Shift in electrocorticography electrode locations after surgical implantation in children

Authors

Stephen T. Foldes, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ, United States; Department of Child Health, University of Arizona - College of Medicine, Phoenix, AZ, United States; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States. Electronic address: sfoldes@phoenixchildrens.com.Follow
Bryce T. Munter, Department of Child Health, University of Arizona - College of Medicine, Phoenix, AZ, United States.
Brian L. Appavu, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ, United States; Department of Child Health, University of Arizona - College of Medicine, Phoenix, AZ, United States; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States.Follow
John F. Kerrigan, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ, United States; Department of Child Health, University of Arizona - College of Medicine, Phoenix, AZ, United States.
P David Adelson, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ, United States; Department of Child Health, University of Arizona - College of Medicine, Phoenix, AZ, United States; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States.Follow

Document Type

Article

Abstract

Interpreting electrocorticography (ECoG) in the context of neuroimaging requires that multimodal information be integrated accurately. However, the implantation of ECoG electrodes can shift the brain impacting the spatial interpretation of electrode locations in the context of pre-implant imaging. We characterized the amount of shift in ECoG electrode locations immediately after implant in a pediatric population. Electrode-shift was quantified as the difference in the electrode locations immediately after surgery (via post-operation CT) compared to the brain surface before the operation (pre-implant T1 MRI). A total of 1140 ECoG contracts were assessed across 18 patients ranging from 3 to 19 (12.1 ± 4.8) years of age who underwent intracranial monitoring in preparation for epilepsy resection surgery. Patients had an average of 63 channels assessed with an average of 5.64 ± 3.27 mm shift from the pre-implant brain surface within 24 h of implant. This shift significantly increased with estimated intracranial volume, but not age. Shift also varied significantly depending of the lobe the contact was over; where contacts on the temporal and frontal lobe had less shift than the parietal. Furthermore, contacts on strips had significantly less shift than those on grids. The shift in the brain surface due to ECoG implantation could lead to a misinterpretation of contact location particularly in patients with larger intracranial volume and for grid contacts over the parietal lobes.

Keywords

Electrocorticography, Pediatric, Surgery

Medical Subject Headings

Adolescent; Brain (surgery); Child; Drug Resistant Epilepsy (surgery); Electrocorticography (methods); Electrodes, Implanted; Electroencephalography (methods); Epilepsy (diagnostic imaging); Female; Humans; Male; Neuroimaging (methods)

Publication Date

11-1-2020

Publication Title

Epilepsy research

E-ISSN

1872-6844

Volume

167

First Page

106410

PubMed ID

32758670

Digital Object Identifier (DOI)

10.1016/j.eplepsyres.2020.106410

Recommended Citation

Foldes, Stephen T.; Munter, Bryce T.; Appavu, Brian L.; Kerrigan, John F.; and Adelson, P David, "Shift in electrocorticography electrode locations after surgical implantation in children" (2020). Translational Neuroscience. 2213.
https://scholar.barrowneuro.org/neurobiology/2213