-Kabara, Peter C Warnke, Jorge Gonzalez-Martinez, Nicholas G Hatsopoulos, Sliman J Bensmaia, Michael L Boninger, Robert A Gaunt, and Jennifer L Collinger
Knockout of the longevity gene Klotho perturbs aging and Alzheimer's disease-linked brain microRNAs and tRNA fragments., Serafima Dubnov, Estelle R Bennett, Nadav Yayon, Or Yakov, David A Bennett, Sudha Seshadri, Elliott J. Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-O, Iddo Paldor, Carmela R Abraham, and Hermona Soreq
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis., Laura Ghezzi, Valeria Tosti, Lisa Shi, Claudia Cantoni, Robert Mikesell, Samantha Lancia, Yanjiao Zhou, Kathleen Obert, Courtney Dula, Monokesh K Sen, Anjie Ge, Miguel Tolentino, Bryan Bollman, Anthony S Don, Giuseppe Matarese, Alessandra Colamatteo, Claudia La Rocca, Maria Teresa Lepore, Cyrus A Raji, Farzaneh Rahmani, Gregory F Wu, Robert T Naismith, Luigi Fontana, Anne H Cross, Amber Salter, and Laura Piccio
Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings., Ann-Charlotte E Granholm, Elisabet Englund, Anah Gilmore, Elizabeth Head, William H Yong, S E Pérez, Samuel J Guzman, Eric D Hamlett, and Elliott J Mufson
Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress., Taichi Ishiguro, Hajime Furukawa, Kyle Polen, Yushiro Take, Hiroki Sato, Daisuke Kudo, Jordan Morgan, Hiroki Uchikawa, Takuma Maeda, Oscar Cisneros, Redi Rahmani, Jinglu Ai, Satoru Eguchi, Michael T Lawton, and Tomoki Hashimoto
A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets., Ruchira M Jha, Dhivyaa Rajasundaram, Chaim Sneiderman, Brent T Schlegel, Casey O'Brien, Zujian Xiong, Keri Janesko-Feldman, Ria Trivedi, Vincent Vagni, Benjamin E Zusman, Joshua S Catapano, Adam Eberle, Shashvat M Desai, Ashutosh P Jadhav, Sandra Mihaljevic, Margaux Miller, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shima Shahjouie, Itay Raphael, Aditya Kumar, Chia-Ling Phuah, Ethan A Winkler, Dennis W Simon, Patrick M Kochanek, and Gary Kohanbash
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy., Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D Kelly, Matthew Goodson, Danica Lee, Fredric P. Manfredsson, Bob M Moore, and Malú Gámez Tansey
Rapid simultaneous estimation of relaxation rates using multi-echo, multi-contrast MRI., Elizabeth G Keeling, Nicholas J Sisco, Molly M McElvogue, Aimee Borazanci, Richard D Dortch, and Ashley M. Stokes
Current Mouse Models of Intracranial Aneurysms: Analysis of Pharmacological Agents Used to Induce Aneurysms and Their Impact on Translational Research., Dilaware Khan, Xuanchen Li, Tomoki Hashimoto, Rokuya Tanikawa, Mika Niemela, Michael Lawton, and Sajjad Muhammad
Vitamin D deficiency promotes intracranial aneurysm rupture., Tetsuro Kimura, Redi Rahmani, Takeshi Miyamoto, Yoshinobu Kamio, Daisuke Kudo, Hiroki Sato, Taichi Ikedo, Jacob F Baranoski, Hiroki Uchikawa, Jinglu Ai, Michael T Lawton, and Tomoki Hashimoto
A validated LC-MS/MS method for determination of neuro-pharmacokinetic behavior of niraparib in brain tumor patients., William Knight, Tigran Margaryan, Nader Sanai, and Artak Tovmasyan
Cardiocerebral Infarction Presenting in a Neurosurgical Emergency: A Case Report and Literature Review., Haruka Kume, Takuma Maeda, Eisuke Tsukagoshi, Takeshi Ogura, Shigehiro Ohmori, and Hiroki Kurita
Debamestrocel multimodal effects on biomarker pathways in amyotrophic lateral sclerosis are linked to clinical outcomes., Stacy R Lindborg, Namita A Goyal, Jonathan Katz, Matthew Burford, Jenny Li, Haggai Kaspi, Natalie Abramov, Bruno Boulanger, James D Berry, Katharine Nicholson, Tahseen Mozaffar, Robert Miller, Liberty Jenkins, Robert H Baloh, Richard Lewis, Nathan P Staff, Margaret Ayo Owegi, Bob Dagher, Netta R Blondheim-Shraga, Yael Gothelf, Yossef S Levy, Ralph Kern, Revital Aricha, Anthony J Windebank, Robert Bowser, Robert H Brown, and Merit E Cudkowicz
