The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 2022

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Effects of dietary restriction on gut microbiota and CNS autoimmunity, Claudia Cantoni, Yair Dorsett, Luigi Fontana, Yanjiao Zhou, and Laura Piccio

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Alterations of host-gut microbiome interactions in multiple sclerosis, Claudia Cantoni, Qingqi Lin, Yair Dorsett, Laura Ghezzi, Zhongmao Liu, Yeming Pan, Kun Chen, Yanhui Han, Zhengze Li, Hang Xiao, Matthew Gormley, Yue Liu, Suresh Bokoliya, Hunter Panier, Cassandra Suther, Emily Evans, Li Deng, Alberto Locca, Robert Mikesell, Kathleen Obert, Pamela Newland, Yufeng Wu, Amber Salter, Anne H. Cross, Phillip I. Tarr, Amy Lovett-Racke, Laura Piccio, and Yanjiao Zhou

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Endovascular treatment of vertebral artery dissecting aneurysms : a 20-year institutional experience, Joshua S. Catapano, Andrew F. Ducruet, Megan S. Cadigan, Dara S. Farhadi, Neil Majmundar, Candice L. Nguyen, Jacob F. Baranoski, Tyler S. Cole, D Andrew Wilkinson, Vance L. Fredrickson, Visish M. Srinivasan, and Felipe C. Albuquerque

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Radiographic clearance of chronic subdural hematomas after middle meningeal artery embolization, Joshua S. Catapano, Andrew F. Ducruet, Visish M. Srinivasan, Kavelin Rumalla, Candice L. Nguyen, Caleb Rutledge, Tyler S. Cole, Jacob F. Baranoski, Michael T. Lawton, Ashutosh P. Jadhav, and Felipe C. Albuquerque

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Endovascular treatment of ruptured anterior communicating aneurysms: a 17-year institutional experience with coil embolization, Joshua S. Catapano, Katherine Karahalios, Kavelin Rumalla, Visish M. Srinivasan, Caleb Rutledge, Jacob F. Baranoski, Tyler S. Cole, Ashutosh P. Jadhav, Andrew F. Ducruet, and Felipe C. Albuquerque

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Chronic headaches and middle meningeal artery embolization, Joshua S. Catapano, Katherine Karahalios, Visish M. Srinivasan, Jacob F. Baranoski, Caleb Rutledge, Tyler S. Cole, Andrew F. Ducruet, Felipe C. Albuquerque, and Ashutosh P. Jadhav

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Total 1-year hospital cost of middle meningeal artery embolization compared to surgery for chronic subdural hematomas: a propensity-adjusted analysis, Joshua S. Catapano, Stefan W. Koester, Visish M. Srinivasan, Kavelin Rumalla, Jacob F. Baranoski, Caleb Rutledge, Tyler S. Cole, Ethan A. Winkler, Michael T. Lawton, Ashutosh P. Jadhav, Andrew F. Ducruet, and Felipe C. Albuquerque

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Direct puncture of the superior ophthalmic vein for carotid cavernous fistulas: a 21-year experience, Joshua S. Catapano, Visish M. Srinivasan, Nicole M. De La Peña, Rohin Singh, Tyler S. Cole, D Andrew Wilkinson, Jacob F. Baranoski, Caleb Rutledge, Mark A. Pacult, Ethan A. Winkler, Ashutosh P. Jadhav, Andrew F. Ducruet, and Felipe C. Albuquerque

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Omeprazole-clopidogrel interaction and neurovascular complications after flow-diverter device placement, Joshua S. Catapano, Visish M. Srinivasan, Andre A. Wakim, Jaclyn N. Lundberg, Caleb Rutledge, Tyler S. Cole, Jacob F. Baranoski, Vance L. Fredrickson, Redi Rahmani, Felipe C. Albuquerque, and Andrew F. Ducruet

