The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 1997
Non-linearity in invasive EEG recordings from patients with temporal lobe epilepsy, M C. Casdagli, L D. Iasemidis, R S. Savit, R L. Gilmore, S N. Roper, and J C. Sackellares
Construction of local vertebral coordinate systems using a digitizing probe: Technical note, Neil R. Crawford and Curtis A. Dickman
Plasticity of galaninergic fibers following neurotoxic damage within the rat basal forebrain: Initial observations, S. De Lacalle, S. Kulkarni, and E. J. Mufson
Comparative mechanical properties of spinal cable and wire fixation systems, Curtis A. Dickman, Stephen M. Papadopoulos, Neil R. Crawford, Anna G.U. Brantley, and Roy L. Gealer
Knee kinematics in-vivo of kneeling in deep flexion examined by bi-planar radiographs., M S Hefzy, B P Kelly, T D Cooke, A M al-Baddah, and L Harrison
The effect of overexpression of amyloid precursor protein in different cell types of vascular tissue, N. Jahroudi, J. Kitnev, J. S. Greenberger, and R. Bowser
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau, Gregory A. Jicha, Robert Bowser, Imrana G. Kazam, and Peter Davies
Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of huntington's disease, Jeffrey H. Kordower, Er Yun Chen, Christian Winkler, Rose Fricker, Vinod Charles, Albee Messing, Elliott J. Mufson, Shou C. Wong, Jeffrey M. Rosenstein, Anders Björklund, Dwaine F. Emerich, Joseph Hammang, and Melissa K. Carpenter
Cellular delivery of NGF does not alter the expression of β-amyloid immunoreactivity in young or aged nonhuman primates, Jeffrey H. Kordower, Elliott J. Mufson, Fox Nathan, Leena Martel, and Dwaine F. Emerich
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease, Allan I. Levey, Craig J. Heilman, James J. Lah, Norman R. Nash, Howard D. Rees, Masakazu Wakai, Suzanne S. Mirra, David B. Rye, David Nochlin, Thomas D. Bird, and Elliott J. Mufson
Connections of the hippocampal formation in humans: II. The endfolial fiber pathway, Chun Lim, Elliott J. Mufson, Jeffrey H. Kordower, Howard W. Blume, Joseph R. Madsen, and Clifford B. Saper
Reduction in p140-trkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease, Elliott J. Mufson, Natalie Lavine, Syed Jaffar, Jeffrey H. Kordower, Rémi Quirion, and H. Uri Saragovi
Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease, Elliott J. Mufson, J. M. Li, T. Sobreviela, and J. H. Kordower
FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord, Xiaojun Mu, Joe E. Springer, and Robert Bowser
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse, Suk P. Oh and En Li
Comparative pull-out strength of tapped and untapped pilot holes for bicortical anterior cervical screws, Juan F. Ronderos, Ronald Jacobowitz, Volker K.H. Sonntag, Neil R. Crawford, and Curtis A. Dickman
Determination of the time course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multiwell plate fluorescence scanner, Rita Sattler, Milton P. Charlton, Mathias Hafner, and Michael Tymianski
Expression of fetal ALZ-50 reactive Clone 1 (FAC1) in dentate gyrus following entorhinal cortex lesion, S. D. Styren, R. Bowser, and S. T. Dekosky
A novel use for a carbodiimide compound for the fixation of fluorescent and non-fluorescent calcium indicators in situ following physiological experiments, M. Tymianski, G. M. Bernstein, K. M. Abdel-Hamid, R. Sattler, A. Velumian, P. L. Carlen, H. Razavi, and O. T. Jones
Preparation, characterization and utility of a novel antibody for resolving the spatial and temporal dynamics of the calcium chelator BAPTA, M. Tymianski, R. Sattler, G. Bernstein, and O. T. Jones
