The heteroyohimbine mayumbine binds with high affinity to rat brain benzodiazepine receptors in vitro

Authors

Jinglu Ai, Sct. Hans HospitalFollow
Kim Dekermendjian, Sct. Hans Hospital
Mogens Nielsen, Sct. Hans Hospital
Michael Robin Witt, Sct. Hans Hospital

Document Type

Article

Abstract

Mayumbine, a naturally occurring heteroyohimbine, was isolated from Rauwolfia vomitoria extracts and shown to potently (IC = 76 ± 3.5 nM) inhibit the in vitro binding of H-diazepam to the benzodiazepine sites within the rat GABA(A) receptor complex. 50 3

Keywords

CNS, GABA(A)/BZD receptors, In vitro-binding, Mayumbine

Publication Date

1-1-1997

Publication Title

Natural Product Letters

ISSN

10575634

Volume

11

Issue

1

First Page

73

Last Page

76

Digital Object Identifier (DOI)

10.1080/10575639708043760

Recommended Citation

Ai, Jinglu; Dekermendjian, Kim; Nielsen, Mogens; and Witt, Michael Robin, "The heteroyohimbine mayumbine binds with high affinity to rat brain benzodiazepine receptors in vitro" (1997). Translational Neuroscience. 969.
https://scholar.barrowneuro.org/neurobiology/969