The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2020
Cost-Effectiveness and Efficacy of a Novel Combination Regimen in Acromegaly: A Prospective, Randomized Trial., Vivien Bonert, James Mirocha, John Carmichael, Kevin C J Yuen, Takako Araki, and Shlomo Melmed
Herpesvirus Infections and Risk of Parkinson's Disease, Alejandra Camacho-Soto, Irene Faust, Brad A. Racette, David B. Clifford, Harvey Checkoway, and Susan Searles Nielsen
Fractures in the prodromal period of Parkinson disease, Alejandra Camacho-Soto, Anat Gross, Susan Searles Nielsen, Anna N. Miller, Mark N. Warden, Amber Salter, and Brad A. Racette
[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers, Susan R. Criswell, Susan Searles Nielsen, Mark N. Warden, Joel S. Perlmutter, Stephen M. Moerlein, Lianne Sheppard, Jason Lenox-Krug, Harvey Checkoway, and Brad A. Racette
Alzheimer's disease drug development pipeline: 2020, Jeffrey Cummings, Garam Lee, Aaron Ritter, Marwan Sabbagh, and Kate Zhong
Emergency Department Length of Stay and Other Factors Contributing to Intracerebral Hemorrhage Patient Outcomes: An Executive Summary, Nicolle W. Davis, Tiffany O. Sheehan, Brian C. Peach, Margaret Ansell, Jeannie P. Cimiotti, Yi Guo, Debra Lynch Kelly, Ann L. Horgas, and Saunjoo L. Yoon
MCLENA-1: A phase ii clinical trial for the assessment of safety, tolerability, and efficacy of lenalidomide in patients with mild cognitive impairment due to alzheimer’s disease, Boris Decourt, Jeffrey Wilson, Aaron Ritter, Christopher Dardis, Frank P. Difilippo, Xiaowei Zhuang, Dietmar Cordes, Garam Lee, Nadia D. Fulkerson, Tessa St Rose, Katurah Hartley, and Marwan N. Sabbagh
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage, Rajat Dhar, Guido J. Falcone, Yasheng Chen, Ali Hamzehloo, Elayna P. Kirsch, Rommell B. Noche, Kilian Roth, Julian Acosta, Andres Ruiz, Chia-Ling Phuah, Daniel Woo, Thomas M. Gill, Kevin N. Sheth, and Jin-Moo Lee
Manganese exposure, parkinsonian signs, and quality of life in South African mine workers, Wendy W. Dlamini, Gill Nelson, Susan Searles Nielsen, and Brad A. Racette
Heterogeneity in Outcome Reporting in Endoscopic Endonasal Skull Base Reconstruction: A Systematic Review, Christina Dorismond, Griffin D. Santarelli, Brian D. Thorp, Adam J. Kimple, Charles S. Ebert, and Adam M. Zanation
Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage, Guido J. Falcone, Elayna Kirsch, Julian N. Acosta, Rommell B. Noche, Audrey Leasure, Sandro Marini, Jaeyoon Chung, Magdy Selim, James F. Meschia, Devin L. Brown, Bradford B. Worrall, David L. Tirschwell, Jeremiasz M. Jagiella, Helena Schmidt, Jordi Jimenez-Conde, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Dipender Gill, Michael Holmes, Chia-Ling Phuah, Nils H. Petersen, Charles N. Matouk Md, Murat Gunel, Lauren Sansing, Derrick Bennett, Zhengming Chen, Luan L. Sun, Robert Clarke, Robin G. Walters, and Thomas M. Gill
Validation of a Parkinson Disease Predictive Model in a Population-Based Study, Irene M. Faust, Brad A. Racette, and Susan Searles Nielsen
Neuro-Otology., Terry D. Fife
A Rare Mutation Associated With Probable Late-Onset Leber's Hereditary Optic Neuropathy, Jacob J. Fondriest and Karl C. Golnik
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, and Nick Fox
