Exosomes in Vascular/Neurological Disorders and the Road Ahead.

Document Type

Article

Abstract

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke, and aneurysms, are characterized by the abnormal accumulation and aggregation of disease-causing proteins in the brain and spinal cord. Recent research suggests that proteins linked to these conditions can be secreted and transferred among cells using exosomes. The transmission of abnormal protein buildup and the gradual degeneration in the brains of impacted individuals might be supported by these exosomes. Furthermore, it has been reported that neuroprotective functions can also be attributed to exosomes in neurodegenerative diseases. The potential neuroprotective functions may play a role in preventing the formation of aggregates and abnormal accumulation of proteins associated with the disease. The present review summarizes the roles of exosomes in neurodegenerative diseases as well as elucidating their therapeutic potential in AD, PD, ALS, HD, stroke, and aneurysms. By elucidating these two aspects of exosomes, valuable insights into potential therapeutic targets for treating neurodegenerative diseases may be provided.

Keywords

Exosomes, Humans, Animals, Neurodegenerative Diseases, Vascular Diseases, Nervous System Diseases

Medical Subject Headings

Exosomes; Humans; Animals; Neurodegenerative Diseases; Vascular Diseases; Nervous System Diseases

Publication Date

4-12-2024

Publication Title

Cells

ISSN

2073-4409

Volume

13

Issue

8

PubMed ID

38667285

Digital Object Identifier (DOI)

10.3390/cells13080670

This document is currently not available here.

Share

COinS