A 3D dual-echo spiral sequence for simultaneous dynamic susceptibility contrast and dynamic contrast-enhanced MRI with single bolus injection., Zhiqiang Li, Dinghui Wang, Melvyn B Ooi, Poonam Choudhary, Sudarshan Ragunathan, John P Karis, James G Pipe, C Chad Quarles, and Ashley M. Stokes
A Late Complication Related to Percutaneous Implantable Leads for Spinal Cord Stimulation: Myelopathy due to Fibrous Scar Tissue., Takuma Maeda, Takashi Agari, Takashi Komori, and Keisuke Takai
Clinical Outcomes in Elderly Patients with Chronic Subdural Hematoma: Validation of Irrigation Assignment Based on Hematoma Characteristics., Takuma Maeda, Yuichiro Kikkawa, Takuro Ehara, Ryosuke Tsuchiya, Shinya Tabata, Koki Onodera, Tatsuki Kimura, Yushiro Take, Kaima Suzuki, and Hiroki Kurita
Neurosurgical Outcomes for Intracerebral Hemorrhage in Patients Undergoing Dialysis., Takuma Maeda, Mayuko Miyata, Nobuaki Naito, Koki Onodera, Yushiro Take, Aoto Shibata, Kaima Suzuki, Hidetoshi Ooigawa, and Hiroki Kurita
Robotics in Microneurosurgery: Beyond the Exoscope., Takuma Maeda and Peyton L Nisson
Initial real-world experience of clazosentan for subarachnoid hemorrhage in Japan., Takuma Maeda, Mai Okawara, Manabu Osakabe, Hiroyuki Yamaguchi, Takahiro Maeda, and Hiroki Kurita
Amyloid β interferes with wound healing of brain microvascular endothelial cells by disorganizing the actin cytoskeleton., Takuma Maeda, Keiya Shimamori, Hiroki Kurita, Kiyotaka Tokuraku, and Masahiro Kuragano
A Window Into Basal Forebrain Cholinergic Dysfunction in Patients With Cortical Basal Syndrome., Elliott J. Mufson
Exploring white matter microstructural alterations in mild cognitive impairment: a multimodal diffusion MRI investigation utilizing diffusion kurtosis and free-water imaging., Megan R Nelson, Elizabeth G Keeling, Ashley M. Stokes, and Maurizio Bergamino
A proposed stratification system to address the heterogeneity of Subdural Hematoma Outcome reporting in the literature., Peyton L Nisson, John Francis, Michelot Michel, Takuma Maeda, and Chirag Patil
Vascular Endothelial Growth Factor and the Pathogenesis of Intracranial Aneurysms: A Systematic Review on the Missing Link in a Complex Pathway., Peyton L Nisson, Michael T Lawton, Oscar Cisneros, Takuma Maeda, Nestor R Gonzalez, Juhana Frösen, and Tomoki Hashimoto
ALSUntangled #75: Portable neuromodulation stimulator therapy., Laurel Officer, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Andrew Brown, Olimpia Mihaela Carbunar, Gregory T Carter, Jesse Crayle, Keelie Denson, Eva Feldman, Timothy Fullam, Terry Heiman-Patterson, Carlayne Jackson, Sartaj Jhooty, Danelle Levinson, Xiaoyan Li, Alexandra Linares, Elise Mallon, Javier Mascias Cadavid, Christopher Mcdermott, Tasnim Mushannen, Lyle Ostrow, Ronak Patel, Gary Pattee, Dylan Ratner, Yuyao Sun, John Sladky, Paul Wicks, and Richard Bedlack
Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy., Camila Ortiz, Andrew Pearson, Robyn McCartan, Shawn Roche, Nolan Carothers, Mackenzie Browning, S E Pérez, Bin He, Stephen D Ginsberg, Michael Mullan, Elliott J Mufson, Fiona Crawford, and Joseph Ojo
Mitochondrial fission inhibition protects against hypertension induced by angiotensin II., Kyle J Preston, Tatsuo Kawai, Keiichi Torimoto, Ryohei Kuroda, Yuki Nakayama, Tomoko Akiyama, Yayoi Kimura, Rosario Scalia, Michael V Autieri, Victor Rizzo, Tomoki Hashimoto, Patrick Osei-Owusu, and Satoru Eguchi
Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment., Richard Smith, Hanna Hovren, Robert Bowser, Nadine Bakkar, Ralph Garruto, Albert Ludolph, John Ravits, Lia Gaertner, Davan Murphy, and Russ Lebovitz
