The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2024
APOLLOE4 Phase 3 study of oral ALZ-801/valiltramiprosate in APOE ε4/ε4 homozygotes with early Alzheimer's disease: Trial design and baseline characteristics, Susan Abushakra, Anton P. Porsteinsson, Marwan Sabbagh, David Watson, Aidan Power, Earvin Liang, Emer MacSweeney, Merce Boada, Susan Flint, Rosalind McLaine, J Patrick Kesslak, John A. Hey, and Martin Tolar
Conjugal Synucleinopathies: A Clinicopathologic Study, Charles H. Adler, Matthew Halverson, Nan Zhang, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Alireza Atri, John N. Caviness, Geidy E. Serrano, David R. Shprecher, Christine M. Belden, Marwan N. Sabbagh, Kathy Long, and Thomas G. Beach
Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial., Michael Benatar, Thomas Hansen, Dror Rom, Marie A Geist, Thomas Blaettler, William Camu, Magdalena Kuzma-Kozakiewicz, Leonard H van den Berg, Raul Juntas Morales, Adriano Chio, Peter M Andersen, Pierre-Francois Pradat, Dale Lange, Philip Van Damme, Gabriele Mora, Mariusz Grudniak, Matthew Elliott, Susanne Petri, Nicholas Olney, Shafeeq Ladha, Namita A Goyal, Thomas Meyer, Michael G Hanna, Colin Quinn, Angela Genge, Lorne Zinman, Duaa Jabari, Christen Shoesmith, Albert C Ludolph, Christoph Neuwirth, Sharon Nations, Jeremy M Shefner, Martin R Turner, Joanne Wuu, Richard Bennett, Hoang Dang, and Claus Sundgreen
Improved Sleep Correlates with Improved Quality of Life and Motor Symptoms with Foslevodopa/Foscarbidopa., K Ray Chaudhuri, Maurizio F Facheris, Bruno Bergmans, Filip Bergquist, S R Criswell, Jia Jia, Pavnit Kukreja, Yohei Mukai, Amy M Spiegel, Resmi Gupta, Lars Bergmann, and Rajesh Pahwa
Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium., Parichita Choudhury, Joyce K Lee-Iannotti, Andrea O Busicescu, Pooja Rangan, Maria Livia Fantini, Alon Y Avidan, Donald L Bliwise, S R Criswell, Emmanuel H During, Jonathan E Elliott, Julie A Fields, Jean-Francois Gagnon, Michael J Howell, Daniel E Huddleston, Jennifer McLeland, Emmanuel Mignot, Mitchell G Miglis, Miranda M Lim, Amélie Pelletier, Carlos H Schenck, David Shprecher, Erik K St Louis, Aleksandar Videnovic, Yo-El S Ju, Bradley F Boeve, and Ronald Postuma
Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review, Elise E. Dunning, Boris Decourt, Nasser H. Zawia, Holly A. Shill, and Marwan N. Sabbagh
Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium., Jonathan E Elliott, Brittany R Ligman, Mohini D Bryant-Ekstrand, Allison T Keil, Katherine Powers, Cosette Olivo, Lee E Neilson, Ronald B Postuma, Amélie Pelletier, Jean-François Gagnon, Ziv Gan-Or, Eric Yu, Lang Liu, Erik K St Louis, Leah K Forsberg, Julie A Fields, Owen A Ross, Daniel E Huddleston, Donald L Bliwise, Alon Y Avidan, Michael J Howell, Carlos H Schenck, Jennifer McLeland, S R Criswell, Aleksandar Videnovic, Emmanuel H During, Mitchell G Miglis, David R Shprecher, Joyce K Lee-Iannotti, Bradley F Boeve, Yo-El S Ju, and Miranda M Lim
Paraneoplastic Calmodulin Kinase-Like Vesicle-Associated Protein (CAMKV) Autoimmune Encephalitis., Michael Gilligan, Connie E Lesnick, Yong Guo, Michael J Bradshaw, Shafeeq S Ladha, Mihaela Nowak, Maulik P Shah, John R Wittenborn, Eati Basal, Shannon Hinson, Binxia Yang, Divyanshu Dubey, John R Mills, Sean J Pittock, Anastasia Zekeridou, and Andrew McKeon
Olfactory tract/bulb metal concentration in Manganese-exposed mineworkers., Luis F Gonzalez-Cuyar, Gill Nelson, Susan Searles Nielsen, Wendy W Dlamini, Amelia Keyser-Gibson, C Dirk Keene, Michael Paulsen, S R Criswell, Natalie Senini, Lianne Sheppard, Shar Samy, Christopher D Simpson, Marissa G Baker, and Brad A Racette
Cerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey., Tatiana Greige, Brian S Tao, Neha S Dangayach, Emily J Gilmore, Christa O'Hana Nobleza, H E Hinson, Sherry H Chou, Ruchira M. Jha, Sarah Wahlster, Meron A Gebrewold, Abhijit V Lele, and Charlene J Ong
