The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.


Submissions from 2020

Optimizing Next-Generation Care Systems for Stroke, D Andrew Wilkinson, Ashutosh P. Jadhav, and Andrew F. Ducruet

Patterns and disparities in human papillomavirus (HPV) vaccine uptake for young female adolescents among U.S. States: NIS-teen (2008–2016), Wonsuk Yoo, Alexis Koskan, Matthew Scotch, Heidi Pottinger, Warner K. Huh, and Deborah Helitzer


CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual., Yeomin Yun, Sung-Ah Hong, Ka-Kyung Kim, Daye Baek, Dongsu Lee, Ashwini M Londhe, Minhyung Lee, Jihyeon Yu, Zachary T McEachin, Gary J Bassell, Robert Bowser, Chadwick M Hales, Sung-Rae Cho, Janghwan Kim, Ae Nim Pae, Eunji Cheong, Sangwoo Kim, Nicholas M Boulis, Sangsu Bae, and Yoon Ha

Submissions from 2019

Neuropathological Correlates Of Amyloid Pet Imaging In Down Syndrome, Eric E. Abrahamson, Elizabeth Head, Ira T. Lott, Benjamin L. Handen, Elliott J. Mufson, Bradley T. Christian, William E. Klunk, and Milos D. Ikonomovic

Connectivity and Centrality Characteristics of the Epileptogenic Focus Using Directed Network Analysis, Joshua A. Adkinson, Bharat Karumuri, Timothy N. Hutson, Rui Liu, Omar Alamoudi, Ioannis Vlachos, and Leonidas Iasemidis

The Role of Complement C3a Receptor in Stroke, Saif Ahmad, Kanchan Bhatia, Adam Kindelin, and Andrew F. Ducruet

Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion, Saif Ahmad, Shah Alam Khan, Adam Kindelin, Tasha Mohseni, Kanchan Bhatia, Md Nasrul Hoda, and Andrew F. Ducruet

C3a receptor inhibition protects brain endothelial cells against oxygen-glucose deprivation/reperfusion, Saif Ahmad, Adam Kindelin, Shah Alam Khan, Maaz Ahmed, Md Nasrul Hoda, Kanchan Bhatia, and Andrew F. Ducruet

First spine surgery utilizing real-time image-guided robotic assistance, A. Karim Ahmed, Corinna C. Zygourakis, Samuel Kalb, Alex M. Zhu, Camilo A. Molina, Bowen Jiang, Ari M. Blitz, Ali Bydon, Neil R. Crawford, and Nicholas Theodore


Approaches to Multimodality Monitoring in Pediatric Traumatic Brain Injury, Brian Appavu, Brian T. Burrows, Stephen Foldes, and P David Adelson


Clinical trials for pediatric traumatic brain injury: definition of insanity?, Brian Appavu, Stephen T. Foldes, and P David Adelson

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis, Sara Bandres-Ciga, Alastair J. Noyce, Gibran Hemani, Aude Nicolas, Andrea Calvo, Gabriele Mora, Alessandro Arosio, Marco Barberis, Ilaria Bartolomei, Stefania Battistini, Michele Benigni, Giuseppe Borghero, Maura Brunetti, Stefania Cammarosano, Antonino Cannas, Antonio Canosa, Margherita Capasso, Claudia Caponnetto, Carla Caredda, Paola Carrera, Federico Casale, Sebastiano Cavallaro, Adriano Chiò, Tiziana Colletti, Francesca L. Conforti, Amelia Conte, Lucia Corrado, Emanuela Costantino, Sandra D'Alfonso, Antonio Fasano, and Cinzia Femiano

Flow-Diverter Stent With an Incorporated Flow Sensor-The Integration of a Treatment and Diagnostic Device for Intracranial Aneurysms, Jacob F. Baranoski and Andrew F. Ducruet

Nanoparticle-Facilitated Delivery of Antioxidant Therapy following Aneurysmal Subarachnoid Hemorrhage, Jacob F. Baranoski and Andrew F. Ducruet

