Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Authors

Ola Bergendorff, Lunds Universitet
Kim Dekermendjian, Sct. Hans Hospital
Mogens Nielsen, Sct. Hans Hospital
Rudong Shan, Lunds Universitet
Robin Witt, Sct. Hans Hospital
Jinglu Ai, Sct. Hans HospitalFollow
Olov Sterner, Lunds Universitet

Document Type

Article

Abstract

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC = 0.36 μM) inhibits the binding of [ H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active. 50 3

Keywords

Angelica dahurica, benzodiazepine receptor, furanocoumarins, phellopterin, roots, Umbelliferae

Publication Date

3-1-1997

Publication Title

Phytochemistry

ISSN

00319422

Volume

44

Issue

6

First Page

1121

Last Page

1124

PubMed ID

9055449

Digital Object Identifier (DOI)

10.1016/S0031-9422(96)00703-0

Recommended Citation

Bergendorff, Ola; Dekermendjian, Kim; Nielsen, Mogens; Shan, Rudong; Witt, Robin; Ai, Jinglu; and Sterner, Olov, "Furanocoumarins with affinity to brain benzodiazepine receptors in vitro" (1997). Translational Neuroscience. 968.
https://scholar.barrowneuro.org/neurobiology/968