Correction: Updated safety results from phase 3 lecanemab study in early Alzheimer's disease, Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck, Reisa A. Sperling, Steven Hersch, Andre Matta, Luigi Giorgi, Michelle Gee, Michio Kanekiyo, David Li, Derk Purcell, Shobha Dhadda, Michael Irizarry, and Lynn Kramer
Updated safety results from phase 3 lecanemab study in early Alzheimer's disease, Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck, Reisa A. Sperling, Steven Hersch, Andre Matta, Luigi Giorgi, Michelle Gee, Michio Kanekiyo, David Li, Derk Purcell, Shobha Dhadda, Michael Irizarry, and Lynn Kramer
Can Long-Term Outcomes of Posttraumatic Headache be Predicted?, Olivia Kingsford, Mustafa Yehya, Glynnis Zieman, and Kerry L Knievel
Outcomes associated to the time to treatment with intravenous tenecteplase for acute ischaemic stroke: subgroup analysis of the TRACE-2 randomised controlled clinical trial, Shuya Li, Runqi Wangqin, Yuesong Pan, Aoming Jin, Hao Li, Lee H. Schwamm, Marc Fisher, Bruce C. Campbell, Mark W. Parsons, Ziran Wang, Hongguo Dai, Deyang Li, Runhui Li, Junhai Wang, David Wang, Yilong Wang, Xingquan Zhao, Zixiao Li, Huaguang Zheng, Yunyun Xiong, Xia Meng, and Yongjun Wang
Multicenter expanded access program for access to investigational products for amyotrophic lateral sclerosis., Dylan V Neel, Clara Baselga-Garriga, Molly Benson, Mackenzie Keegan, Marianne Chase, Derek D'Agostino, Kristin Drake, Jennifer Linn Hagar, Meredith Gibbons Hasenoehrl, Jennifer Kulesa-Kelley, Alex Leite, Silpa Mohapatra, Susanna Marie Portaro, Lindsay M Pothier, Jesse Rosenthal, Alexander V Sherman, Hong Yu, Alexandra McCaffrey, Doreen Ho, Sarah Luppino, Richard Bedlack, Daragh Heitzman, Senda Ajroud-Driss, Jonathan Katz, Kevin Felice, Charles Whitaker, Shafeeq Ladha, Gustavo Alameda, Eduardo Locatelli, Irfan A Qureshi, Michael T Hotchkin, Michael R Hayden, Merit E Cudkowicz, Suma Babu, James D Berry, and Sabrina Paganoni
A Protocol for the Inclusion of Minoritized Persons in Alzheimer Disease Research From the ADNI3 Diversity Taskforce, Ozioma C. Okonkwo, Monica Rivera Mindt, Miriam T. Ashford, Catherine Conti, Joe Strong, Rema Raman, Michael C. Donohue, Rachel L. Nosheny, Derek Flenniken, Melanie J. Miller, Adam Diaz, Annabelle M. Soto, Beau M. Ances, Maryam R. Beigi, P Murali Doraiswamy, Ranjan Duara, Martin R. Farlow, Hillel T. Grossman, Jacobo E. Mintzer, Christopher Reist, Emily J. Rogalski, Marwan N. Sabbagh, Stephen Salloway, Lon S. Schneider, Raj C. Shah, Ronald C. Petersen, Paul S. Aisen, and Michael W. Weiner
The Influence of CYP2B6 Variants and Administration of Propofol on Patient Outcomes after Traumatic Brain Injury., Katherine O'Meara, Ava M Puccio, Dianxu Ren, Sandra Deslouches, Ruchira M. Jha, David O Okonkwo, and Yvette P Conley
In Reply to Halperin, C Leland Rogers, Sarah K. Lageman, James Fontanesi, George D. Wilson, Peter A. Boling, Surbhi Bansal, John P. Karis, Marwan Sabbagh, Minesh P. Mehta, and Timothy J. Harris
Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors, James L. Rogers, Thomas Wall, Alvina A. Acquaye-Mallory, Lisa Boris, Yeonju Kim, Kenneth Aldape, Martha M. Quezado, John A. Butman, James G. Smirniotopoulos, Huma Chaudhry, Christina I. Tsien, Prashant Chittiboina, Kareem Zaghloul, Orwa Aboud, Nicholas G. Avgeropoulos, Eric C. Burton, David M. Cachia, Karan S. Dixit, Jan Drappatz, Erin M. Dunbar, Peter Forsyth, Edina Komlodi-Pasztor, Jacob Mandel, Byram H. Ozer, Eudocia Q. Lee, Surabhi Ranjan, Rimas V. Lukas, Margarita Raygada, Michael E. Salacz, Matthew A. Smith-Cohn, and James Snyder
Dark Adaptometry and Optical Coherence Tomography Angiography in Huntington Disease., Aaditya Shah, Spencer Fuller, S R Criswell, and Rajendra S Apte
Impact of incidental synucleinopathy in mild cognitive impairment due to Alzheimer disease, Jahnavi Shriram, Michael Malek-Ahmadi, Chase Irwin, and Marwan Sabbagh
Nonmedication Devices in Development for the Treatment of Alzheimer's Disease, Tamara Sleem, Boris Decourt, and Marwan N. Sabbagh
