The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Document Type
Article
Abstract
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. Understanding the role of sTREM2 in AD may reveal new pathological mechanisms and lead to the identification of therapeutic targets. We performed a genome-wide association study (GWAS) to identify genetic modifiers of CSF sTREM2 obtained from the Alzheimer's Disease Neuroimaging Initiative. Common variants in the membrane-spanning 4-domains subfamily A (
Keywords
Alzheimer Disease, Female, Genome-Wide Association Study, Humans, Macrophages, Male, Membrane Glycoproteins, Membrane Proteins, Meta-Analysis as Topic, Multigene Family, Receptors, Immunologic
Medical Subject Headings
Alzheimer Disease; Female; Genome-Wide Association Study; Humans; Macrophages; Male; Membrane Glycoproteins; Membrane Proteins; Meta-Analysis as Topic; Multigene Family; Receptors, Immunologic
Publication Date
8-14-2019
Publication Title
Sci Transl Med
ISSN
1946-6242
Volume
11
Issue
505
PubMed ID
31413141
Digital Object Identifier (DOI)
10.1126/scitranslmed.aau2291
Recommended Citation
Deming, Yuetiva; Filipello, Fabia; Cignarella, Francesca; Cantoni, Claudia; Hsu, Simon; Mikesell, Robert; Li, Zeran; Del-Aguila, Jorge L; Dube, Umber; Farias, Fabiana Geraldo; Bradley, Joseph; Budde, John; Ibanez, Laura; Fernandez, Maria Victoria; Blennow, Kaj; Zetterberg, Henrik; Heslegrave, Amanda; Johansson, Per M; Svensson, Johan; Nellgård, Bengt; Lleo, Alberto; Alcolea, Daniel; Clarimon, Jordi; Rami, Lorena; Molinuevo, José Luis; Suárez-Calvet, Marc; Morenas-Rodríguez, Estrella; Kleinberger, Gernot; Ewers, Michael; Harari, Oscar; Haass, Christian; Brett, Thomas J; Benitez, Bruno A; Karch, Celeste M; Piccio, Laura; and Cruchaga, Carlos, "The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk" (2019). Translational Neuroscience. 2355.
https://scholar.barrowneuro.org/neurobiology/2355