The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.


Submissions from 2021


Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions, Lucas Vu, Asmita Ghosh, Chelsea Tran, Walters Aji Tebung, Hadjara Sidibé, Krystine Garcia-Mansfield, Victoria David-Dirgo, Ritin Sharma, Patrick Pirrotte, Robert Bowser, and Christine Vande Velde

Adjacent-segment effects of lumbar cortical screw-rod fixation versus pedicle screw-rod fixation with and without interbody support, Piyanat Wangsawatwong, Anna G. Sawa, Bernardo de Andrada Pereira, Jennifer N. Lehrman, Luke K. O'Neill, Jay D. Turner, Juan S. Uribe, and Brian P. Kelly

Does the Choice of Spinal Interbody Fusion Approach Significantly Affect Adjacent Segment Mobility?, Piyanat Wangsawatwong, Anna G. Sawa, Bernardo de Pereira, Jennifer N. Lehrman, Jay D. Turner, Juan S. Uribe, and Brian P. Kelly

Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage, Hoyee Wan, Shakira Brathwaite, Jinglu Ai, Kullervo Hynynen, and R. Loch Macdonald

Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS, Sarah Waters, Molly E. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow, and Emma Scotter

Electrophysiologic Mapping for Target Acquisition in Deep Brain Stimulation May Become Unnecessary in the Era of Intraoperative Imaging, Baltazar Zavala, Zaman Mirzadeh, Tsinsue Chen, Margaret Lambert, Kristina M. Chapple, Rohit Dhall, and Francisco A. Ponce

T, J Zhu, N Hu, J Hou, X Liang, Y Wang, H Zhang, P Wang, T Chen, W Chen, and L Wang

Submissions from 2020

C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke., Saif Ahmad, Chirayu Pandya, Adam Kindelin, Kanchan Bhatia, Rafay Chaudhary, Alok Kumar Dwivedi, Jennifer M Eschbacher, Qiang Liu, Michael F Waters, Md Nasrul Hoda, and Andrew F. Ducruet

Impact of COVID-19 on the cerebrovascular system and the prevention of RBC lysis., N Akhter, S Ahmad, F A Alzahrani, S A Dar, M Wahid, S Haque, K Bhatia, S Sr Almalki, R A Alharbi, and A A A Sindi

Letter: An International Investigation Into the COVID-19 Pandemic and Workforce Depletion in Highly Specialized Neurointerventional Units - Insights From Stroke Thrombectomy and Aneurysm Registry and Endovascular Neurosurgery Research Group, Ali Alawieh, Sami Al Kasab, Eyad Almallouhi, Michael R. Levitt, Pascal M. Jabbour, Ahmad Sweid, Robert M. Starke, Vasu Saini, Kyle M. Fargen, Stacey Q. Wolfe, Adam S. Arthur, Nitin Goyal, Isabel Fragata, Ilko Maier, Charles Matouk, Brian M. Howard, Jonathan A. Grossberg, Michael Cawley, Peter Kan, Muhammad Hafeez, Justin Singer, R Webster Crowley, Krishna C. Joshi, Waleed Brinjikji, Luis E. Savastano, Christopher S. Ogilvy, Santiago Gomez-Paz, Elad Levy, Muhammad Waqas, Maxim Mokin, Erol Veznedaroglu, and Mandy Binning

International experience of mechanical thrombectomy during the COVID-19 pandemic: insights from STAR and ENRG, Sami Al Kasab, Eyad Almallouhi, Ali Alawieh, Michael R. Levitt, Pascal Jabbour, Ahmad Sweid, Robert M. Starke, Vasu Saini, Stacey Q. Wolfe, Kyle M. Fargen, Adam S. Arthur, Nitin Goyal, Abhi Pandhi, Isabel Fragata, Ilko Maier, Charles Matouk, Jonathan A. Grossberg, Brian M. Howard, Peter Kan, Muhammad Hafeez, Clemens M. Schirmer, R Webster Crowley, Krishna C. Joshi, Stavropoula I. Tjoumakaris, Shakeel Chowdry, William Ares, Christopher Ogilvy, Santiago Gomez-Paz, Ansaar T. Rai, Maxim Mokin, Waldo Guerrero, and Min S. Park

Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats, Kimberly M. Alonge, Zaman Mirzadeh, Jarrad M. Scarlett, Aric F. Logsdon, Jenny M. Brown, Elaine Cabrales, Christina K. Chan, Karl J. Kaiyala, Marie A. Bentsen, William A. Banks, Miklos Guttman, Thomas N. Wight, Gregory J. Morton, and Michael W. Schwartz


Quantitative Electroencephalography After Pediatric Anterior Circulation Stroke, Brian L. Appavu, M'hamed H. Temkit, Stephen T. Foldes, Brian T. Burrows, Austin M. Jacobson, Tara K. Mangum, Varina L. Boerwinkle, Iris Marku, Todd A. Abruzzo, and Phillip D. Adelson

Selective inversion recovery quantitative magnetization transfer imaging: Toward a 3 T clinical application in multiple sclerosis., Francesca Bagnato, Giulia Franco, Fei Ye, Run Fan, Patricia Commiskey, Seth A Smith, Junzhong Xu, and Richard Dortch


The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis, Alexander Bampton, Lauren M. Gittings, Pietro Fratta, Tammaryn Lashley, and Ariana Gatt

ALSUntangled 56: “ten red flags”-things to be wary of in alternative or off-label products, Richard Bedlack, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Michael Benatar, Michael Bereman, Robert Bowser, Mark Bromberg, Lev Brylev, James Caress, Greg Carter, Amy Chen, Nick Cole, Jesse Crayle, Merit Cudkocwicz, Eva Feldman, Americo Fernandes, Stephen Goutman, Volkan Granit, Lawrence Hayward, Carlayne Jackson, Leanne Jiang, Pamela Kittrell, Stephen Kolb, Nicholas Maragakis, Christopher McDermott, Kathy Mitchell, Natasha Olby, Lyle Ostrow, Sabrina Paganoni, and Gary Pattee

Analysis of postprocessing steps for residue function dependent dynamic susceptibility contrast (DSC)-MRI biomarkers and their clinical impact on glioma grading for both 1.5 and 3T., Laura C Bell, A. Stokes, and C. Quarles

Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission, Marie A. Bentsen, Dylan M. Rausch, Zaman Mirzadeh, Kenjiro Muta, Jarrad M. Scarlett, Jenny M. Brown, Vicente Herranz-Pérez, Arian F. Baquero, Jonatan Thompson, Kimberly M. Alonge, Chelsea L. Faber, Karl J. Kaiyala, Camdin Bennett, Charles Pyke, Cecilia Ratner, Kristoffer L. Egerod, Birgitte Holst, Thomas H. Meek, Burak Kutlu, Yu Zhang, Thomas Sparso, Kevin L. Grove, Gregory J. Morton, Birgitte R. Kornum, José-Manuel García-Verdugo, Anna Secher, Rasmus Jorgensen, Michael W. Schwartz, and Tune H. Pers

Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI: A Systematic Review, Maurizio Bergamino, Elizabeth G. Keeling, Virendra R. Mishra, Ashley M. Stokes, and Ryan R. Walsh

Radicava / edaravone findings in biomarkers from ALS (REFINE ALS): Protocol and study design, James Berry, Benjamin Brooks, Angela Genge, Terry Heiman-Patterson, Stanley Appel, Michael Benatar, Robert Bowser, Merit Cudkowicz, Clifton Gooch, Jeremy Shefner, Jurjen Westra, Wendy Agnese, Charlotte Merrill, Sally Nelson, and Stephen Apple


Resting-state functional MRI connectivity impact on epilepsy surgery plan and surgical candidacy: prospective clinical work, Varina L. Boerwinkle, Lucia Mirea, William D. Gaillard, Bethany L. Sussman, Diana Larocque, Alexandra Bonnell, Jennifer S. Ronecker, Matthew M. Troester, John F. Kerrigan, Stephen T. Foldes, Brian Appavu, Randa Jarrar, Korwyn Williams, Angus A. Wilfong, and P David Adelson


Range of Motion Testing of a Novel 3D-Printed Synthetic Spine Model., Michael A Bohl, Sarah McBryan, Anna G U S Newcomb, Jennifer N Lehrman, Brian P. Kelly, Peter Nakaji, Steve W Chang, Juan S. Uribe, Jay D Turner, and U Kumar Kakarla

