Cholinergic and non-cholinergic septohippocampal pathways
Document Type
Article
Abstract
Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.
Medical Subject Headings
Acetylcholinesterase (metabolism); Animals; Choline O-Acetyltransferase (metabolism); Cholinergic Fibers; Hippocampus (cytology, enzymology); Male; Neural Pathways (cytology, enzymology); Rats; Rats, Inbred Strains; Septum Pellucidum (cytology, enzymology)
Publication Date
2-28-1985
Publication Title
Neuroscience letters
ISSN
0304-3940
Volume
54
Issue
1
First Page
45
Last Page
52
PubMed ID
3974944
Digital Object Identifier (DOI)
10.1016/s0304-3940(85)80116-6
Recommended Citation
Wainer, B H.; Levey, A I.; Rye, D B.; Mesulam, M M.; and Mufson, E J., "Cholinergic and non-cholinergic septohippocampal pathways" (1985). Translational Neuroscience. 1742.
https://scholar.barrowneuro.org/neurobiology/1742