The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.


Submissions from 2019


Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway, Junxiang Yin, Megan Nielsen, Tanner Carcione, Shiping Li, and Jiong Shi

Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms, Xiaoran Zhang, William J. Ares, Philipp Taussky, Andrew F. Ducruet, and Ramesh Grandhi

Left Far Lateral Craniotomy for Clipping of a Posterior Inferior Cerebellar Artery Aneurysm, Xiaochun Zhao, Robert T. Wicks, Celene B. Mulholland, Andrew F. Ducruet, and Peter Nakaji

Submissions from 2018


Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance, Rawan Al-Mutairi, Artak Tovmasyan, Ines Batinic-Haberle, and Ludmil Benov

Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis, Wanda Anselmo, Emanuela Branchetti, Juan B. Grau, Gen Li, Salma Ayoub, Eric K. Lai, Nancy Rioux, Artak Tovmasyan, Jacqueline H. Fortier, Michael S. Sacks, Ines Batinic-Haberle, Stanley L. Hazen, Robert J. Levy, and Giovanni Ferrari

Diagnostic Accuracy of Somatosensory Evoked Potential Monitoring in Evaluating Neurological Complications During Endovascular Aneurysm Treatment, William J. Ares, Ramesh M. Grandhi, David M. Panczykowski, Gregory M. Weiner, Parthasarathy Thirumala, Miguel E. Habeych, Donald J. Crammond, Michael B. Horowitz, Brian T. Jankowitz, Ashutosh Jadhav, Tudor G. Jovin, Andrew F. Ducruet, and Jeffrey Balzer

ALSUntangled 41: “Eric Is Winning”, Yvonne Baker, Richard Bedlack, Paul Wicks, Meraida Polak, John Kissel, Carlayne Jackson, Mark Bromberg, Nicholas Maragakis, Terry Heiman-Patterson, Kathy Mitchell, Lucie Bruijn, Stephen Kolb, Paul Barkhaus, Jonathan Glass, James Caress, Tulio Bertorini, Eric Valor, Gregory Carter, Larry Phillips, Jeff Rothstein, Lyle Ostrow, Gregory Ringkamp, Michael Benatar, Fernando Vieira, Laurie Gutmann, Martina Wiedau, Carmel Armon, Michael Rivner, Sabrina Paganoni, Gleb Levitsky, and Kristiana Salmon

Artificial Intelligence In Neurodegenerative Disease Research: Use Of Ibm Watson To Identify Additional Rna-Binding Proteins Altered In Amyotrophic Lateral Sclerosis, Nadine Bakkar, Tina Kovalik, Ileana Lorenzini, Scott Spangler, Alix Lacoste, Kyle Sponaugle, Philip Ferrante, Elenee Argentinis, Rita Sattler, and Robert Bowser

In Vivo Neuroimaging And Behavioral Correlates In A Rat Model Of Chemotherapy-Induced Cognitive Dysfunction, Robert L. Barry, Nellie E. Byun, M. Noor Tantawy, Chase A. Mackey, George H. Wilson, Adam J. Stark, Michael P. Flom, Laura C. Gee, and C. Chad Quarles


Mn porphyrin-based redox-active drugs: Differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury, Ines Batinic-Haberle, Artak Tovmasyan, and Ivan Spasojevic

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity, Matthew J. Benskey, Rhyomi C. Sellnow, Ivette M. Sandoval, Caryl E. Sortwell, Jack W. Lipton, and Fredric P. Manfredsson

RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases, Ashley Boehringer and Robert Bowser


Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma, Varina L. Boerwinkle, Stephen T. Foldes, Salvatore J. Torrisi, Hamy Temkit, William D. Gaillard, John F. Kerrigan, Virendra R. Desai, Jeffrey S. Raskin, Aditya Vedantam, Randa Jarrar, Korwyn Williams, Sandi Lam, Manish Ranjan, Janna S. Broderson, David Adelson, Angus A. Wilfong, and Daniel J. Curry

