The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 2019

Unique Characteristics of Optical Coherence Tomography (OCT) Results and Visual Acuity Testing in Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Positive Pediatric Patients, Ram N. Narayan, Morgan McCreary, Darrel Conger, Cynthia Wang, and Benjamin M. Greenberg

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Motor Learning Deficits in Parkinson's Disease (PD) and Their Effect on Training Response in Gait and Balance: A Narrative Review, Markey Olson, Thurmon E. Lockhart, and Abraham N. Lieberman

Safety Tolerability Pharmacokinetics Pharmacodynamics and Exploratory Efficacy of the Novel Enzyme Replacement Therapy Avalglucosidase Alfa (Neogaa) in Treatment-naïve and Alglucosidase Alfa-Treated Patients With Late-Onset Pompe Disease: A Phase 1 Open-Label Multicenter Multinational Ascending Dose Study, Loren D.M. Pena, Richard J. Barohn, Barry J. Byrne, Claude Desnuelle, Ozlem Goker-Alpan, Shafeeq S. Ladha, Pascal Laforêt, Karl Eugen Mengel, Alan Pestronk, Jean Pouget, Benedikt Schoser, Volker Straub, Jaya Trivedi, Philip Van Damme, John Vissing, Peter Young, Katherine Kacena, Raheel Shafi, Beth L. Thurberg, and et al.

Clinical and functional outcomes after total laryngectomy and laryngopharyngectomy: Analysis by tumor subsite, salvage status, and extent of resection, Christopher J. Perdoni, Griffin D. Santarelli, Elliot Y. Koo, Daniel W. Karakla, and Matthew J. Bak

Predicting Progression to Mild Cognitive Impairment, Ronald C. Petersen, Emily S. Lundt, Terry M. Therneau, Stephen D. Weigand, David S. Knopman, Michelle M. Mielke, Rosebud O. Roberts, Val J. Lowe, Mary M. Machulda, Walter K. Kremers, Yonas E. Geda, and Clifford R. Jack

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Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings, Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly, John Duda, Stephen Gomperts, Holly A. Shill, and et al.

Brain MR radiomics to differentiate cognitive disorders, Sara Ranjbar, Stefanie N. Velgos, Amylou C. Dueck, Yonas E. Geda, and J. Ross Mitchell

Meeting Report: Report on the 9th International Congress of the Growth Hormone Research and IGF Societies, September 14-17, 2018, in Seattle, Washington, USA., Charles T Roberts and Kevin C J Yuen

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Movement Disorders in Prionopathies: A Systematic Review, Federico Rodriguez-Porcel, Vinícius Boaratti Ciarlariello, Alok K. Dwivedi, Lilia Lovera, Gustavo Da Prat, Ricardo Lopez-Castellanos, Ritika Suri, Holly Laub, Ruth H. Walker, Orlando Barsottini, José Luiz Pedroso, and Alberto J. Espay

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ALS Longitudinal Studies With Frequent Data Collection at Home: Study Design and Baseline Data, Seward B. Rutkove, Kristin Qi, Kerisa Shelton, Julie Liss, Visar Berisha, and Jeremy M. Shefner

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Neurology and Therapy: Looking Back on 2018 and Forward to 2019, Marwan Sabbagh and Antonio Bertolotto

Peripheral Biomarkers for Alzheimer's Disease: Update and Progress, Marwan N. Sabbagh and Kaj Blennow

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FDA position statement “Early Alzheimer's disease: Developing drugs for treatment, Guidance for Industry”, Marwan N. Sabbagh, Suzanne Hendrix, and John E. Harrison

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Cingulate cortex in pre-MCI cognition, Nathalie Sambuchi, Yonas Endale Geda, and Bernard François Michel

Establishing Urinary Leukotriene E4 as a Diagnostic Biomarker for Chronic Rhinosinusitis with Comorbid Asthma and Atopy, Griffin D. Santarelli, Kent K. Lam, and Joseph K. Han

Lewy Body Pathology in Alzheimer's Disease: A Clinicopathological Prospective Study, Rodolfo Savica, Thomas G. Beach, Joseph G. Hentz, Marwan N. Sabbagh, Geidy E. Serrano, Lucia I. Sue, Brittany N. Dugger, Holly A. Shill, Erika Driver-Dunckley, John N. Caviness, Shyamal H. Mehta, Sandra A. Jacobson, Christine M. Belden, Kathryn J. Davis, Edward Zamrini, David R. Shprecher, and Charles H. Adler

