Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms

Document Type

Article

Abstract

Intracranial aneurysms (IAs) are a result of complex interactions between biochemical and mechanical forces and can lead to significant morbidity if they rupture and cause subarachnoid hemorrhage. This review explores the role of matrix metalloproteinases (MMPs) in the pathogenesis and progression of IAs. In addition to providing a review of the normal function of MMPs, it is intended to explore the interaction between inflammation and abnormal blood flow and the resultant pathological vascular remodeling processes seen in the development and rupture of IAs. Also reviewed is the potential for the use of MMPs as a diagnostic tool for assessment of aneurysm development and progression.

Keywords

AAA = abdominal aortic aneurysm, ECM = extracellular matrix, IA = intracranial aneurysm, IEL = internal elastic lamina, IL = interleukin, MMP = matrix metalloproteinase, SAH = subarachnoid hemorrhage, TIMP = tissue inhibitor of metalloproteinases, TNFa = tumor necrosis factor–a, VSMC = vascular smooth muscle cell, WSS = wall shear stress, extracellular matrix, inflammation, intracranial aneurysm, matrix metalloproteinase, vascular remodeling

Medical Subject Headings

Animals; Cerebrovascular Circulation; Encephalitis (pathology); Humans; Intracranial Aneurysm (enzymology, pathology); Matrix Metalloproteinases (metabolism); Subarachnoid Hemorrhage (pathology)

Publication Date

7-1-2019

Publication Title

Neurosurgical focus

E-ISSN

1092-0684

Volume

47

Issue

1

First Page

E4

PubMed ID

31261127

Digital Object Identifier (DOI)

10.3171/2019.4.FOCUS19214

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