The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 2016

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Teaching and Practicing Neuro-Ophthalmology in Low-Resource Countries, Bradley J. Katz, Bradley K. Farris, Karl C. Golnik, Mitchell Lawlor, and Douglas G. Postels

Geo-spatial Informatics in International Public Health Nursing Education, Madeleine J. Kerr, Michelle L. Honey, and Brittany Krzyzanowski

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ER Protein Processing Under Oxidative Stress: Implications and Prevention, Mahmoud F. Khalil, Carlos Valenzuela, Daniella Sisniega, Rachid Skouta, and Mahesh Narayan

Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment, Janina Krell-Roesch, Anna Pink, Rosebud O. Roberts, Gorazd B. Stokin, Michelle M. Mielke, Kathleen A. Spangehl, Mairead M. Bartley, David S. Knopman, Teresa J.H. Christianson, Ronald C. Petersen, and Yonas E. Geda

FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging, Janina Krell-Roesch, Hanna Ruider, Val J. Lowe, Gorazd B. Stokin, Anna Pink, Rosebud O. Roberts, Michelle M. Mielke, David S. Knopman, Teresa J. Christianson, Mary M. MacHulda, Clifford R. Jack, Ronald C. Petersen, and Yonas E. Geda

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Effective Treatment of Paroxysmal Nonkinesigenic Dyskinesia With Oxcarbazepine, Aditya Kumar, Anna Szekely, and Bahman Jabbari

Headache, migraine and obesity: an overview on plausible links., D Laino, G Vitaliti, P Parisi, P Pavone, A Verrotti, R Lubrano, N Matin, and R Falsaperla

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Exacerbation of myasthenia gravis in a patient with melanoma treated with pembrolizumab, K H. Lau, Aditya Kumar, Irene Hwa Yang, and Richard J. Nowak

Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research, Jong Woo Lee, Suzette LaRoche, Hyunmi Choi, Andres A. Rodriguez Ruiz, Evan Fertig, Jeffrey M. Politsky, Susan T. Herman, Tobias Loddenkemper, Arnold J. Sansevere, Pearce J. Korb, Nicholas S. Abend, Joshua L. Goldstein, Saurabh R. Sinha, Keith E. Dombrowski, Eva K. Ritzl, Michael B. Westover, Jay R. Gavvala, Elizabeth E. Gerard, Sarah E. Schmitt, Jerzy P. Szaflarski, Kan Ding, Kevin F. Haas, Richard Buchsbaum, Lawrence J. Hirsch, Courtney J. Wusthoff, Jennifer L. Hopp, and Cecil D. Hahn

Exploring the efficacy of a 5-day course of transcranial direct current stimulation (TDCS) on depression and memory function in patients with well-controlled temporal lobe epilepsy, Anli Liu, Andrew Bryant, Ashley Jefferson, Daniel Friedman, Preet Minhas, Sarah Barnard, William Barr, Thomas Thesen, Margaret O'Connor, Mouhsin Shafi, Susan Herman, Orrin Devinsky, Alvaro Pascual-Leone, and Steven Schachter

Substantial Progress Yet Significant Opportunity for Improvement in Stroke Care in China., Zixiao Li, Chunjuan Wang, Xingquan Zhao, Liping Liu, Chunxue Wang, Hao Li, Haipeng Shen, Li Liang, Janet Bettger, Qing Yang, David Z. Wang, Anxin Wang, Yuesong Pan, Yong Jiang, Xiaomeng Yang, Changqing Zhang, Gregg C Fonarow, Lee H Schwamm, Bo Hu, Eric D Peterson, Ying Xian, Yilong Wang, and Yongjun Wang

Treatment Effect of Clopidogrel Plus Aspirin Within 12 Hours of Acute Minor Stroke or Transient Ischemic Attack., Zixiao Li, Yilong Wang, Xingquan Zhao, Liping Liu, David Z. Wang, Chunxue Wang, Xia Meng, Hao Li, Yuesong Pan, Xianwei Wang, Chunjuan Wang, Xiaomeng Yang, Changqing Zhang, Jing Jing, Ying Xian, S Claiborne Johnston, and Yongjun Wang

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease, Andres M. Lozano, Lisa Fosdick, M. Mallar Chakravarty, Jeannie Marie Leoutsakos, Cynthia Munro, Esther Oh, Kristen E. Drake, Christopher H. Lyman, Paul B. Rosenberg, William S. Anderson, David F. Tang-Wai, Jo Cara Pendergrass, Stephen Salloway, Wael F. Asaad, Francisco A. Ponce, Anna D. Burke, Marwan Sabbagh, David A. Wolk, Gordon Baltuch, and et al.

