Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity

Document Type

Article

Abstract

We report a case of a 69-year-old woman with an 11-year history of progressive dementia, who was found at autopsy to have classic Pick's disease pathology, as well as extensive paired helical filament -- immunoreactive neurities, with few Alzheimer's disease (AD)-like neurofibrillary tangles and no senile plaques. Both Pick bodies and neuritic degeneration were extensive in the neocortex and hippocampal complex. In addition, synaptophysin immunostaining of the hippocampal complex showed a bilaminar pattern of immunoreactivity in the outer molecular layer as previously described in AD.

Medical Subject Headings

Alzheimer Disease (pathology); Brain (pathology); Dementia (pathology); Female; Humans; Immunohistochemistry; Middle Aged; Neurites (pathology); Synaptophysin (analysis)

Publication Date

1-1-1994

Publication Title

Acta neuropathologica

ISSN

0001-6322

Volume

88

Issue

5

First Page

479

Last Page

84

PubMed ID

7847079

Digital Object Identifier (DOI)

10.1007/BF00389503

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