The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2025
A unique case of heavy-ion therapy-induced intracranial pseudoaneurysm rupture., Soshi Gotan, Takuma Maeda, Masataka Yoshimura, Hiroki Kurita, and Shinya Kohyama
Calcified cerebral emboli following coil embolization: a case report., Soshi Gotan, Takuma Maeda, Masataka Yoshimura, Hiroki Kurita, and Shinya Kohyama
Histopathological analysis of duragen collagen matrix over time in humans., Takuma Maeda, Kaima Suzuki, Peyton L Nisson, Yoshiki Mochizuki, Reina Mizuno, Akio Teranishi, Yushiro Take, Tomomichi Kayahara, and Hiroki Kurita
Ventral Midline Hysterectomy, Ovariectomy, and Ovariohysterectomy in Mus Musculus: A Surgical Protocol., Peyton L Nisson, Takuma Maeda, Hiroki Uchikawa, Oscar Cisneros, Michael T Lawton, and Tomoki Hashimoto
Submissions from 2024
Down Syndrome Biobank Consortium: A perspective., Iban Aldecoa, Isabel Barroeta, Steven L Carroll, Juan Fortea, Anah Gilmore, Stephen D Ginsberg, Samuel J Guzman, Eric D Hamlett, Elizabeth Head, S E Pérez, Huntington Potter, Laura Molina-Porcel, Ruma Raha-Chowdhury, Thomas Wisniewski, William H Yong, Shahid Zaman, Sujay Ghosh, Elliott J Mufson, and Ann-Charlotte Granholm
Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome., Melissa J Alldred, Harshitha Pidikiti, Kyrillos W Ibrahim, Sang Han Lee, Adriana Heguy, Gabriel E Hoffman, Panos Roussos, Thomas Wisniewski, Jerzy Wegiel, Grace E Stutzmann, Elliott J. Mufson, and Stephen D Ginsberg
Exosomes in Vascular/Neurological Disorders and the Road Ahead., Faisal A Alzahrani, Yasir M Riza, Thamir M Eid, Reema Almotairi, Lea Scherschinski, Jessica Contreras, Muhammed Nadeem, Sylvia E Perez, Sudhanshu P Raikwar, Ruchira M Jha, Mark C Preul, Andrew F Ducruet, Michael T Lawton, Kanchan Bhatia, Naseem Akhter, and Saif Ahmad
"Advanced" Parkinson's disease: A review., Sana Aslam, Fredric P. Manfredsson, Ashley Stokes, and Holly Shill
Altered resting-state functional connectivity and dynamic network properties in cognitive impairment: an independent component and dominant-coactivation pattern analyses study., Maurizio Bergamino, Anna Burke, Marwan N Sabbagh, Richard J Caselli, Leslie C Baxter, and Ashley M. Stokes
EGFRvIII Confers Sensitivity to Saracatinib in a STAT5-Dependent Manner in Glioblastoma., Mylan R Blomquist, Ryan Eghlimi, Angad Beniwal, Dustin Grief, David G Nascari, Landon Inge, Christopher P Sereduk, Serdar Tuncali, Alison Roos, Hannah Inforzato, Ritin Sharma, Patrick Pirrotte, Shwetal Mehta, Shannon P Fortin Ensign, Joseph C Loftus, and Nhan L Tran
ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO., Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, and David C Butler
Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy., Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Md Akkas Ali, Ivette M Sandoval, Fredric P. Manfredsson, Jeffrey H Kordower, Daniel J Tyrrell, and Ashley S Harms
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy., Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H Kordower, and Ashley S Harms
A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation., John E Downey, Hunter R Schone, Stephen T. Foldes, Charles Greenspon, Fang Liu, Ceci Verbaarschot, Daniel Biro, David Satzer, Chan Hong Moon, Brian A Coffman, Vahab Youssofzadeh, Daryl Fields, Taylor G Hobbs, Elizaveta Okorokova, Elizabeth C Tyler-Kabara, Peter C Warnke, Jorge Gonzalez-Martinez, Nicholas G Hatsopoulos, Sliman J Bensmaia, Michael L Boninger, Robert A Gaunt, and Jennifer L Collinger
