Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease
Document Type
Article
Abstract
In situ hybridization for TrkA mRNA was combined with quantitative optical densitometry to evaluate whether the expression of this gene is altered within cholinergic basal forebrain neurons (CBF) in Alzheimer's disease (AD). TrkA mRNA within individual nucleus basalis neurons was significantly reduced (66%) in AD cases relative to aged controls. Reverse transcription polymerase chain reaction quantitative analyses confirmed that TrkA mRNA levels decreased markedly in AD. In contrast, expression of the gene coding for the low affinity p75(NTR) was not significantly altered in AD relative to aged controls. These data indicate that there is a selective defect in trkA gene expression in AD, supporting the hypothesis that the degeneration of CBF neurons seen in this disease results from impaired nerve growth factor trophic support.
Keywords
Ageing, Disease, Gene, Human, In situ hybridization, Receptors, TrkA
Publication Date
1-1-1997
Publication Title
NeuroReport
ISSN
09594965
Volume
8
Issue
1
First Page
25
Last Page
29
PubMed ID
9051746
Digital Object Identifier (DOI)
10.1097/00001756-199612200-00006
Recommended Citation
Mufson, Elliott J.; Li, J. M.; Sobreviela, T.; and Kordower, J. H., "Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease" (1997). Translational Neuroscience. 1772.
https://scholar.barrowneuro.org/neurobiology/1772