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Retained radial catheters associated with variant radial anatomy in neurointerventional procedures, Joshua S. Catapano, Ethan A. Winkler, Visish M. Srinivasan, Evan L. Dishion, Caleb Rutledge, Jacob F. Baranoski, Tyler S. Cole, Robert F. Rudy, Kavelin Rumalla, Martin P. Zomaya, Ashutosh P. Jadhav, Andrew F. Ducruet, and Felipe C. Albuquerque

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Endoplasmic Reticulum Chemical Chaperone 3-Hydroxy-2-Naphthoic Acid Reduces Angiotensin II-Induced Vascular Remodeling and Hypertension In Vivo and Protein Synthesis In Vitro, Stephanie Cicalese, Keiichi Torimoto, Keisuke Okuno, Katherine J. Elliott, Victor Rizzo, Tomoki Hashimoto, and Satoru Eguchi

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The multimodal serotonin compound Vilazodone alone, but not combined with the glutamate antagonist Amantadine, reduces l-DOPA-induced dyskinesia in hemiparkinsonian rats, Sophie R. Cohen, Michelle L. Terry, Michael Coyle, Emily Wheelis, Ashley Centner, Samantha Smith, John Glinski, Natalie Lipari, Carla Budrow, Fredric P. Manfredsson, and Christopher Bishop

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Relationship between cerebral vasospasm vascular territory and functional outcome after aneurysmal subarachnoid hemorrhage, Tyler S. Cole, Robert F. Rudy, Erfan Faridmoayer, Sirin Gandhi, Claudio Cavallo, Joshua S. Catapano, Ashutosh P. Jadhav, Michael T. Lawton, Felipe C. Albuquerque, and Andrew F. Ducruet

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Subtle segmental angle changes of single-level lumbar fusions and adjacent-level biomechanics: cadaveric study of optically measured disc strain, Bernardo de Andrada Pereira, Piyanat Wangsawatwong, Jennifer N. Lehrman, Anna G. Sawa, S Harrison Farber, Jakub Godzik, Luke K. O'Neill, Juan S. Uribe, Brian P. Kelly, and Jay D. Turner

Biomechanics of a laterally placed sacroiliac joint fusion device supplemental to S2 alar-iliac fixation in a long-segment adult spinal deformity construct: a cadaveric study of stability and strain distribution, Bernardo de Andrada Pereira, Piyanat Wangsawatwong, Jennifer N. Lehrman, Anna G. Sawa, Derek P. Lindsey, Scott A. Yerby, Jakub Godzik, Alexis M. Waguespack, Juan S. Uribe, and Brian P. Kelly

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Towards differentiation of brain tumor from radiation necrosis using multi-parametric MRI: Preliminary results at 4.7 T using rodent models, Sean P. Devan, Xiaoyu Jiang, Hakmook Kang, Guozhen Luo, Jingping Xie, Zhongliang Zu, Ashley M. Stokes, John C. Gore, Colin D. McKnight, Austin N. Kirschner, and Junzhong Xu

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Treatment of Spinal Arteriovenous Malformation and Fistula, Jeff Ehresman, Joshua S. Catapano, Jacob F. Baranoski, Ashutosh P. Jadhav, Andrew F. Ducruet, and Felipe C. Albuquerque

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Management of basilar fenestration aneurysms: a systematic review with an illustrative case report, Muhammed Amir Essibayi, Visish M. Srinivasan, Humberto José Madriñán-Navia, Marian T. Park, Lea Scherschinski, Joshua S. Catapano, Emmajane G. Rhodenhiser, Christopher S. Graffeo, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton

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The Gut Microbiome-Brain Crosstalk in Neurodegenerative Diseases, Laura Ghezzi, Claudia Cantoni, Emanuela Rotondo, and Daniela Galimberti

Optimizing Cervicothoracic Junction Biomechanics after C7 Pedicle Subtraction Osteotomy: A Cadaveric Study of Stability and Rod Strain, Jakub Godzik, Jennifer N. Lehrman, S Harrison Farber, Bernardo de Andrada Pereira, Anna G. Sawa, Christopher P. Ames, Heiko Koller, Kevin Lee, Jay D. Turner, and Brian P. Kelly