Knockout of the longevity gene Klotho perturbs aging and Alzheimer's disease-linked brain microRNAs and tRNA fragments., Serafima Dubnov, Estelle R Bennett, Nadav Yayon, Or Yakov, David A Bennett, Sudha Seshadri, Elliott J. Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-O, Iddo Paldor, Carmela R Abraham, and Hermona Soreq
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis., Laura Ghezzi, Valeria Tosti, Lisa Shi, Claudia Cantoni, Robert Mikesell, Samantha Lancia, Yanjiao Zhou, Kathleen Obert, Courtney Dula, Monokesh K Sen, Anjie Ge, Miguel Tolentino, Bryan Bollman, Anthony S Don, Giuseppe Matarese, Alessandra Colamatteo, Claudia La Rocca, Maria Teresa Lepore, Cyrus A Raji, Farzaneh Rahmani, Gregory F Wu, Robert T Naismith, Luigi Fontana, Anne H Cross, Amber Salter, and Laura Piccio
Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings., Ann-Charlotte E Granholm, Elisabet Englund, Anah Gilmore, Elizabeth Head, William H Yong, S E Pérez, Samuel J Guzman, Eric D Hamlett, and Elliott J Mufson
Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress., Taichi Ishiguro, Hajime Furukawa, Kyle Polen, Yushiro Take, Hiroki Sato, Daisuke Kudo, Jordan Morgan, Hiroki Uchikawa, Takuma Maeda, Oscar Cisneros, Redi Rahmani, Jinglu Ai, Satoru Eguchi, Michael T Lawton, and Tomoki Hashimoto
A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets., Ruchira M Jha, Dhivyaa Rajasundaram, Chaim Sneiderman, Brent T Schlegel, Casey O'Brien, Zujian Xiong, Keri Janesko-Feldman, Ria Trivedi, Vincent Vagni, Benjamin E Zusman, Joshua S Catapano, Adam Eberle, Shashvat M Desai, Ashutosh P Jadhav, Sandra Mihaljevic, Margaux Miller, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shima Shahjouie, Itay Raphael, Aditya Kumar, Chia-Ling Phuah, Ethan A Winkler, Dennis W Simon, Patrick M Kochanek, and Gary Kohanbash
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy., Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D Kelly, Matthew Goodson, Danica Lee, Fredric P. Manfredsson, Bob M Moore, and Malú Gámez Tansey
Rapid simultaneous estimation of relaxation rates using multi-echo, multi-contrast MRI., Elizabeth G Keeling, Nicholas J Sisco, Molly M McElvogue, Aimee Borazanci, Richard D Dortch, and Ashley M. Stokes
Current Mouse Models of Intracranial Aneurysms: Analysis of Pharmacological Agents Used to Induce Aneurysms and Their Impact on Translational Research., Dilaware Khan, Xuanchen Li, Tomoki Hashimoto, Rokuya Tanikawa, Mika Niemela, Michael Lawton, and Sajjad Muhammad
Vitamin D deficiency promotes intracranial aneurysm rupture., Tetsuro Kimura, Redi Rahmani, Takeshi Miyamoto, Yoshinobu Kamio, Daisuke Kudo, Hiroki Sato, Taichi Ikedo, Jacob F Baranoski, Hiroki Uchikawa, Jinglu Ai, Michael T Lawton, and Tomoki Hashimoto
A validated LC-MS/MS method for determination of neuro-pharmacokinetic behavior of niraparib in brain tumor patients., William Knight, Tigran Margaryan, Nader Sanai, and Artak Tovmasyan
Cardiocerebral Infarction Presenting in a Neurosurgical Emergency: A Case Report and Literature Review., Haruka Kume, Takuma Maeda, Eisuke Tsukagoshi, Takeshi Ogura, Shigehiro Ohmori, and Hiroki Kurita