The neuronal system of the saccus vasculosus of trout (Salmo trutta fario and Oncorhynchus mykiss): an immunocytochemical and nerve tracing study., J Yáñez, M Rodríguez, S Pérez, F Adrio, I Rodríguez-Moldes, M J Manso, and R Anadón
Submissions from 1996
Organisation of the cerebellar nucleus of the dogfish, Scyliorhinus canicula L.: a light microscopic, immunocytochemical, and ultrastructural study., R Alvarez-Otero, S E Perez, M A Rodriguez, and R Anadón
Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization, Robert Bowser
Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: Genotype analysis and relationships to neuropathological changes, Luc Buée, Jordi Pérez-Tur, Béatrice Leveugle, Valérie Buée-Scherrer, Elliott J. Mufson, Arthur J. Loerzel, Marie Christine Chartier-Harlin, Daniel P. Perl, André Delacourte, and Patrick R. Hof
Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate, Vinod Charles, Elliott J. Mufson, Phillip M. Friden, Raymond T. Bartus, and Jeffrey H. Kordower
TRK and p75 neurotrophin receptor systems in the developing human brain, E. R.Yun Chen, Elliott J. Mufson, and Jeffrey H. Kordower
Methods for determining spinal flexion/extension, lateral bending, and axial rotation from marker coordinate data: Analysis and refinement, Neil R. Crawford, Gary T. Yamaguchi, and Curtis A. Dickman
Characterisation of the furanocoumarin phellopterin as a rat brain benzodiazepine receptor partial agonist in vitro, Kim Dekermendjian, Jinglu Ai, Mogens Nielsen, Olov Sterner, Rudong Shan, and Michael Robin Witt
Biomechanical characteristics of C1-2 cable fixations, Curtis A. Dickman, Neil R. Crawford, and Christopher G. Paramore
Sensitivity And Specificity Of Paired Capillary Prolactin Measurement In Diagnosis Of Seizures, Tajammul Ehsan, Robert S. Fisher, Donald Johns, Ronald J. Lukas, David Blum, and Jennifer Eskola
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys, A H. Gazzaley, S J. Siegel, J H. Kordower, E J. Mufson, and J H. Morrison
Effects Of Steroid Exposure On Ligand Binding And Functional Activities Of Diverse Nicotinic Acetylcholine Receptor Subtypes, Lei Ke and Ronald J. Lukas
Functional fetal nigral grafts in a patient with Parkinson's disease: Chemoanatomic, ultrastructural, and metabolic studies, Jeffrey H. Kordower, Jeffrey M. Rosenstein, Timothy J. Collier, Melanie A. Burke, Er Yun Chen, Jing Min Li, Leena Martel, Allan E. Levey, Elliott J. Mufson, Thomas B. Freeman, and C. Warren Olanow
Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: Trophic effects upon cholinergic and noncholinergic striatal neurons, J. H. Kordower, E. Y. Chen, E. J. Mufson, S. R. Winn, and D. F. Emerich
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells, Hong Lei, Suk P. Oh, Masaki Okano, Ruth Jüttermann, Kendrick A. Goss, Rudolf Jaenisch, and En Li
Interactions Between Tachykinins And Diverse Human Nicotinic Acetylcholine Receptor Subtypes, Ronald J. Lukas and Cynthia M. Eisenhour
Regulation By Nicotine Of Its Own Receptors, Ronald J. Lukas, Lei Ke, Merouane Bencherif, and Cynthia M. Eisenhour
Amyloid load and neural elements in Alzheimer's disease and nondemented individuals with high amyloid plaque density, Akihide Mochizuki, John W. Peterson, Elliott J. Mufson, and Bruce D. Trapp
Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: Distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neurons, E. J. Mufson, J. S. Kroin, Y. T. Liu, T. Sobreviela, R. D. Penn, J. A. Miller, and J. H. Kordower
