NGF and Alzheimer's disease: Unfulfilled promise and untapped potential

Authors

Jeffrey H. Kordower, University of Illinois College of Medicine
Elliott J. Mufson, Institute for Biogerontology Research Arizona

Document Type

Article

Abstract

A role for impaired NGF mechanisms as an underlying component in the pathogenesis of Alzheimer's disease has yet to be realized. However, circumspect examination of the available data fails to provide sufficient evidence for rejecting this notion and further systematic evaluation along each step of NGF's mechanism of neurotrophic action is still required. This commentary argues that NGF may be involved in the degeneration observed in the basal forebrain in AD, or at the very least, plays a dynamic role in the disease process. © 1989.

Publication Date

1-1-1989

Publication Title

Neurobiology of Aging

ISSN

01974580

Volume

10

Issue

5

First Page

543

Last Page

544

PubMed ID

2812223

Digital Object Identifier (DOI)

10.1016/0197-4580(89)90123-1

Recommended Citation

Kordower, Jeffrey H. and Mufson, Elliott J., "NGF and Alzheimer's disease: Unfulfilled promise and untapped potential" (1989). Translational Neuroscience. 1901.
https://scholar.barrowneuro.org/neurobiology/1901