Factors Contributing to Spinal Cord Stimulation Outcomes for Chronic Pain, Dakota T. Graham, Margaret Lambert, Zaman Mirzadeh, and Francisco A. Ponce

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Microscale electrophysiological functional connectivity in human cortico-basal ganglia network, Ashley C. Guest, Kevin J. O'Neill, Dakota Graham, Zaman Mirzadeh, Francisco A. Ponce, and Bradley Greger

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PNJ scaffolds promote microenvironmental regulation of glioblastoma stem-like cell enrichment and radioresistance, John M. Heffernan, James B. McNamara, Brent L. Vernon, Shwetal Mehta, and Rachael W. Sirianni

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Folic Acid Improves Parkin-Null Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and Glutathione Redox Equilibrium, Katherine L. Houlihan, Petros P. Keoseyan, Amber N. Juba, Tigran Margaryan, Max E. Voss, Alexander M. Babaoghli, Justin M. Norris, Greg J. Adrian, Artak Tovmasyan, and Lori M. Buhlman

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Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders, Christy M. Kelley, Stephen D. Ginsberg, Winnie S. Liang, Scott E. Counts, and Elliott J. Mufson

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Use of digital imaging correlation techniques for full-field strain distribution analysis of implantable devices and tissue in spinal biomechanics research, Brian P. Kelly, Casey R. Silva, Jennifer N. Lehrman, Anna G. Sawa, Bernardo de Andrada Pereira, Jakub Godzik, and Jay D. Turner

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Assessing the volume-outcome relationship of carotid artery stenting in nationwide administrative data: a challenge of patient population bias, Stefan W. Koester, Tyler S. Cole, Anna R. Kimata, Kevin L. Ma, Dimitri Benner, Joshua S. Catapano, Kavelin Rumalla, Michael T. Lawton, Andrew F. Ducruet, and Felipe C. Albuquerque

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Influence of Spinal Deformity Construct Design on Adjacent-Segment Biomechanics, Robert M. Koffie, Bernardo de Andrada Pereira, Jennifer N. Lehrman, Jakub Godzik, Anna G. Sawa, Shashank V. Gandhi, Brian P. Kelly, Juan S. Uribe, and Jay D. Turner

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Simultaneous determination of LY3214996, abemaciclib, and M2 and M20 metabolites in human plasma, cerebrospinal fluid, and brain tumor by LC-MS/MS, Tigran Margaryan, Mackenna Elliott, Nader Sanai, and Artak Tovmasyan

2021 Workshop: Neurodegenerative Diseases in the Gut-Brain Axis - Parkinson's Disease, Gary M. Mawe, Kirsteen N. Browning, Fredric P. Manfredsson, Michael Camilleri, Frank A. Hamilton, Jonathan A. Hollander, Beth-Anne Sieber, Patricia Greenwel, Terez Shea-Donohue, and John W. Wiley

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A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma, Shwetal Mehta, Roberto Fiorelli, Xun Bao, Chelsea Pennington-Krygier, Alanna Derogatis, Seongho Kim, Wonsuk Yoo, Jing Li, and Nader Sanai

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Editorial: Mechanisms of Action in Neurodegenerative Proteinopathies, Sean J. Miller, Selina Wray, Rita Sattler, and Can Zhang

Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?, Zaman Mirzadeh, Chelsea L. Faber, and Michael W. Schwartz

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The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells, Michael A. Paley, Brandi J. Baker, S Richard Dunham, Nicole Linskey, Claudia Cantoni, Kenneth Lee, Lynn M. Hassman, Jennifer Laurent, Elisha D. Roberson, David B. Clifford, and Wayne M. Yokoyama

Pedicle Subtraction Osteotomy Construct Optimization: A Cadaveric Study of Various Multirod and Interbody Configurations, Bernardo de Pereira, Jakub Godzik, Jennifer N. Lehrman, Anna G. Sawa, Randall J. Hlubek, Juan S. Uribe, Brian P. Kelly, and Jay D. Turner