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration, Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, Michael Weiner, Paul Aisen, Gerald Novak, Robert C. Green, Tom Montine, Ronald Petersen, Anthony Gamst, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Laurel Beckett, Danielle Harvey, John Kornak, Clifford R. Jack, Anders Dale, Matthew Bernstein, and Joel Felmlee
Gender Disparity and Potential Strategies for Improvement in Neurology and Clinical Neurophysiology, Gloria Galloway, Sarah Schmitt, Susan T. Herman, and Suzette La Roche
Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report, Serge Gauthier, P. S. Aisen, J. Cummings, M. J. Detke, F. M. Longo, R. Raman, M. Sabbagh, L. Schneider, R. Tanzi, P. Tariot, M. Weiner, J. Touchon, and B. Vellas
The Pursuit of Training Meritorious Learners of Diverse Backgrounds: Mayo Clinic College of Medicine and Science, Yonas E. Geda and Fredric B. Meyer
Multidisciplinary management of acromegaly: A consensus., Andrea Giustina, Garni Barkhoudarian, Albert Beckers, Anat Ben-Shlomo, Nienke Biermasz, Beverly Biller, Cesar Boguszewski, Marek Bolanowski, Jens Bollerslev, Vivien Bonert, Marcello D Bronstein, Michael Buchfelder, Felipe Casanueva, Philippe Chanson, David Clemmons, Maria Fleseriu, Anna Maria Formenti, Pamela Freda, Monica Gadelha, Eliza Geer, Mark Gurnell, Anthony P Heaney, Ken K Y Ho, Adriana G Ioachimescu, Steven Lamberts, Edward Laws, Marco Losa, Pietro Maffei, Adam Mamelak, Moises Mercado, Mark Molitch, Pietro Mortini, Alberto M Pereira, Stephan Petersenn, Kalmon Post, Manuel Puig-Domingo, Roberto Salvatori, Susan L Samson, Ilan Shimon, Christian Strasburger, Brooke Swearingen, Peter Trainer, Mary L Vance, John Wass, Margaret E Wierman, Kevin C J Yuen, Maria Chiara Zatelli, and Shlomo Melmed
High-Density Adaptive Ten Ten: Proposal for Electrode Nomenclature for High-Density EEG, Walter Heine, Mary Ann Dobrota, Donald Schomer, Rebekah Wigton, and Susan Herman
Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/s41598-019-49970-9), Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, and M. Marcel Mesulam
Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke, Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H. Farias, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia-Ling Phuah, Robin Lemmens, Alessandro A. Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, Tomas Segura, and Gemma Serrano-Heras
Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence, Ruchira M. Jha, Josh Bell, Giuseppe Citerio, J Claude Hemphill, W Taylor Kimberly, Raj K. Narayan, Juan Sahuquillo, Kevin N. Sheth, and J Marc Simard
Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists, Huijuan Jin, Candong Hong, Shengcai Chen, Yifan Zhou, Yong Wang, Ling Mao, Yanan Li, Quanwei He, Man Li, Ying Su, David Wang, Longde Wang, and Bo Hu
A feasibility assessment of functioning and quality-of-life patient-reported outcome measures in adult epilepsy clinics: A systematic review, Felipe J.S. Jones, Farrah L. Ezzeddine, Susan T. Herman, Jeffrey Buchhalter, Brandy Fureman, and Lidia M.V.R. Moura
Implementing standardized provider documentation in a tertiary epilepsy clinic, Felipe J.S. Jones, Jason R. Smith, Neishay Ayub, Susan T. Herman, Jeffrey R. Buchhalter, Brandy E. Fureman, Sydney S. Cash, Daniel B. Hoch, and Lidia M.V.R. Moura