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Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer’s Dementia, Lucas Porcello Schilling, Tharick A. Pascoal, Eduardo R. Zimmer, Sulantha Mathotaarachchi, Monica Shin, Carlos Roberto de Mello Rieder, Serge Gauthier, André Palmini, Pedro Rosa-Neto, Michael W. Weiner, Paul Aisen, Ronald Petersen, Ronald Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, and Sonia Pawluczyk

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Radiographic appearance of leptomeningeal disease in patients with EGFR-mutated non-small-cell lung carcinoma treated with tyrosine kinase inhibitors: a case series, Ugur Sener, Nassim Matin, Helena Yu, Andrew Lin, T Jonathan Yang, and Rachna Malani

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A Phase III Trial of Tirasemtiv as a Potential Treatment for Amyotrophic Lateral Sclerosis, Jeremy M. Shefner, Merit E. Cudkowicz, Orla Hardiman, Bettina M. Cockroft, Jacqueline H. Lee, Fady I. Malik, Lisa Meng, Stacy A. Rudnicki, Andrew A. Wolff, and Jinsy A. Andrews

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Challenges of targeting V600E mutations in adult primary brain tumor patients: a report of two cases, Matthew Smith-Cohn, Christian Davidson, Howard Colman, and Adam L. Cohen

A prospective study on gait dominant normal pressure hydrocephalus., Melissa Song, Abraham Lieberman, Terry D. Fife, Megan Nielsen, Sharon Hayden, Marwan Sabbagh, and Jiong Shi

Altered Functional Network Topology Correlates With Clinical Measures in Very Early-Stage Drug-Naïve Parkinson's Disease, Karthik Sreenivasan, Virendra Mishra, Christopher Bird, Xiaowei Zhuang, Zhengshi Yang, Dietmar Cordes, and Ryan R. Walsh

Impact of Zumba on Cognition and Quality of Life is Independent of APOE4 Carrier Status in Cognitively Unimpaired Older Women: A 6-Month Randomized Controlled Pilot Study, Cynthia M. Stonnington, Janina Krell-Roesch, Dona E.C. Locke, Joseph G. Hentz, Amylou C. Dueck, Yonas E. Geda, Pierre N. Tariot, and Richard J. Caselli

Emergency Preparedness of Secondary School Athletic Programs in Arizona, Tamara C. Valovich and Javier F. Cardenas

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Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics, Yogatheesan Varatharajah, Vijay K. Ramanan, Ravishankar Iyer, Prashanthi Vemuri, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, and Peter Snyder

Informant-based hearing difficulties and the risk for mild cognitive impairment and dementia, Maria Vassilaki, Jeremiah A. Aakre, David S. Knopman, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, Razan Al Fakir, Chaitanya Undavalli, Rosebud O. Roberts, and Ronald C. Petersen

The association of multimorbidity with preclinical AD stages and SNAP in cognitively unimpaired persons, Maria Vassilaki, Jeremiah A. Aakre, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Rabe E. Alhurani, Taru Dutt, Mary M. Machulda, David S. Knopman, Prashanthi Vemuri, Preciosa M. Coloma, Barbara Schauble, Val J. Lowe, Clifford R. Jack, Ronald C. Petersen, and Rosebud O. Roberts

Current treatment practice of Guillain-Barré syndrome, Christine Verboon, Alex Y. Doets, Giuliana Galassi, Amy Davidson, Waqar Waheed, Yann Péréon, Nortina Shahrizaila, Susumu Kusunoki, Helmar C. Lehmann, Thomas Harbo, Soledad Monges, Peter Van Den Bergh, Hugh J. Willison, David R. Cornblath, Bart C. Jacobs, R. A.C. Hughes, K. C. Gorson, H. P. Hartung, P. A. Van Doorn, B. Van den Berg, J. Roodbol, M. Van Woerkom, R. C. Reisin, S. W. Reddel, Z. Islam, B. Islam, Q. D. Mohammad, T. E. Feasby, E. Dardiotis, E. Nobile-Orazio, and K. Bateman