Submissions from 2023
Predictors of matching into an ophthalmology fellowship for international medical graduates: a San Francisco match analysis, Muhammad Ali, Safa Saeed, Sidra Zafar, Karl C. Golnik, and Fasika Woreta
Examination of parkinsonism in former elite American football players, Michael L. Alosco, Charles H. Adler, David W. Dodick, Yorghos Tripodis, Laura J. Balcer, Charles Bernick, Sarah J. Banks, William B. Barr, Jennifer V. Wethe, Joseph N. Palmisano, Brett Martin, Kaitlin Hartlage, Robert C. Cantu, Yonas E. Geda, Douglas I. Katz, Jesse Mez, Jeffery L. Cummings, Martha E. Shenton, Eric M. Reiman, and Robert A. Stern
Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy, Thomas G. Beach, Lucia I. Sue, Sarah Scott, Anthony J. Intorcia, Jessica E. Walker, Richard A. Arce, Michael J. Glass, Claryssa I. Borja, Madison P. Cline, Spencer J. Hemmingsen, Sanaria Qiji, Analisa Stewart, Kayleigh N. Martinez, Addison Krupp, Rylee McHattie, Monica Mariner, Ileana Lorenzini, Angela Kuramoto, Kathy E. Long, Cécilia Tremblay, Richard J. Caselli, Bryan K. Woodruff, Steven Z. Rapscak, Christine M. Belden, Danielle Goldfarb, Parichita Choudhury, Erika D. Driver-Dunckley, Shyamal H. Mehta, Marwan N. Sabbagh, Holly A. Shill, Alireza Atri, and Charles H. Adler
White Matter Microstructural Differences between Essential Tremor and Parkinson Disease, Evaluated Using Advanced Diffusion MRI Biomarkers, Maurizio Bergamino, Sana Aslam, Jacob J. Knittel, Lea Alhilali, and Ashley M. Stokes
The relevance of rich club regions for functional outcome post-stroke is enhanced in women, Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sungmin Hong, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa C. McIntosh, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, Jaume Roquer, and Tatjana Rundek
Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke, Martin Bretzner, Anna K. Bonkhoff, Markus D. Schirmer, Sungmin Hong, Adrian Dalca, Kathleen Donahue, Anne-Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Robert W. Regenhardt, Xavier Leclerc, Renaud Lopes, Morgan Gautherot, Clinton Wang, Oscar R. Benavente, John W. Cole, Amanda Donatti, Christoph Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Patrick F. McArdle, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, and Arndt Rolfs
Missorting of plasma miRNAs in aging and Alzheimer's disease, Maria Čarna, Jan S. Novotny, Neda Dragišić, Hanuš Slavik, Kateřina Sheardova, Yonas E. Geda, Martin Vyhnalek, Jan Laczo, Jakub Hort, Zixu Mao, Robert A. Rissman, Marian Hajduch, Eric B. Dammer, and Gorazd B. Stokin
Outcomes in patients with aneurysmal subarachnoid hemorrhage receiving sulfonylureas: a propensity-adjusted analysis, Joshua S. Catapano, Stefan W. Koester, Kamila M. Bond, Visish M. Srinivasan, Dara S. Farhadi, Kavelin Rumalla, Tyler S. Cole, Jacob F. Baranoski, Ethan A. Winkler, Christopher S. Graffeo, Amanda Muñoz-Casabella, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, Michael T. Lawton, and Ruchira M. Jha
Incidence and Prediction of Chronic Depression Following Aneurysmal Subarachnoid Hemorrhage: A Single-Center 17-Year Experience, Joshua S. Catapano, Kavelin Rumalla, Stefan W. Koester, Ethan A. Winkler, Robert F. Rudy, Tyler S. Cole, Jacob F. Baranoski, Christopher S. Graffeo, Visish M. Srinivasan, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Toward Automated Detection of Silent Cerebral Infarcts in Children and Young Adults With Sickle Cell Anemia, Yasheng Chen, Yan Wang, Chia-Ling Phuah, Melanie E. Fields, Kristin P. Guilliams, Slim Fellah, Martin N. Reis, Michael M. Binkley, Hongyu An, Jin-Moo Lee, Robert C. McKinstry, Lori C. Jordan, Michael R. DeBaun, and Andria L. Ford
Association between physical activity and longitudinal change in body mass index in middle-aged and older adults, Laura Cleven, Jeremy A. Syrjanen, Yonas E. Geda, Luke R. Christenson, Ronald C. Petersen, Maria Vassilaki, Alexander Woll, and Janina Krell-Roesch
