Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease

Authors

William C. Benzing, Department of Neurosciences
Elliott J. Mufson, Institute for Biogerontology Research Arizona
Lothar Jennes, Wright State University Boonshoft School of Medicine
David M. Armstrong, Georgetown University

Document Type

Article

Abstract

The density of neurotensin immunoreactivity (NT-IR) was dramatically decreased in 6 of 12 amygdaloid nuclear subregions in patients with Alzheimer's disease (AD) compared to age-matched normals. Dimunution of NT-IR was most pronounced in amygdaloid regions containing the greatest number of senile plaques. This contrasts to our previous findings of little, if any, loss of substance P or somatostatin immunoreactivity within these same regions. The present findings corroborate biochemical reports of a decrease in NT-IR in the AD amygdala and suggest that this peptide may be selectively affected relative to other neuropeptides. © 1990.

Keywords

Alzheimer's disease, Amygdala, Immunocytochemistry, Neuropathology, Neuropeptide, Neurotensin

Publication Date

12-24-1990

Publication Title

Brain Research

ISSN

00068993

Volume

537

Issue

1-2

First Page

298

Last Page

302

PubMed ID

1707731

Digital Object Identifier (DOI)

10.1016/0006-8993(90)90372-I

Recommended Citation

Benzing, William C.; Mufson, Elliott J.; Jennes, Lothar; and Armstrong, David M., "Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease" (1990). Translational Neuroscience. 1937.
https://scholar.barrowneuro.org/neurobiology/1937