NADPH-diaphorase histochemistry reveals oligodendrocytes in the rainbow trout (teleosts)., S E Perez, F Adrio, M A Rodriguez, I Rodriguez-Moldes, and R Anadon
Similarity Between Rat Brain Nicotinic α-Bungarotoxin Receptors And Stably Expressed α-Bungarotoxin Binding Sites, M. Quik, J. Choremis, J. Komourian, R. J. Lukas, and E. Puchacz
Voltage-sensitive calcium channels mediate calcium entry into cultured mammalian sympathetic neurons following neurite transection, Rita Sattler, Michael Tymianski, Imran Feyaz, Mathias Hafner, and Charles H. Tator
Immunolocalization and redistribution of the FAC1 protein in Alzheimer's disease, Susan Schoonover, Peter Davies, and Robert Bowser
Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo- and limbic cortex in rat: Relationship to BDNF mRNA expressing neurons, Teresa Sobreviela, Maria Pagcatipunan, Jeffrey S. Kroin, and Elliott J. Mufson
Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes., B R Stevens, D K Kakuda, K Yu, M Waters, C B Vo, and M K Raizada
Identification and analysis of the complete cDNA sequence for the human FAC1 gene, Ping Zhu and Robert Bowser
Submissions from 1995
GABAergic neuronal circuits in the cerebellum of the dogfish Scyliorhinus canicula (Elasmobranchs): an immunocytochemical study., R Alvarez-Otero, S E Pérez, M A Rodríguez, F Adrio, and R Anadón
The electric lobes of the electric ray (Torpedo marmorata) are innervated by GABAergic fibres: immunocytochemical evidence for dual innervation of electromotoneurons., R Anadón, S E Pérez, M A Rodríguez, F Adrio, and I Rodríguez-Moldes
Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia, Maria Andersson, Ola Bergendorff, Mogens Nielsen, Olov Sterner, Robin Witt, Jinglu Ai, Aiping Lu, and An Min Wang
The 'Calcium Antagonist' Tmb-8 [345-Trimethoxybenzoic Acid 8- (Diethylamino)Octyl Ester] Is A Potent Non-Competitive Functional Antagonist At Diverse Nicotinic Acetylcholine Receptor Subtypes, M. Bencherif, C. M. Eisenhour, R. J. Prince, P. M. Lippiello, and R. J. Lukas
Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to tau and PHF in Alzheimer's disease, William C. Benzing and Elliott J. Mufson
Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease, William C. Benzing and Elliott J. Mufson
Primary structure of the long and short splice variants of mouse collagen XII and their tissue‐specific expression during embryonic development, Kathrin Böhme, Yefu Li, Paul S. Oh, and Bjorn R. Olsen
FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain, R. Bowser, A. Giambrone, and P. Davies
The Sea Anemone Purine Caissarone: Adenosine Receptor Antagonism, Rol A. Cooper, JC De Freitas, Frank Porreca, Cynthia M. Eisenhour, Ronald Lukas, and Ryan J. Huxtable
An apparatus for applying pure nonconstraining moments to spine segments in vitro, Neil R. Crawford, Anna G.U. Brantley, Curtis A. Dickman, and Edward J. Koeneman
Galanin receptors in human basal forebrain differ from receptors in the hypothalamus: Characterization using [125I]galanin (porcine) and [125I]galantide, D. C. Deecher, O. O. Odusan, and E. J. Mufson
Biomechanical effects of transoral odontoidectomy, Curtis A. Dickman, Neil R. Crawford, Anna G.U. Brantley, and Volker K.H. Sonntag
The role of Myo2, a yeast class V myosin, in vesicular transport, Brinda Govindan, Robert Bowser, and Peter Novick
Is λ An Appropriate Control Variable For Locomotion?, Thomas M. Hamm and Zong Sheng Han
Human orbitofrontal cortex: Cytoarchitecture and quantitative immunohistochemical parcellation, Patrick R. Hof, Elliotf J. Mufson, and John H. Morrison