GO-ing for Gold: Global Perspectives on Creating a Gold Standard for Global Ophthalmology (GO) Education, Emily Cole, Wanjiku Mathenge, Daniel Kiage, Thulasiraj Ravilla, Eduardo Mayorga, Ana G. Palis, Jacquelyn O'Banion, Karl Golnik, Jeff Pettey, Grace Sun, David Hunter Cherwek, Deepak Edward, Katherine Joltikov, R V. Chan, and Peter W. MacIntosh
Neuroinflammation and white matter alterations in occupational manganese exposure assessed by diffusion basis spectrum imaging, Susan R. Criswell, Susan Searles Nielsen, Irene M. Faust, Joshua S. Shimony, Robert L. White, Jason Lenox-Krug, and Brad A. Racette
Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis, Jessica Cummings, Yijen L. Wu, C Edward Dixon, Jeremy Henchir, J Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, and Rajesh K. Aneja
Baseline characteristics of the North American prodromal Synucleinopathy cohort., Jonathan E Elliott, Miranda M Lim, Allison T Keil, Ronald B Postuma, Amelie Pelletier, Jean-François Gagnon, Erik K St Louis, Leah K Forsberg, Julie A Fields, Daniel E Huddleston, Donald L Bliwise, Alon Y Avidan, Michael J Howell, Carlos H Schenck, Jennifer McLeland, Susan R Criswell, Aleksandar Videnovic, Emmanuel H During, Mitchell G Miglis, David R Shprecher, Joyce K Lee-Iannotti, Bradley F Boeve, and Yo-El S Ju
A predictive algorithm to identify ever smoking in medical claims-based epidemiologic studies, Irene Faust, Mark Warden, Alejandra Camacho-Soto, Brad A. Racette, and Susan Searles Nielsen
NANOS NOTE Neuro-Ophthalmology Techniques of Examination, Karl C. Golnik
ARIA in patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease, Lawrence S. Honig, Jerome Barakos, Shobha Dhadda, Michio Kanekiyo, Larisa Reyderman, Michael Irizarry, Lynn D. Kramer, Chad J. Swanson, and Marwan Sabbagh
When treating acute ischaemic stroke of LVO type, time window prevails over tissue window, Xiaochuan Huo, Aoming Jin, Zhongrong Miao, Yongjun Wang, and David Wang
ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium, Lavanya Jain, Maria Khrestian, Shane Formica, Elizabeth D. Tuason, Jagan A. Pillai, Stephen Rao, Odinachi Oguh, Carol F. Lippa, Oscar L. Lopez, Sarah B. Berman, Debby W. Tsuang, Cyrus P. Zabetian, David J. Irwin, Douglas R. Galasko, Irene Litvan, Karen S. Marder, Lawrence S. Honig, Jori E. Fleisher, James E. Galvin, Andrea C. Bozoki, Angela S. Taylor, Marwan N. Sabbagh, James B. Leverenz, and Lynn M. Bekris
Intracranial Pressure Monitoring in Traumatic Brain Injury-A Tool of the Trade or One That Betrays Us?, Ruchira M. Jha
The impact of thrombus surface morphology of the basilar artery on the successful rate of mechanical thrombectomy, Xinzhao Jiang, Shufeng Yu, David Wang, Y I. Dong, and Peng Wang
Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks: A Phase 3 Randomized Clinical Trial, Priya S. Kishnani, Jordi Diaz-Manera, Antonio Toscano, Paula R. Clemens, Shafeeq Ladha, Kenneth I. Berger, Hani Kushlaf, Volker Straub, Gerson Carvalho, Tahseen Mozaffar, Mark Roberts, Shahram Attarian, Yin-Hsiu Chien, Young-Chul Choi, John W. Day, Sevim Erdem-Ozdamar, Sergey Illarioshkin, Ozlem Goker-Alpan, Anna Kostera-Pruszczyk, Ans T. van der Ploeg, Kristina An Haack, Olivier Huynh-Ba, Swathi Tammireddy, Nathan Thibault, Tianyue Zhou, Mazen M. Dimachkie, and Benedikt Schoser
Propensity-adjusted analysis of ultra-early aneurysmal subarachnoid hemorrhage treatment and patient outcomes, Stefan W. Koester, Joshua S. Catapano, Emmajane G. Rhodenhiser, Robert F. Rudy, Ethan A. Winkler, Dimitri Benner, Tyler S. Cole, Jacob F. Baranoski, Visish M. Srinivasan, Christopher S. Graffeo, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging, Janina Krell-Roesch, Jeremy A. Syrjanen, Jelena Bezold, Sandra Trautwein, Bettina Barisch-Fritz, Walter K. Kremers, Julie A. Fields, Eugene L. Scharf, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Darko Jekauc, Alexander Woll, Maria Vassilaki, and Yonas E. Geda