Proactive interference apraxic agraphia: a writing and drawing disorder associated with corticobasal syndrome, Parunyou Julayanont, David W. Burks, and Kenneth M. Heilman
Early-Motor Phenotype Relates to Neuropsychiatric and Cognitive Disorders in Huntington's Disease, Parunyou Julayanont, Kenneth M. Heilman, and Nikolaus R. McFarland
Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence, Parunyou Julayanont, Nikolaus R. McFarland, and Kenneth M. Heilman
Lasmiditan for the acute treatment of migraine: Subgroup analyses by prior response to triptans., Kerry Knievel, Andrew S Buchanan, Louise Lombard, Simin Baygani, Joel Raskin, John H Krege, Li Shen Loo, Mika Komori, and Joshua Tobin
Neuropathological Findings in Parkinson's Disease With Mild Cognitive Impairment, Molly G. Knox, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal A. Mehta, Christine Belden, Edward Zamrini, Geidy Serrano, Marwan N. Sabbagh, John N. Caviness, Lucia I. Sue, Kathryn J. Davis, Brittany N. Dugger, and Thomas G. Beach
Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision, Patrick M. Kochanek, Travis C. Jackson, Ruchira M. Jha, Robert S. Clark, David O. Okonkwo, Hülya Bayır, Samuel M. Poloyac, Amy K. Wagner, Philip E. Empey, Yvette P. Conley, Michael J. Bell, Anthony E. Kline, Corina O. Bondi, Dennis W. Simon, Shaun W. Carlson, Ava M. Puccio, Christopher M. Horvat, Alicia K. Au, Jonathan Elmer, Amery Treble-Barna, Milos D. Ikonomovic, Lori A. Shutter, D Lansing Taylor, Andrew M. Stern, Steven H. Graham, Valerian E. Kagan, Edwin K. Jackson, Stephen R. Wisniewski, and C Edward Dixon
"Take a Number"-Precision Monitoring Directs Precision Therapy, Patrick M. Kochanek, Ruchira M. Jha, and Robert S. Clark
Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging, Janina Krell-Roesch, Jeremy A. Syrjanen, Michelle M. Mielke, Teresa J. Christianson, Walter K. Kremers, Mary M. MacHulda, David S. Knopman, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda
Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Michelle M. Mielke, Mary M. Machulda, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, and Yonas E. Geda
Exercise as a treatment for sleep apnea., Joyce K Lee-Iannotti and James M Parish
Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions, Enrique C. Leira, Andrew N. Russman, José Biller, Devin L. Brown, Cheryl D. Bushnell, Valeria Caso, Angel Chamorro, Claire J. Creutzfeldt, Salvador Cruz-Flores, Mitchell S. Elkind, Pierre Fayad, Michael T. Froehler, Larry B. Goldstein, Nicole R. Gonzales, Brian Kaskie, Pooja Khatri, Sarah Livesay, David S. Liebeskind, Jennifer J. Majersik, Asma M. Moheet, Jose G. Romano, Nerses Sanossian, Lauren H. Sansing, Brian Silver, Alexis N. Simpkins, Wade Smith, David L. Tirschwell, David Z. Wang, Dileep R. Yavagal, and Bradford B. Worrall
Placebo effect in chronic inflammatory demyelinating polyneuropathy: The PATH study and a systematic review, Richard A. Lewis, David R. Cornblath, Hans Peter Hartung, Gens Sobue, John Philip Lawo, Orell Mielke, Billie L. Durn, Vera Bril, Ingemar S.J. Merkies, Paul Bassett, Alexa Cleasby, Ivo N. van Schaik, A. Sabet, K. George, L. Roberts, R. Carne, S. Blum, R. Henderson, P. Van Damme, J. Demeestere, S. Larue, C. D’Amour, P. Kunc, M. Valis, J. Sussova, T. Kalous, R. Talab, M. Bednar, T. Toomsoo, I. Rubanovits, and K. Gross-Paju