ALSUntangled 42: Elysium health's "basis"., Robert Bowser and ALSUntangled Group

ALSUntangled 44: curcumin., Robert Bowser and ALSUntangled Group

ALSUntangled 45: Antiretrovirals., Robert Bowser and ALSUntangled Group


Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite, Sebastián Carballal, Valeria Valez, Damián Alvarez-Paggi, Artak Tovmasyan, Ines Batinic-Haberle, Gerardo Ferrer-Sueta, Daniel H. Murgida, and Rafael Radi

Erratum to "Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite" [Free Radic. Biol. Med. 126 (2018) 379-392], Sebastián Carballal, Valeria Valez, Damián Alvarez-Paggi, Artak Tovmasyan, Ines Batinic-Haberle, Gerardo Ferrer-Sueta, Daniel H. Murgida, and Rafael Radi

The Segmental Distribution Of Cervical Range Of Motion: A Comparison Of Acdf Versus Tdr-C, Steve W. Chang, Michael A. Bohl, Brian P. Kelly, and Chip Wade

Pharmacological And Functional Comparisons Of α6/α3β2β3-Nachrs And α4β2-Nachrs Heterologously Expressed In The Human Epithelial Sh-Ep1 Cell Line, De jie Chen, Fen fei Gao, Xiao Kuang Ma, Gang gang Shi, Yuan bing Huang, Quang xi Su, Sterling Sudweeks, Ming Gao, Turner Dharshaun, Jason Brek Eaton, Yong Chang, J. Michael Mcintosh, Ronald J. Lukas, Paul Whiteaker, Scott C. Steffensen, and Jie Wu

Tdp-43 Pathology Disrupts Nuclear Pore Complexes And Nucleocytoplasmic Transport In Als/Ftd, Ching Chieh Chou, Yi Zhang, Mfon E. Umoh, Spencer W. Vaughan, Ileana Lorenzini, Feilin Liu, Melissa Sayegh, Paul G. Donlin-Asp, Yu Han Chen, Duc M. Duong, Nicholas T. Seyfried, Maureen A. Powers, Thomas Kukar, Chadwick M. Hales, Marla Gearing, Nigel J. Cairns, Kevin B. Boylan, Dennis W. Dickson, Rosa Rademakers, Yong Jie Zhang, Leonard Petrucelli, Rita Sattler, Daniela C. Zarnescu, Jonathan D. Glass, and Wilfried Rossoll


Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota, Francesca Cignarella, Claudia Cantoni, Laura Ghezzi, Amber Salter, Yair Dorsett, Lei Chen, Daniel Phillips, George M. Weinstock, Luigi Fontana, Anne H. Cross, Yanjiao Zhou, and Laura Piccio

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation, John Mark Cline, Greg Dugan, John Daniel Bourland, Donna L. Perry, Joel D. Stitzel, Ashley A. Weaver, Chen Jiang, Artak Tovmasyan, Kouros Owzar, Ivan Spasojevic, Ines Batinic-Haberle, and Zeljko Vujaskovic


Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis, Daniel L. Cooke, David B. McCoy, Van V. Halbach, Steven W. Hetts, Matthew R. Amans, Christopher F. Dowd, Randall T. Higashida, Devon Lawson, Jeffrey Nelson, Chih Yang Wang, Helen Kim, Zena Werb, Charles McCulloch, Tomoki Hashimoto, Hua Su, and Zhengda Sun

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema., Rachelle Crescenzi, Adriana Marton, Paula M C Donahue, Helen B Mahany, Sarah K Lants, Ping Wang, Joshua A Beckman, Manus J Donahue, and Jens Titze

In Vitro Biomechanical Evaluation Of A Novel Minimally Invasive Sacroiliac Joint Fixation Device, William W. Cross, Sigurd H. Berven, Nick Slater, Jennifer N. Lehrman, Anna G.U.S. Newcomb, and Brian P. Kelly