Recent Advances in Basic Research for Brain Arteriovenous Malformation, Leandro Barbosa Do Prado, Chul Han, S. Paul Oh, and Hua Su

Evaluating Multisite Rcbv Consistency From Dsc-Mri Imaging Protocols And Postprocessing Software Across The Nci Quantitative Imaging Network Sites Using A Digital Reference Object (Dro), Laura C. Bell, Natenael Semmineh, Hongyu An, Cihat Eldeniz, Richard Wahl, Kathleen M. Schmainda, Melissa A. Prah, Bradley J. Erickson, Panagiotis Korfiatis, Chengyue Wu, Anna G. Sorace, Thomas E. Yankeelov, Neal Rutledge, Thomas L. Chenevert, Dariya Malyarenko, Yichu Liu, Andrew Brenner, Lel S. Hu, Yuxiang Zhou, Jerrold L. Boxerman, Yi Fen Yen, Jayashree Kalpathy-Cramer, Andrew L. Beers, Mark Muzi, Ananth J. Madhuranthakam, Marco Pinho, Brian Johnson, and C. Chad Quarles

Analysis Of Postprocessing Steps For Residue Function Dependent Dynamic Susceptibility Contrast (Dsc)-Mri Biomarkers And Their Clinical Impact On Glioma Grading For Both 1.5 And 3T, Laura C. Bell, Ashley M. Stokes, and C. Chad Quarles

Neurofilaments in pre-symptomatic ALS and the impact of genotype., Michael Benatar, Joanne Wuu, Vittoria Lombardi, Andreas Jeromin, Robert Bowser, Peter M Andersen, and Andrea Malaspina

Basic Concepts in Viral Vector-Mediated Gene Therapy, Matthew J. Benskey, Ivette M. Sandoval, Kathryn Miller, Rhyomi L. Sellnow, Aysegul Gezer, Nathan C. Kuhn, Roslyn Vashon, and Fredric P. Manfredsson

Revisiting How the Brain Senses Glucose-And Why, Marie Aare Bentsen, Zaman Mirzadeh, and Michael W. Schwartz


Resting-state fMRI in disorders of consciousness to facilitate early therapeutic intervention, Varina L. Boerwinkle, Salvatore J. Torrisi, Stephen T. Foldes, Iris Marku, Manish Ranjan, Angus A. Wilfong, and P David Adelson

Biomechanical Testing of a 3D-printed L5 Vertebral Body Model, Michael A. Bohl, Clinton D. Morgan, Michael A. Mooney, Garrett J. Repp, Jennifer N. Lehrman, Brian P. Kelly, Steve W. Chang, Jay D. Turner, and U Kumar Kakarla

ALSUntangled 48: Perampanel (Fycompa)., Robert Bowser

ALSUntangled No. 47: RT001., Robert Bowser

ALSUntangled 46: penicillin G/hydrocortisone., Robert Bowser and ALSUntangled Group

ALSUntangled no. 49: resveratrol., Robert Bowser and ALSUntangled Group

ALSUntangled No. 50: Antifungal Therapy., Robert Bowser and ALSUntangled Group


Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis, Giulia Cardamone, Elvezia M. Paraboschi, Giulia Soldà, Claudia Cantoni, Domenico Supino, Laura Piccio, Stefano Duga, and Rosanna Asselta

Iatrogenic pseudoaneurysm rupture of the anterior cerebral artery after placement of an external ventricular drain, treated with clip-wrapping: a case report and review of the literature, Joshua S. Catapano, Michaela Lee, Damjan Veljanoski, Alexander C. Whiting, Scott Brigeman, Clinton D. Morgan, Mohamed A. Labib, Andrew F. Ducruet, and Peter Nakaji

Highlights of the 13th International Hereditary Hemorrhagic Telangiectasia Scientific conference, Hyunwoo Choi, Miles B. Conrad, S. Paul Oh, Beth L. Roman, and Andrew J. White