Differential response to rituximab in anti-AChR and anti-MuSK positive myasthenia gravis patients: a single-center retrospective study, Tess Litchman, Bhaskar Roy, Aditya Kumar, Aditi Sharma, Valentine Njike, and Richard J. Nowak
Approaches to global stroke care during the COVID-19 pandemic, Liping Liu, David Wang, Michael Brainin, Mitchell S. Elkind, Enrique Leira, and Yongjun Wang
Intracranial Pressure Monitoring via External Ventricular Drain: Are We Waiting Long Enough Before Recording the Real Value?, Xiuyun Liu, Margaret Griffith, Hannah J Jang, Nerissa Ko, Michele M Pelter, Jacob Abba, Maximilian Vuong, Nate Tran, Kelly Bushman, and Xiao Hu
Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study, Yanan Li, Man Li, Mengdie Wang, Yifan Zhou, Jiang Chang, Ying Xian, David Wang, Ling Mao, Huijuan Jin, and Bo Hu
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China, Ling Mao, Huijuan Jin, Mengdie Wang, Yu Hu, Shengcai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Xiaoping Miao, Yanan Li, and Bo Hu
Prevalence of ideal cardiovascular health in a Central European community: results from the Kardiovize Brno 2030 Project, Jose R. Medina-Inojosa, Manlio Vinciguerra, Andrea Maugeri, Sarka Kunzova, Ondřej Sochor, Narine Movsisyan, Yonas E. Geda, Gorazd B. Stokin, and Francisco Lopez-Jimenez
Long-Acting Growth Hormone Preparations - Current Status and Future Considerations., Bradley S Miller, Eric Velazquez, and Kevin C J Yuen
Phase 1-2 Trial of antisense oligonucleotide tofersen for SOD1 ALS, T. Miller, M. Cudkowicz, P. J. Shaw, P. M. Andersen, N. Atassi, R. C. Bucelli, A. Genge, J. Glass, S. Ladha, A. L. Ludolph, N. J. Maragakis, C. J. McDermott, A. Pestronk, J. Ravits, F. Salachas, R. Trudell, P. Van Damme, L. Zinman, C. F. Bennett, R. Lane, A. Sandrock, H. Runz, D. Graham, H. Houshyar, A. McCampbell, I. Nestorov, I. Chang, M. McNeill, L. Fanning, S. Fradette, and T. A. Ferguson
Rituximab in refractory chronic inflammatory demyelinating polyneuropathy, Suraj A. Muley, Bill Jacobsen, Gareth Parry, Uzma Usman, Erik Ortega, David Walk, Jeff Allen, Mamatha Pasnoor, Matthew Varon, and Mazen M. Dimachkie
Autoimmune Vestibulocerebellar Syndromes., Ram N Narayan, Andrew McKeon, and Terry D. Fife
Validation of Parkinson's Disease-Related Questionnaires in South Africa, Gill Nelson, Ntombizodwa Ndlovu, Nicola Christofides, Tintswalo M. Hlungwani, Irene Faust, and Brad A. Racette
Risk Factors Underlying COVID-19 Lockdown-Induced Mental Distress, Jan Sebastian Novotný, Juan Pablo Gonzalez-Rivas, Šárka Kunzová, Mária Skladaná, Anna Pospíšilová, Anna Polcrová, Jose Ramon Medina-Inojosa, Francisco Lopez-Jimenez, Yonas Endale Geda, and Gorazd Bernard Stokin
Depressive symptoms and myeloproliferative neoplasms: Understanding the confounding factor in a complex condition, Leslie Padrnos, Robyn Scherber, Holly Geyer, Blake T. Langlais, Amylou C. Dueck, Heidi E. Kosiorek, Zhenya Senyak, Matthew Clark, Michael Boxer, Mary Cotter, Claire Harrison, Cynthia Stonnington, Yonas Geda, and Ruben Mesa