Remapping cortical modulation for electrocorticographic brain-computer interfaces: a somatotopy-based approach in individuals with upper-limb paralysis, Alan D. Degenhart, Shivayogi V. Hiremath, Ying Yang, Stephen Foldes, Jennifer L. Collinger, Michael Boninger, Elizabeth C. Tyler-Kabara, and Wei Wang


Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy, Virendra R. Desai, Aditya Vedantam, Sandi K. Lam, Lucia Mirea, Stephen T. Foldes, Daniel J. Curry, P David Adelson, Angus A. Wilfong, and Varina L. Boerwinkle

In Reply to the Letter to the Editor "C2 Spinous Process Screws", NingNing Dou, Jennifer N. Lehrman, Anna G. Newcomb, and Brian P. Kelly

A Novel C2 Screw Trajectory: Preliminary Anatomic Feasibility And Biomechanical Comparison, Ning Ning Dou, Jennifer N. Lehrman, Anna G.U.S. Newcomb, and Brian P. Kelly

Commentary on 'Inflammatory changes in the aneurysm wall: a review', Andrew F. Ducruet

Microglia Changes Associated To Alzheimer'S Disease Pathology In Aged Chimpanzees, Melissa K. Edler, Chet C. Sherwood, Richard S. Meindl, Emily L. Munger, William D. Hopkins, John J. Ely, Joseph M. Erwin, Daniel P. Perl, Elliott J. Mufson, Patrick R. Hof, and Mary Ann Raghanti

A survey of intracranial aneurysm treatment practices among United States physicians, Kyle M. Fargen, Hector E. Soriano-Baron, Julia T. Rushing, William Mack, J Mocco, Felipe Albuquerque, Andrew F. Ducruet, Maxim Mokin, Italo Linfante, Stacey Q. Wolfe, John A. Wilson, and Joshua A. Hirsch

Introducing a Novel Method of Intravascular Adeno-associated Virus-mediated Gene Delivery., Z H Fazal, K Hosaka, F P Manfredsson, and B L Hoh

Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas, Sherise D. Ferguson, Shouhao Zhou, Jason T. Huse, John F. de Groot, Joanne Xiu, Deepa S. Subramaniam, Shwetal Mehta, Zoran Gatalica, Jeffrey Swensen, Nader Sanai, David Spetzler, and Amy B. Heimberger

Multimorbidity patterns and associations with functional limitations among an aging population in prison, Madison L. Gates, Elizabeth G. Hunter, Vivian Dicks, Peace N. Jessa, Veronica Walker, and Wonsuk Yoo


Representing Diversity In The Dish: Using Patient-Derived In Vitro Models To Recreate The Heterogeneity Of Neurological Disease, Layla T. Ghaffari, Alexander Starr, Andrew T. Nelson, and Rita Sattler

Biomechanical evaluation of interbody fixation with secondary augmentation: lateral lumbar interbody fusion versus posterior lumbar interbody fusion, Jakub Godzik, Samuel Kalb, Marco T. Reis, Phillip M. Reyes, Vaneet Singh, Anna G. Newcomb, Steve W. Chang, Brian P. Kelly, and Neil R. Crawford

Biomechanical Stability Afforded By Unilateral Versus Bilateral Pedicle Screw Fixation With And Without Interbody Support Using Lateral Lumbar Interbody Fusion, Jakub Godzik, Eduardo Martinez-del-Campo, Anna G.U.S. Newcomb, Marco T. Reis, Luis Perez-Orribo, Alexander C. Whiting, Vaneet Singh, Brian P. Kelly, and Neil R. Crawford