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk, Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J Brett, Bruno A Benitez, Celeste M Karch, Laura Piccio, and Carlos Cruchaga

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation, Daniel Duran, Xue Zeng, Sheng Chih Jin, Jungmin Choi, Carol Nelson-Williams, Bogdan Yatsula, Jonathan Gaillard, Charuta Gavankar Furey, Qiongshi Lu, Andrew T. Timberlake, Weilai Dong, Michelle A. Sorscher, Erin Loring, Jennifer Klein, August Allocco, Ava Hunt, Sierra Conine, Jason K. Karimy, Mark W. Youngblood, Jinwei Zhang, Michael L. DiLuna, Charles C. Matouk, Shrikant Mane, Irina R. Tikhonova, Christopher Castaldi, Francesc López-Giráldez, James Knight, Shozeb Haider, Mariya Soban, Seth L. Alper, Masaki Komiyama, and Andrew F. Ducruet

Organized Social Activity, Physical Exercise, and the Risk of Insomnia Symptoms Among Community-Dwelling Older Adults, Yohannes W. Endeshaw and Wonsuk Yoo

Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia, Marie E. Faughnan, James R. Gossage, Murali M. Chakinala, S. Paul Oh, Raj Kasthuri, Christopher C.W. Hughes, Justin P. McWilliams, Joseph G. Parambil, Nicholas Vozoris, Jill Donaldson, Gitanjali Paul, Pamela Berry, and Dennis L. Sprecher

Alpha6-Containing Nicotinic Acetylcholine Receptor Is A Highly Sensitive Target Of Alcohol, Fenfei Gao, Dejie Chen, Xiaokuang Ma, Sterling Sudweeks, Jordan T. Yorgason, Ming Gao, Dharshaun Turner, Jason Brek Eaton, J. Michael McIntosh, Ronald J. Lukas, Paul Whiteaker, Yongchang Chang, Scott C. Steffensen, and Jie Wu

Brain-Derived Neurotrophic Factor (Bdnf) And Trkb Hippocampal Gene Expression Are Putative Predictors Of Neuritic Plaque And Neurofibrillary Tangle Pathology, Stephen D. Ginsberg, Michael H. Malek-Ahmadi, Melissa J. Alldred, Yinghua Chen, Kewei Chen, Moses V. Chao, Scott E. Counts, and Elliott J. Mufson

Selective Decline Of Neurotrophin And Neurotrophin Receptor Genes Within Ca1 Pyramidal Neurons And Hippocampus Proper: Correlation With Cognitive Performance And Neuropathology In Mild Cognitive Impairment And Alzheimer'S Disease, Stephen D. Ginsberg, Michael H. Malek-Ahmadi, Melissa J. Alldred, Shaoli Che, Irina Elarova, Yinghua Chen, Freddy Jeanneteau, Thorsten M. Kranz, Moses V. Chao, Scott E. Counts, and Elliott J. Mufson


Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS, Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs, and Tammaryn Lashley

Biomechanical Evaluation Of Cervicothoracic Junction Fusion Constructs, Jakub Godzik, Jonathan F. Dalton, Eduardo Martinez-del-Campo, Anna G.U.S. Newcomb, Felix Dominguez, Phillip M. Reyes, Nicholas Theodore, Brian P. Kelly, and Neil R. Crawford

Supplemental Rods Are Needed To Maximally Reduce Rod Strain Across The Lumbosacral Junction With Tlif But Not Alif In Long Constructs, Jakub Godzik, Randall J. Hlubek, Anna G.U.S. Newcomb, Jennifer N. Lehrman, Bernardo de Andrada, S. Harrison Farber, Lawrence G. Lenke, Brian P. Kelly, and Jay D. Turner

Impact Of Connector Placement And Design On Bending Stiffness Of Spinal Constructs, Jakub Godzik, Nick Hool, Jonathan F. Dalton, Alexander C. Whiting, Anna G.U.S. Newcomb, Brian P. Kelly, and Neil R. Crawford

