ALSUntangled #75: Portable neuromodulation stimulator therapy.

Document Type

Article

Abstract

Spurred by patient interest, ALSUntangled herein examines the potential of the Portable Neuromodulation Stimulator (PoNS™) in treating amyotrophic lateral sclerosis (ALS). The PoNS™ device, FDA-approved for the treatment of gait deficits in adult patients with multiple sclerosis, utilizes translingual neurostimulation to stimulate trigeminal and facial nerves via the tongue, aiming to induce neuroplastic changes. While there are early, promising data for PoNS treatment to improve gait and balance in multiple sclerosis, stroke, and traumatic brain injury, no pre-clinical or clinical studies have been performed in ALS. Although reasonably safe, high costs and prescription requirements will limit PoNS accessibility. At this time, due to the lack of ALS-relevant data, we cannot endorse the use of PoNS as an ALS treatment.

Keywords

Humans, Amyotrophic Lateral Sclerosis, Electric Stimulation Therapy

Medical Subject Headings

Humans; Amyotrophic Lateral Sclerosis; Electric Stimulation Therapy

Publication Date

8-1-2024

Publication Title

Amyotroph Lateral Scler Frontotemporal Degener

ISSN

2167-9223

Volume

25

Issue

5-6

First Page

648

Last Page

652

PubMed ID

38666601

Digital Object Identifier (DOI)

10.1080/21678421.2024.2346825

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