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment, Amelie Griveau, Giorgio Seano, Samuel J. Shelton, Robert Kupp, Arman Jahangiri, Kirsten Obernier, Shanmugarajan Krishnan, Olle R. Lindberg, Tracy J. Yuen, An-Chi Tien, Jennifer K. Sabo, Nancy Wang, Ivy Chen, Jonas Kloepper, Louis Larrouquere, Mitrajit Ghosh, Itay Tirosh, Emmanuelle Huillard, Arturo Alvarez-Buylla, Michael C. Oldham, Anders I. Persson, William A. Weiss, Tracy T. Batchelor, Anat Stemmer-Rachamimov, Mario L. Suvà, Joanna J. Phillips, Manish K. Aghi, Shwetal Mehta, Rakesh K. Jain, and David H. Rowitch


Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function, Eva-Maria Hock, Zuzanna Maniecka, Marian Hruska-Plochan, Stefan Reber, Florent Laferrière, Sonu Sahadevan M K, Helena Ederle, Lauren Gittings, Lucas Pelkmans, Luc Dupuis, Tammaryn Lashley, Marc-David Ruepp, Dorothee Dormann, and Magdalini Polymenidou

A Novel Microbiosensor Microarray for Continuous Monitoring of Gamma-Aminobutyric Acid in Real-Time, Imran Hossain, Chao Tan, Phillip T. Doughty, Gaurab Dutta, Teresa A. Murray, Shabnam Siddiqui, Leonidas Iasemidis, and Prabhu U. Arumugam

pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma, Kyle T. Householder, Danielle M. DiPerna, Eugene P. Chung, Anne Rosa Luning, Duong T. Nguyen, Sarah E. Stabenfeldt, Shwetal Mehta, and Rachael W. Sirianni

Predictability and Resetting in a Case of Convulsive Status Epilepticus, Timothy Hutson, Diana Pizarro, Sandipan Pati, and Leon D. Iasemidis

Pedicle screw accuracy assessment in ExcelsiusGPS® robotic spine surgery: Evaluation of deviation from pre-planned trajectory, Bowen Jiang, A. Karim Ahmed, Corinna C. Zygourakis, Samuel Kalb, Alex M. Zhu, Jakub Godzik, Camilo A. Molina, Ari M. Blitz, Ali Bydon, Neil Crawford, and Nicholas Theodore

Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia., Wei-Na Jin, Andrew F Ducruet, Qiang Liu, Samuel Xiang-Yu Shi, Michael Waters, Ming Zou, Kevin N Sheth, Rayna Gonzales, and Fu-Dong Shi

Activation of JAK/STAT3 Restores NK-Cell Function and Improves Immune Defense After Brain Ischemia, Wei Na Jin, Andrew F. Ducruet, Qiang Liu, Samuel Xiang Yu Shi, Michael F. Waters, Ming Zou, Kevin N. Sheth, Rayna Gonzales, and Fu-Dong Shi

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury, Wei Na Jin, Rayna Gonzales, Yan Feng, Kristofer Wood, Zhi Chai, Jing Fei Dong, Antonio La Cava, Fu Dong Shi, and Qiang Liu


α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease, Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Ivette M. Sandoval, Susov Dhakal, P. Michael Iuvone, Xuebing Cao, and Keqiang Ye

SMAD4 deficiency leads to development of arteriovenous malformations in neonatal and adult mice, Yong Hwan Kim, Se Woon Choe, Min Young Chae, Suntaek Hong, and S. Paul Oh

ALSUntangled 43: copper., Stephen Kolb, Jeffrey Rothstein, Eric Valor, Greg Carter, Terry Heiman-Patterson, Carmel Armon, Mark Bromberg, Pamela Kittrell, Jim Caress, Tulio Bertorini, Nicholas Maragakis, Kristiana Salmon, Christopher McDermott, Jon Glass, Rup Tandan, Gary Pattee, Erik Pioro, Sabrina Paganoni, Fernando Viera, Vernoica Peschansky, Ceri Weber, Neta Zach, and Robert Bowser