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Acetaminophen administration in pediatric age: an observational prospective cross-sectional study, Riccardo Lubrano, Sara Paoli, Marco Bonci, Luigi Di Ruzza, Corrado Cecchetti, Raffaele Falsaperla, Piero Pavone, Nassim Matin, Giovanna Vitaliti, and Isotta Gentile

Converging mediators from immune and trophic pathways to identify Parkinson disease dementia, Lih-Fen Lue, Christopher T. Schmitz, Noelle L. Snyder, Kewei Chen, Douglas G. Walker, Kathryn J. Davis, Christine Belden, John N. Caviness, Erika Driver-Dunckley, Charles H. Adler, Marwan N. Sabbagh, and Holly A. Shill

Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain, Duarte Machado, Aditya Kumar, and Bahman Jabbari

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Governing the reform of the medical internship, Heather G. Mack, Helena Filipe, and Karl Golnik

Efficacy and safety of omalizumab in paediatric age: an update of literature data., N Matin, O Tabatabaie, R Falsaperla, P Pavone, A Serra, S Cocuzza, P Di Mauro, L Licciardello, R Lubrano, and G Vitaliti

Parkinson's Disease Outcomes After Intraoperative CT-Guided Asleep Deep Brain Stimulation in the Globus Pallidus Internus, Zaman Mirzadeh, Kristina Chapple, Margaret Lambert, Virgilio G. Evidente, Padma R. Mahant, Maria C. Ospina, Johan Samanta, Guillermo Moguel-Cobos, Naomi Salins, Abraham N. Lieberman, Alexander I. Tröster, Rohit Dhall, and Francisco A. Ponce

Predictors and characteristics of seizures in survivors of progressive multifocal leukoencephalopathy, Dhanashri P. Miskin, Susan T. Herman, Long H. Ngo, and Igor J. Koralnik

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Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage, Andrea Morotti, Andreas Charidimou, Chia-Ling Phuah, Michael J. Jessel, Kristin Schwab, Alison M. Ayres, Javier M. Romero, Anand Viswanathan, M Edip Gurol, Steven M. Greenberg, Christopher D. Anderson, Jonathan Rosand, and Joshua N. Goldstein

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Leukocyte Count and Intracerebral Hemorrhage Expansion, Andrea Morotti, Chia-Ling Phuah, Christopher D. Anderson, Michael J. Jessel, Kristin Schwab, Alison M. Ayres, Alessandro Pezzini, Alessandro Padovani, M Edip Gurol, Anand Viswanathan, Steven M. Greenberg, Joshua N. Goldstein, and Jonathan Rosand

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Validity of ophthalmology surgical competency assessment rubric for strabismus surgery in resident training, W Walker Motley, Karl C. Golnik, Irene Anteby, Huban Atilla, Glen A. Gole, Claudia Murillo, Scott E. Olitsky, Rachel F. Pilling, Aravind R. Reddy, Pradeep Sharma, R Michael Siatkowski, and Maria B. Yadarola

Dopamine Transporter (DA+A164t) Scan Utilization in a Movement Disorder Center, Srivadee Oravivattanakul, Lucas Benchaya, Guiyun Wu, Anwar Ahmed, Ilia Itin, Scott Cooper, Michal Gostkowski, Joseph Rudolph, Kristin Appleby, Patrick Sweeney, and Hubert H. Fernandez

Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community, Ronald C. Petersen, Heather J. Wiste, Stephen D. Weigand, Walter A. Rocca, Rosebud O. Roberts, Michelle M. Mielke, Val J. Lowe, David S. Knopman, Vernon S. Pankratz, Mary M. Machulda, Yonas E. Geda, and Clifford R. Jack

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APOE polymorphisms influence longitudinal lipid trends preceding intracerebral hemorrhage, Chia-Ling Phuah, Miriam R. Raffeld, Alison M. Ayres, M Edip Gurol, Anand Viswanathan, Steven M. Greenberg, Alessandro Biffi, Jonathan Rosand, and Christopher D. Anderson

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Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage, Chia-Ling Phuah, Miriam R. Raffeld, Alison M. Ayres, Anand Viswanathan, Steven M. Greenberg, Alessandro Biffi, Jonathan Rosand, and Christopher D. Anderson

