Epidermal growth factor receptor expression in demented and aged human brain

Authors

Scot D. Styren, School of Life Sciences
Elliot J. Mufson, Institute for Biogerontology Research Arizona
Gisele C. Styren, Institute for Biogerontology Research Arizona
W. Harold Civin, Institute for Biogerontology Research Arizona
Joseph Rogers, School of Life Sciences

Document Type

Article

Abstract

Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of13/13 demented elderly patients, but absent in9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells. © 1990 Elsevier Science Publishers B. V. (Biomedical Division).

Keywords

Alzheimer's disease, Endothelial cell, Epidermal growth factor, Epidermal growth factor receptor, Parkinson's disease

Publication Date

4-2-1990

Publication Title

Brain Research

ISSN

00068993

Volume

512

Issue

2

First Page

347

Last Page

352

PubMed ID

2354367

Digital Object Identifier (DOI)

10.1016/0006-8993(90)90647-T

Recommended Citation

Styren, Scot D.; Mufson, Elliot J.; Styren, Gisele C.; Harold Civin, W.; and Rogers, Joseph, "Epidermal growth factor receptor expression in demented and aged human brain" (1990). Translational Neuroscience. 1797.
https://scholar.barrowneuro.org/neurobiology/1797