Role Of Myeloid Lineage Cell Autophagy In Ischemic Brain Injury, Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, Masaaki Korai, Fumiaki Shikata, Atsushi Kuwabara, Xiaoxing Xiong, Caleb Rutledge, Rona G. Giffard, and Tomoki Hashimoto


Upregulation Of Microglial Zeb1 Ameliorates Brain Damage After Acute Ischemic Stroke, Daojing Li, Wenjing Lang, Chen Zhou, Chao Wu, Fang Zhang, Qiang Liu, Shuang Yang, and Junwei Hao

Multivariate Matching Pursuit Decomposition and Normalized Gabor Entropy for Quantification of Preictal Trends in Epilepsy, Rui Liu, Bharat Karumuri, Joshua Adkinson, Timothy Noah Hutson, Ioannis Vlachos, and Leon Iasemidis


Astrocytic Interleukin-15 Reduces Pathology Of Neuromyelitis Optica In Mice, Zhiguo Li, Jinrui Han, Honglei Ren, Cun Gen Ma, Fu Dong Shi, Qiang Liu, and Minshu Li

Engineered Agrin Attenuates The Severity Of Experimental Autoimmune Myasthenia Gravis, Zhiguo Li, Minshu Li, Kristofer Wood, Steffan Hettwer, Suraj A. Muley, Fu Dong Shi, Qiang Liu, and Shafeeq S. Ladha


Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count, Erin E. Longbrake, Claudia Cantoni, Salim Chahin, Francesca Cignarella, Anne H. Cross, and Laura Piccio


RNA editing deficiency in neurodegeneration, Ileana Lorenzini, Stephen Moore, and Rita Sattler

Suramin Is A Novel Competitive Antagonist Selective To α1β2γ2 Gaba A Over ρ1 Gaba C Receptors, Hui Luo, Kristofer Wood, Fu Dong Shi, Fenfei Gao, and Yongchang Chang

Frontal Cortex Epigenetic Dysregulation During The Progression Of Alzheimer'S Disease, Laura Mahady, Muhammad Nadeem, Michael Malek-Ahmadi, Kewei Chen, Sylvia E. Perez, and Elliott J. Mufson


Cognitive Composite Score Association With Alzheimer'S Disease Plaque And Tangle Pathology, Michael Malek-Ahmadi, Kewei Chen, Sylvia E. Perez, Anna He, and Elliott J. Mufson


Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology, Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, and Jeffrey H. Kordower


Challenges in Passive Immunization Strategies to Treat Parkinson Disease, Fredric P. Manfredsson, Malú G. Tansey, and Todd E. Golde

Demographic and clinical predictors of multiple intracranial aneurysms in patients with subarachnoid hemorrhage, Michael M. McDowell, Yin Zhao, Christopher P. Kellner, Sunjay M. Barton, Eric Sussman, Jan Claassen, Andrew F. Ducruet, and E Sander Connolly

Quantifying the mechanical and histological properties of thrombus analog made from human blood for the creation of synthetic thrombus for thrombectomy device testing, William Merritt, Anne Marie Holter, Sharna Beahm, Connor Gonzalez, Timothy A. Becker, Aaron Tabor, Andrew F. Ducruet, Laura S. Bonsmann, Trevor R. Cotter, and Sergey Frenklakh

Provocative Testing Prior to Anterior Cerebral Artery Fusiform Aneurysm Embolization, Pouria Moshayedi, Dan-Victor Giurgiutiu, Andrew F. Ducruet, Brian T. Jankowitz, and Ashutosh P. Jadhav

Impact Of Age On Acute Post-Tbi Neuropathology In Mice Expressing Humanized Tau: A Chronic Effects Of Neurotrauma Consortium Study, Benoit Mouzon, Nicole Saltiel, Scott Ferguson, Joseph Ojo, Carlyn Lungmus, Cillian Lynch, Moustafa Algamal, Alexander Morin, Benjamin Carper, Gayle Bieler, Elliott J. Mufson, William Stewart, Michael Mullan, and Fiona Crawford

