Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy.
Document Type
Article
Abstract
Epidemiological studies have unveiled a robust link between exposure to repetitive mild traumatic brain injury (r-mTBI) and elevated susceptibility to develop neurodegenerative disorders, notably chronic traumatic encephalopathy (CTE). The pathogenic lesion in CTE cases is characterized by the accumulation of hyperphosphorylated tau in neurons around small cerebral blood vessels which can be accompanied by astrocytes that contain phosphorylated tau, the latter termed tau astrogliopathy. However, the contribution of tau astrogliopathy to the pathobiology and functional consequences of r-mTBI/CTE or whether it is merely a consequence of aging remains unclear. We addressed these pivotal questions by utilizing a mouse model harboring tau-bearing astrocytes, GFAP
Keywords
Animals, Humans, Male, Mice, Aquaporin 4, Astrocytes, Brain Concussion, Excitatory Amino Acid Transporter 2, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, tau Proteins, Tauopathies
Medical Subject Headings
Animals; Humans; Male; Mice; Aquaporin 4; Astrocytes; Brain Concussion; Excitatory Amino Acid Transporter 2; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; tau Proteins; Tauopathies
Publication Date
5-15-2024
Publication Title
Journal of neuroinflammation [electronic resource]
ISSN
1742-2094
Volume
21
Issue
1
First Page
130
Last Page
130
PubMed ID
38750510
Digital Object Identifier (DOI)
10.1186/s12974-024-03117-4
Recommended Citation
Ortiz, Camila; Pearson, Andrew; McCartan, Robyn; Roche, Shawn; Carothers, Nolan; Browning, Mackenzie; Pérez, S E; He, Bin; Ginsberg, Stephen D; Mullan, Michael; Mufson, Elliott J; Crawford, Fiona; and Ojo, Joseph, "Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy." (2024). Translational Neuroscience. 2397.
https://scholar.barrowneuro.org/neurobiology/2397