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Biomechanical Effects of Proximal Polyetheretherketone Rod Extension on the Upper Instrumented and Adjacent Levels in a Human Long-Segment Construct: A Cadaveric Model, Bernardo de Pereira, Jennifer N. Lehrman, Anna G. Sawa, Piyanat Wangsawatwong, Jakub Godzik, David S. Xu, Jay D. Turner, Brian P. Kelly, and Juan S. Uribe

Imaging Glioblastoma With F-Fluciclovine Amino Acid Positron Emission Tomography, Matthew L. Scarpelli, Debbie R. Healey, Shwetal Mehta, and C Chad Quarles

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Cytochemical Characterization of Cerebrospinal Fluid Macrophage Inclusions in Pediatric Patients Receiving Intrathecal Nusinersen (SPINRAZA®) for Spinal Muscular Atrophy, Kristian T. Schafernak, Jeffrey R. Jacobsen, Dulce Hernandez, Robin D. Kaye, and Sylvia E. Perez

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Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review, Jeremy M. Shefner, Richard Bedlack, Jinsy A. Andrews, James D. Berry, Robert Bowser, Robert Brown, Jonathan D. Glass, Nicholas J. Maragakis, Timothy M. Miller, Jeffrey D. Rothstein, and Merit E. Cudkowicz

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Rapid parameter estimation for selective inversion recovery myelin imaging using an open-source Julia toolkit, Nicholas J. Sisco, Ping Wang, Ashley M. Stokes, and Richard D. Dortch

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Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study, Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Güttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefanía Conde-Blanco, Jose Carlos Pariente, Saül Pascual-Diaz, Ignacio Delgado-Martínez, Carmen Pérez-Enríquez, Ilaria Lagorio, Eugenio Abela, and Nandini Mullatti

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Challenging access during flow diversion treatment of a giant cavernous ICA aneurysm, Visish M. Srinivasan, Joelle N. Hartke, Joshua S. Catapano, Ethan A. Winkler, Ashutosh P. Jadhav, Felipe C. Albuquerque, and Andrew F. Ducruet

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ALSUntangled #64: butyrates, Yuyao Sun, Richard Bedlack, Carmel Armon, Morgan Beauchamp, Tulio Bertorini, Robert Bowser, Mark Bromberg, James Caress, Gregory Carter, Jesse Crayle, Merit E. Cudkowicz, Jonathan D. Glass, Carlayne Jackson, Isaac Lund, Sarah Martin, Sabrina Paganoni, Gary Pattee, Dylan Ratner, Kristiana Salmon, and Paul Wicks

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Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide, Hélène Tran, Michael P. Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L. Douthwright, Courtney Pinto, Jake Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit Puri, Alexandra Weiss, Nicholas Wightman, Heather Gray-Edwards, Miklos Marosfoi, Robert M. King, Thomas Kenderdine, Daniele Fabris, Robert Bowser, Jonathan K. Watts, and Robert H. Brown

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Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome, Emma C. Utagawa, David G. Moreno, Kristian T. Schafernak, Nicoleta C. Arva, Michael H. Malek-Ahmadi, Elliott J. Mufson, and Sylvia E. Perez

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Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study, Konrad Wagstyl, Kirstie Whitaker, Armin Raznahan, Jakob Seidlitz, Petra E. Vértes, Stephen Foldes, Zachary Humphreys, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Mathilde Ripart, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefanía Conde-Blanco, Jose Carlos Pariente, Saül Pascual-Diaz, Ignacio Delgado-Martínez, Carmen Pérez-Enríquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Caligiuri, and Ben Sinclair

Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: a nonhuman primate model of Alzheimer's disease, Dustin R. Wakeman, Michael R. Weed, Sylvia E. Perez, Erika N. Cline, Kirsten L. Viola, Kyle C. Wilcox, David S. Moddrelle, Ernell Z. Nisbett, Anish M. Kurian, Amanda F. Bell, Ricaldo Pike, Peer B. Jacobson, William L. Klein, Elliott J. Mufson, Matthew S. Lawrence, and John D. Elsworth