Plasma-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community-based study, Janina Krell-Roesch, Isabella Zaniletti, Jeremy A. Syrjanen, Walter K. Kremers, Alicia Algeciras-Schimnich, Jeffrey L. Dage, Argonde C. van Harten, Julie A. Fields, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda
Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model., Collin J Kreple, Susan Searles Nielsen, Kathleen M Schoch, Tao Shen, Mark Shabsovich, Yizhe Song, Brad A Racette, and Timothy M Miller
Editorial: minor stroke is not minor, Xinyi Leng and David Wang
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update, Liping Liu, Zixiao Li, Hongyu Zhou, Wanying Duan, Xiaochuan Huo, Weihai Xu, Shujuan Li, Ximing Nie, Huihui Liu, Jinjie Liu, Dapeng Sun, Yufei Wei, Guitao Zhang, Weizhuang Yuan, Lina Zheng, Jingyi Liu, David Wang, Zhongrong Miao, and Yongjun Wang
Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial, Liping Liu, Xuewei Xie, Yuesong Pan, Aili Wang, Yufei Wei, Jingyi Liu, Ximing Nie, Dacheng Liu, Zilin Zhao, Penglian Wang, Suwen Shen, Chongke Zhong, Tan Xu, Dali Wang, Gui-Chun Wang, Denghua Song, Yunsheng Ma, Jinguo Zhao, Yong Jiang, Jing Jing, Xia Meng, Katherine Obst, Chung-Shiuan Chen, David Wang, Yilong Wang, Yonghong Zhang, Yongjun Wang, and Jiang He
Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy, Ya-Nan Li, Hong-Wen Liang, Chun-Lin Zhang, Yan-Mei Qiu, David Wang, Hai-Ling Wang, An-Qi Chen, Can-Dong Hong, Lei Wang, Hao Wang, and Bo Hu
Faculty Development of CPD Teachers in Low-Resource Environments Post-COVID-19, Heather Mack, Karl Golnik, and Helena Prior Filipe
Cancer drugs with high repositioning potential for Alzheimer's disease, Jad Majeed, Marwan N. Sabbagh, Min H. Kang, J Josh Lawrence, Kevin Pruitt, Sarah Bacus, Ellie Reyna, Maddy Brown, and Boris Decourt
The long-term effects of consecutive COVID-19 waves on mental health, Jan Sebastian Novotný, Juan Pablo Gonzalez-Rivas, Šárka Kunzová, Mária Skladaná, Anna Pospíšilová, Anna Polcrová, Maria Vassilaki, Jose Ramon Medina-Inojosa, Francisco Lopez-Jimenez, Yonas Endale Geda, and Gorazd Bernard Stokin
Precision Medicine in Neurocritical Care for Cerebrovascular Disease Cases, Nils H. Petersen, Kevin N. Sheth, and Ruchira M. Jha
A New Framework for Dementia Nomenclature, Ronald C. Petersen, Sandra Weintraub, Marwan Sabbagh, Jason Karlawish, Charles H. Adler, Peggye Dilworth-Anderson, Lori Frank, Cynthia Huling Hummel, and Angela Taylor
Interactions Between Neuropsychiatric Symptoms and Alzheimer's Disease Neuroimaging Biomarkers in Predicting Longitudinal Cognitive Decline, Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Luke R. Christenson, Val J. Lowe, Prashanthi Vemuri, Julie A. Fields, Gorazd B. Stokin, Walter K. Kremers, Eugene L. Scharf, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda
Ophthalmology Surgical Assessment of Tube Shunt Glaucoma Surgery, Mary Qiu, Ema Avdagic, Pradeep Y. Ramulu, Karl Golnik, and Michael V. Boland
Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study, Christopher J. Roberts, Jason Barber, Nancy R. Temkin, Athena Dong, Claudia S. Robertson, Alex B. Valadka, John K. Yue, Amy J. Markowitz, Geoffrey T. Manley, and Lindsay D. Nelson
Low-Dose Whole Brain Radiation Therapy for Alzheimer's Dementia: Results From a Pilot Trial in Humans, C Leland Rogers, Sarah K. Lageman, James Fontanesi, George D. Wilson, Peter A. Boling, Surbhi Bansal, John P. Karis, Marwan Sabbagh, Minesh P. Mehta, and Timothy J. Harris
Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients, David J. Roh, Tiffany R. Chang, Aditya Kumar, Devin Burke, Glenda Torres, Katherine Xu, Winni Yang, Azzurra Cottarelli, Ernest Moore, Angela Sauaia, Kirk Hansen, Angela Velazquez, Amelia Boehme, Athina Vrosgou, Shivani Ghoshal, Soojin Park, Sachin Agarwal, Jan Claassen, E Sander Connolly, Gebhard Wagener, Richard O. Francis, and Eldad Hod
