A novel meningioma with tyrosine-rich crystals in a 6-year-old Great Dane

Authors

• Kara Majors, Wheat Ridge Animal Hospital, Wheat Ridge, Colorado, USA.
• Savannah M. Rocha, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
• Rebecca Windsor, Wheat Ridge Animal Hospital, Wheat Ridge, Colorado, USA.
• Ronald B. Tjalkens, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
• Julia Engelien, Wheat Ridge Animal Hospital, Wheat Ridge, Colorado, USA.
• Tawfik Aboellail, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.

Document Type

Article

Abstract

A 6-year-old female spayed Great Dane was evaluated for acute onset cluster seizures. Magnetic resonance imaging (MRI) identified a mass in the olfactory bulbs with a large mucoid component caudal to the primary mass. The mass was removed via transfrontal craniotomy and histopathology revealed a tyrosine crystalline-rich, fibrous meningioma with a high mitotic index. Repeat MRI at 6 months showed no detectable tumor regrowth. The dog is clinically normal with no seizures at the time of publication 10 months after surgery. This meningioma subtype is rare in humans. This unique meningioma occurred in a dog of younger age and uncommon breed for intracranial meningioma. Biological progression of this tumor subtype is unknown; however, growth rate might be slow despite the high mitotic index.

Keywords

atypical, brain tumor, crystal, dog, frontal, neoplasia, olfactory

Medical Subject Headings

Humans; Female; Animals; Dogs; Meningioma (diagnostic imaging, surgery, veterinary); Meningeal Neoplasms (diagnostic imaging, surgery, veterinary); Seizures (veterinary); Craniotomy (methods, veterinary); Magnetic Resonance Imaging (veterinary); Tyrosine; Dog Diseases (diagnostic imaging, surgery)

Publication Date

1-1-2023

Publication Title

Journal of veterinary internal medicine

E-ISSN

1939-1676

Volume

37

Issue

4

First Page

1501

Last Page

1506

PubMed ID

37312432

Digital Object Identifier (DOI)

10.1111/jvim.16789

Recommended Citation

Majors, Kara; Rocha, Savannah M.; Windsor, Rebecca; Tjalkens, Ronald B.; Engelien, Julia; and Aboellail, Tawfik, "A novel meningioma with tyrosine-rich crystals in a 6-year-old Great Dane" (2023). Translational Neuroscience. 2496.
https://scholar.barrowneuro.org/neurobiology/2496