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Editorial for "Differentiation Between Lipomas and Atypical Lipomatous Tumors of the Extremities Using Radiomics", Ping Wang

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Avoiding the Radial Paradox: Neuroendovascular Femoral Access Outcomes After Radial Access Adoption, D Andrew Wilkinson, Neil Majmundar, Joshua S. Catapano, Tyler S. Cole, Jacob F. Baranoski, Benjamin K. Hendricks, Daniel D. Cavalcanti, Vance L. Frederickson, Andrew F. Ducruet, and Felipe C. Albuquerque

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Transradial cerebral angiography becomes more efficient than transfemoral angiography: lessons from 500 consecutive angiograms, D Andrew Wilkinson, Neil Majmundar, Joshua S. Catapano, Vance L. Fredrickson, Daniel D. Cavalcanti, Jacob F. Baranoski, Caleb Rutledge, Andrew F. Ducruet, and Felipe C. Albuquerque

Submissions from 2021

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Multimodal Assessment of Cerebral Autoregulation and Autonomic Function After Pediatric Cerebral Arteriovenous Malformation Rupture, Brian Appavu, Stephen Foldes, Brian T. Burrows, Austin Jacobson, Todd Abruzzo, Varina Boerwinkle, Anthony Willyerd, Tara Mangum, Vishal Gunnala, Iris Marku, and P D. Adelson

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Treatment Timing, EEG, Neuroimaging, and Outcomes After Acute Necrotizing Encephalopathy in Children, Brian Appavu, Stephen Foldes, Jordana Fox, Sheetal Shetty, Ann Oh, Freddy Bassal, Iris Marku, Tara Mangum, Varina Boerwinkle, Derek Neilson, and Michael Kruer

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Association of Outcomes with Model-Based Indices of Cerebral Autoregulation After Pediatric Traumatic Brain Injury, Brian Appavu, M 'Hamed Temkit, Stephen Foldes, Brian T. Burrows, Michael Kuwabara, Austin Jacobson, and P David Adelson

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease, Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, and Robert Bowser

Quantitative protein expression of blood-brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer, Xun Bao, Jianmei Wu, Jun Jiang, An-Chi Tien, Nader Sanai, and Jing Li

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H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways, Ines Batinic-Haberle, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, and Angeles Alvarez Secord

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ALSUntangled #60: light therapy, Richard Bedlack, Paul Barkhaus, Ben Barnes, Michael Bereman, Tulio Bertorini, Gregory Carter, Jesse Crayle, Sky Kihuwa-Mani, Robert Bowser, Pamela Kittrell, Christopher McDermott, Gary Pattee, Kristiana Salmon, and Paul Wicks

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Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery, Evgenii Belykh, Jubran H. Jubran, Laeth L. George, Liudmila Bardonova, Deborah R. Healey, Joseph F. Georges, Chad C. Quarles, Jennifer M. Eschbacher, Shwetal Mehta, Adrienne C. Scheck, Peter Nakaji, and Mark C. Preul

Neurosurgical Treatments for Cancer Pain, Sharona Ben-Haim, Zaman Mirzadeh, and William S. Rosenberg

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Systematic assessment of the impact of DTI methodology on fractional anisotropy measures in Alzheimer’s disease, Maurizio Bergamino, Elizabeth G. Keeling, Ryan R. Walsh, and Ashley M. Stokes

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Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer’s disease, Maurizio Bergamino, Ryan R. Walsh, and Ashley M. Stokes

Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design, James Berry, Benjamin Brooks, Angela Genge, Terry Heiman-Patterson, Stanley Appel, Michael Benatar, Robert Bowser, Merit Cudkowicz, Clifton Gooch, Jeremy Shefner, Jurjen Westra, Wendy Agnese, Charlotte Merrill, Sally Nelson, and Stephen Apple

