A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment

Authors

Anna Pink, Department of Geriatrics, Paracelsus Medical University, Salzburg, Austria.
Janina Krell-Roesch, Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Jeremy A. Syrjanen, Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Maria Vassilaki, Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Val J. Lowe, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Prashanthi Vemuri, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Gorazd B. Stokin, International Clinical Research Center/St. Anne Hospital, Brno, Czech Republic.
Teresa J. Christianson, Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Walter K. Kremers, Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Clifford R. Jack, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
David S. Knopman, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Ronald C. Petersen, Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Yonas E. Geda, Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.Follow

Document Type

Article

Abstract

INTRODUCTION: We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI). METHODS: We followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity. RESULTS: Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58-12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI. DISCUSSION: Anxiety modified the association between PiB+ and incident MCI.

Publication Date

12-8-2021

Publication Title

Alzheimer's & dementia : the journal of the Alzheimer's Association

E-ISSN

1552-5279

PubMed ID

34877794

Digital Object Identifier (DOI)

10.1002/alz.12504

Recommended Citation

Pink, Anna; Krell-Roesch, Janina; Syrjanen, Jeremy A.; Vassilaki, Maria; Lowe, Val J.; Vemuri, Prashanthi; Stokin, Gorazd B.; Christianson, Teresa J.; Kremers, Walter K.; Jack, Clifford R.; Knopman, David S.; Petersen, Ronald C.; and Geda, Yonas E., "A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment" (2021). Neurology. 1216.
https://scholar.barrowneuro.org/neurology/1216