Gene Profiling Of Nucleus Basalis Tau Containing Neurons In Chronic Traumatic Encephalopathy: A Chronic Effects Of Neurotrauma Consortium Study, Elliott J. Mufson, Bin He, Stephen D. Ginsberg, Benjamin A. Carper, Gayle S. Bieler, Fiona Crawford, Victor E. Alvarez, Bertr R. Huber, Thor D. Stein, Ann C. McKee, and Sylvia E. Perez

Letter to Editor: Strain in Posterior Instrumentation Resulted by Different Combinations of Posterior and Anterior Devices for Long Spine Fusion Constructs, Anna G. Newcomb, Jay D. Turner, and Brian P. Kelly

Multisite Concordance Of Apparent Diffusion Coefficient Measurements Across The Nci Quantitative Imaging Network, David C. Newitt, Dariya Malyarenko, Thomas L. Chenevert, C. Chad Quarles, Laura Bell, Andriy Fedorov, Fiona Fennessy, Michael A. Jacobs, Meiyappan Solaiyappan, Stefanie Hectors, Bachir Taouli, Mark Muzi, Paul E. Kinahan, Kathleen M. Schmainda, Melissa A. Prah, Erin N. Taber, Christopher Kroenke, Wei Huang, Lori R. Arlinghaus, Thomas E. Yankeelov, Yue Cao, Madhava Aryal, Yi Fen Yen, Jayashree Kalpathy-Cramer, Amita Shukla-Dave, Maggie Fung, Jiachao Liang, Michael Boss, and Nola Hylton

α1-Fangs: Protein Ligands Selective For The α-Bungarotoxin Site Of The α1-Nicotinic Acetylcholine Receptor, Aaron L. Nichols, Kaori Noridomi, Christopher R. Hughes, Farzad Jalali-Yazdi, J. Brek Eaton, Lan Huong Lai, Gaurav Advani, Ronald J. Lukas, Henry A. Lester, Lin Chen, and Richard W. Roberts


Genome-Wide Analyses Identify Kif5A As A Novel Als Gene, Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Shankaracharya, Bradley N. Smith, Giuseppe Marangi, Simon D. Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D. Eicher, Aoife Kenna, Francesco O. Logullo, Isabella L. Simone, Giancarlo Logroscino, Fabrizio Salvi, Ilaria Bartolomei, Giuseppe Borghero, Maria Rita Murru, Emanuela Costantino, Carla Pani, Roberta Puddu, Carla Caredda, Valeria Piras, Stefania Tranquilli, Stefania Cuccu, Daniela Corongiu, Maurizio Melis, Antonio Milia, Francesco Marrosu, Maria Giovanna Marrosu, Gianluca Floris, Antonino Cannas, Margherita Capasso, Claudia Caponnetto, Gianluigi Mancardi, Paola Origone, and Robert Bowser


Nf-κb Inhibition Rescues Cardiac Function By Remodeling Calcium Genes In A Duchenne Muscular Dystrophy Model, Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M.L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, and Denis C. Guttridge


The Molecular Mechanism Of Alpha-Synuclein Dependent Regulation Of Protein Phosphatase 2A Activity, Jing Qu, Hongxia Yan, Yuan Zheng, Fenqin Xue, Yan Zheng, Hongjuan Fang, Yongchang Chang, Hui Yang, and Jianliang Zhang


Glycomic and proteomic changes in aging brain nigrostriatal pathway, Rekha Raghunathan, Nicole K. Polinski, Joshua Klein, John D. Hogan, Chun Shao, Kshitij Khatri, Deborah Leon, Mark E. McComb, Fredric P. Manfredsson, Caryl E. Sortwell, and Joseph Zaia