Tailoring selection of transforaminal interbody spacers based on biomechanical characteristics and surgical goals: evaluation of an expandable spacer., Jakub Godzik, Jennifer N Lehrman, Anna G U S Newcomb, Ram Kumar Menon, Alexander C Whiting, Brian P. Kelly, and Laura A Snyder

A clinical comparison of Atlas and LVIS Jr stent-assisted aneurysm coiling, Bradley A. Gross, William J. Ares, Andrew F. Ducruet, Ashutosh P. Jadhav, Tudor G. Jovin, and Brian Thomas Jankowitz

Exosome Release And Cargo In Down Syndrome, Eric D. Hamlett, Angela LaRosa, Elliott J. Mufson, Juan Fortea, Aurélie Ledreux, and Ann Charlotte Granholm

Iliac Screws May Not Be Necessary In Long-Segment Constructs With L5€“S1 Anterior Lumbar Interbody Fusion: Cadaveric Study Of Stability And Instrumentation Strain, Randall J. Hlubek, Jakub Godzik, Anna G.U.S. Newcomb, Jennifer N. Lehrman, Bernardo de Andrada, Michael A. Bohl, Samuel H. Farber, Brian P. Kelly, and Jay D. Turner

Translating Preclinical Mri Methods To Clinical Oncology, David A. Hormuth, Anna G. Sorace, John Virostko, Richard G. Abramson, Zaver M. Bhujwalla, Pedro Enriquez-Navas, Robert Gillies, John D. Hazle, Ralph P. Mason, C. Chad Quarles, Jared A. Weis, Jennifer G. Whisenant, Junzhong Xu, and Thomas E. Yankeelov

Accurate Patient-Specific Machine Learning Models Of Glioblastoma Invasion Using Transfer Learning, L. S. Hu, H. Yoon, J. M. Eschbacher, L. C. Baxter, A. C. Dueck, A. Nespodzany, K. A. Smith, P. Nakaji, Y. Xu, L. Wang, J. P. Karis, A. J. Hawkins-Daarud, K. W. Singleton, P. R. Jackson, B. J. Anderies, B. R. Bendok, R. S. Zimmerman, C. Quarles, A. B. Porter-Umphrey, M. M. Mrugala, A. Sharma, J. M. Hoxworth, M. G. Sattur, N. Sanai, P. E. Koulemberis, C. Krishna, J. R. Mitchell, T. Wu, N. L. Tran, K. R. Swanson, and J. Li


Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool, Stefan Jordan, Navpreet Tung, Maria Casanova-Acebes, Christie Chang, Claudia Cantoni, Dachuan Zhang, Theresa H. Wirtz, Shruti Naik, Samuel A. Rose, Chad N. Brocker, Anastasiia Gainullina, Daniel Hornburg, Sam Horng, Barbara B. Maier, Paolo Cravedi, Derek LeRoith, Frank J. Gonzalez, Felix Meissner, Jordi Ochando, Adeeb Rahman, Jerry E. Chipuk, Maxim N. Artyomov, Paul S. Frenette, Laura Piccio, Marie-Luise Berres, Emily J. Gallagher, and Miriam Merad

GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion, Ella A. Kasanga, Catherine L. Owens, Mark A. Cantu, Adam D. Richard, Richard W. Davis, Lisa M. McDivitt, Blake Blancher, Brandon S. Pruett, Christopher Tan, Austin Gajewski, Fredric P. Manfredsson, Vicki A. Nejtek, and Michael F. Salvatore

Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression In The Ts65Dn Mouse Model Of Down Syndrome, Christy M. Kelley, Stephen D. Ginsberg, Melissa J. Alldred, Barbara J. Strupp, and Elliott J. Mufson


Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study, Christy M. Kelley, Sylvia E. Perez, and Elliott J. Mufson

Enhancing Natural Killer Cells Is Beneficial In Multiple Sclerosis €“ No, Qiang Liu and Fu Dong Shi