Innovative Long-Dose Neurorehabilitation for Balance and Mobility in Chronic Stroke: A Preliminary Case Series, Catherine Boissoneault, Tyler Grimes, Dorian K. Rose, Michael F. Waters, Anna Khanna, Somnath Datta, and Janis J. Daly

ALSUntangled 51: RCH4., Robert Bowser and ALSUntangled Group

ALSUntangled 53: Carnitine supplements., Robert Bowser and ALSUntangled Group

ALSUntangled 58: Azathioprine., Robert Bowser and ALSUntangled Group

ALSUntangled No. 52: Glutathione., Robert Bowser and ALSUntangled Group

ALSUntangled No. 54: "LEAP2BFIT"., Robert Bowser and ALSUntangled Group


Multicenter postmarket analysis of the neuroform atlas stent for stent-assisted coil embolization of intracranial aneurysms, J. K. Burkhardt, V. Srinivasan, A. Srivatsan, F. Albuquerque, A. F. Ducruet, B. Hendricks, B. A. Gross, B. T. Jankowitz, A. J. Thomas, C. S. Ogilvy, G. A. Maragkos, A. Enriquez-Marulanda, R. W. Crowley, M. R. Levitt, L. J. Kim, C. J. Griessenauer, C. M. Schirmer, S. Dalal, K. Piper, M. Mokin, E. A. Winkler, A. A. Abla, C. McDougall, L. Birnbaum, J. Mascitelli, M. Litao, O. Tanweer, H. Riina, J. Johnson, S. Chen, and P. Kan

Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation., D A Carranza-León, A Oeser, A Marton, P Wang, J C Gore, J Titze, C M Stein, C P Chung, and M J Ormseth

Middle Meningeal Artery Embolization for Chronic Subdural Hematoma, Joshua S. Catapano, Candice L. Nguyen, Andre A. Wakim, Felipe C. Albuquerque, and Andrew F. Ducruet

Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix, Ganne Chaitanya, Emilia Toth, Diana Pizarro, Leonidas Iasemidis, Teresa A. Murray, Kristen Riley, and Sandipan Pati

Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington's Disease, Shreaya Chakroborty, Fredric P. Manfredsson, Alexander M. Dec, Peter W. Campbell, Grace E. Stutzmann, Vahri Beaumont, and Anthony R. West

Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity., Ke Chen, Xiaokuang Ma, Antoine Nehme, Jing Wei, Yan Cui, Yuehua Cui, Dezhong Yao, Jie Wu, Trent Anderson, Deveroux Ferguson, Pat Levitt, and Shenfeng Qiu


Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease, Yaping Chu, Raymond T. Bartus, Fredric P. Manfredsson, C. Warren Olanow, and Jeffrey H. Kordower


TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis, Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A. Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M. Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi, and Laura Piccio


RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases, Mahlon Collins, Yang Li, and Robert Bowser

Rapid whole-brain quantitative magnetization transfer imaging using 3D selective inversion recovery sequences., Matthew J Cronin, Junzhong Xu, Francesca Bagnato, Daniel F Gochberg, John C Gore, and Richard Dortch

A comparison of AAV-vector production methods for gene therapy and preclinical assessment, Marcus Davidsson, Matilde Negrini, Swantje Hauser, Alexander Svanbergsson, Marcus Lockowandt, Giuseppe Tomasello, Fredric P. Manfredsson, and Andreas Heuer

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis., Ramita Dewan, Ruth Chia, Jinhui Ding, Richard A Hickman, Thor D Stein, Yevgeniya Abramzon, Sarah Ahmed, Marya S Sabir, Makayla K Portley, Arianna Tucci, Kristina Ibáñez, F N U Shankaracharya, Pamela Keagle, Giacomina Rossi, Paola Caroppo, Fabrizio Tagliavini, Maria L Waldo, Per M Johansson, Christer F Nilsson, James B Rowe, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Edwin Jabbari, Coralie Viollet, Jonathan D Glass, Andrew B Singleton, Vincenzo Silani, Owen A Ross, Mina Ryten, Ali Torkamani, Toshiko Tanaka, Luigi Ferrucci, Susan M Resnick, Stuart Pickering-Brown, Christopher B Brady, Neil Kowal, John A Hardy, Vivianna Van Deerlin, Jean Paul Vonsattel, Matthew B Harms, Huw R Morris, Raffaele Ferrari, John E Landers, Adriano Chiò, J Raphael Gibbs, Clifton L Dalgard, Sonja W Scholz, Bryan J Traynor, and Robert Bowser


Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain: Aging in chimpanzee brain, Melissa K. Edler, Emily L. Munger, Richard S. Meindl, William D. Hopkins, John J. Ely, Joseph M. Erwin, Elliott J. Mufson, Patrick R. Hof, Chet C. Sherwood, and Mary Ann Raghanti


Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation, Ekaterina Esaulova, Claudia Cantoni, Irina Shchukina, Konstantin Zaitsev, Robert C. Bucelli, Gregory F. Wu, Maxim N. Artyomov, Anne H. Cross, and Brian T. Edelson

Diffusion Tensor Tractrography Visualizes Partial Nerve Laceration Severity as Early as 1 Week After Surgical Repair in a Rat Model Ex Vivo., Angel F Farinas, Isaac V Manzanera Esteve, Alonda C Pollins, Nancy L Cardwell, Mark D Does, Richard Dortch, and Wesley P Thayer


Effects of MEG-based neurofeedback for hand rehabilitation after tetraplegia: preliminary findings in cortical modulations and grip strength, Stephen T. Foldes, Michael L. Boninger, Douglas J. Weber, and Jennifer L. Collinger


Shift in electrocorticography electrode locations after surgical implantation in children, Stephen T. Foldes, Bryce T. Munter, Brian L. Appavu, John F. Kerrigan, and P David Adelson

Mast Cell Promotes the Development of Intracranial Aneurysm Rupture, Hajime Furukawa, Kosuke Wada, Yoshiteru Tada, Atsushi Kuwabara, Hiroki Sato, Jinglu Ai, Michael T. Lawton, and Tomoki Hashimoto

Dual Effect of 5-HT, Ming Gao, Taleen S Der-Ghazarian, Shuangtao Li, Shenfeng Qiu, Janet L Neisewander, and Jie Wu


T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients, Laura Ghezzi, Claudia Cantoni, Francesca Cignarella, Bryan Bollman, Anne H. Cross, Amber Salter, Daniela Galimberti, Marina Cella, and Laura Piccio


Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity, Lauren M. Gittings, Steven Boeynaems, Daniel Lightwood, Alison Clargo, Sarfaraj Topia, Lisa Nakayama, Claire Troakes, David M. Mann, Aaron D. Gitler, Tammaryn Lashley, and Adrian M. Isaacs

Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies, Lauren M. Gittings and Rita Sattler

Optimizing biomechanics of anterior column realignment for minimally invasive deformity correction., Jakub Godzik, Bernardo de Andrada Pereira, Anna G U S Newcomb, Jennifer N Lehrman, Gregory M Mundis, Randall J Hlubek, Juan S. Uribe, Brian P. Kelly, and Jay D Turner

A multi-center study of neurofilament assay reliability and inter-laboratory variability, Elizabeth Gray, Patrick Oeckl, Maria D.M. Amador, Ulf Andreasson, Jiyan An, Kaj Blennow, Robert Bowser, Maxim De Schaepdryver, Amanda Heslegrave, Jens Kuhle, Aleksandra Maceski, Marleen Koel-Simmelink, Foudil Lamari, Vittoria Lombardi, Andrea Malaspina, Irina Nilsson, Koen Poesen, François Salachas, Petra Steinacker, Charlotte E. Teunissen, Philip Van Damme, Henrik Zetterberg, Albert Ludolph, Andreas Jeromin, Martin R. Turner, and Markus Otto

Expression profiling of precuneus layer III cathepsin D-immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability., Bin He, Sylvia E Perez, Sang H Lee, Stephen D Ginsberg, Michael Malek-Ahmadi, and Elliott J. Mufson


Performance of standardized relative CBV for quantifying regional histologic tumor burden in recurrent high-grade glioma: Comparison against normalized relative CBV using image-localized stereotactic biopsies, J. M. Hoxworth, J. M. Eschbacher, A. C. Gonzales, K. W. Singleton, G. D. Leon, K. A. Smith, A. M. Stokes, Y. Zhou, G. L. Mazza, A. B. Porter, M. M. Mrugala, R. S. Zimmerman, B. R. Bendok, D. P. Patra, C. Krishna, J. L. Boxerman, L. C. Baxter, K. R. Swanson, C. C. Quarles, K. M. Schmainda, and L. S. Hu