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MR imaging findings of endophthalmitis, Rupa Radhakrishnan, Rebecca Cornelius, Mary Beth Cunnane, Karl Golnik, and Humberto Morales

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Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults, Shannon L. Risacher, Brenna C. McDonald, Eileen F. Tallman, John D. West, Martin R. Farlow, Fredrick W. Unverzagt, Sujuan Gao, Malaz Boustani, Paul K. Crane, Ronald C. Petersen, Clifford R. Jack, William J. Jagust, Paul S. Aisen, Michael W. Weiner, Andrew J. Saykin, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, and Howard Fillit

Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia, Rosebud O. Roberts, Teresa J.H. Christianson, Walter K. Kremers, Michelle M. Mielke, Mary M. Machulda, Maria Vassilaki, Rabe E. Alhurani, Yonas E. Geda, David S. Knopman, and Ronald C. Petersen

Chemical and neuropathological analyses of an alzheimer’s disease patient treated with solanezumab, Alex E. Roher, Chera L. Maarouf, Tyler A. Kokjohn, Christine Belden, Geidy Serrano, Marwan S. Sabbagh, and Thomas G. Beach

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Cardiac Arrhythmias and Abnormal Electrocardiograms After Acute Stroke, Doungporn Ruthirago, Parunyou Julayanont, Pakpoom Tantrachoti, Jongyeol Kim, and Kenneth Nugent

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Clinical assessment of cognitive decline in adults with down syndrome, Marwan Sabbagh and Jamie Edgin

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Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region, Marwan Sabbagh, Seolheui Han, Sangyun Kim, Hae Ri Na, Jae Hong Lee, Nagaendran Kandiah, Kammant Phanthumchinda, Chuthamanee Suthisisang, Vorapun Senanarong, Ming Chyi Pai, Diatri Narilastri, Ajit M. Sowani, Encarnita Ampil, and Amitabh Dash

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Editorial Introduction, Marwan N. Sabbagh

HPV Vaccines for Treatment and Prevention of Recurrent Respiratory Papillomatosis, Griffin D. Santarelli and Craig S. Derkay

Evaluation of the PROPEL® mini sinus implant for the treatment of frontal sinus disease, Griffin D. Santarelli and Joseph K. Han

Implantable Devices/Drugs in the Management of Nasal Polyps, Griffin D. Santarelli and Joseph K. Han

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Sensor-based balance training with motion feedback in people with mild cognitive impairment, Michael Schwenk, Marwan Sabbagh, Ivy Lin, Pharah Morgan, Gurtej S. Grewal, Jane Mohler, David W. Coon, and Bijan Najafi

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Impact of training method on the robustness of the visual assessment of 18F-florbetaben PET scans: Results from a phase-3 study, John Seibyl, Ana M. Catafau, Henryk Barthel, Kenji Ishii, Christopher C. Rowe, James B. Leverenz, Bernardino Ghetti, James W. Ironside, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Santiago Bullich, Andre Mueller, Norman Koglin, Walter J. Schulz-Schaeffer, Anja Hoffmann, Marwan N. Sabbagh, Andrew W. Stephens, and Osama Sabri

Quantitative Strength Testing in ALS Clinical Trials, Jeremy M. Shefner, Dawei Liu, Melanie L. Leitner, David Schoenfeld, Donald R. Johns, Toby Ferguson, and Merit Cudkowicz

A Randomized Placebo-Controlled Double-Blind Phase IIb Trial Evaluating the Safety and Efficacy of Tirasemtiv in Patients With Amyotrophic Lateral Sclerosis, Jeremy M. Shefner, Andrew A. Wolff, Lisa Meng, Amy Bian, Jacqueline Lee, Donna Barragan, and Jinsy A. Andrews

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Unawareness of Hyposmia in Elderly People With and Without Parkinson's Disease, Holly A. Shill, Joseph G. Hentz, John N. Caviness, Erika Driver-Dunckley, Sandra Jacobson, Christine Belden, Marwan N. Sabbagh, Thomas G. Beach, and Charles H. Adler

Periodic Discharges: Insight From Magnetoencephalography, Vladimir Shvarts, Gabor Zoltay, Susan M. Bowyer, Andrew Zillgitt, John E. Moran, Karen Mason, Norman Tepley, and David Burdette

