Sparing of NADPH-diaphorase striatal neurons in parkinson’s and alzheimer’s diseases
Document Type
Article
Abstract
The free radical neuromodulator, nitric oxide (NO) has been implicated as a neurotoxin. Neurons containing NO synthase (NOS) also contain NADPH-diaphorase (NADPH-d) and are resistant to NO toxicity. We report that NADPH-d-containing neurons within the striatum are spared in patients with Parkinson’s (PD) and Alzheimer’s disease (AD). However, a number of these neurons in both diseases appeared shrunken or bulbous with foreshortened dendritic processes. Quantitative analysis of cell areas revealed a significant difference only in the size of putamenal AD neurons which were decreased compared to normal controls. The possible involvement of NO in the neuropathogenesis of striatal derangement is discussed. © Rapid Communications of Oxford Ltd.
Keywords
Alzheimer’s disease, NADPH-diaphorase, Parkinson’s disease, Striatum
Publication Date
1-1-1994
Publication Title
NeuroReport
ISSN
09594965
E-ISSN
1473558X
Volume
5
Issue
6
First Page
705
Last Page
708
PubMed ID
8199342
Digital Object Identifier (DOI)
10.1097/00001756-199402000-00011
Recommended Citation
Mufson, Elliot J. and Brandabur, Melanie M., "Sparing of NADPH-diaphorase striatal neurons in parkinson’s and alzheimer’s diseases" (1994). Translational Neuroscience. 1953.
https://scholar.barrowneuro.org/neurobiology/1953