Trial of sodium phenylbutyrate-taurursodiol for amyotrophic lateral sclerosis, Sabrina Paganoni, Eric A. Macklin, Suzanne Hendrix, James D. Berry, Michael A. Elliott, Samuel Maiser, Chafic Karam, James B. Caress, Margaret A. Owegi, Adam Quick, James Wymer, Stephen A. Goutman, Daragh Heitzman, Terry Heiman-Patterson, Carlayne E. Jackson, Colin Quinn, Jeffrey D. Rothstein, Edward J. Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq Ladha, Timothy M. Miller, Stephen N. Scelsa, Tuan H. Vu, Christina N. Fournier, Jonathan D. Glass, Kristin M. Johnson, Andrea Swenson, Namita A. Goyal, Gary L. Pattee, and Patricia L. Andres
Newer Immunotherapies for the Treatment of Acute Neuromuscular Disease in the Critical Care Unit, Alok Patel, Fiona Lynch, and Starane A. Shepherd
Associations between high triglycerides and arterial stiffness in a population-based sample: Kardiovize Brno 2030 study, Iuliia Pavlovska, Sarka Kunzova, Juraj Jakubik, Jana Hruskova, Maria Skladana, Irma Magaly Rivas-Serna, Jose R. Medina-Inojosa, Francisco Lopez-Jimenez, Robert Vysoky, Yonas E. Geda, Gorazd B. Stokin, and Juan P. González-Rivas
Continuous EEG findings in patients with COVID-19 infection admitted to a New York academic hospital system, Jacob Pellinen, Elizabeth Carroll, Daniel Friedman, Michael Boffa, Patricia Dugan, David E. Friedman, Deana Gazzola, Amy Jongeling, Alcibiades J. Rodriguez, and Manisha Holmes
Degenerative dementia with proximal radial and lower vertical spatial neglect, Kulrithra Pisanuwongrak, Parunyou Julayanont, and Kenneth M. Heilman
ACI-24 vaccine in adults with Down syndrome, Michael S. Rafli, William C. Mobley, Brian G. Skotko, Marwan N. Sabbagh, Anna D. Burke, Shauna Yuan, Robert A. Rissman, Ronelyn Chavez, Saskia Delpretti, Oliver Sol, Greg Beth, Julian JG Gray, Antonio Melo dos Santos, Valerie Hliva, Marija Vukicevic, Marie Kosco-Vilbois, Andrea Pfeifer, and Howard H. Feldman
Alzheimer’s Disease Drug Development Pipeline 2020, Marwan N. Sabbagh
Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) supported by Emerging Digital Technologies, Marwan N. Sabbagh, M. Boada, S. Borson, M. Chilukuri, P. M. Doraiswamy, B. Dubois, J. Ingram, A. Iwata, A. P. Porsteinsson, K. L. Possin, G. D. Rabinovici, B. Vellas, S. Chao, A. Vergallo, and H. Hampel
Early Detection of Mild Cognitive Impairment (MCI) in Primary Care, Marwan N. Sabbagh, M. Boada, S. Borson, M. Chilukuri, B. Dubois, J. Ingram, A. Iwata, A. P. Porsteinsson, K. L. Possin, G. D. Rabinovici, B. Vellas, S. Chao, A. Vergallo, and H. Hampel
Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting, Marwan N. Sabbagh, M. Boada, S. Borson, P. M. Doraiswamy, B. Dubois, J. Ingram, A. Iwata, A. P. Porsteinsson, K. L. Possin, G. D. Rabinovici, B. Vellas, S. Chao, A. Vergallo, and H. Hampel
Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease, Marwan Sabbagh, Carl Sadowsky, Babak Tousi, Marc E. Agronin, Gustavo Alva, Carmel Armon, Charles Bernick, Andrew P. Keegan, Stella Karantzoulis, Eyal Baror, Moran Ploznik, and Alvaro Pascual-Leone
Editorial: Alzheimer's Disease Drug Development Pipeline 2020, M N. Sabbagh
Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke, Markus D. Schirmer, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Steven J. Mocking, Elissa C. McIntosh, John W. Cole, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, James F. Meschia, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Tara M. Stanne, Achala Vagal, Johan Wasselius, Daniel Woo, Stephen Bevan, Laura Heitsch, Chia-Ling Phuah, Daniel Strbian, and Turgut Tatlisumak
A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS, Jeremy M. Shefner, Jinsy A. Andrews, Angela Genge, Carlayne Jackson, Noah Lechtzin, Timothy M. Miller, Bettina M. Cockroft, Lisa Meng, Jenny Wei, Andrew A. Wolff, Fady I. Malik, Cynthia Bodkin, Benjamin R. Brooks, James Caress, Annie Dionne, Dominic Fee, Stephen A. Goutman, Namita A. Goyal, Orla Hardiman, Ghazala Hayat, Terry Heiman-Patterson, Daragh Heitzman, Robert D. Henderson, Wendy Johnston, Chafic Karam, Matthew C. Kiernan, Stephen J. Kolb, Lawrence Korngut, Shafeeq Ladha, Genevieve Matte, and Jesus S. Mora
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology, Xinpeng Shen, Sisi Ma, Prashanthi Vemuri, Gyorgy Simon, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, and Peter Snyder
Alzheimer's disease beyond amyloid: Strategies for future therapeutic interventions, Jiong Shi, Marwan N. Sabbagh, and Bruno Vellas
Auditory Mapping With MEG: An Update on the Current State of Clinical Research and Practice With Considerations for Clinical Practice Guidelines, Vladimir Shvarts and Jyrki P. Mäkelä
Well Water and Parkinson's Disease in Medicare Beneficiaries: A Nationwide Case-Control Study, Maya R. Silver, Brad A. Racette, Umber Dube, Irene M. Faust, and Susan Searles Nielsen
Accuracy of ICD-10-CM claims-based definitions for epilepsy and seizure type, Jason R. Smith, Felipe J.S. Jones, Brandy E. Fureman, Jeffrey R. Buchhalter, Susan T. Herman, Neishay Ayub, Christopher McGraw, Sydney S. Cash, Daniel B. Hoch, and Lidia M.V.R. Moura
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease, Margherita Squillario, Giulia Abate, Federico Tomasi, Veronica Tozzo, Annalisa Barla, Daniela Uberti, Michael W. Weiner, Paul Aisen, Ronald Petersen, Jack R. Clifford, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, and M. Marcel Mesulam
Coining the Pablo Picasso Syndrome, Ritika Suri and Ashhar Ali
Rapidly progressive dementia-associated N-type voltage-gated calcium channel antibody encephalopathy, Smathorn Thakolwiboon, Amputch Karukote, Gyeongmo Sohn, Walter R. Duarte-Celada, and Parunyou Julayanont
Olfactory gyrus intracerebral hemorrhage in a patient with COVID-19 infection, Sai Si Thu, Nassim Matin, and Steven R. Levine
Aducanumab, gantenerumab, BAN2401, and ALZ-801 - The first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval, Martin Tolar, Susan Abushakra, John A. Hey, Anton Porsteinsson, and Marwan Sabbagh
The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis, Martin Tolar, Susan Abushakra, and Marwan Sabbagh
Large Infarct Volume Post Thrombectomy: Characteristics, Outcomes, and Predictors, Daniel A. Tonetti, Shashvat M. Desai, Joseph Hudson, Bradley A. Gross, Ruchira M. Jha, Bradley J. Molyneaux, Brian T. Jankowitz, Tudor G. Jovin, and Ashutosh P. Jadhav
Benefit and risk of early intravenous heparin after thrombolysis in patients with acute ischemic stroke., Xu Tong, Yibin Cao, Wenzhi Wang, David Z. Wang, Yongjun Wang, and Yilong Wang
Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline, D. L. Tudorascu, C. M. Laymon, M. Zammit, D. S. Minhas, S. J. Anderson, P. A. Ellison, S. Zaman, B. M. Ances, M. Sabbagh, S. C. Johnson, C. A. Mathis, W. E. Klunk, B. L. Handen, B. T. Christian, and A. D. Cohen
DCE-MRI perfusion predicts pseudoprogression in metastatic melanoma treated with immunotherapy, Yoshie Umemura, Diane Wang, Kyung K. Peck, Jessica Flynn, Zhigang Zhang, Robin Fatovic, Erik S. Anderson, Kathryn Beal, Alexander N. Shoushtari, Thomas Kaley, and Robert J. Young
Brain amyloid, cortical thickness, and changes in activities of daily living, Maria Vassilaki, Jeremiah A. Aakre, Walter K. Kremers, Timothy G. Lesnick, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, David S. Knopman, Lesley Butler, Martin Traber, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack, Rosebud O. Roberts, and Ronald C. Petersen
Medical Doctors and Dementia: A Longitudinal Study, Maria Vassilaki, Jeremy A. Syrjanen, Walter K. Kremers, Philip T. Hagen, David S. Knopman, Michelle M. Mielke, Yonas E. Geda, Rabe E. Alhurani, Mary M. Machulda, Rosebud O. Roberts, and Ronald C. Petersen
Original research: Second IVIg course in Guillain-Barré syndrome with poor prognosis: the non-randomised ISID study., Christine Verboon, Bianca van den Berg, David R Cornblath, Esmee Venema, Kenneth C Gorson, Michael P Lunn, Hester Lingsma, Peter Van den Bergh, Thomas Harbo, Kathleen Bateman, Yann Pereon, Søren H Sindrup, Susumu Kusunoki, James Miller, Zhahirul Islam, Hans-Peter Hartung, Govindsinh Chavada, Bart C Jacobs, Richard A C Hughes, Pieter A van Doorn, and Shafeeq S. Ladha
Subthalamic nucleus deep brain stimulation with a multiple independent constant current-controlled device in Parkinson's disease (INTREPID): a multicentre, double-blind, randomised, sham-controlled study., Jerrold L Vitek, Roshini Jain, Lilly Chen, Alexander I Tröster, Lauren E Schrock, Paul A House, Monique L Giroux, Adam O Hebb, Sierra M Farris, Donald M Whiting, Timothy A Leichliter, Jill L Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A Karl, Mustafa S Siddiqui, Stephen B Tatter, Ihtsham Ul Haq, Andre G Machado, Michal Gostkowski, Michele Tagliati, Adam N Mamelak, Michael S Okun, Kelly D Foote, Guillermo Moguel-Cobos, Francisco A Ponce, Rajesh Pahwa, Jules M Nazzaro, Cathrin M Buetefisch, Robert E Gross, Corneliu C Luca, Jonathan R Jagid, Gonzalo J Revuelta, Istvan Takacs, Michael H Pourfar, Alon Y Mogilner, Andrew P Duker, George T Mandybur, Joshua M Rosenow, Scott E Cooper, Michael C Park, Suketu M Khandhar, Mark Sedrak, Fenna T Phibbs, Julie G Pilitsis, Ryan J Uitti, and Philip A Starr
Safety and Efficacy of Nivolumab in Patients With Advanced Non-Clear Cell Renal Cell Carcinoma: Results From the Phase IIIb/IV CheckMate 374 Study, Nicholas J. Vogelzang, Mark R. Olsen, Joshua J. McFarlane, Edward Arrowsmith, Todd M. Bauer, Rohit K. Jain, Bradley Somer, Elaine T. Lam, Mark D. Kochenderfer, Ana Molina, Gurjyot Doshi, Brian Lingerfelt, Ralph J. Hauke, Vijay Gunuganti, Ian Schnadig, Peter Van Veldhuizen, Mark Fleming, Robert Galamaga, Mukul Gupta, Hugo Hool, Thomas Hutson, Joshua Zhang, M Brent McHenry, Jennifer L. Johansen, and Scott S. Tykodi