Debamestrocel multimodal effects on biomarker pathways in amyotrophic lateral sclerosis are linked to clinical outcomes., Stacy R Lindborg, Namita A Goyal, Jonathan Katz, Matthew Burford, Jenny Li, Haggai Kaspi, Natalie Abramov, Bruno Boulanger, James D Berry, Katharine Nicholson, Tahseen Mozaffar, Robert Miller, Liberty Jenkins, Robert H Baloh, Richard Lewis, Nathan P Staff, Margaret Ayo Owegi, Bob Dagher, Netta R Blondheim-Shraga, Yael Gothelf, Yossef S Levy, Ralph Kern, Revital Aricha, Anthony J Windebank, Robert Bowser, Robert H Brown, and Merit E Cudkowicz
A 3D dual-echo spiral sequence for simultaneous dynamic susceptibility contrast and dynamic contrast-enhanced MRI with single bolus injection., Zhiqiang Li, Dinghui Wang, Melvyn B Ooi, Poonam Choudhary, Sudarshan Ragunathan, John P Karis, James G Pipe, C Chad Quarles, and Ashley M. Stokes
A Late Complication Related to Percutaneous Implantable Leads for Spinal Cord Stimulation: Myelopathy due to Fibrous Scar Tissue., Takuma Maeda, Takashi Agari, Takashi Komori, and Keisuke Takai
Clinical Outcomes in Elderly Patients with Chronic Subdural Hematoma: Validation of Irrigation Assignment Based on Hematoma Characteristics., Takuma Maeda, Yuichiro Kikkawa, Takuro Ehara, Ryosuke Tsuchiya, Shinya Tabata, Koki Onodera, Tatsuki Kimura, Yushiro Take, Kaima Suzuki, and Hiroki Kurita
Neurosurgical Outcomes for Intracerebral Hemorrhage in Patients Undergoing Dialysis., Takuma Maeda, Mayuko Miyata, Nobuaki Naito, Koki Onodera, Yushiro Take, Aoto Shibata, Kaima Suzuki, Hidetoshi Ooigawa, and Hiroki Kurita
Robotics in Microneurosurgery: Beyond the Exoscope., Takuma Maeda and Peyton L Nisson
Initial real-world experience of clazosentan for subarachnoid hemorrhage in Japan., Takuma Maeda, Mai Okawara, Manabu Osakabe, Hiroyuki Yamaguchi, Takahiro Maeda, and Hiroki Kurita
Amyloid β interferes with wound healing of brain microvascular endothelial cells by disorganizing the actin cytoskeleton., Takuma Maeda, Keiya Shimamori, Hiroki Kurita, Kiyotaka Tokuraku, and Masahiro Kuragano
A Window Into Basal Forebrain Cholinergic Dysfunction in Patients With Cortical Basal Syndrome., Elliott J. Mufson
Exploring white matter microstructural alterations in mild cognitive impairment: a multimodal diffusion MRI investigation utilizing diffusion kurtosis and free-water imaging., Megan R Nelson, Elizabeth G Keeling, Ashley M. Stokes, and Maurizio Bergamino
A proposed stratification system to address the heterogeneity of Subdural Hematoma Outcome reporting in the literature., Peyton L Nisson, John Francis, Michelot Michel, Takuma Maeda, and Chirag Patil
Vascular Endothelial Growth Factor and the Pathogenesis of Intracranial Aneurysms: A Systematic Review on the Missing Link in a Complex Pathway., Peyton L Nisson, Michael T Lawton, Oscar Cisneros, Takuma Maeda, Nestor R Gonzalez, Juhana Frösen, and Tomoki Hashimoto
ALSUntangled #75: Portable neuromodulation stimulator therapy., Laurel Officer, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Andrew Brown, Olimpia Mihaela Carbunar, Gregory T Carter, Jesse Crayle, Keelie Denson, Eva Feldman, Timothy Fullam, Terry Heiman-Patterson, Carlayne Jackson, Sartaj Jhooty, Danelle Levinson, Xiaoyan Li, Alexandra Linares, Elise Mallon, Javier Mascias Cadavid, Christopher Mcdermott, Tasnim Mushannen, Lyle Ostrow, Ronak Patel, Gary Pattee, Dylan Ratner, Yuyao Sun, John Sladky, Paul Wicks, and Richard Bedlack
Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy., Camila Ortiz, Andrew Pearson, Robyn McCartan, Shawn Roche, Nolan Carothers, Mackenzie Browning, S E Pérez, Bin He, Stephen D Ginsberg, Michael Mullan, Elliott J Mufson, Fiona Crawford, and Joseph Ojo
Mitochondrial fission inhibition protects against hypertension induced by angiotensin II., Kyle J Preston, Tatsuo Kawai, Keiichi Torimoto, Ryohei Kuroda, Yuki Nakayama, Tomoko Akiyama, Yayoi Kimura, Rosario Scalia, Michael V Autieri, Victor Rizzo, Tomoki Hashimoto, Patrick Osei-Owusu, and Satoru Eguchi
Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment., Richard Smith, Hanna Hovren, Robert Bowser, Nadine Bakkar, Ralph Garruto, Albert Ludolph, John Ravits, Lia Gaertner, Davan Murphy, and Russ Lebovitz
Exoscopic Transcortical-Transventricular Approach With Tubular Retractor for Chronic Encapsulated Expanding Hematoma in the Thalamus., Katsuya Ueno, Akina Iwasaki, Takuma Maeda, Daisuke Tanikawa, Aoto Shibata, Masahito Kobayashi, and Hiroki Kurita
A Sudden Unilateral Visual Field Loss in a Recreational Tennis Player: Cervical Internal Carotid Artery Dissection Associated With Low-Impact Sports., Keijiro Yoshida, Takuma Maeda, Yusuke Nitta, Kaima Suzuki, and Hiroki Kurita
Quantifying cerebral blood flow changes using arterial spin labeling: A comparative study of idiopathic rapid eye movement sleep behavior disorder and Parkinson's disease., Yuqi Zhi, Mingshen Chen, Chunshan Zhou, Yongxu Yang, Yan Huang, Xiaoyun Liang, Ping Wang, Xiaoyu Cheng, Chengjie Mao, Zhen Jiang, Yakang Dai, Bo Peng, and Jiangtao Zhu
Reciprocal Changes in Sagittal Spinal Alignment After L5-S1 Anterior Lumbar Interbody Fusion., James J Zhou, S Harrison Farber, Nima Alan, Charuta G Furey, Luke K O'Neill, Juan P Giraldo, Zaman Mirzadeh, Jay D Turner, and Juan S Uribe
Submissions from 2023
Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device, Nimer Adeeb, Mahmoud Dibas, Jose Danilo Diestro, Kevin Phan, Hugo H. Cuellar-Saenz, Ahmad Sweid, Sovann V. Lay, Adrien Guenego, Assala Aslan, Leonardo Renieri, Sri Hari Sundararajan, Guillaume Saliou, Markus Möhlenbruch, Robert W. Regenhardt, Justin E. Vranic, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Vedran Župančić, Muhammad U. Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M. Tutino, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna L. Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M. Starke, and Ameer Hassan
Molecular Signaling in Stroke, Naseem Akhter and Saif Ahmad
Identification of single-dose, dual-echo based CBV threshold for fractional tumor burden mapping in recurrent glioblastoma, Aliya Anil, Ashley M. Stokes, Renee Chao, Leland S. Hu, Lea Alhilali, John P. Karis, Laura C. Bell, and C Chad Quarles
A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates, Danish M. Anwer, Francesco Gubinelli, Yunus A. Kurt, Livija Sarauskyte, Febe Jacobs, Chiara Venuti, Ivette M. Sandoval, Yiyi Yang, Jennifer Stancati, Martina Mazzocchi, Edoardo Brandi, Gerard O'Keeffe, Kathy Steece-Collier, Jia-Yi Li, Tomas Deierborg, Fredric P. Manfredsson, Marcus Davidsson, and Andreas Heuer