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Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke, Abhilasha Sood, Aditya Kumar, Devinder K. Dhawan, and Rajat Sandhir

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ICO-OSCAR for pediatric cataract surgical skill assessment, Meenakshi Swaminathan, Srikanth Ramasubramanian, Rachel Pilling, Junhong Li, and Karl Golnik

Smoking-Thrombolysis Relationship Depends on Ischemic Stroke Subtype., Xu Tong, Chunjuan Wang, Xiaoling Liao, Yuesong Pan, Hongyi Yan, Yibin Cao, Liping Liu, Huaguang Zheng, Xingquan Zhao, Chunxue Wang, Hao Li, David Z. Wang, Yilong Wang, and Yongjun Wang

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Reproducibility and Bias in Healthy Brain Segmentation: Comparison of Two Popular Neuroimaging Platforms, Dana L. Tudorascu, Helmet T. Karim, Jacob M. Maronge, Lea Alhilali, Saeed Fakhran, Howard J. Aizenstein, John Muschelli, and Ciprian M. Crainiceanu

Graph Theory Network Function in Parkinson's Disease Assessed With Electroencephalography, Rene L. Utianski, John N. Caviness, Elisabeth C.W. van Straaten, Thomas G. Beach, Brittany N. Dugger, Holly A. Shill, Erika D. Driver-Dunckley, Marwan N. Sabbagh, Shyamal Mehta, Charles H. Adler, and Joseph G. Hentz

Multimorbidity and neuroimaging biomarkers among cognitively normal persons, Maria Vassilaki, Jeremiah A. Aakre, Michelle M. Mielke, Yonas E. Geda, Walter K. Kremers, Rabe E. Alhurani, Mary M. Machulda, David S. Knopman, Ronald C. Petersen, Val J. Lowe, Clifford R. Jack, and Rosebud O. Roberts

Effect of intellectual enrichment on AD biomarker trajectories, Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Mary Machulda, Val J. Lowe, Michelle M. Mielke, Rosebud O. Roberts, Jeffrey L. Gunter, Matthew L. Senjem, Yonas E. Geda, Walter A. Rocca, Ronald C. Petersen, and Clifford R. Jack

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Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases, Giovanna Vitaliti, Omidreza Tabatabaie, Nassim Matin, Giovanni Roberto Giugno, Piero Pavone, Riccardo Lubrano, and Raffaele Falsaperla

Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial., David Z. Wang, Li Gui, Yi Dong, Hao Li, Shujuan Li, Huaguang Zheng, Anxin Wang, Xia Meng, Li-Ping Liu, Yi-Long Wang, Guangyao Wang, Jing Jing, Zixiao Li, Xing-Quan Zhao, and Yong-Jun Wang

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At a loss for words, David A. Weidman, Anna D. Burke, Garret H. Riggs, Helle Brand, Jacquelynn N. Copeland, and William J. Burke

A Randomized Trial of Mexiletine in ALS, Michael D. Weiss, Eric A. Macklin, Zachary Simmons, Angela S. Knox, David J. Greenblatt, Nazem Atassi, Michael Graves, Nicholas Parziale, Johnny S. Salameh, Colin Quinn, Robert H. Brown, Jane B. Distad, Jaya Trivedi, Jeremy M. Shefner, Richard J. Barohn, Alan Pestronk, Andrea Swenson, and Merit E. Cudkowicz

Autoantibody to MOG Suggests two Distinct Clinical Subtypes of Nmosd, Yaping Yan, Yujing Li, Ying Fu, Li Yang, Lei Su, Kaibin Shi, Minshu Li, Qiang Liu, Aimee Borazanci, Yaou Liu, Yong He, Jeffrey L. Bennett, Timothy L. Vollmer, and Fu-Dong Shi

Ketones Block Amyloid Entry and Improve Cognition in an Alzheimer's Model, Jun Xiang Yin, Marwan Maalouf, Pengcheng Han, Minglei Zhao, Ming Gao, Turner Dharshaun, Christopher Ryan, Julian Whitelegge, Jie Wu, David Eisenberg, Eric M. Reiman, Felix E. Schweizer, and Jiong Shi

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A Cataract Surgery Training Program: 2-Year Outcome After Launching, A-Yong Yu, Qin-Mei Wang, Jin Li, Fang Huang, and Karl Golnik

Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack: CHANCE Substudy (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events)., Yilun Zhou, Yuesong Pan, Yu Wu, Xingquan Zhao, Hao Li, David Z. Wang, S Claiborne Johnston, Liping Liu, Chunxue Wang, Xia Meng, Yilong Wang, and Yongjun Wang

Submissions from 2015

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Evaluation of White Matter Injury Patterns Underlying Neuropsychiatric Symptoms after Mild Traumatic Brain Injury, Lea M. Alhilali, Joseph A. Delic, Serter Gumus, and Saeed Fakhran

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Early investigational drugs targeting tau protein for the treatment of Alzheimers disease, Keshav Anand and Marwan Sabbagh

Neuromythology of Manganism., Kristin M Andruska and And Brad A Racette

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE, Scott Ayton, Noel G. Faux, Ashley I. Bush, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, and Sarah Walter

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Neurological outcomes associated with low-level manganese exposure in an inception cohort of asymptomatic welding trainees, Marissa G. Baker, Susan R. Criswell, Brad A. Racette, Christopher D. Simpson, Lianne Sheppard, Harvey Checkoway, and Noah S. Seixas

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Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program, Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Geidy Serrano, Holly A. Shill, Douglas G. Walker, Lihfen Lue, Alex E. Roher, Brittany N. Dugger, Chera Maarouf, Alex C. Birdsill, Anthony Intorcia, Megan Saxon-Labelle, Joel Pullen, Alexander Scroggins, Jessica Filon, Sarah Scott, Brittany Hoffman, Angelica Garcia, John N. Caviness, Joseph G. Hentz, Erika Driver-Dunckley, Sandra A. Jacobson, Kathryn J. Davis, Christine M. Belden, Kathy E. Long, Michael Malek-Ahmadi, Jessica J. Powell, Lisa D. Gale, Lisa R. Nicholson, Richard J. Caselli, and Bryan K. Woodruff

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Clinical characterization of mild cognitive impairment as a prodrome to dementia with lewy bodies, Christine M. Belden, Vickram Kahlon, Michael Malek-Ahmadi, Andrew Tsai, and Marwan N. Sabbagh

Phase 1/2 Trials of Temozolomide Motexafin Gadolinium and 60-Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme: Final Results of RTOG 0513, David G. Brachman, Stephanie L. Pugh, Lynn S. Ashby, Theresa A. Thomas, Erin M. Dunbar, Samir Narayan, H. Ian Robins, Joseph A. Bovi, Jason K. Rockhill, Minhee Won, and Walter P. Curran

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Neuropsychological correlates of the alzheimer's questionnaire, Katherine Budolfson, Michael Malek-Ahmadi, Christine M. Belden, Jessica Powell, Kathryn Davis, Sandra Jacobson, and Marwan N. Sabbagh

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Pocket reference to alzheimer’s disease management, Anna Burke, Jan Dougherty, Geri R. Hall, Jeffrey Young, Roy Yaar, Helle Brand, Adam Fleisher, and Pierre Tariot

BCNU Wafer Placement With Temozolomide (TMZ) in the Immediate Postoperative Period After Tumor Resection Followed by Radiation Therapy With TMZ in Patients With Newly Diagnosed High Grade Glioma: Final Results of a Prospective Multi-Institutional Phase II Trial, Stuart H. Burri, Roshan S. Prabhu, Ashley L. Sumrall, Wendy Brick, Brian D. Blaker, Brent E. Heideman, Peggy Boltes, Renee Kelly, James T. Symanowski, Walter F. Wiggins, Lynn S. Ashby, H. James Norton, Kevin Judy, and Anthony L. Asher

Sex-Based Memory Advantages and Cognitive Aging: A Challenge to the Cognitive Reserve Construct?, Richard J. Caselli, Amylou C. Dueck, Dona E.C. Locke, Leslie C. Baxter, Bryan K. Woodruff, and Yonas E. Geda

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Longitudinal EEG changes correlate with cognitive measure deterioration in Parkinson's disease, John N. Caviness, Joseph G. Hentz, Christine M. Belden, Holly A. Shill, Erika D. Driver-Dunckley, Marwan N. Sabbagh, Jessica J. Powell, and Charles H. Adler

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Matrix Metalloproteinase-12 Induces Blood-Brain Barrier Damage After Focal Cerebral Ischemia, Bharath Chelluboina, Jeffrey D. Klopfenstein, David M. Pinson, David Z. Wang, Raghu Vemuganti, and Krishna Kumar Veeravalli