Selective Disruption Of Tlr2-Myd88 Interaction Inhibits Inflammation And Attenuates Alzheimer'S Pathology, Suresh B. Rangasamy, Malabendu Jana, Avik Roy, Grant T. Corbett, Madhuchhanda Kundu, Sujyoti Chandra, Susanta Mondal, Sridevi Dasarathi, Elliott J. Mufson, Rama K. Mishra, Chi Hao Luan, David A. Bennett, and Kalipada Pahan

Selective Nlrp3 (Pyrin Domain-Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage, Honglei Ren, Ying Kong, Zhijia Liu, Dongyun Zang, Xiaoxia Yang, Kristofer Wood, Minshu Li, and Qiang Liu

Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients, Nader Sanai, Jing Li, Julie Boerner, Karri Stark, Jianmei Wu, Seongho Kim, Alanna Derogatis, Shwetal Mehta, Harshil D. Dhruv, Lance K. Heilbrun, Michael E. Berens, and Patricia M. LoRusso

Multisite Concordance Of Dsc-Mri Analysis For Brain Tumors: Results Of A National Cancer Institute Quantitative Imaging Network Collaborative Project, K. M. Schmainda, M. A. Prah, S. D. Rand, Y. Liu, B. Logan, M. Muzi, S. D. Rane, X. Da, Y. F. Yen, J. Kalpathy-Cramer, T. L. Chenevert, B. Hoff, B. Ross, Y. Cao, M. P. Aryal, B. Erickson, P. Korfiatis, T. Dondlinger, L. Bell, L. Hu, P. E. Kinahan, and C. C. Quarles

Optimization Of Acquisition And Analysis Methods For Clinical Dynamic Susceptibility Contrast Mri Using A Population-Based Digital Reference Object, N. B. Semmineh, L. C. Bell, A. M. Stokes, L. S. Hu, J. L. Boxerman, and C. C. Quarles

Cyclic-GMP-elevating agents suppress polyposis in Apc Min mice by targeting the preneoplastic epithelium, Sarah K. Sharman, Bianca N. Islam, Yali Hou, Nagendra Singh, Franklin G. Berger, Subbaramiah Sridhar, Wonsuk Yoo, and Darren D. Browning

Venous sinus stenting shortens the duration of medical therapy for increased intracranial pressure secondary to venous sinus stenosis, Tarek A. Shazly, Ashutosh P. Jadhav, Amin Aghaebrahim, Andrew F. Ducruet, Brian T. Jankowitz, Tudor G. Jovin, and Gabrielle R. Bonhomme

Stroke-Induced Immunosuppression And Poststroke Infection, Kaibin Shi, Kristofer Wood, Fu Dong Shi, Xiaoying Wang, and Qiang Liu


Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning, Eva Sidlauskaite, Jack W. Gibson, Ian L. Megson, Philip D. Whitfield, Artak Tovmasyan, Ines Batinic-Haberle, Michael P. Murphy, Peter R. Moult, and James N. Cobley

Determinants of adherence to physical activity guidelines among overweight and obese African American breast cancer survivors: Implications for an intervention approach, Selina A. Smith, Benjamin E. Ansa, Wonsuk Yoo, Mary S. Whitehead, and Steven S. Coughlin

Biomechanical Analysis Of An Expandable Lumbar Interbody Spacer, Hector Soriano-Baron, Anna G.U.S. Newcomb, Devika Malhotra, Atilio E. Palma, Eduardo Martinez-del-Campo, Neil R. Crawford, Nicholas Theodore, Brian P. Kelly, and Taro Kaibara

Synaptic Dysfunction And Altered Excitability In C9Orf72 Als/Ftd, Alexander Starr and Rita Sattler

Biomechanical evaluation of the ProDisc-C stability following graded posterior cervical injury, Michael D. Staudt, Doron Rabin, Ali A. Baaj, Neil R. Crawford, and Neil Duggal

