Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy

Authors

Virendra R. Desai, Division of Pediatric Neurosurgery, Texas Children's Hospital/Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Aditya Vedantam, Division of Pediatric Neurosurgery, Texas Children's Hospital/Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Sandi K. Lam, Division of Pediatric Neurosurgery, Texas Children's Hospital/Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Lucia Mirea, Department of Research, Phoenix Children's Hospital, Phoenix, Arizona.
Stephen T. Foldes, Department of Neuroscience Research.Follow
Daniel J. Curry, Division of Pediatric Neurosurgery, Texas Children's Hospital/Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
P David Adelson, Division of Pediatric Neurosurgery, and.Follow
Angus A. Wilfong, Division of Pediatric Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona.
Varina L. Boerwinkle, Division of Pediatric Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona.Follow

Document Type

Article

Abstract

In Brief: The study compared two types of functional MRI (fMRI) to see which side of the brain is most responsible for language: traditional task-based fMRI, which requires a high level of patient interaction, and resting-state fMRI, which is typically performed with the patient under light sedation and has no interaction requirement. The authors found that the test correlation was 93%, indicating resting state fMRI has potential to locate language in those unable to participate in task-based fMRI.

Keywords

BOLD = blood oxygen level–dependent, RSN = resting-state network, fMRI = functional MRI, language lateralization, pediatric epilepsy, resting-state fMRI, resting-state functional MRI, rs-fMRI = resting-state fMRI, surgical technique, task-based fMRI, task-based functional MRI, tb-fMRI = task-based fMRI

Medical Subject Headings

Adolescent; Brain Mapping (methods); Epilepsy (diagnostic imaging, physiopathology); Female; Functional Laterality (physiology); Humans; Language; Magnetic Resonance Imaging (methods, statistics & numerical data); Male; Retrospective Studies

Publication Date

10-19-2018

Publication Title

Journal of neurosurgery. Pediatrics

E-ISSN

1933-0715

Volume

23

Issue

2

First Page

171

Last Page

177

PubMed ID

30485177

Digital Object Identifier (DOI)

10.3171/2018.7.PEDS18162

Recommended Citation

Desai, Virendra R.; Vedantam, Aditya; Lam, Sandi K.; Mirea, Lucia; Foldes, Stephen T.; Curry, Daniel J.; Adelson, P David; Wilfong, Angus A.; and Boerwinkle, Varina L., "Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy" (2018). Translational Neuroscience. 2206.
https://scholar.barrowneuro.org/neurobiology/2206