ACR Appropriateness Criteria Acute Mental Status Change, Delirium, and New Onset Psychosis, Michael D. Luttrull, Daniel J. Boulter, Claudia F. Kirsch, Joseph M. Aulino, Joshua S. Broder, Santanu Chakraborty, Asim F. Choudhri, Andrew F. Ducruet, A Tuba Kendi, Ryan K. Lee, David S. Liebeskind, William Mack, Toshio Moritani, Robert P. Roca, Lubdha M. Shah, Aseem Sharma, Robert Y. Shih, Sophia C. Symko, and Julie Bykowski

Hdac2 Dysregulation In The Nucleus Basalis Of Meynert During The Progression Of Alzheimer'S Disease, L. Mahady, M. Nadeem, M. Malek-Ahmadi, K. Chen, S. E. Perez, and E. J. Mufson

Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer, Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta, and Joyce Schroeder


Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies, Petra Majerova, Alena Michalicova, Martin Cente, Jozef Hanes, Jozef Vegh, Agnes Kittel, Nina Kosikova, Viera Cigankova, Sandra Mihaljevic, Santosh Jadhav, and Andrej Kovac

Cerebral Amyloid Angiopathy And Neuritic Plaque Pathology Correlate With Cognitive Decline In Elderly Non-Demented Individuals, Michael Malek-Ahmadi, Kewei Chen, Sylvia E. Perez, and Elliott J. Mufson


Glycolysis Upregulation Is Neuroprotective As A Compensatory Mechanism In Als, Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G. O'Conner, Jordan M. Barrows, Alexander Starr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean Charles Liévens, Robert Bowser, Rita Sattler, and Daniela C. Zarnescu

Disruption Of Met Receptor Tyrosine Kinase An Autism Risk Factor Impairs Developmental Synaptic Plasticity In The Hippocampus, Xiaokuang Ma, Ke Chen, Zhongming Lu, Mariel Piechowicz, Qiang Liu, Jie Wu, and Shenfeng Qiu


Mechanisms Of Cannabinoid Cb 2 Receptor-Mediated Reduction Of Dopamine Neuronal Excitability In Mouse Ventral Tegmental Area, Zegang Ma, Fenfei Gao, Brett Larsen, Ming Gao, Zhihua Luo, Dejie Chen, Xiaokuang Ma, Shenfeng Qiu, Yu Zhou, Junxia Xie, Zheng Xiong Xi, and Jie Wu

Cocaine Potently Blocks Neuronal α3β4 Nicotinic Acetylcholine Receptors In Sh-Sy5Y Cells, Ze gang Ma, Nan Jiang, Yuan bing Huang, Xiao kuang Ma, Jason Brek Eaton, Ming Gao, Yong Chang, Ronald J. Lukas, Paul Whiteaker, Janet Neisewander, and Jie Wu

Lipid And Polymer Blended Polyester Nanoparticles Loaded With Adapalene For Activation Of Retinoid Signaling In The Cns Following Intravenous Administration, David X. Medina, Eugene P. Chung, Robert Bowser, and Rachael W. Sirianni

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin, Sean J. Miller, Thomas Philips, Namho Kim, Raha Dastgheyb, Zhuoxun Chen, Yi-Chun Hsieh, J Gavin Daigle, Malika Datta, Jeannie Chew, Svetlana Vidensky, Jacqueline T. Pham, Ethan G. Hughes, Michael B. Robinson, Rita Sattler, Raju Tomer, Jung Soo Suk, Dwight E. Bergles, Norman Haughey, Mikhail Pletnikov, Justin Hanes, and Jeffrey D. Rothstein

Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus, Zaman Mirzadeh, Kimberly M. Alonge, Elaine Cabrales, Vicente Herranz-Pérez, Jarrad M. Scarlett, Jenny M. Brown, Rim Hassouna, Miles E. Matsen, Hong T. Nguyen, Jose Manuel Garcia-Verdugo, Lori M. Zeltser, and Michael W. Schwartz