α6 Subunit-Containing Nicotinic Receptors Mediate Low-Dose Ethanol Effects On Ventral Tegmental Area Neurons And Ethanol Reward, Scott C. Steffensen, Samuel I. Shin, Ashley C. Nelson, Stephanie S. Pistorius, Stephanie B. Williams, Taylor J. Woodward, Hyun Jung Park, Lindsey Friend, Ming Gao, Fenfei Gao, Devin H. Taylor, M. Foster Olive, Jeffrey G. Edwards, Sterling N. Sudweeks, Lori M. Buhlman, J. Michael McIntosh, and Jie Wu

Fingolimod Enhances the Efficacy of Delayed Alteplase Administration in Acute Ischemic Stroke by Promoting Anterograde Reperfusion and Retrograde Collateral Flow, De Cai Tian, Kaibin Shi, Zilong Zhu, Jia Yao, Xiaoxia Yang, Lei Su, Sheng Zhang, Meixia Zhang, Rayna J. Gonzales, Qiang Liu, De Ren Huang, Michael F. Waters, Kevin N. Sheth, Andrew F. Ducruet, Ying Fu, Min Lou, and Fu-Dong Shi


Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease, Chelsea T. Tiernan, Stephen D. Ginsberg, Bin He, Sarah M. Ward, Angela L. Guillozet-Bongaarts, Nicholas M. Kanaan, Elliott J. Mufson, and Scott E. Counts


Tau oligomer pathology in nucleus basalis neurons during the progression of Alzheimer Disease, Chelsea T. Tiernan, Elliott J. Mufson, Nicholas M. Kanaan, and Scott E. Counts


Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate, Artak Tovmasyan, Jacqueline C. Bueno-Janice, Melba C. Jaramillo, Romulo S. Sampaio, Julio S. Reboucas, Natalia Kyui, Ludmil Benov, Brian Deng, Ting Ting Huang, Margaret E. Tome, Ivan Spasojevic, and Ines Batinic-Haberle

Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis, Ashley M. Wabnitz, Colin P. Derdeyn, David J. Fiorella, Michael J. Lynn, George A. Cotsonis, David S. Liebeskind, Michael F. Waters, Helmi Lutsep, Elena López-Cancio, Tanya N. Turan, Jean Montgomery, L Scott Janis, Bethany Lane, and Marc I. Chimowitz


Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1, Jinkun Wang, Yan Gan, Pengcheng Han, Junxiang Yin, Qingwei Liu, Soha Ghanian, Feng Gao, Guanghui Gong, and Zhiwei Tang

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease, Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, and Keqiang Ye


BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT, Zhi Hao Wang, Wanqiang Wu, Seong Su Kang, Xia Liu, Zhiping Wu, Junmin Peng, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Xuebo Liu, Jian Zhi Wang, and Keqiang Ye

Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage, H. Wan, Y. Wang, J. Ai, S. Brathwaite, H. Ni, R. L. Macdonald, E. M. Hol, J. C.M. Meijers, and M. D.I. Vergouwen

A multicenter study evaluating the frequency and time requirement of mechanical thrombectomy, Taylor A. Wilson, Thabele Leslie-Mazwi, Joshua A. Hirsch, Casey Frey, Teddy E. Kim, Alejandro M. Spiotta, Reade de Leacy, J Mocco, Felipe C. Albuquerque, Andrew F. Ducruet, Ahmed Cheema, Adam Arthur, Visish M. Srinivasan, Peter Kan, Maxim Mokin, Travis Dumont, Ansaar Rai, Jasmeet Singh, Stacey Q. Wolfe, and Kyle M. Fargen

The Effects Of Intravoxel Contrast Agent Diffusion On The Analysis Of Dce-Mri Data In Realistic Tissue Domains, Ryan T. Woodall, Stephanie L. Barnes, David A. Hormuth, Anna G. Sorace, C. Chad Quarles, and Thomas E. Yankeelov