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with parkinson's disease, Jeffrey H. Kordower, Thomas B. Freeman, Barry J. Snow, François J.G. Vingerhoets, Elliott J. Mufson, Paul R. Sanberg, Robert A. Hauser, Donald A. Smith, G. Michael Nauert, Daniel P. Perl, and C. Warren Olanow
Binding of Alz 50 depends on Phe8 in tau synthetic peptides and varies between native and denatured tau proteins, Hanna Ksiezak-Reding, Rebecca L. Leibowitz, Robert Bowser, and Peter Davies
Diversity And Patterns Of Regulation Of Nicotinic Receptor Subtypes, Ronald J. Lukas
Dissociation of galaninergic and neurotrophic plasticity in Down syndrome and Alzheimer disease, E J. Mufson, W C. Benzing, and J H. Kordower
Nerve growth factor in alzheimer’s disease: Defective retrograde transport to nucleus basalis, Elliott J. Mufson, James M. Conner, and Jeffrey H. Kordower
Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones, Yasuteru Muragaki, Sheila Timmons, C. May Griffith, Suk P. Oh, Bahaa Fadel, Thomas Quertermous, and Bjorn R. Olsen
The nitric oxide synthase (NOS)-like immunoreactive extrahypophysial projections of the neurosecretory preoptic nucleus of the electric ray (elasmobranchs) suggest a neuroregulatory role for this nucleus., S E Pérez, F Adrio, M A Rodríguez, R Anadón, and I Rodríguez-Moldes
Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis, Samuel A. Scott, Elliott J. Mufson, Jean A. Weingartner, Kenneth A. Skau, and Keith A. Crutcher
Reduced nicotinamide adenine dinucleotide phosphate‐diaphorase/nitric oxide synthase profiles in the human hippocampal formation and perirhinal cortex, Teresa Sobreviela and Elliott J. Mufson
Submissions from 1994
Age-related vulnerability of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus, M A. Burke, J R. Apter, B H. Wainer, E J. Mufson, and J H. Kordower
Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity, E J. Cochran, J H. Fox, and E J. Mufson
Cholinergic innervation in the human hippocampal formation including the entorhinal cortex, Sonsoles De Lacalle, Chun Lim, Teresa Sobreviela, Elliott J. Mufson, Louis B. Hersh, and Clifford B. Saper
Morphology and kinematics of the baboon upper cervical spine: A model of the atlantoaxial complex, Curtis A. Dickman, Neil R. Crawford, Teiji Tominaga, Anna G.U. Brantley, Stephen Coons, and Volker K.H. Sonntag
Time dependencies in the occurrences of epileptic seizures, L D. Iasemidis, L D. Olson, R S. Savit, and J C. Sackellares
TRK‐immunoreactivity in the monkey central nervous system: Forebrain, Jeffrey H. Kordower, Er‐Yun ‐Y Chen, John R. Sladek, and Elliott J. Mufson
The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor, Jeffrey H. Kordower, Shelley R. Winn, Yue Ting Liu, Elliott J. Mufson, John R. Sladek, Joseph P. Hammang, E. Edward Baetge, and Dwaine F. Emerich
Spatial And Temporal Features Of Recurrent Facilitation Among Motoneurons Innervating Synergistic Muscles Of The Cat, M. L. McCurdy and T. M. Hamm
Topography Of Recurrent Inhibitory Postsynaptic Potentials Between Individual Motoneurons In The Cat, M. L. McCurdy and T. M. Hamm
Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer's brains, M. A. Morán, E. J. Mufson, and P. Gómez-Ramos
Intrastriatal infusions of brain-derived neurotrophic factor: retrograde transport and colocalization with dopamine containing substantia nigra neurons in rat, E J. Mufson, J S. Kroin, T Sobreviela, M A. Burke, J H. Kordower, R D. Penn, and J A. Miller
Sparing of NADPH-diaphorase striatal neurons in parkinson’s and alzheimer’s diseases, Elliot J. Mufson and Melanie M. Brandabur