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Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage, Bharath Chelluboina, Aditi Warhekar, Matt Dillard, Jeffrey D. Klopfenstein, David M. Pinson, David Z. Wang, and Krishna Kumar Veeravalli

Physical activity level and future risk of mild cognitive impairment or dementia a critically appraised topic, Gretchen E.Schlosser Covell, Charlene R. Hoffman-Snyder, Kay E. Wellik, Bryan K. Woodruff, Yonas E. Geda, Richard J. Caselli, Bart M. Demaerschalk, and Dean M. Wingerchuk

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Ex vivo magnetic resonance imaging in South African manganese mine workers, Susan R. Criswell, Gill Nelson, Luis F. Gonzalez-Cuyar, John Huang, Joshua S. Shimony, Harvey Checkoway, Christopher D. Simpson, Russell Dills, Noah S. Seixas, and Brad A. Racette

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density, Craig Curtis, Jose E. Gamez, Upinder Singh, Carl H. Sadowsky, Teresa Villena, Marwan N. Sabbagh, Thomas G. Beach, Ranjan Duara, Adam S. Fleisher, Kirk A. Frey, Zuzana Walker, Arvinder Hunjan, Clive Holmes, Yavir M. Escovar, Carla X. Vera, Marc E. Agronin, Joel Ross, Andrea Bozoki, Jiong Shi, and et al.

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Biopsy vs. Extensive Resection for First Recurrence of Glioblastoma: Is a Prospective Clinical Trial Warranted?, Christopher Dardis, Lynn Ashby, William Shapiro, and Nader Sanai

Langerhans Cell Histiocytosis in an Adult With Involvement of the Calvarium Cerebral Cortex and Brainstem: Discussion of Pathophysiology and Rationale for the use of Intravenous Immune Globulin, Christopher Dardis, Thandar Aung, William Shapiro, John Fortune, and Stephen Coons

Transient Coma Due to Epidural Anesthesia: the Role of Loss of Sensory Input, Christopher Dardis, David Lawlor, and Courtney M. Schusse

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Vascular Risk Factors in Patients with Different Subtypes of Ischemic Stroke May Affect Their Outcome after Intravenous tPA, Yi Dong, Wenjie Cao, Jinma Ren, Deepak S. Nair, Sarah Parker, Jan L. Jahnel, Teresa G. Swanson-Devlin, Judith M. Beck, Maureen Mathews, Clayton J. McNeil, Manas Upadhyaya, Yuan Gao, Qiang Dong, and David Z. Wang

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Intravenous Tissue Plasminogen Activator Can Be Safely Given without Complete Blood Count Results Back, Yi Dong, Lumeng Yang, Jinma Ren, Deepak S. Nair, Sarah Parker, Jan L. Jahnel, Teresa G. Swanson-Devlin, Judith M. Beck, Maureen Mathews, Clayton J. McNeil, Yifeng Ling, Xin Cheng, Yuan Gao, Qiang Dong, and David Z. Wang

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Neuropathological comparisons of amnestic and nonamnestic mild cognitive impairment, Brittany N. Dugger, Kathryn Davis, Michael Malek-Ahmadi, Joseph G. Hentz, Shawn Sandhu, Thomas G. Beach, Charles H. Adler, Richard J. Caselli, Travis A. Johnson, Geidy E. Serrano, Holly A. Shill, Christine Belden, Erika Driver-Dunckley, John N. Caviness, Lucia I. Sue, Sandra Jacobson, Jessica Powell, and Marwan N. Sabbagh

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Assessment of rates of acute adverse reactions to gadobenate dimeglumine: review of more than 130,000 administrations in 7.5 years, Saeed Fakhran, Lea Alhilali, Hrishikesh Kale, and Emanuel Kanal

Persistent Vertigo and Dizziness After Mild Traumatic Brain Injury, Terry D. Fife and Deepak Kalra

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Clinical Perspectives on Medical Marijuana (Cannabis) for Neurologic Disorders, Terry D. Fife, Heidi Moawad, Constantine Moschonas, Katie Shepard, and Nancy Hammond

Benign Paroxysmal Positional Vertigo in the Acute Care Setting, Terry D. Fife and Michael von Brevern

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The Development of Cortical Microinfarcts Is Associated with Intracranial Atherosclerosis: Data from the Chinese Intracranial Atherosclerosis Study, Rui Fu, Yilong Wang, Yongjun Wang, Liping Liu, Xingquan Zhao, David Z. Wang, Yuesong Pan, Yuehua Pu, and Changqing Zhang