Socioeconomic Drivers of Outcomes After Aneurysmal Subarachnoid Hemorrhage Treatment at a Large Comprehensive Stroke Center, Kavelin Rumalla, Joshua S. Catapano, Varun Mahadevan, Samuel R. Sorkhi, Stefan W. Koester, Ethan A. Winkler, Christopher S. Graffeo, Visish M. Srinivasan, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Biomarker-based diagnosis of preclinical Alzheimer disease: time for the clinic?, Marwan N. Sabbagh and Boris DeCourt
Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel, Marwan N. Sabbagh, Angela Taylor, Douglas Galasko, James E. Galvin, Jennifer G. Goldman, James B. Leverenz, Kathleen L. Poston, Bradley F. Boeve, David J. Irwin, and Joseph F. Quinn
Unmet needs in the diagnosis and treatment of Parkinson's disease psychosis and dementia-related psychosis, Marwan Sabbagh, Gary W. Small, Stuart H. Isaacson, Yasar Torres-Yaghi, Fernando Pagan, and Rajesh Pahwa
Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke, Marwan Sabbagh and Christopher H. van Dyck
B-complex vitamins for patients with TANGO2-deficiency disorder., Sarah E Sandkuhler, Lilei Zhang, Joshua K Meisner, Lina Ghaloul-Gonzalez, Cheyenne M Beach, David Harris, Pascale de Lonlay, Seema R Lalani, Christina Y Miyake, and Samuel J Mackenzie
Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics, Muralidharan Sargurupremraj, Aicha Soumare, Joshua C. Bis, Ida Surakka, Tuuli Jurgenson, Pierre Joly, Maria J. Knol, Ruiqi Wang, Qiong Yang, Claudia L. Satizabal, Alexander Gudjonsson, Aniket Mishra, Vincent Bouteloup, Chia-Ling Phuah, Cornelia M. van Duijn, Carlos Cruchaga, Carole Dufouil, Geneviève Chêne, Oscar Lopez, Bruce M. Psaty, Christophe Tzourio, Philippe Amouyel, Hieab H. Adams, Hélène Jacqmin-Gadda, Mohammad Arfan Ikram, Vilmundur Gudnason, Lili Milani, Bendik S. Winsvold, Kristian Hveem, Paul M. Matthews, and W T. Longstreth
Metabolomic profiles of human glioma inform patient survival, Andrew J. Scott, Luis O. Correa, Donna Edwards, Yilun Sun, Visweswaran Ravikumar, Anthony C. Andren, Li Zhang, Sudharsan Srinivasan, Neil Jairath, Kait Verbal, Karin Muraszko, Oren Sagher, Shannon A. Carty, Shawn Hervey-Jumper, Daniel Orringer, Michelle M. Kim, Larry Junck, Yoshie Umemura, Denise Leung, Sriram Venneti, Sandra Camelo-Piragua, Theodore S. Lawrence, Joseph E. Ippolito, Wajd N. Al-Holou, Prakash Chinnaiyan, Jason Heth, Arvind Rao, Costas A. Lyssiotis, and Daniel R. Wahl
Neuropsychiatric Symptoms and Commonly Used Biomarkers of Alzheimer's Disease: A Literature Review from a Machine Learning Perspective, Jay Shah, Md Mahfuzur Rahman Siddiquee, Janina Krell-Roesch, Jeremy A. Syrjanen, Walter K. Kremers, Maria Vassilaki, Erica Forzani, Teresa Wu, and Yonas E. Geda
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke, Jesse A. Stokum, Bosung Shim, Serban Negoita, Natalya Tsymbalyuk, Orest Tsymbalyuk, Svetlana Ivanova, Kaspar Keledjian, Joseph Bryan, Mordecai P. Blaustein, Ruchira M. Jha, Kristopher T. Kahle, Volodymyr Gerzanich, and J Marc Simard
White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease, Jeremy Fuller Strain, Chia-Ling Phuah, Babatunde Adeyemo, Kathleen Cheng, Kyle B. Womack, John McCarthy, Manu Goyal, Yasheng Chen, Aristeidis Sotiras, Hongyu An, Chengjie Xiong, Andrea Scharf, Catherine Newsom-Stewart, John Carl Morris, Tammie Lee Benzinger, Jin-Moo Lee, and Beau M. Ances
Blood-based biomarkers in Alzheimer's disease: Future directions for implementation, Ivonne Suridjan, Wiesje M. van der Flier, Andreas U. Monsch, Nerida Burnie, Robert Baldor, Marwan Sabbagh, Josep Vilaseca, Dongming Cai, Margherita Carboni, and James J. Lah
Standardized perioperative care reduces colorectal surgical site infection in children: A Western Pediatric Surgery Research Consortium multicenter analysis, Joseph Tobias, Benjamin E. Padilla, Justin Lee, Stephanie Chen, Kasper S. Wang, Lorraine I. Kelley-Quon, Claudia Mueller, Stephen B. Shew, Katie Joskowitz, Romeo C. Ignacio, Lauren L. Evans, Aaron R. Jensen, Shannon N. Acker, Andrew Mason, Alicia Johnson, Jessica McConahey, Erik Hansen, Samir R. Pandya, Scott S. Short, Katie W. Russell, Lauren Nicassio, Caitlin A. Smith, and Elizabeth Fialkowski