C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A, Thomas G. Moens, Teresa Niccoli, Katherine M. Wilson, Magda L. Atilano, Nicol Birsa, Lauren M. Gittings, Benedikt V. Holbling, Miranda C. Dyson, Annora Thoeng, Jacob Neeves, Idoia Glaria, Lu Yu, Julia Bussmann, Erik Storkebaum, Mercedes Pardo, Jyoti S. Choudhary, Pietro Fratta, Linda Partridge, and Adrian M. Isaacs

Adar2 Mislocalization And Widespread Rna Editing Aberrations In C9Orf72-Mediated Als/Ftd, Stephen Moore, Eric Alsop, Ileana Lorenzini, Alexander Starr, Benjamin E. Rabichow, Emily Mendez, Jennifer L. Levy, Camelia Burciu, Rebecca Reiman, Jeannie Chew, Veronique V. Belzil, Dennis W. Dickson, Janice Robertson, Kim A. Staats, Justin K. Ichida, Leonard Petrucelli, Kendall Van Keuren-Jensen, and Rita Sattler


Nerve Growth Factor Pathobiology During The Progression Of Alzheimer's Disease, Elliott J. Mufson, Scott E. Counts, Stephen D. Ginsberg, Laura Mahady, Sylvia E. Perez, Stephen M. Massa, Frank M. Longo, and Milos D. Ikonomovic

Astrocytic Changes With Aging And Alzheimer'S Disease-Type Pathology In Chimpanzees, Emily L. Munger, Melissa K. Edler, William D. Hopkins, John J. Ely, Joseph M. Erwin, Daniel P. Perl, Elliott J. Mufson, Patrick R. Hof, Chet C. Sherwood, and Mary Ann Raghanti


Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module, Roeben Nocon Munji, Allison Luen Soung, Geoffrey Aaron Weiner, Fabien Sohet, Bridgette Deanne Semple, Alpa Trivedi, Kayleen Gimlin, Masakazu Kotoda, Masaaki Korai, Sidar Aydin, Austin Batugal, Anne Christelle Cabangcala, Patrick Georg Schupp, Michael Clark Oldham, Tomoki Hashimoto, Linda J. Noble-Haeusslein, and Richard Daneman

GSTA4 mediates reduction of cisplatin ototoxicity in female mice., Hyo-Jin Park, Mi-Jung Kim, Christina Rothenberger, Ashok Kumar, Edith M Sampson, Dalian Ding, Chul Han, Karessa White, Kevin Boyd, Senthilvelan Manohar, Yong-Hwan Kim, Maria S Ticsa, Aaron S Gomez, Isabela Caicedo, Upal Bose, Paul J Linser, Takuya Miyakawa, Masaru Tanokura, Thomas C Foster, Richard Salvi, and Shinichi Someya


Probing glioblastoma and its microenvironment using single-nucleus and single-cell sequencing, Sen Peng, Seungchan Kim, Harshil Dhruv, Sanhita Rath, Connor Vuong, Saumya Bollam, Jenny Eschbacher, Xishuang Dong, Shwetal Mehta, Nader Sanai, and Michael Berens

Frontal Cortex And Striatal Cellular And Molecular Pathobiology In Individuals With Down Syndrome With And Without Dementia, Sylvia E. Perez, Jennifer C. Miguel, Bin He, Michael Malek-Ahmadi, Eric E. Abrahamson, Milos D. Ikonomovic, Ira Lott, Eric Doran, Melissa J. Alldred, Stephen D. Ginsberg, and Elliott J. Mufson

Spectral organization of focal seizures within the thalamotemporal network, Diana Pizarro, Adeel Ilyas, Ganne Chaitanya, Emilia Toth, Auriana Irannejad, Andrew Romeo, Kristen O. Riley, Leonidas Iasemidis, and Sandipan Pati

Imaging Vascular And Hemodynamic Features Of The Brain Using Dynamic Susceptibility Contrast And Dynamic Contrast Enhanced Mri, C. Chad Quarles, Laura C. Bell, and Ashley M. Stokes