Complement C3a receptor-mediated vascular dysfunction: A complex interplay between aging and neurodegeneration, Kanchan Bhatia, Saif Ahmad, Adam Kindelin, and Andrew F. Ducruet

Trajectories of stroke recovery of impairment, function, and quality of life in response to 12-month mobility and fitness intervention, Catherine Boissoneault, Dorian K. Rose, Tyler Grimes, Michael F. Waters, Anna Khanna, Somnath Datta, and Janis J. Daly

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Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system, Ekin Bolukbasi, Nathaniel S. Woodling, Dobril K. Ivanov, Jennifer Adcott, Andrea Foley, Arjunan Rajasingam, Lauren M. Gittings, Benjamin Aleyakpo, Teresa Niccoli, Janet M. Thornton, and Linda Partridge

ALSUntangled 55: vitamin E (α-tocopherol)., Robert Bowser and ALSUntangled Group

ALSUntangled 57: Vinpocetine., Robert Bowser and ALSUntangled Group

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Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells, Costanza Lo Cascio, James B. McNamara, Ernesto L. Melendez, Erika M. Lewis, Matthew E. Dufault, Nader Sanai, Christopher L. Plaisier, and Shwetal Mehta

Middle meningeal artery embolization for chronic subdural hematoma: an institutional technical analysis, Joshua S. Catapano, Andrew F. Ducruet, Candice L. Nguyen, Jacob F. Baranoski, Tyler S. Cole, Neil Majmundar, D Andrew Wilkinson, Vance L. Fredrickson, Daniel D. Cavalcanti, and Felipe C. Albuquerque

Corrigendum: Middle Meningeal Artery Embolization for Chronic Subdural Hematoma, Joshua S. Catapano, Candice L. Nguyen, Andre A. Wakim, Felipe C. Albuquerque, and Andrew F. Ducruet

Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9, Diptaman Chatterjee, David J. Marmion, Jodi L. McBride, Fredric P. Manfredsson, David Butler, Anne Messer, and Jeffrey H. Kordower

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies, Guiqin Chen, Seong Su Kang, Zhihao Wang, Eun Hee Ahn, Yiyuan Xia, Xia Liu, Ivette M. Sandoval, Fredric P. Manfredsson, Zhaohui Zhang, and Keqiang Ye

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α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease, Tracy A. Cole, Hien Zhao, Timothy J. Collier, Ivette Sandoval, Caryl E. Sortwell, Kathy Steece-Collier, Brian F. Daley, Alix Booms, Jack Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle Graham, Andreas Weihofen, Stephanie Celano, Emily Schulz, Allyson Cole-Strauss, Esteban Luna, Duc Quach, Apoorva Mohan, C. Frank Bennett, Eric E. Swayze, Holly B. Kordasiewicz, Kelvin C. Luk, and Katrina L. Paumier

Biomechanical effects of a novel posteriorly placed sacroiliac joint fusion device integrated with traditional lumbopelvic long-construct instrumentation, Bernardo de Andrada Pereira, Jennifer N. Lehrman, Anna G. Sawa, Derek P. Lindsey, Scott A. Yerby, Jakub Godzik, Alexis M. Waguespack, Juan S. Uribe, and Brian P. Kelly

Influence of Lumbar Lordosis on Posterior Rod Strain in Long-Segment Construct During Biomechanical Loading: A Cadaveric Study, Bernardo de Andrada Pereira, Anna G. Sawa, Jakub Godzik, Jennifer N. Lehrman, Juan S. Uribe, Jay D. Turner, and Brian P. Kelly

Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism, Chelsea L. Faber, Jennifer D. Deem, Bao Anh Phan, Tammy P. Doan, Kayoko Ogimoto, Zaman Mirzadeh, Michael W. Schwartz, and Gregory J. Morton

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Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas Magnetoencephalography in Tetraplegia, Stephen T. Foldes, Santosh Chandrasekaran, Joseph Camerone, James Lowe, Richard Ramdeo, John Ebersole, and Chad E. Bouton

