Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With
Document Type
Article
Abstract
BACKGROUND AND PURPOSE: Dysglycemia may influence the predictive value of
METHODS: The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) included 2933 patients who had GA levels and
RESULTS: There was significant interaction between carrier status and antiplatelet therapy regimen on the risk of recurrent stroke (
CONCLUSIONS: In patients with minor stroke or high-risk transient ischemic attack, clopidogrel-aspirin when compared with aspirin alone reduced stroke recurrence only in noncarriers of
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589.
Medical Subject Headings
Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Female; Glycation End Products, Advanced; Heterozygote; Humans; Ischemic Attack, Transient; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Recurrence; Risk; Serum Albumin; Stroke; Ticlopidine; Glycated Serum Albumin
Publication Date
4-1-2017
Publication Title
Stroke; a journal of cerebral circulation
ISSN
1524-4628
Volume
48
Issue
4
First Page
998
Last Page
1004
PubMed ID
28289237
Digital Object Identifier (DOI)
10.1161/STROKEAHA.116.016463
Recommended Citation
Lin, Yi; Wang, Anxin; Li, Jiejie; Lin, Jinxi; Wang, David Z.; Meng, Xia; Ou, Lixian; Chen, Weiqi; Zhao, Xingquan; Liu, Liping; Wang, Yilong; and Wang, Yongjun, "Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With" (2017). Neurology. 1870.
https://scholar.barrowneuro.org/neurology/1870