Exosomal Dna Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits In A Mouse Parkinson'S Disease Model, Xiaoxi Ren, Yun Zhao, Fenqin Xue, Yan Zheng, Haixia Huang, Wei Wang, Yongchang Chang, Hui Yang, and Jianliang Zhang


Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption, Benedetto Romoli, Adrian F. Lozada, Ivette M. Sandoval, Fredric P. Manfredsson, Thomas S. Hnasko, Darwin K. Berg, and Davide Dulcis

Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing, Ivette M. Sandoval, Timothy J. Collier, and Fredric P. Manfredsson


Multimodal production of adeno-associated virus, Ivette M. Sandoval, Nathan M. Kuhn, and Fredric P. Manfredsson

Comparing The Biomechanical Stability Of Cortical Screw Trajectory Versus Standard Pedicle Screw Trajectory For Short- And Long-Segment Posterior Fixation In 3-Column Thoracic Spinal Injury, Amey R. Savardekar, Nestor G. Rodriguez-Martinez, Anna G.U.S. Newcomb, Phillip M. Reyes, Hector Soriano-Baron, Steve W. Chang, Brian P. Kelly, and Neil R. Crawford

Moving Toward A Consensus Dsc-Mri Protocol: Validation Of A Low-Flip Angle Single-Dose Option As A Reference Standard For Brain Tumors, K. M. Schmainda, M. A. Prah, L. S. Hu, C. C. Quarles, N. Semmineh, S. D. Rand, J. M. Connelly, B. Anderies, Y. Zhou, Y. Liu, B. Logan, A. Stokes, G. Baird, and J. L. Boxerman

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia, Rhyomi C. Sellnow, Jordan H. Newman, Nicole Chambers, Anthony R. West, Kathy Steece-Collier, Ivette M. Sandoval, Matthew J. Benskey, Christopher Bishop, and Fredric P. Manfredsson

Potential Influences Of Gut Microbiota On The Formation Of Intracranial Aneurysm, Fumiaki Shikata, Kenji Shimada, Hiroki Sato, Taichi Ikedo, Atsushi Kuwabara, Hajime Furukawa, Masaaki Korai, Masakazu Kotoda, Kimihiko Yokosuka, Hiroshi Makino, Emma A. Ziegler, Daisuke Kudo, Michael T. Lawton, and Tomoki Hashimoto

Biomechanical implications of unilateral facetectomy, unilateral facetectomy plus partial contralateral facetectomy, and complete bilateral facetectomy in minimally invasive transforaminal interbody fusion., Laura A Snyder, Jennifer N Lehrman, Ram Kumar Menon, Jakub Godzik, Anna G U S Newcomb, and Brian P. Kelly

Biomechanical Effects Of An Oblique Lumbar Peek Cage And Posterior Augmentation, Hector Soriano-Baron, Anna G.U.S. Newcomb, Devika Malhotra, Eduardo Martinez del Campo, Atilio E. Palma, Nicholas Theodore, Neil R. Crawford, Brian P. Kelly, and Taro Kaibara

Early postmarket results with PulseRider for treatment of wide-necked intracranial aneurysms: a multicenter experience, Visish M. Srinivasan, Aditya Srivatsan, Alejandro M. Spiotta, Benjamin K. Hendricks, Andrew F. Ducruet, Felipe C. Albuquerque, Ajit Puri, Matthew R. Amans, Steven W. Hetts, Daniel L. Cooke, Christopher S. Ogilvy, Ajith J. Thomas, Alejandro Enriquez-Marulanda, Ansaar Rai, SoHyun Boo, Andrew P. Carlson, R Webster Crowley, Leonardo Rangel-Castilla, Giuseppe Lanzino, Peng Roc Chen, Orlando Diaz, Bradley N. Bohnstedt, Kyle P. O'Connor, Jan-Karl Burkhardt, Jeremiah N. Johnson, Stephen R. Chen, and Peter Kan


Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia, Kathy Steece-Collier, Jennifer A. Stancati, Nicholas J. Collier, Ivette M. Sandoval, Natosha M. Mercado, Caryl E. Sortwell, Timothy J. Collier, and Fredric P. Manfredsson


