Further understanding the connection between Alzheimer's disease and Down syndrome
Document Type
Article
Abstract
Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.
Keywords
Alzheimer's disease, Down syndrome, trisomy, vascular contributions
Publication Date
7-1-2020
Publication Title
Alzheimer's and Dementia
ISSN
15525260
E-ISSN
15525279
Volume
16
Issue
7
First Page
1065
Last Page
1077
PubMed ID
32544310
Digital Object Identifier (DOI)
10.1002/alz.12112
Recommended Citation
Snyder, Heather M.; Bain, Lisa J.; Brickman, Adam M.; Carrillo, Maria C.; Esbensen, Anna J.; Espinosa, Joaquin M.; Fernandez, Fabian; Fortea, Juan; Hartley, Sigan L.; Head, Elizabeth; Hendrix, James; Kishnani, Priya S.; Lai, Florence; Lao, Patrick; Lemere, Cynthia; Mobley, William; Mufson, Elliott J.; Potter, Huntington; Zaman, Shahid H.; Granholm, Ann Charlotte; Rosas, H. Diana; Strydom, Andre; Whitten, Michelle Sie; and Rafii, Michael S., "Further understanding the connection between Alzheimer's disease and Down syndrome" (2020). Translational Neuroscience. 1812.
https://scholar.barrowneuro.org/neurobiology/1812