Tissue‐specific expression of type XII collagen during mouse embryonic development

Authors

Suk Paul Oh, Harvard Medical SchoolFollow
C. May Griffith, Harvard Medical School
Elizabeth D. Hay, Harvard Medical School
Bjorn R. Olsen, Harvard Medical School

Document Type

Article

Abstract

Polyclonal antibodies were raised in rabbits against a fusion peptide representing a portion of the amino‐terminal non‐triplehelical domain of mouse type XII collagen. The antibodies reacted with bands of 220 and 350 kDa on Western blots of mouse tissue extracts. Immunohistochemical analyses of mouse embryos demonstrated that type XII collagen is expressed mainly in dense connective tissues of tendons, ligaments, dermis, cornea, blood vessel walls, meninges, and developing membranous bones. Comparison of skin extracts and medium of cultured mouse skin fibroblasts by Western blotting showed that while tissues contain short 220 kDa type XII collagen polypeptides as well as the long form, cultured cells produce mainly the long form with 350 kDa polypeptides. © 1993 wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc.

Publication Date

1-1-1993

Publication Title

Developmental Dynamics

ISSN

10588388

E-ISSN

10970177

Volume

196

Issue

1

First Page

37

Last Page

46

PubMed ID

8334298

Digital Object Identifier (DOI)

10.1002/aja.1001960105

Recommended Citation

Oh, Suk Paul; May Griffith, C.; Hay, Elizabeth D.; and Olsen, Bjorn R., "Tissue‐specific expression of type XII collagen during mouse embryonic development" (1993). Translational Neuroscience. 724.
https://scholar.barrowneuro.org/neurobiology/724