Primum non nocere: a call for balance when reporting on CTE, William Stewart, Kieren Allinson, Safa Al-Sarraj, Corbin Bachmeier, Karen Barlow, Antonio Belli, Mark P. Burns, Alan Carson, Fiona Crawford, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, C. Edward Dixon, Brian L. Edlow, Scott Ferguson, Bruce Fischl, Rebecca D. Folkerth, Steve Gentleman, Christopher C. Giza, M. Sean Grady, Adel Helmy, Mark Herceg, Janice L. Holton, David Howell, Peter J. Hutchinson, Diego Iacono, Juan E. Iglesias, Milos D. Ikonomovic, Victoria E. Johnson, C. Dirk Keene, Julia K. Kofler, Vassilis E. Koliatsos, and Edward B. Lee

Systematic Assessment Of Multi-Echo Dynamic Susceptibility Contrast Mri Using A Digital Reference Object, Ashley M. Stokes, Natenael B. Semmineh, Ashley Nespodzany, Laura C. Bell, and C. Chad Quarles

Noninvasive Vagus Nerve Stimulation Prevents Ruptures And Improves Outcomes In A Model Of Intracranial Aneurysm In Mice, Tomoaki Suzuki, Tsubasa Takizawa, Yoshinobu Kamio, Tao Qin, Tomoki Hashimoto, Yukihiko Fujii, Yuichi Murayama, Aman B. Patel, and Cenk Ayata

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia, Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, and Eran Hornstein


A phase 0 trial of ribociclib in recurrent glioblastoma patients incorporating a tumor pharmacodynamic- And pharmacokinetic-guided expansion cohort, An Chi Tien, Jing Li, Xun Bao, Alanna Derogatis, Seongho Kim, Shwetal Mehta, and Nader Sanai

A three-dimensional (3D) organotypic microfluidic model for glioma stem cells - Vascular interactions, Danh Truong, Roberto Fiorelli, Eric S. Barrientos, Ernesto Luna Melendez, Nader Sanai, Shwetal Mehta, and Mehdi Nikkhah

Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease, Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, and Keqiang Ye

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease, Zhi-Hao Wang, Jie Xiang, Xia Liu, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Shengxi Wu, Jian-Zhi Wang, and Keqiang Ye

Validity of a food and fluid exercise questionnaire for macronutrient intake during exercise against observations, Floris C. Wardenaar, Daan Hoogervorst, Nancy Van Der Burg, Joline Versteegen, Wonsuk Yoo, and Natasha Tasevska


Distinctive Single-Channel Properties Of α4β2-Nicotinic Acetylcholine Receptor Isoforms, Maegan M. Weltzin, Andrew A. George, Ronald J. Lukas, and Paul Whiteaker

IL6 receptor(358)Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis., Marlena Wosiski-Kuhn, Mac Robinson, Jane Strupe, Phonepasong Arounleut, Matthew Martin, James Caress, Michael Cartwright, Robert Bowser, Merit Cudkowicz, Carl Langefeld, Gregory A Hawkins, and Carol Milligan


Nanocarriers Of Fe3O4 As A Novel Method For Delivery Of The Antineoplastic Agent Doxorubicin Into Hela Cells In Vitro, Kun Kun Xia, Yong Lyu, Wei Tang Yuan, Gui Xian Wang, Harrison Stratton, Shui Jun Zhang, and Jie Wu

Heterogeneity Of Cannabinoid Ligand-Induced Modulations In Intracellular Ca 2+ Signals Of Mouse Pancreatic Acinar Cells In Vitro, Kun kun Xia, Jian xin Shen, Ze bing Huang, Hui min Song, Ming Gao, De jie Chen, Shui jun Zhang, and Jie Wu


Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies, Jie Xiang, Zhi Hao Wang, Eun Hee Ahn, Xia Liu, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Gong Ju, Shengxi Wu, and Keqiang Ye