A 3D dual-echo spiral sequence for simultaneous dynamic susceptibility contrast and dynamic contrast-enhanced MRI with single bolus injection.

Document Type

Article

Abstract

PURPOSE: Perfusion MRI reveals important tumor physiological and pathophysiologic information, making it a critical component in managing brain tumor patients. This study aimed to develop a dual-echo 3D spiral technique with a single-bolus scheme to simultaneously acquire both dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) data and overcome the limitations of current EPI-based techniques.

METHODS: A 3D spiral-based technique with dual-echo acquisition was implemented and optimized on a 3T MRI scanner with a spiral staircase trajectory and through-plane SENSE acceleration for improved speed and image quality, in-plane variable-density undersampling combined with a sliding-window acquisition and reconstruction approach for increased speed, and an advanced iterative deblurring algorithm. Four volunteers were scanned and compared with the standard of care (SOC) single-echo EPI and a dual-echo EPI technique. Two patients were scanned with the spiral technique during a preload bolus and compared with the SOC single-echo EPI collected during the second bolus injection.

RESULTS: Volunteer data demonstrated that the spiral technique achieved high image quality, reduced geometric artifacts, and high temporal SNR compared with both single-echo and dual-echo EPI. Patient perfusion data showed that the spiral acquisition achieved accurate DSC quantification comparable to SOC single-echo dual-dose EPI, with the additional DCE information.

CONCLUSION: A 3D dual-echo spiral technique was developed to simultaneously acquire both DSC and DCE data in a single-bolus injection with reduced contrast use. Preliminary volunteer and patient data demonstrated increased temporal SNR, reduced geometric artifacts, and accurate perfusion quantification, suggesting a competitive alternative to SOC-EPI techniques for brain perfusion MRI.

Keywords

Humans, Contrast Media, Imaging, Three-Dimensional, Algorithms, Brain Neoplasms, Brain, Magnetic Resonance Imaging, Echo-Planar Imaging, Artifacts, Male, Female, Adult, Image Processing, Computer-Assisted, Signal-To-Noise Ratio, Image Enhancement, Image Interpretation, Computer-Assisted

Medical Subject Headings

Humans; Contrast Media; Imaging, Three-Dimensional; Algorithms; Brain Neoplasms; Brain; Magnetic Resonance Imaging; Echo-Planar Imaging; Artifacts; Male; Female; Adult; Image Processing, Computer-Assisted; Signal-To-Noise Ratio; Image Enhancement; Image Interpretation, Computer-Assisted

Publication Date

8-1-2024

Publication Title

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine

ISSN

1522-2594

Volume

92

Issue

2

First Page

631

Last Page

644

PubMed ID

38469930

Digital Object Identifier (DOI)

10.1002/mrm.30077

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