Stress hyperglycemia may have higher risk of stroke recurrence than previously diagnosed diabetes mellitus

Document Type

Article

Abstract

We aim to evaluate the risk of stroke recurrence among non-diabetes mellitus (non-DM), previously diagnosed diabetes mellitus (PDDM), newly diagnosed diabetes mellitus-related hyperglycemia (NDDM-RH) and stress hyperglycemia after minor stroke or TIA. Totally, 3026 patients with baseline fasting glucose and glycated albumin from the CHANCE trial (Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events) were included. Patients were classified as non-DM, PDDM, NDDM-RH and stress hyperglycemia according to the status of glucose metabolism. The primary outcome was stroke recurrence during 90-day follow up. Cox regression was performed to estimate the relationship between the status of glucose metabolism and risk of 90-day stroke recurrence. Compared with PDDM, NDDM-RH had a similar risk of 90-day stroke recurrence (hazard ratios [HR]1.39, 95% confidence intervals [CI] 0.94-2.04), while stress hyperglycemia had approximately a 5.3-fold increased risk of 90-day stroke recurrence after adjusted for confounding covariates (HR 5.32, 95% CI 3.43-8.26). Parallel results were found for 90-day recurrent ischemic stroke and composite events. Compared with PDDM in minor stroke or TIA, a parallel risk of 90-day stroke recurrence were observed for NDDM-RH, while stress hyperglycemia might relate to higher risk of 90-day stroke recurrence.

Medical Subject Headings

Aged; Blood Glucose; Diabetes Mellitus, Type 1 (blood, epidemiology); Female; Humans; Hyperglycemia (blood, epidemiology); Incidence; Male; Middle Aged; Recurrence; Risk; Stroke (blood, epidemiology)

Publication Date

3-22-2021

Publication Title

Aging

E-ISSN

1945-4589

Volume

13

Issue

6

First Page

9108

Last Page

9118

PubMed ID

33752174

Digital Object Identifier (DOI)

10.18632/aging.202797

Link to Full Text

Share

COinS