Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease

Authors

William C. Benzing, Rush University Medical Center
Elliott J. Mufson, Rush University Medical Center

Document Type

Article

Abstract

NADPH-diaphorase histochemistry labels neurons containing nitric oxide synthase, the synthesizing for nitric oxide within the central nervous system. Quantitation revealed a statistically significant increase in the density of intensely (type 1) and moderately (type 2) but not lightly (type 3) NADPH-diaphroase stained neurons within the substantia innominata in AD as compared with age-matched controls. Increased numbers of NADPH-diaphorase neurons suggest excess nitric oxide production which may be neurotoxic to surrounding cholinergic neurons within the substantia innominata in Alzheimer's disease. © 1995 Elsevier Science B.V. All rights reserved.

Keywords

Aging, Basal forebrain, Histochemistry, Human, Nitric oxide, Nitric oxide synthase, Plasticity

Publication Date

1-30-1995

Publication Title

Brain Research

ISSN

00068993

Volume

670

Issue

2

First Page

351

Last Page

355

PubMed ID

7743205

Digital Object Identifier (DOI)

10.1016/0006-8993(94)01362-L

Recommended Citation

Benzing, William C. and Mufson, Elliott J., "Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease" (1995). Translational Neuroscience. 1845.
https://scholar.barrowneuro.org/neurobiology/1845