Decoding the brain through research-the future of brain health, David Z. Wang, Lee H. Schwamm, Tianyi Qian, and Qionghai Dai
Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association, Xia Wang, Menglu Ouyang, Cheryl Carcel, Chen Chen, Lingli Sun, Jie Yang, Yao Zhang, Guofang Chen, Shoujiang You, Yongjun Cao, Lu Ma, Xin Hu, Yi Sui, Craig Anderson, Lili Song, Yongjun Wang, and David Wang
Providing uninterrupted care during COVID-19 pandemic: experience from Beijing Tiantan Hospital, Xiaoyan Wang, Yu Chen, Zixiao Li, David Wang, and Yongjun Wang
China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations, Yong-Jun Wang, Zi-Xiao Li, Hong-Qiu Gu, Yi Zhai, Yong Jiang, Xing-Quan Zhao, Yi-Long Wang, Xin Yang, Chun-Juan Wang, Xia Meng, Hao Li, Li-Ping Liu, Jing Jing, Jing Wu, An-Ding Xu, Qiang Dong, David Wang, and Ji-Zong Zhao
The association of white matter hyperintensities with stroke outcomes and antiplatelet therapy in minor stroke patients, Yu-Yuan Xu, Li-Xia Zong, Chang-Qing Zhang, Yue-Song Pan, Jing Jing, Xia Meng, Hao Li, Xing-Quan Zhao, Li-Ping Liu, David Wang, Yi-Long Wang, and Yong-Jun Wang
FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease, Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Arthur W. Toga, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, and Bryan M. Spann
Effect of ApoE isoforms on mitochondria in Alzheimer disease, Junxiang Yin, Eric M. Reiman, Thomas G. Beach, Geidy E. Serrano, Marwan N. Sabbagh, Megan Nielsen, Richard J. Caselli, and Jiong Shi
Alterations of the GH/IGF-I Axis and Gut Microbiome after Traumatic Brain Injury: A New Clinical Syndrome?, Kevin C J Yuen, Brent E Masel, Kent L Reifschneider, Melinda Sheffield-Moore, Randall J Urban, and Richard B Pyles
Fellowship Match Outcomes in the U.S. From 2010 to 2017: Analysis of San Francisco Match, Sidra Zafar, Neil M. Bressler, Karl C. Golnik, Divya Srikumaran, Zara Ghous, Samantha Ip, Xinyi Chen, and Fasika A. Woreta
Amyloid accumulation in Down syndrome measured with amyloid load, Matthew D. Zammit, Charles M. Laymon, Tobey J. Betthauser, Karly A. Cody, Dana L. Tudorascu, Davneet S. Minhas, Marwan N. Sabbagh, Sterling C. Johnson, Shahid H. Zaman, Chester A. Mathis, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, and Bradley T. Christian
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma, Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, and Daniel R. Wahl
Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management, Yifan Zhou, Wei Li, David Wang, Ling Mao, Huijuan Jin, Yanan Li, Candong Hong, Shengcai Chen, Jiang Chang, Quanwei He, Mengdie Wang, and Bo Hu
Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy, Benjamin E. Zusman, Patrick M. Kochanek, and Ruchira M. Jha
Submissions from 2019
Unified staging system for Lewy body disorders: Clinicopathologic correlations and comparison to Braak staging, Charles H. Adler, Thomas G. Beach, Nan Zhang, Holly A. Shill, Erika Driver-Dunckley, John N. Caviness, Shyamal H. Mehta, Marwan N. Sabbagh, Geidy E. Serrano, Lucia I. Sue, Christine M. Belden, Jessica Powell, Sandra A. Jacobson, Edward Zamrini, David Shprecher, Kathryn J. Davis, Brittany N. Dugger, and Joseph G. Hentz