Longitudinal biomarkers in amyotrophic lateral sclerosis, Fen Huang, Yuda Zhu, Jennifer Hsiao-Nakamoto, Xinyan Tang, Jason C. Dugas, Miriam Moscovitch-Lopatin, Jonathan D. Glass, Robert H. Brown, Shafeeq S. Ladha, David Lacomis, Jeffrey M. Harris, Kimberly Scearce-Levie, Carole Ho, Robert Bowser, and James D. Berry

Smartphone-based meditation for myeloproliferative neoplasm patients: Feasibility study to inform future trials, Jennifer Huberty, Ryan Eckert, Linda Larkey, Jonathan Kurka, Sue A.Rodriguez De Jesus, Wonsuk Yoo, and Ruben Mesa

Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP, T Noah Hutson, Farnaz Rezaei, Nicole M. Gautier, Jagadeeswaran Indumathy, Edward Glasscock, and Leonidas Iasemidis

Neurothrombectomy for Acute Ischemic Stroke Across Clinical Trial Design and Technique: A Single Center Pooled Analysis, Tudor G. Jovin, Shashvat M. Desai, Amin Aghaebrahim, Andrew F. Ducruet, Dan-Victor Giurgiutiu, Bradley A. Gross, Maxim Hammer, Brian T. Jankowitz, Mouhammad A. Jumaa, Cynthia Kenmuir, Guillermo Linares, Vivek Reddy, Marcelo Rocha, Matthew Starr, Viktoria Totoraitis, Lawrence Wechsler, Syed Zaidi, and Ashutosh P. Jadhav


Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus., Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P Manfredsson, Xifei Yang, Hongbo R Luo, L Cameron Liles, David Weinshenker, and Keqiang Ye

ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy, Annapoorna Kannan, Xiaoting Jiang, Lan He, Saif Ahmad, and Laxman Gangwani

Morphological Changes in Astrocytes by Self-Oxidation of Dopamine to Polydopamine and Quantification of Dopamine through Multivariate Regression Analysis of Polydopamine Images, Anik Karan, Elnaz Khezerlou, Farnaz Rezaei, Leon Iasemidis, and Mark A. DeCoster


Overexpression of activin receptor-like kinase 1 in endothelial cells suppresses development of arteriovenous malformations in mouse models of hereditary hemorrhagic telangiectasia, Yong Hwan Kim, Phuong Nhung Vu, Se Woon Choe, Chang Jin Jeon, Helen M. Arthur, Calvin P.H. Vary, Young Jae Lee, and S. Paul Oh

Evaluation of abnormal styloid anatomy as a cause of internal jugular vein compression using a 3D-printed model: a laboratory investigation., Jennifer N Lehrman, Mohan Narayanan, Claudio Cavallo, Anna G U S Newcomb, Xiaochun Zhao, Brian P. Kelly, Neil R Crawford, and Peter Nakaji


Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue, L. Lemoine, A. Ledreux, E. J. Mufson, S. E. Perez, G. Simic, E. Doran, I. Lott, S. Carroll, K. Bharani, S. Thomas, A. Gilmore, E. D. Hamlett, A. Nordberg, and A. C. Granholm

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (HO)MnTnHex-2-PyP, Litao Li, Artak Tovmasyan, Huaxin Sheng, Bin Xu, Romulo S. Sampaio, Julio S. Reboucas, David S. Warner, Ines Batinic-Haberle, and Ivan Spasojevic

Braak Stage, Cerebral Amyloid Angiopathy, and Cognitive Decline in Early Alzheimer's Disease., Michael Malek-Ahmadi, Sylvia E Perez, Kewei Chen, and Elliott J. Mufson

The Future of GDNF in Parkinson's Disease, Fredric P. Manfredsson, Nicole K. Polinski, Thyagarajan Subramanian, Nicholas Boulis, Dustin R. Wakeman, and Ronald J. Mandel

Cocaine potently blocks neuronal α, Ze-Gang Ma, Nan Jiang, Yuan-Bing Huang, Xiao-Kuang Ma, Jason Brek Eaton, Ming Gao, Yong-Chang Chang, Ronald J. Lukas, Paul Whiteaker, Janet Neisewander, and Jie Wu


Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1, David X. Medina, Eugene P Chung, Collin D Teague, Robert Bowser, and Rachael W Sirianni

Spatial Mechanisms for Segregation of Competing Sounds, and a Breakdown in Spatial Hearing, John C. Middlebrooks and Michael F. Waters

Neurosurgical Management of Cancer Facial Pain, Zaman Mirzadeh, John P. Sheehy, Sharona Ben-Haim, and William S. Rosenberg

TLR4 (Toll-Like Receptor 4) Mediates the Development of Intracranial Aneurysm Rupture., Kazuha Mitsui, Taichi Ikedo, Yoshinobu Kamio, Hajime Furukawa, Michael T. Lawton, and Tomoki Hashimoto


Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II, Masashi Miyao, Stephanie Cicalese, Tatsuo Kawai, Hannah A. Cooper, Michael J. Boyer, Katherine J. Elliott, Steven J. Forrester, Ryohei Kuroda, Victor Rizzo, Tomoki Hashimoto, Rosario Scalia, and Satoru Eguchi

TMEM100 is a key factor for specification of lymphatic endothelial progenitors, Eun Hye Moon, Yong Hwan Kim, Phuong Nhung Vu, Hyunjin Yoo, Kwonho Hong, Young Jae Lee, and S. Paul Oh

The Hitchhiker's Guide to Nucleocytoplasmic Trafficking in Neurodegeneration., Stephen Moore, Benjamin E Rabichow, and Rita Sattler


Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease., Marta Moreno-Rodriguez, Sylvia E Perez, Muhammad Nadeem, Michael Malek-Ahmadi, and Elliott J. Mufson


Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations, Bethan Morris, Lee Curtin, Andrea Hawkins-Daarud, Matthew E. Hubbard, Ruman Rahman, Stuart J. Smith, Dorothee Auer, Nhan L. Tran, Leland S. Hu, Jennifer M. Eschbacher, Kris A. Smith, Ashley Stokes, Kristin R. Swanson, and Markus R. Owen

Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy, Muhammad Nadeem, Adam Kindelin, Laura Mahady, Kanchan Bhatia, Md Nasrul Hoda, Andrew F. Ducruet, and Saif Ahmad


Targeting Molecular Mechanism of Vascular Smooth Muscle Senescence Induced by Angiotensin II, A Potential Therapy via Senolytics and Senomorphics, Keisuke Okuno, Stephanie Cicalese, Katherine J. Elliott, Tatsuo Kawai, Tomoki Hashimoto, and Satoru Eguchi


Length-dependent MRI of hereditary neuropathy with liability to pressure palsies., Michael Pridmore, Ryan Castoro, Megan Simmons McCollum, Hakmook Kang, Jun Li, and Richard Dortch


Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia., Mercedes Prudencio, Jack Humphrey, Sarah Pickles, Anna-Leigh Brown, Sarah E Hill, Jennifer M Kachergus, J Shi, Michael G Heckman, Matthew R Spiegel, Casey Cook, Yuping Song, Mei Yue, Lillian M Daughrity, Yari Carlomagno, Karen Jansen-West, Cristhoper Fernandez de Castro, Michael DeTure, Shunsuke Koga, Ying-Chih Wang, Prasanth Sivakumar, Cristian Bodo, Ana Candalija, Kevin Talbot, Bhuvaneish T Selvaraj, Karen Burr, Siddharthan Chandran, Jia Newcombe, Tammaryn Lashley, Isabel Hubbard, Demetra Catalano, Duyang Kim, Nadia Propp, Samantha Fennessey, Delphine Fagegaltier, Hemali Phatnani, Maria Secrier, Elizabeth Mc Fisher, Björn Oskarsson, Marka van Blitterswijk, Rosa Rademakers, Neil R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Keith A Josephs, E Aubrey Thompson, Towfique Raj, Michael Ward, Dennis W Dickson, Tania F Gendron, Pietro Fratta, Leonard Petrucelli, and Robert Bowser


Preclinical testing of a novel niclosamide stearate prodrug therapeutic (NSPT) shows efficacy against osteosarcoma, Gireesh B. Reddy, David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham, and William C. Eward

Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models., Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot K Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine N Metz, S Paul Oh, Lionel Blanc, Fabien Campagne, and Philippe Marambaud

Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models, Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot K. Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine N. Metz, S. Paul Oh, Lionel Blanc, Fabien Campagne, and Philippe Marambaud

