Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity

Authors

Lauren M. Gittings, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
Steven Boeynaems, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Daniel Lightwood, UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK.
Alison Clargo, UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK.
Sarfaraj Topia, UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK.
Lisa Nakayama, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Claire Troakes, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
David M. Mann, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Salford Royal Hospital, Salford, UK.
Aaron D. Gitler, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Tammaryn Lashley, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
Adrian M. Isaacs, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK. a.isaacs@ucl.ac.uk.

Document Type

Article

Medical Subject Headings

Amyotrophic Lateral Sclerosis (genetics, metabolism, pathology); Arginine (metabolism); C9orf72 Protein (physiology); DNA Repeat Expansion; Frontotemporal Lobar Degeneration (genetics, metabolism, pathology); Humans; Methylation

Publication Date

2-1-2020

Publication Title

Acta neuropathologica

E-ISSN

1432-0533

Volume

139

Issue

2

First Page

407

Last Page

410

PubMed ID

31832771

Digital Object Identifier (DOI)

10.1007/s00401-019-02104-x

Recommended Citation

Gittings, Lauren M.; Boeynaems, Steven; Lightwood, Daniel; Clargo, Alison; Topia, Sarfaraj; Nakayama, Lisa; Troakes, Claire; Mann, David M.; Gitler, Aaron D.; Lashley, Tammaryn; and Isaacs, Adrian M., "Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity" (2020). Translational Neuroscience. 2313.
https://scholar.barrowneuro.org/neurobiology/2313