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Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings, Stephen T. Foldes, Amanda R. Jensen, Austin Jacobson, Sarah Vassall, Emily Foldes, Ann Guthery, Danni Brown, Todd Levine, William James Tyler, and Richard E. Frye

Comparison of aspiration-first versus stentriever-first techniques in performing mechanical thrombectomy for large vessel occlusions, Vance L. Fredrickson, Phillip A. Bonney, Shivani D. Rangwala, Joshua S. Catapano, Tyler S. Cole, Daniel D. Cavalcanti, Neil Majmundar, D Andrew Wilkinson, Luis San Roman, Michael F. Waters, Felipe C. Albuquerque, and Andrew F. Ducruet

In reply: Is aspiration first-pass technique a better choice in mechanical thrombectomy for large vessel occlusions?, Vance L. Fredrickson and Andrew F. Ducruet

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Comparative neuropathology in aging primates: A perspective, Carmen Freire-Cobo, Melissa K. Edler, Merina Varghese, Emily Munger, Jessie Laffey, Sophia Raia, Selena S. In, Bridget Wicinski, Maria Medalla, Sylvia E. Perez, Elliott J. Mufson, Joseph M. Erwin, Elaine E. Guevara, Chet C. Sherwood, Jennifer I. Luebke, Agnès Lacreuse, Mary A. Raghanti, and Patrick R. Hof

Implications of Oligomeric Amyloid-Beta (oAβ, Andrew A. George, Jaime M Vieira, Cameron Xavier-Jackson, Michael T Gee, John R Cirrito, Heather A Bimonte-Nelson, Marina R Picciotto, Ronald J. Lukas, and Paul Whiteaker

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Targeting the gut to treat multiple sclerosis, Laura Ghezzi, Claudia Cantoni, Gabriela V. Pinget, Yanjiao Zhou, and Laura Piccio

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α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism, Soumitra Ghosh, Seok Joon Won, Jiejie Wang, Rebecca Fong, Nicholas J.M. Butler, Arianna Moss, Candance Wong, June Pan, Jennifer Sanchez, Annie Huynh, Long Wu, Fredric P. Manfredsson, and Raymond A. Swanson

Impact of dual-headed pedicle screws on the biomechanics of lumbosacral junction multirod constructs, Jakub Godzik, Bernardo de Andrada Pereira, Anna G. Sawa, Jennifer N. Lehrman, Randall J. Hlubek, Brian P. Kelly, and Jay D. Turner

Biomechanics of open versus minimally invasive deformity correction:​ comparison of stability and rod strain between pedicle subtraction osteotomy and anterior column realignment, Jakub Godzik, Bernardo de Andrada Pereira, Anna G. Sawa, Jennifer N. Lehrman, Gregory M. Mundis, Randall J. Hlubek, Juan S. Uribe, Brian P. Kelly, and Jay D. Turner

TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila, Lindsey D. Goodman, Heidi Cope, Zelha Nil, Thomas A. Ravenscroft, Wu-Lin Charng, Shenzhao Lu, An-Chi Tien, Rolph Pfundt, David A. Koolen, Charlotte A. Haaxma, Hermine E. Veenstra-Knol, Jolien S. Wassink-Ruiter, Marijke R. Wevers, Melissa Jones, Laurence E. Walsh, Victoria H. Klee, Miel Theunis, Eric Legius, Dora Steel, Katy E. Barwick, Manju A. Kurian, Shekeeb S. Mohammad, Russell C. Dale, Paulien A. Terhal, Ellen van Binsbergen, Brian Kirmse, Bethany Robinette, Benjamin Cogné, Bertrand Isidor, Theresa A. Grebe, Peggy Kulch, and Bryan E. Hainline

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Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease, Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, and Viviane Labrie

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Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors, Zachary A. Grieb, Emma G. Ford, Mahircan Yagan, Billy Y.B. Lau, Fredric P. Manfredsson, Keerthi Krishnan, and Joseph S. Lonstein