Identification of a pathogenic intronic KIF5A mutation in an ALS-FTD kindred, Sara Saez-Atienzar, Clifton L. Dalgard, Jinhui Ding, Adriano Chiò, Camile Alba, Dan N. Hupalo, Matthew D. Wilkerson, Robert Bowser, Erik P. Pioro, Richard Bedlack, and Bryan J. Traynor


Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis, J. Saul, E. Hutchins, R Reiman, M Saul, L W. Ostrow, B T. Harris, K Van Keuren-Jensen, R Bowser, and N Bakkar

Variations among human lumbar spine segments and their relationships to in vitro biomechanics: A retrospective analysis of 281 motion segments from 85 cadaveric spines, Anna G.U. Sawa, Jennifer N. Lehrman, Neil R. Crawford, and Brian P. Kelly


A practical method for multimodal registration and assessment of whole-brain disease burden using PET, MRI, and optical imaging, Matthew L. Scarpelli, Debbie R. Healey, Shwetal Mehta, Vikram D. Kodibagkar, and Christopher C. Quarles

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease, Rhyomi C. Sellnow, Kathy Steece-Collier, Feras Altwal, Ivette M. Sandoval, Jeffrey H. Kordower, Timothy J. Collier, Caryl E. Sortwell, Anthony R. West, and Fredric P. Manfredsson


Further understanding the connection between Alzheimer's disease and Down syndrome, Heather M. Snyder, Lisa J. Bain, Adam M. Brickman, Maria C. Carrillo, Anna J. Esbensen, Joaquin M. Espinosa, Fabian Fernandez, Juan Fortea, Sigan L. Hartley, Elizabeth Head, James Hendrix, Priya S. Kishnani, Florence Lai, Patrick Lao, Cynthia Lemere, William Mobley, Elliott J. Mufson, Huntington Potter, Shahid H. Zaman, Ann Charlotte Granholm, H. Diana Rosas, Andre Strydom, Michelle Sie Whitten, and Michael S. Rafii

Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats, Kathy Steece-Collier, Timothy J. Collier, Jack W. Lipton, Jennifer A. Stancati, Mary E. Winn, Allyson Cole-Strauss, Rhyomi Sellnow, Melissa M. Conti, Natosha M. Mercado, Eduardo A. Nillni, Caryl E. Sortwell, Fredric P. Manfredsson, and Christopher Bishop

Systematic assessment of multi-echo dynamic susceptibility contrast MRI using a digital reference object., A. Stokes, Natenael B Semmineh, Ashley Nespodzany, Laura C Bell, and C. Quarles


YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology., Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-Ichi Muramatsu, Hideyuki Okano, Elliott J. Mufson, Gen Sobue, Shigeo Murayama, and Hitoshi Okazawa

Antibacterial Activity of Synthetic Cationic Iron Porphyrins, Artak Tovmasyan, Ines Batinic-Haberle, and Ludmil Benov

Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury, Kumar Vaibhav, Molly Braun, Katelyn Alverson, Hesam Khodadadi, Ammar Kutiyanawalla, Ayobami Ward, Christopher Banerjee, Tyler Sparks, Aneeq Malik, Mohammad H. Rashid, Mohammad Badruzzaman Khan, Michael F. Waters, David C. Hess, Ali S. Arbab, John R. Vender, Nasrul Hoda, Babak Baban, and Krishnan M. Dhandapani

Robotic Spine Surgery: Current State in Minimally Invasive Surgery, Chau D. Vo, Bowen Jiang, Tej D. Azad, Neil R. Crawford, Ali Bydon, and Nicholas Theodore


Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes., Lucas Vu, Jiyan An, Tina Kovalik, Tania Gendron, Leonard Petrucelli, and Robert Bowser

Surgical Approaches to Stroke Risk Reduction, Michael F. Waters

Optimizing Next-Generation Care Systems for Stroke, D Andrew Wilkinson, Ashutosh P. Jadhav, and Andrew F. Ducruet

Patterns and disparities in human papillomavirus (HPV) vaccine uptake for young female adolescents among U.S. States: NIS-teen (2008–2016), Wonsuk Yoo, Alexis Koskan, Matthew Scotch, Heidi Pottinger, Warner K. Huh, and Deborah Helitzer