Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With

Document Type

Article

Abstract

BACKGROUND AND PURPOSE: Dysglycemia may influence the predictive value of

METHODS: The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) included 2933 patients who had GA levels and

RESULTS: There was significant interaction between carrier status and antiplatelet therapy regimen on the risk of recurrent stroke (

CONCLUSIONS: In patients with minor stroke or high-risk transient ischemic attack, clopidogrel-aspirin when compared with aspirin alone reduced stroke recurrence only in noncarriers of

CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589.

Medical Subject Headings

Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Female; Glycation End Products, Advanced; Heterozygote; Humans; Ischemic Attack, Transient; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Recurrence; Risk; Serum Albumin; Stroke; Ticlopidine; Glycated Serum Albumin

Publication Date

4-1-2017

Publication Title

Stroke; a journal of cerebral circulation

ISSN

1524-4628

Volume

48

Issue

4

First Page

998

Last Page

1004

PubMed ID

28289237

Digital Object Identifier (DOI)

10.1161/STROKEAHA.116.016463

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