5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades, Evgenii Belykh, Liudmila Bardonova, Irakliy Abramov, Vadim A. Byvaltsev, Talgat Kerymbayev, Kwanha Yu, Debbie R. Healey, Ernesto Luna-Melendez, Benjamin Deneen, Shwetal Mehta, James K. Liu, and Mark C. Preul
Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice, Michael Benatar, Lyle W. Ostrow, Joseph W. Lewcock, Frank Bennett, Jeremy Shefner, Robert Bowser, Paul Larkin, Lucie Bruijn, and Joanne Wuu
Structural connectivity and brain network analyses in Parkinson's disease: A cross-sectional and longitudinal study, Maurizio Bergamino, Elizabeth G. Keeling, Nicola J. Ray, Antonella Macerollo, Monty Silverdale, and Ashley M. Stokes
Assessment of complementary white matter microstructural changes and grey matter atrophy in a preclinical model of Alzheimer's disease, Maurizio Bergamino, Megan R. Nelson, Asfia Numani, Matthew Scarpelli, Deborah Healey, Alberto Fuentes, Gregory Turner, and Ashley M. Stokes
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse, George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser, and Sarah E. Stabenfeldt
Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial, Robert Bowser, Jiyan An, Lahar Mehta, Junliang Chen, Jamie Timmons, Merit Cudkowicz, and Sabrina Paganoni
Broad Serotonergic Actions of Vortioxetine as a Promising Avenue for the Treatment of L-DOPA-Induced Dyskinesia, Carla Budrow, Kayla Elder, Michael Coyle, Ashley Centner, Natalie Lipari, Sophie Cohen, John Glinski, N'Senga Kinzonzi, Emily Wheelis, Grace McManus, Fredric Manfredsson, and Christopher Bishop
Targeting miR-223 enhances myeloid-derived suppressor cell suppressive activities in multiple sclerosis patients, Claudia Cantoni, Laura Ghezzi, Jasmine Choi, Anne H. Cross, and Laura Piccio
The circular RNA landscape in multiple sclerosis: Disease-specific associated variants and exon methylation shape circular RNA expression profile, Giulia Cardamone, Elvezia Maria Paraboschi, Giulia Soldà, Giuseppe Liberatore, Valeria Rimoldi, Javier Cibella, Federica Airi, Veronica Tisato, Claudia Cantoni, Francesca Gallia, Donato Gemmati, Laura Piccio, Stefano Duga, Eduardo Nobile-Orazio, and Rosanna Asselta
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus, Maria Čarna, Isaac G. Onyango, Stanislav Katina, Dušan Holub, Jan Sebastian Novotny, Marketa Nezvedova, Durga Jha, Zuzana Nedelska, Valentina Lacovich, Thijs Vande Vyvere, Ruben Houbrechts, Krystine Garcia-Mansfield, Ritin Sharma, Victoria David-Dirgo, Martin Vyhnalek, Kateřina Texlova, Hernan Chaves, Nadine Bakkar, Lucia Pertierra, Mojmir Vinkler, Hana Markova, Jan Laczo, Kateřina Sheardova, Marcela Hortova-Kohoutkova, Jan Frič, Giancarlo Forte, Petr Kaňovsky, Silvie Belaškova, Jiři Damborsky, Jakub Hort, Nicholas T. Seyfried, and Robert Bowser
Association between external ventricular drain removal or replacement and prophylactic anticoagulation in patients with aneurysmal subarachnoid hemorrhage: a propensity-adjusted analysis, Joshua S. Catapano, Stefan W. Koester, Parth P. Parikh, Kavelin Rumalla, Henry O. Stonnington, Rohin Singh, Ethan A. Winkler, Christopher S. Graffeo, Robert F. Rudy, Visish M. Srinivasan, Ruchira M. Jha, Ashutosh P. Jadhav, Felipe C. Albuquerque, Michael T. Lawton, and Andrew F. Ducruet
The Role of Striatal Cav1.3 Calcium Channels in Therapeutics for Parkinson's Disease, Margaret E. Caulfield, Fredric P. Manfredsson, and Kathy Steece-Collier
