Three-dimensional representation and cortical projection topography of the nucleus basalis (Ch4) in the macaque: concurrent demonstration of choline acetyltransferase and retrograde transport with a stabilized tetramethylbenzidine method for horseradish peroxidase
Document Type
Article
Abstract
Ninety-six percent of the nucleus basalis neurons that project to the neocortex contain choline acetyltransferase. These projections from the cholinergic component of the nucleus basalis (Ch4) are topographically organized so that each cortical area receives most of its cholinergic input from a different Ch4 sector. The three-dimensional reconstruction of these sectors reveals the presence of a complex structure. A stabilization procedure that was used in these experiments maintains all the advantages of the tetramethylbenzidine method for horseradish peroxidase while eliminating the vulnerability of the reaction-product to high pH and dehydrating agents. © 1986.
Keywords
choline acetyltransferase, cholinergic projection, horseradish peroxidase, nucleus basalis, tetramethylbenzidine
Publication Date
3-5-1986
Publication Title
Brain Research
ISSN
00068993
Volume
367
Issue
1-2
First Page
301
Last Page
308
PubMed ID
3516304
Digital Object Identifier (DOI)
10.1016/0006-8993(86)91607-0
Recommended Citation
Mesulam, M. Marsel; Mufson, Elliott J.; and Wainer, Bruce H., "Three-dimensional representation and cortical projection topography of the nucleus basalis (Ch4) in the macaque: concurrent demonstration of choline acetyltransferase and retrograde transport with a stabilized tetramethylbenzidine method for horseradish peroxidase" (1986). Translational Neuroscience. 1978.
https://scholar.barrowneuro.org/neurobiology/1978