Quantitative Electroencephalography After Pediatric Anterior Circulation Stroke
Document Type
Article
Abstract
OBJECTIVE: Regional differences were investigated in quantitative EEG (QEEG) characteristics and associations of QEEG to hemodynamics after pediatric acute stroke. METHODS: Quantitative EEG was analyzed, including power in delta, theta, alpha, and beta bands, alpha-delta power ratio, total power, and spectral edge frequency from 11 children with unilateral, anterior circulation strokes during the first 24 hours of continuous EEG recording. Differences between injured and uninjured hemispheres were assessed using multivariate dynamic structural equations modeling. Dynamic structural equations modeling was applied to six children with hemorrhagic stroke undergoing arterial blood pressure, heart rate, and cerebral oximetry monitoring to investigate associations between hemodynamics with QEEG adjacent to anterior circulation regions. RESULTS: All patients with acute ischemic stroke (n = 5) had lower alpha and beta power and spectral edge frequency on injured compared with uninjured regions. This was not consistent after hemorrhagic stroke (n = 6). All hemorrhagic stroke patients demonstrated negative association of total power with arterial blood pressure within injured regions. No consistency was observed for direction or strength of association in other QEEG measures to arterial blood pressure nor were such consistent relationships observed for any QEEG measure studied in relation to heart rate or cerebral oximetry. CONCLUSIONS: After pediatric anterior circulation acute ischemic stroke, reduced spectral edge frequency and alpha and beta power can be observed on injured as compared with noninjured regions. After pediatric anterior circulation hemorrhagic stroke, total power can be negatively associated with arterial blood pressure within injured regions. Larger studies are needed to understand conditions in which QEEG patterns manifest and relate to hemodynamics and brain penumbra.
Publication Date
12-29-2020
Publication Title
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
E-ISSN
1537-1603
Volume
Publish Ahead of Print
PubMed ID
33417384
Digital Object Identifier (DOI)
10.1097/WNP.0000000000000813
Recommended Citation
Appavu, Brian L.; Temkit, M'hamed H.; Foldes, Stephen T.; Burrows, Brian T.; Jacobson, Austin M.; Mangum, Tara K.; Boerwinkle, Varina L.; Marku, Iris; Abruzzo, Todd A.; and Adelson, Phillip D., "Quantitative Electroencephalography After Pediatric Anterior Circulation Stroke" (2020). Translational Neuroscience. 2209.
https://scholar.barrowneuro.org/neurobiology/2209