Downregulation of striatal Ca1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age, Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, and Kathy Steece-Collier
MRI and amino acid PET detection of whole-brain tumor burden, Peng Chen, Matthew L. Scarpelli, Debbie R. Healey, Shwetal Mehta, and C Chad Quarles
BMP10 functions independently from BMP9 for the development of a proper arteriovenous network, Hyunwoo Choi, Bo-Gyeong Kim, Yong Hwan Kim, Se-Jin Lee, Young Jae Lee, and S Paul Oh
Naturally occurring histological findings and Alzheimer's-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus), Tatiana M. Corey, Oscar Illanes, Matthew Lawrence, Sylvia E. Perez, Shervin Liddie, and John J. Callanan
Biomechanical Assessment of a Novel Sharp-Tipped Screw for 1-Step Minimally Invasive Pedicle Screw Placement Under Navigation, Bernardo de Andrada Pereira, Luke K. O'Neill, Anna G. Sawa, James J. Zhou, Piyanat Wangsawatwong, Jennifer N. Lehrman, Jakub Godzik, Alton J. Oldham, Jay D. Turner, Brian P. Kelly, and Juan S. Uribe
MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS, Marissa Dominick, Nicole Houchins, Vinisha Venugopal, Aamir R. Zuberi, Cathleen M. Lutz, Bessie Meechooveet, Kendall Van Keuren-Jensen, Robert Bowser, and David X. Medina
Molecular subtypes of ALS are associated with differences in patient prognosis, Jarrett Eshima, Samantha A. O'Connor, and Ethan Marschall
Clip Reconstruction of a Ruptured Thoracic Anterior Spinal Artery Aneurysm Utilizing a Costotransversectomy Approach: 2-Dimensional Operative Video, S Harrison Farber, Redi Rahmani, Lea Scherschinski, Joseph D. DiDomenico, Luke A. Mugge, Arnau Benet, Jennifer E. Kim, Andrew F. Ducruet, Jay D. Turner, and Michael T. Lawton
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation, Fabia Filipello, Shih-Feng You, Farzaneh S. Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A. Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A. Minaya, Arun Renganathan, Anil G. Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K. Iyer, Marina Cella, Wendy H. Raskind, Laura Piccio, and Celeste M. Karch
ALSUntangled # 69: astaxanthin, Timothy Fullam, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Javier Mascias Cadavid, Gregory T. Carter, Mazen Dimachkie, Dave Ennist, Eva L. Feldman, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Dylan Ratner, Paul Wicks, and Richard Bedlack
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease, Megan K. Gautier, Christy M. Kelley, Sang Han Lee, Melissa J. Alldred, John McDaid, Elliott J. Mufson, Grace E. Stutzmann, and Stephen D. Ginsberg
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum, Lauren M. Gittings, Eric B. Alsop, Jerry Antone, Mo Singer, Timothy G. Whitsett, Rita Sattler, and Kendall Van Keuren-Jensen
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits, R Keating Godfrey, Eric Alsop, Reed T. Bjork, Brijesh S. Chauhan, Hillary C. Ruvalcaba, Jerry Antone, Lauren M. Gittings, Allison F. Michael, Christi Williams, Grace Hala'ufia, Alexander D. Blythe, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, and Daniela C. Zarnescu