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Neuro-Ophthalmology Annual Review, Karl C. Golnik

Association of Pituitary Adenylate Cyclase-Activating Polypeptide With Cognitive Decline in Mild Cognitive Impairment Due to Alzheimer Disease, Pengcheng Han, Richard J. Caselli, Leslie Baxter, Geidy Serrano, Junxiang Yin, Thomas G. Beach, Eric M. Reiman, and Jiong Shi

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Hypocalcemia-Induced Seizure: Demystifying the Calcium Paradox, Pengcheng Han, Bradley J. Trinidad, and Jiong Shi

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Down syndrome and Alzheimer's disease: Common pathways, common goals, Dean Hartley, Thomas Blumenthal, Maria Carrillo, Gilbert DiPaolo, Lucille Esralew, Katheleen Gardiner, Ann Charlotte Granholm, Khalid Iqbal, Michael Krams, Cynthia Lemere, Ira Lott, William Mobley, Seth Ness, Ralph Nixon, Huntington Potter, Roger Reeves, Marwan Sabbagh, Wayne Silverman, Benjamin Tycko, Michelle Whitten, and Thomas Wisniewski

Author Response: Concerns about Utility and Cost-Effectiveness of Continuous Critical-Care EEG, Susan T. Herman and Nicholas S. Abend

Author Response: The Timing of Continuous EEG in Critically Ill Patients: Stat? ASAP? Routine?, Susan T. Herman and Nicholas S. Abend

Consensus statement on continuous EEG in critically Ill adults and children, part I: Indications, Susan T. Herman, Nicholas S. Abend, Thomas P. Bleck, Kevin E. Chapman, Frank W. Drislane, Ronald G. Emerson, Elizabeth E. Gerard, Cecil D. Hahn, Aatif M. Husain, Peter W. Kaplan, Suzette M. LaRoche, Marc R. Nuwer, Mark Quigg, James J. Riviello, Sarah E. Schmitt, Liberty A. Simmons, Tammy N. Tsuchida, and Lawrence J. Hirsch

Consensus statement on continuous EEG in critically Ill adults and children, Part II: Personnel, technical specifications, and clinical practice, Susan T. Herman, Nicholas S. Abend, Thomas P. Bleck, Kevin E. Chapman, Frank W. Drislane, Ronald G. Emerson, Elizabeth E. Gerard, Cecil D. Hahn, Aatif M. Husain, Peter W. Kaplan, Suzette M. LaRoche, Marc R. Nuwer, Mark Quigg, James J. Riviello, Sarah E. Schmitt, Liberty A. Simmons, Tammy N. Tsuchida, and Lawrence J. Hirsch

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Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia: Design of the ADvance Randomized Controlled Trial, Kathryn B. Holroyd, Lisa Fosdick, Gwenn S. Smith, Jeannie Marie Leoutsakos, Cynthia A. Munro, Esther S. Oh, Kristen E. Drake, Paul B. Rosenberg, William S. Anderson, Stephen Salloway, J. Cara Pendergrass, Anna D. Burke, David A. Wolk, David F. Tang-Wai, Francisco A. Ponce, Wael F. Asaad, Marwan N. Sabbagh, Michael S. Okun, Gordon Baltuch, and et al.

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Age dependence of brain b-amyloid deposition in Down syndrome: An [18F]florbetaben PET study, Danna Jennings, John Seibyl, Marwan Sabbagh, Florence Lai, William Hopkins, Santi Bullich, Monica Gimenez, Cornelia Reininger, Barbara Putz, Andrew Stephens, Ana M. Catafau, and Ken Marek

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The Montreal Cognitive Assessment-Basic: A Screening Tool for Mild Cognitive Impairment in Illiterate and Low-Educated Elderly Adults, Parunyou Julayanont, Sookjaroen Tangwongchai, Solaphat Hemrungrojn, Chawit Tunvirachaisakul, Kammant Phanthumchinda, Juntanee Hongsawat, Panida Suwichanarakul, Saowaluck Thanasirorat, and Ziad S. Nasreddine

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Clinical performance of seven prescreening tools for osteoporosis in Iranian postmenopausal women, Abbas Keshtkar, Omidreza Tabatabaie, Nassim Matin, Zahra Mohammadi, Mehdi Ebrahimi, Patricia Khashayar, and Mojgan Asadi