Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms
Document Type
Article
Abstract
Intracranial aneurysms (IAs) are a result of complex interactions between biochemical and mechanical forces and can lead to significant morbidity if they rupture and cause subarachnoid hemorrhage. This review explores the role of matrix metalloproteinases (MMPs) in the pathogenesis and progression of IAs. In addition to providing a review of the normal function of MMPs, it is intended to explore the interaction between inflammation and abnormal blood flow and the resultant pathological vascular remodeling processes seen in the development and rupture of IAs. Also reviewed is the potential for the use of MMPs as a diagnostic tool for assessment of aneurysm development and progression.
Keywords
AAA = abdominal aortic aneurysm, ECM = extracellular matrix, IA = intracranial aneurysm, IEL = internal elastic lamina, IL = interleukin, MMP = matrix metalloproteinase, SAH = subarachnoid hemorrhage, TIMP = tissue inhibitor of metalloproteinases, TNFa = tumor necrosis factor–a, VSMC = vascular smooth muscle cell, WSS = wall shear stress, extracellular matrix, inflammation, intracranial aneurysm, matrix metalloproteinase, vascular remodeling
Medical Subject Headings
Animals; Cerebrovascular Circulation; Encephalitis (pathology); Humans; Intracranial Aneurysm (enzymology, pathology); Matrix Metalloproteinases (metabolism); Subarachnoid Hemorrhage (pathology)
Publication Date
7-1-2019
Publication Title
Neurosurgical focus
E-ISSN
1092-0684
Volume
47
Issue
1
First Page
E4
PubMed ID
31261127
Digital Object Identifier (DOI)
10.3171/2019.4.FOCUS19214
Recommended Citation
Zhang, Xiaoran; Ares, William J.; Taussky, Philipp; Ducruet, Andrew F.; and Grandhi, Ramesh, "Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms" (2019). Translational Neuroscience. 2161.
https://scholar.barrowneuro.org/neurobiology/2161