Exoscopic Transcortical-Transventricular Approach With Tubular Retractor for Chronic Encapsulated Expanding Hematoma in the Thalamus., Katsuya Ueno, Akina Iwasaki, Takuma Maeda, Daisuke Tanikawa, Aoto Shibata, Masahito Kobayashi, and Hiroki Kurita
A Sudden Unilateral Visual Field Loss in a Recreational Tennis Player: Cervical Internal Carotid Artery Dissection Associated With Low-Impact Sports., Keijiro Yoshida, Takuma Maeda, Yusuke Nitta, Kaima Suzuki, and Hiroki Kurita
Quantifying cerebral blood flow changes using arterial spin labeling: A comparative study of idiopathic rapid eye movement sleep behavior disorder and Parkinson's disease., Yuqi Zhi, Mingshen Chen, Chunshan Zhou, Yongxu Yang, Yan Huang, Xiaoyun Liang, Ping Wang, Xiaoyu Cheng, Chengjie Mao, Zhen Jiang, Yakang Dai, Bo Peng, and Jiangtao Zhu
Reciprocal Changes in Sagittal Spinal Alignment After L5-S1 Anterior Lumbar Interbody Fusion., James J Zhou, S Harrison Farber, Nima Alan, Charuta G Furey, Luke K O'Neill, Juan P Giraldo, Zaman Mirzadeh, Jay D Turner, and Juan S Uribe
Submissions from 2023
Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device, Nimer Adeeb, Mahmoud Dibas, Jose Danilo Diestro, Kevin Phan, Hugo H. Cuellar-Saenz, Ahmad Sweid, Sovann V. Lay, Adrien Guenego, Assala Aslan, Leonardo Renieri, Sri Hari Sundararajan, Guillaume Saliou, Markus Möhlenbruch, Robert W. Regenhardt, Justin E. Vranic, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Vedran Župančić, Muhammad U. Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M. Tutino, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna L. Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M. Starke, and Ameer Hassan
Molecular Signaling in Stroke, Naseem Akhter and Saif Ahmad
Identification of single-dose, dual-echo based CBV threshold for fractional tumor burden mapping in recurrent glioblastoma, Aliya Anil, Ashley M. Stokes, Renee Chao, Leland S. Hu, Lea Alhilali, John P. Karis, Laura C. Bell, and C Chad Quarles
A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates, Danish M. Anwer, Francesco Gubinelli, Yunus A. Kurt, Livija Sarauskyte, Febe Jacobs, Chiara Venuti, Ivette M. Sandoval, Yiyi Yang, Jennifer Stancati, Martina Mazzocchi, Edoardo Brandi, Gerard O'Keeffe, Kathy Steece-Collier, Jia-Yi Li, Tomas Deierborg, Fredric P. Manfredsson, Marcus Davidsson, and Andreas Heuer
5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades, Evgenii Belykh, Liudmila Bardonova, Irakliy Abramov, Vadim A. Byvaltsev, Talgat Kerymbayev, Kwanha Yu, Debbie R. Healey, Ernesto Luna-Melendez, Benjamin Deneen, Shwetal Mehta, James K. Liu, and Mark C. Preul
Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice, Michael Benatar, Lyle W. Ostrow, Joseph W. Lewcock, Frank Bennett, Jeremy Shefner, Robert Bowser, Paul Larkin, Lucie Bruijn, and Joanne Wuu
Structural connectivity and brain network analyses in Parkinson's disease: A cross-sectional and longitudinal study, Maurizio Bergamino, Elizabeth G. Keeling, Nicola J. Ray, Antonella Macerollo, Monty Silverdale, and Ashley M. Stokes
Assessment of complementary white matter microstructural changes and grey matter atrophy in a preclinical model of Alzheimer's disease, Maurizio Bergamino, Megan R. Nelson, Asfia Numani, Matthew Scarpelli, Deborah Healey, Alberto Fuentes, Gregory Turner, and Ashley M. Stokes
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse, George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser, and Sarah E. Stabenfeldt
Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial, Robert Bowser, Jiyan An, Lahar Mehta, Junliang Chen, Jamie Timmons, Merit Cudkowicz, and Sabrina Paganoni