ALSUntangled #75: Portable neuromodulation stimulator therapy.
Document Type
Article
Abstract
Spurred by patient interest, ALSUntangled herein examines the potential of the Portable Neuromodulation Stimulator (PoNS™) in treating amyotrophic lateral sclerosis (ALS). The PoNS™ device, FDA-approved for the treatment of gait deficits in adult patients with multiple sclerosis, utilizes translingual neurostimulation to stimulate trigeminal and facial nerves via the tongue, aiming to induce neuroplastic changes. While there are early, promising data for PoNS treatment to improve gait and balance in multiple sclerosis, stroke, and traumatic brain injury, no pre-clinical or clinical studies have been performed in ALS. Although reasonably safe, high costs and prescription requirements will limit PoNS accessibility. At this time, due to the lack of ALS-relevant data, we cannot endorse the use of PoNS as an ALS treatment.
Keywords
Humans, Amyotrophic Lateral Sclerosis, Electric Stimulation Therapy
Medical Subject Headings
Humans; Amyotrophic Lateral Sclerosis; Electric Stimulation Therapy
Publication Date
8-1-2024
Publication Title
Amyotroph Lateral Scler Frontotemporal Degener
ISSN
2167-9223
Volume
25
Issue
5-6
First Page
648
Last Page
652
PubMed ID
38666601
Digital Object Identifier (DOI)
10.1080/21678421.2024.2346825
Recommended Citation
Officer, Laurel; Armon, Carmel; Barkhaus, Paul; Beauchamp, Morgan; Benatar, Michael; Bertorini, Tulio; Bowser, Robert; Bromberg, Mark; Brown, Andrew; Carbunar, Olimpia Mihaela; Carter, Gregory T; Crayle, Jesse; Denson, Keelie; Feldman, Eva; Fullam, Timothy; Heiman-Patterson, Terry; Jackson, Carlayne; Jhooty, Sartaj; Levinson, Danelle; Li, Xiaoyan; Linares, Alexandra; Mallon, Elise; Mascias Cadavid, Javier; Mcdermott, Christopher; Mushannen, Tasnim; Ostrow, Lyle; Patel, Ronak; Pattee, Gary; Ratner, Dylan; Sun, Yuyao; Sladky, John; Wicks, Paul; and Bedlack, Richard, "ALSUntangled #75: Portable neuromodulation stimulator therapy." (2024). Translational Neuroscience. 2379.
https://scholar.barrowneuro.org/neurobiology/2379