Pathophysiology of the choroid plexus in brain diseases

Document Type

Article

Abstract

The choroid plexus, located in the ventricular system of the central nervous system (CNS), obtains numerous roles critical for the proper development and operating of the CNS. The functions range from the best-known ones of the barrier and cerebrospinal fluid (CSF) producer, through participation in immune answer, 'nourishment, detoxification and reparation of the rest of the CNS. Increase number of studies point out the association between choroid plexus dysfunction, characterized by alterations in secretory, transport and barrier capabilities, and the broad spectrum of clinical conditions, as well as physiological aging. We present a brief overview of pathological states known or speculated to be connected to choroid plexus dysfunction, ranging from neurodevelopmental, to autoimmune and neurodegenerative diseases. We also cover the topic of choroid plexus tumors, as well explained involvement of the choroid plexus in pathogen invasion of the CNS, also referring to the currently actual SARS-CoV-2 infection. Finally, we have also touched conducted studies on the choroid plexus regenerative potential. With the information provided in the review we want to point out the importance and call for further research on the role of the choroid plexus in the sustainability of central nervous system health.

Medical Subject Headings

Blood-Brain Barrier; Brain Diseases; COVID-19; Choroid Plexus; Humans; SARS-CoV-2

Publication Date

11-1-2021

Publication Title

General physiology and biophysics

ISSN

0231-5882

Volume

40

Issue

6

First Page

443

Last Page

462

PubMed ID

34897020

Digital Object Identifier (DOI)

10.4149/gpb_2021032

Link to Full Text

Share

COinS