Novel experimental model of brain arteriovenous malformations using conditional Alk1 gene deletion in transgenic mice., Chul Han, Michael J Lang, Candice L Nguyen, Ernesto Luna Melendez, Shwetal Mehta, Gregory H Turner, Michael T Lawton, and S Paul Oh

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Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes, Bader Hasan, Artak Tovmasyan, Ines Batinic-Haberle, and Ludmil Benov

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Uncertainty quantification in the radiogenomics modeling of EGFR amplification in glioblastoma, Leland S. Hu, Lujia Wang, Andrea Hawkins-Daarud, Jennifer M. Eschbacher, Kyle W. Singleton, Pamela R. Jackson, Kamala Clark-Swanson, Christopher P. Sereduk, Sen Peng, Panwen Wang, Junwen Wang, Leslie C. Baxter, Kris A. Smith, Gina L. Mazza, Ashley M. Stokes, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Alyx B. Porter, Maciej M. Mrugala, Joseph M. Hoxworth, Teresa Wu, Nhan L. Tran, Kristin R. Swanson, and Jing Li

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Emerging therapeutic targets for cerebral edema, Ruchira M. Jha, Sudhanshu P. Raikwar, Sandra Mihaljevic, Amanda M. Casabella, Joshua S. Catapano, Anupama Rani, Shashvat Desai, Volodymyr Gerzanich, and J Marc Simard

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Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review, Ruchira M. Jha, Anupama Rani, Shashvat M. Desai, Sudhanshu Raikwar, Sandra Mihaljevic, Amanda Munoz-Casabella, Patrick M. Kochanek, Joshua Catapano, Ethan Winkler, Giuseppe Citerio, J Claude Hemphill, W Taylor Kimberly, Raj Narayan, Juan Sahuquillo, Kevin N. Sheth, and J Marc Simard

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Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis, Janel O. Johnson, Ruth Chia, Danny E. Miller, Rachel Li, Ravindran Kumaran, Yevgeniya Abramzon, Nada Alahmady, Alan E. Renton, Simon D. Topp, J Raphael Gibbs, Mark R. Cookson, Marya S. Sabir, Clifton L. Dalgard, Claire Troakes, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Ahmad Al Khleifat, Nicola Ticozzi, Vincenzo Silani, Cinzia Gellera, Ian P. Blair, Carol Dobson-Stone, John B. Kwok, Emily S. Bonkowski, Robin Palvadeau, Pentti J. Tienari, Karen E. Morrison, Pamela J. Shaw, Ammar Al-Chalabi, Robert H. Brown, and Andrea Calvo

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Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia, Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, and Satoru Eguchi

Human papillomavirus vaccine guideline adherence among Arizona's Medicaid beneficiaries, Alexis Koskan, Lynne Klasko-Foster, Chad Stecher, Sue Rodriguez, Deborah Helitzer, and Wonsuk Yoo

Neurovascular networks in epilepsy: Correlating ictal blood perfusion with intracranial electrophysiology, Balu Krishnan, Simon Tousseyn, Chetan Sateesh Nayak, Thandar Aung, Ammar Kheder, Z Irene Wang, Guiyun Wu, Jorge Gonzalez-Martinez, Dileep Nair, Richard Burgess, Leonidas Iasemidis, Imad Najm, Juan Bulacio, and Andreas V. Alexopoulos

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation, Deepti Lall, Ileana Lorenzini, Thomas A. Mota, Shaughn Bell, Thomas E. Mahan, Jason D. Ulrich, Hayk Davtyan, Jessica E. Rexach, A K. Muhammad, Oksana Shelest, Jesse Landeros, Michael Vazquez, Junwon Kim, Layla Ghaffari, Jacqueline Gire O'Rourke, Daniel H. Geschwind, Mathew Blurton-Jones, David M. Holtzman, Rita Sattler, and Robert H. Baloh

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Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia, Kathryn Lanza, Ashley Centner, Michael Coyle, Isabella Del Priore, Fredric P. Manfredsson, and Christopher Bishop