ALSUntangled #70: caffeine, Jessica Hatch, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Andrew Brown, Javier Mascias Cadavid, Gregory T. Carter, Nicholas Cole, Jesse Crayle, Mazen Dimachkie, David Ennist, Eva Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Todd Levine, Xiaoyan Li, Isaac Lund, Elise Mallon, Nicholas Maragakis, Christopher McDermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Kim Staats, Paul Wicks, Martina Wiedau, and Richard Bedlack
Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling, Ella A. Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K. Shifflet, Caleb Parry, Arturo Barahona, Fredric P. Manfredsson, Vicki A. Nejtek, Jason R. Richardson, and Michael F. Salvatore
Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs, Ella A. Kasanga, Yoonhee Han, Marla K. Shifflet, Walter Navarrete, Robert McManus, Caleb Parry, Arturo Barahona, Vicki A. Nejtek, Fredric P. Manfredsson, Jeffrey H. Kordower, Jason R. Richardson, and Michael F. Salvatore
Analysis of the Weekend Effect at a High-Volume Center for the Treatment of Intracranial Aneurysms, Stefan W. Koester, Joshua S. Catapano, Kavelin Rumalla, Visish M. Srinivasan, Emmajane G. Rhodenhiser, Joelle N. Hartke, Dimitri Benner, Ethan A. Winkler, Tyler S. Cole, Jacob F. Baranoski, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Ischemic stroke in a young adult with a known epileptogenic arteriovenous malformation: illustrative case., Seiji Kuribara, Takuma Maeda, Taro Yanagawa, Eisuke Tsukagoshi, Shinya Kohyama, and Hiroki Kurita
Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model, Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P. Manfredsson, Susan B. Powell, and Davide Dulcis
Characterizing the relationship between L-DOPA-induced-dyskinesia and psychosis-like behaviors in a bilateral rat model of Parkinson's disease, Natalie Lipari, Ashley Centner, John Glinski, Sophie Cohen, Fredric P. Manfredsson, and Christopher Bishop
Quisinostat is a brain-penetrant radiosensitizer in glioblastoma, Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, and Shwetal Mehta
Moderate intrinsic phenotypic alterations in ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features, Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, and Rita Sattler
Giant saccular aneurysm of the cervical internal carotid artery treated with aneurysmectomy and side-to-end anastomosis., Takuma Maeda, Shiho Sakai, Manabu Osakabe, Mai Okawara, Tatsufumi Nomura, Hiroyuki Yamaguchi, Takahiro Maeda, and Hiroki Kurita
Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease, Laura J. Mahady, Sylvia E. Perez, Michael Malek-Ahmadi, and Elliott J. Mufson
Application of robust regression in translational neuroscience studies with non-Gaussian outcome data., Michael Malek-Ahmadi, Stephen D Ginsberg, Melissa J Alldred, Scott E Counts, Milos D Ikonomovic, Eric E Abrahamson, S E Pérez, and Elliott J Mufson
Large, Wide-Neck, Side-Wall Aneurysm Treatment in Canines Using NeuroCURE: A Novel Liquid Embolic, William C. Merritt, Nicholas Norris, Sophia Robertson, Mark C. Preul, Andrew F. Ducruet, and Timothy A. Becker
Vesicular Glutamate Transporter Changes in the Cortical Default Mode Network During the Clinical and Pathological Progression of Alzheimer's Disease, Zhiping Mi, Eric E. Abrahamson, Angela Y. Ryu, Michael Malek-Ahmadi, Julia K. Kofler, Kenneth N. Fish, Robert A. Sweet, Victor L. Villemagne, Julie A. Schneider, Elliott J. Mufson, and Milos D. Ikonomovic