Lecanemab in Early Alzheimer's Disease. Reply, Christopher H. van Dyck, Marwan Sabbagh, and Sharon Cohen
Lecanemab in Early Alzheimer's Disease, Christopher H. van Dyck, Chad J. Swanson, Paul Aisen, Randall J. Bateman, Christopher Chen, Michelle Gee, Michio Kanekiyo, David Li, Larisa Reyderman, Sharon Cohen, Lutz Froelich, Sadao Katayama, Marwan Sabbagh, Bruno Vellas, David Watson, Shobha Dhadda, Michael Irizarry, Lynn D. Kramer, and Takeshi Iwatsubo
Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease, Grace E. Vitek, Boris Decourt, and Marwan N. Sabbagh
Factors Associated with Early Withdrawal of Life-Sustaining Treatments After Out-of-Hospital Cardiac Arrest: A Subanalysis of a Randomized Trial of Prehospital Therapeutic Hypothermia, Sarah Wahlster, Kyle Danielson, Lindy Craft, Nassim Matin, James A. Town, Vasisht Srinivasan, Glenn Schubert, David Carlbom, Francis Kim, Nicholas J. Johnson, and David Tirschwell
Antithrombotic therapy in patients with COVID-19: indications, pharmacotherapy and controversy, David Wang, Christopher Leo, Liping Liu, Li Huang, Lisa Huang, and Yun Lu
ADVISING score: a reliable grading scale based on injury and response for intracerebral haemorrhage, Yan Wan, Hongxiu Guo, Shaoli Chen, Jiang Chang, David Wang, Rentang Bi, Man Li, Ke Shi, Zhaowei Wang, Daokai Gong, Jingwen Xu, Quanwei He, and Bo Hu
Manifestations and Outcomes of Intracerebral Hemorrhage During the COVID-19 Pandemic in China: Multicenter, Longitudinal Cohort Study, Yan Wan, Quan Wei He, Shaoli Chen, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, David Wang, Jiang Chang, and Bo Hu
Effect of the Shanghai Stroke Service System (4S) on the quality of stroke care and outcomes: A prospective quality improvement project, Jiawen Xu, Yanan Xie, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, JianRen Liu, Jianhua Zhuang, Ying Xian, Haipeng Shen, Hao Li, David Z. Wang, Bruce Cv Campbell, Mark W. Parsons, Yi Dong, and Qiang Dong
Association of white matter hyperintensities with long-term EGFR-TKI treatment and prediction of progression risk, Hang Yang, Rui Meng, Junjie Jiang, Yan Luo, Xiaolin Deng, Sibo Yang, Shengcai Chen, Jiehong Wu, Yan Wan, Yanan Li, Huijuan Jin, Quanwei He, David Wang, Jiang Chang, Kunyu Yang, Yifan Zhou, and Bo Hu
Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study., John K Yue, Nishanth Krishnan, John H Kanter, Hansen Deng, David O Okonkwo, Ava M Puccio, Debbie Y Madhok, Patrick J Belton, Britta E Lindquist, Gabriela G Satris, Young M Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L Yuh, Alex B Valadka, Anthony M DiGiorgio, Phiroz E Tarapore, Michael C Huang, and Geoffrey T Manley
GTP signaling links metabolism, DNA repair, and responses to genotoxic stress, Weihua Zhou, Zitong Zhao, Angelica Lin, John Yang, Jie Xu, Wilder-Romans Kari, Annabel Yang, Jing Li, Sumeet Solanki, Jennifer Speth, Natalie Walker, Andrew J. Scott, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M. Obrien, Ameer L. Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N. Al-Holou, Yoshie Umemura, Meredith A. Morgan, Theodore S. Lawrence, and Costas A. Lyssiotis
Treatment patterns for patients initiating novel acute migraine specific medications (nAMSMs) in the context of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway., Zifan Zhou, Robert Urman, Karminder Gill, Andrew S Park, Fiston Vuvu, Leah B Patel, Jingsong Lu, Rolin L Wade, Lindsay Frerichs, and Mark E Bensink
Benchmarking Hospital Practices and Policies on Intrahospital Neurocritical Care Transport: The Safe-Neuro-Transport Study, Kapil G. Zirpe, Bhunyawee Alunpipatthanachai, Nassim Matin, Bernice G. Gulek, Patricia A. Blissitt, Katherine Palmieri, Kathryn Rosenblatt, Umeshkumar Athiraman, Suneeta Gollapudy, Marie Angele Theard, Sarah Wahlster, Monica S. Vavilala, Abhijit V. Lele, and Safe-Neuro-Transport Collaborators
Submissions from 2022
Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values., Samuel Arends, Judith Drenthen, Peter van den Bergh, Hessel Franssen, Robert D M Hadden, Badrul Islam, Satoshi Kuwabara, Ricardo C Reisin, Nortina Shahrizaila, Hiroshi Amino, Giovanni Antonini, Shahram Attarian, Claudia Balducci, Fabio Barroso, Tulio Bertorini, Davide Binda, Thomas H Brannagan, Jan Buermann, Carlos Casasnovas, Guido Cavaletti, Chi-Chao Chao, Mazen M Dimachkie, Ernesto A Fulgenzi, Giuliana Galassi, Gerardo Gutiérrez Gutiérrez, Thomas Harbo, Hans-Peter Hartung, Sung-Tsang Hsieh, Lynette Kiers, Helmar C Lehmann, Fiore Manganelli, Girolama A Marfia, Giorgia Mataluni, Julio Pardo, Yann Péréon, Yusuf A Rajabally, Lucio Santoro, Yukari Sekiguchi, Beth Stein, Mark Stettner, Antonino Uncini, Christine Verboon, Camiel Verhamme, Michal Vytopil, Waqar Waheed, Min Wang, Sasha Zivkovic, Bart C Jacobs, David R Cornblath, and Shafeeq S. Ladha
Increased serum uric acid level is associated with better outcome after endovascular treatment for acute ischemic stroke-a prospective cohort study, Haiwei Bai, Ximing Nie, Xinyi Leng, David Wang, Yuesong Pan, Hongyi Yan, Zhonghua Yang, Miao Wen, Yuehua Pu, Zhe Zhang, Wanying Duan, Ning Ma, Zhongrong Miao, Xiran Liu, Qixuan Lu, Yufei Wei, Liping Liu, and Junyan Liu
Sex-specific lesion pattern of functional outcomes after stroke, Anna K. Bonkhoff, Martin Bretzner, Sungmin Hong, Markus D. Schirmer, Alexander Cohen, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, Stephen Bevan, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, and Arndt Rolfs
Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome, Anna K. Bonkhoff, Sungmin Hong, Martin Bretzner, Markus D. Schirmer, Robert W. Regenhardt, E Murat Arsava, Kathleen Donahue, Marco Nardin, Adrian Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa McIntosh, John Attia, Oscar Benavente, John W. Cole, Amanda Donatti, Christoph Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven Kittner, Robin Lemmens, Christopher Levi, Caitrin W. McDonough, James Meschia, Chia-Ling Phuah, Arndt Rolfs, and Stefan Ropele
Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics, Anna K. Bonkhoff, Teresa Ullberg, Martin Bretzner, Sungmin Hong, Markus D. Schirmer, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa C. McIntosh, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, and Jaume Roquer
Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury., Lanya T Cai, Benjamin L Brett, Eva M Palacios, Esther L Yuh, Ioanna Bourla, Jamie Wren-Jarvis, Yang Wang, Christine Mac Donald, Ramon Diaz-Arrastia, Joseph T Giacino, David O Okonkwo, Harvey S Levin, Claudia S Robertson, Nancy Temkin, Amy J Markowitz, Geoffrey T Manley, Murray B Stein, Michael A McCrea, Ross D Zafonte, Lindsay D Nelson, and Pratik Mukherjee
Incidence of Amyotrophic Lateral Sclerosis in Older Adults., Alejandra Camacho-Soto, Susan Searles Nielsen, Irene M Faust, Robert C Bucelli, Timothy M Miller, and Brad A Racette
Liver Cirrhosis and Inpatient Mortality in Aneurysmal Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis, Joshua S. Catapano, Katriel E. Lee, Kavelin Rumalla, Visish M. Srinivasan, Tyler S. Cole, Jacob F. Baranoski, Ethan A. Winkler, Christopher S. Graffeo, Muhaiman Alabdly, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia, Boris Decourt, Keith Noorda, Kevin Noorda, Jiong Shi, and Marwan N. Sabbagh
The importance of genomics in advancing the diagnosis and treatment of dementia, Boris Decourt and Marwan N. Sabbagh
Long-term Safety and Efficacy of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease, Mazen M. Dimachkie, Richard J. Barohn, Barry Byrne, Ozlem Goker-Alpan, Priya S. Kishnani, Shafeeq Ladha, Pascal Laforêt, Karl Eugen Mengel, Loren D. Peña, Sabrina Sacconi, Volker Straub, Jaya Trivedi, Philip Van Damme, Ans T. van der Ploeg, John Vissing, Peter Young, Kristina An Haack, Meredith Foster, Jane M. Gilbert, Patrick Miossec, Olivier Vitse, Tianyue Zhou, and Benedikt Schoser