Lack of neocortical nerve cell loss in Alzheimer's disease: Reality or methodological artifact, Elliott J. Mufson and William C. Benzing
Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques, Elliott J. Mufson, William C. Benzing, Greg M. Cole, Hua Wang, Dwaine F. Emerich, John R. Sladek, John H. Morrison, and Jeffrey H. Kordower
Nerve growth factor‐like immunoreactive profiles in the primate basal forebrain and hippocampal formation, Elliott J. Mufson, James M. Conner, Silvio Varon, and Jeffrey H. Kordower
Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins, Suk Paul Oh, Yusuke Kamagata, Yasuteru Muragaki, Sheila Timmons, Akira Ooshima, and Bjorn R. Olsen
Cloning of cdna and genomic dna encoding human type xviii collagen and localization of the α1(xviii) collagen gene to mouse chromosome 10 and human chromosome 21, Suk P. Oh, Matthew L. Warman, Michael F. Seldin, Sou De Cheng, Joan H.M. Knoll, Sheila Timmons, and Bjorn R. Olsen
Functional Expression Of Nicotinic Acetylcholine Receptors Containing Rat α7 Subunits In Human Sh-Sy5Y Neuroblastoma Cells, Elzbieta Puchacz, Bruno Buisson, Daniel Bertrand, and Ronald J. Lukas
TrkA‐immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin, Teresa Sobreviela, Douglas O. Clary, Louis F. Reichardt, Melanie M. Brandabur, Jeffrey H. Kordower, and Elliott J. Mufson
Submissions from 1993
Cytochalasin Modulation Of Nicotinic Cholinergic Receptor Expression And Muscarinic Receptor Function In Human Te671/Rd Cells: A Possible Functional Role Of The Cytoskeleton, Merouane Bencherif and Ronald J. Lukas
Evidence that transmitter-containing dystrophic neurites precede those containing paired helical filaments within senile plaques in the entorhinal cortex of nondemented elderly and Alzheimer's disease patients, William C. Benzing, Daniel R. Brady, Elliott J. Mufson, and David M. Armstrong
Evidence that transmitter‐containing dystrophic neurites precede paired helical filament and Alz‐50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease, William C. Benzing, Milos D. Ikonomovic, Daniel R. Brady, Elliott J. Mufson, and David M. Armstrong
Galanin immunoreactivity within the primate basal forebrain: Evolutionary change between monkeys and apes, William C. Benzing, Jeffrey H. Kordower, and Elliott J. Mufson
Alzheimer's disease-like dystrophic neurites characteristically associated with senile plaques are not found within other neurodegenerative disease unless amyloid β-protein deposition is present, William C. Benzing, Elliott J. Mufson, and David M. Armstrong
Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques, William C. Benzing, Elliott J. Mufson, and David M. Armstrong
Striatal Extracts from Patients with Parkinson’s Disease Promote Dopamine Neuron Growth in Mesencephalic Cultures, P. M. Carvey, L. R. Ptak, S. T. Nath, D. K. Sierens, E. J. Mufson, C. G. Goetz, and H. L. Klawans
Difference in methylation patterns within the D15S9 region of chromosome 15q11-13 in first cousins with Angelman syndrome and Prader-Willi syndrome., J Clayton-Smith, D J Driscoll, M F Waters, T Webb, T Andrews, S Malcolm, M E Pembrey, and R D Nicholls
Photoaffinity Labeling Of Muscle-Type Nicotinic Acetylcholine Receptors And Neuronal/Nicotinic α-Bungarotoxin Binding Sites With A Derivative Of α-Bungarotoxin, Anna M. Joy, Hal N. Siegel, and Ronald J. Lukas
NGF receptor (p75)‐immunoreactivity in the developing primate basal ganglia, Jeffrey H. Kordower and Elliott J. Mufson
Delivery of trophic factors to the primate brain, J H. Kordower, E J. Mufson, A C. Granholm, B Hoffer, and P M. Friden