Cerebrospinal Fluid Biomarkers for Diagnosis and the Prognostication of Acute Ischemic Stroke: A Systematic Review, Anant Naik, Olufunmilola Adeleye, Stefan W. Koester, Ethan A. Winkler, Joelle N. Hartke, Katherine Karahalios, Sandra Mihaljevic, Anupama Rani, Sudhanshu Raikwar, Jarrod D. Rulney, Shashvat M. Desai, Lea Scherschinski, Andrew F. Ducruet, Felipe C. Albuquerque, Michael T. Lawton, Joshua S. Catapano, Ashutosh P. Jadhav, and Ruchira M. Jha
Intraarterial urokinase for thrombus migration after mechanical thrombectomy for large vessel ischemic stroke., Hiroaki Neki, Takehiro Katano, Takuma Maeda, Aoto Shibata, Hiroyuki Komine, and Yuichiro Kikkawa
Asymptomatic subarachnoid hemorrhage following carotid endarterectomy: illustrative case., Shin Nemoto, Takuma Maeda, Keiichi Yamashita, Taro Yanagawa, Masataka Torii, Masaru Kiyomoto, Masaki Tanaka, Eishi Sato, Yoichi Harada, Toru Hatayama, Takuji Kono, and Hiroki Kurita
Smooth muscle angiotensin II type 1A receptor is required for abdominal aortic aneurysm formation induced by angiotensin II plus β-aminopropionitrile, Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Tomoki Hashimoto, Matthew A. Sparks, Victor Rizzo, and Satoru Eguchi
Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II, Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, and Satoru Eguchi
Intraventricular Tissue Plasminogen Activator and Shunt Dependency in Aneurysmal Subarachnoid Hemorrhage, Mark A. Pacult, Joshua S. Catapano, Kavelin Rumalla, Ethan A. Winkler, Christopher S. Graffeo, Visish M. Srinivasan, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Robot-Assisted Transcranial Doppler Versus Transthoracic Echocardiography for Right to Left Shunt Detection, Mark N. Rubin, Ruchir Shah, Thomas Devlin, Teddy S. Youn, Michael F. Waters, John J. Volpi, Aaron Stayman, Colleen M. Douville, Ted Lowenkopf, Georgios Tsivgoulis, and Andrei V. Alexandrov
Republished: Resolution of an enlarging subdural haematoma after contralateral middle meningeal artery embolisation, Caleb Rutledge, Jacob F. Baranoski, Joshua S. Catapano, Ashutosh P. Jadhav, Felipe C. Albuquerque, and Andrew F. Ducruet
Obesity, gut microbiota, and multiple sclerosis: Unraveling the connection, Amjad Samara, Claudia Cantoni, Laura Piccio, Anne H. Cross, and Salim Chahin
Rod Attachment Induces Significant Strain in Lumbosacral Fixation, Anna G. Sawa, Piyanat Wangsawatwong, Jennifer N. Lehrman, Taylor Hostetler, Bernardo de Andrada Pereira, Jakub Godzik, Randall J. Hlubek, Juan S. Uribe, Jay D. Turner, and Brian P. Kelly
Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia, Lea Scherschinski, Chul Han, Yong Hwan Kim, Ethan A. Winkler, Joshua S. Catapano, Tyler D. Schriber, Peter Vajkoczy, Michael T. Lawton, and S Paul Oh
The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPI-Dynamic Contrast-Enhanced challenge, Eve S. Shalom, Harrison Kim, Rianne A. van der Heijden, Zaki Ahmed, Reyna Patel, David A. Hormuth, Julie C. DiCarlo, Thomas E. Yankeelov, Nicholas J. Sisco, Richard D. Dortch, Ashley M. Stokes, Marianna Inglese, Matthew Grech-Sollars, Nicola Toschi, Prativa Sahoo, Anup Singh, Sanjay K. Verma, Divya K. Rathore, Anum S. Kazerouni, Savannah C. Partridge, Eve LoCastro, Ramesh Paudyal, Ivan A. Wolansky, Amita Shukla-Dave, Pepijn Schouten, Oliver J. Gurney-Champion, Radovan Jiřík, Ondřej Macíček, Michal Bartoš, Jiří Vitouš, and Ayesha Bharadwaj Das