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The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest, Jessica S. Wallisch, Keri Janesko-Feldman, Henry Alexander, Ruchira M. Jha, George W. Farr, Paul R. McGuirk, Anthony E. Kline, Travis C. Jackson, Marc F. Pelletier, Robert S. Clark, Patrick M. Kochanek, and Mioara D. Manole

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Low-dose versus standard-dose alteplase in acute ischemic stroke in Asian stroke registries: an individual patient data pooling study, Xia Wang, Jingwei Li, Tom J. Moullaali, Keon-Joo Lee, Beom Joon Kim, Hee-Joon Bae, Anxin Wang, Yilong Wang, David Z. Wang, Yongjun Wang, Masaya Kumamoto, Kazunori Toyoda, Masatoshi Koga, Shoichiro Sato, Sohei Yoshimura, Yi Sui, Bing Xu, Ying Xiao, Tsong-Hai Lee, Chia-Wei Liou, Jiann-Der Lee, Tsung-I Peng, Yen-Chu Huang, Prakash R. Paliwal, Manasi Sharma, Cyrus Escabillas, Jose C. Navarro, Mu-Chien Sun, Yi Dong, Qiang Dong, and Craig S. Anderson

Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint, randomised controlled phase II trial., Yilong Wang, Weiqi Chen, Yi Lin, Xia Meng, Guohua Chen, Zhimin Wang, Jialing Wu, Dali Wang, Jianhua Li, Yibin Cao, Yuming Xu, Guohua Zhang, Xiaobo Li, Yuesong Pan, Hao Li, Xingquan Zhao, Liping Liu, Jinxi Lin, Kehui Dong, Jing Jing, S Claiborne Johnston, David Z. Wang, and Yongjun Wang

Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack., Yongjun Wang, S Claiborne Johnston, Philip M Bath, James C Grotta, Yuesong Pan, Pierre Amarenco, Yilong Wang, Tabassome Simon, Jong Sung Kim, Jiann-Shing Jeng, Liping Liu, Yi Lin, Ka Sing Lawrence Wong, David Z. Wang, and Hao Li

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial, Gil I. Wolfe, Henry J. Kaminski, Inmaculada B. Aban, Greg Minisman, Hui Chien Kuo, Alexander Marx, Philipp Ströbel, Claudio Mazia, Joel Oger, J. Gabriel Cea, Jeannine M. Heckmann, Amelia Evoli, Wilfred Nix, Emma Ciafaloni, Giovanni Antonini, Rawiphan Witoonpanich, John O. King, Said R. Beydoun, Colin H. Chalk, Alexandru C. Barboi, Anthony A. Amato, Aziz I. Shaibani, Bashar Katirji, Bryan R.F. Lecky, Camilla Buckley, Angela Vincent, Elza Dias-Tosta, Hiroaki Yoshikawa, Márcia Waddington-Cruz, Michael T. Pulley, and Michael H. Rivner

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Ketones Improves Apolipoprotein E4-Related Memory Deficiency Via Sirtuin 3, Junxiang Yin, Megan Nielsen, Shiping Li, and Jiong Shi

Adult growth hormone deficiency: clinical advances and approaches to improve adherence., Kevin C J Yuen, Sofia Llahana, and Bradley S Miller

New causes of hypophysitis., Kevin C J Yuen, Vera Popovic, and Peter J Trainer

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Non-coding variability at the APOE locus contributes to the Alzheimer’s risk, Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C.Y. Kwok, Vincent C.T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowski, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, Marek M. Mesulam, and William Potter

Submissions from 2018

EEG reactivity evaluation practices for adult and pediatric hypoxic-ischemic coma prognostication in North America, Edilberto Amorim, Emily J. Gilmore, Nicholas S. Abend, Cecil D. Hahn, Nicolas Gaspard, Susan T. Herman, Lawrence J. Hirsch, Jong Woo Lee, Sydney S. Cash, and M. Brandon Westover

Developing training programmes for eye teams, Lynn Anderson and Karl Golnik

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Vitality-ALS a Phase III Trial of Tirasemtiv a Selective Fast Skeletal Muscle Troponin Activator as a Potential Treatment for Patients With Amyotrophic Lateral Sclerosis: Study Design and Baseline Characteristics, Jinsy A. Andrews, Merit E. Cudkowicz, Orla Hardiman, Lisa Meng, Amy Bian, Jacqueline Lee, Andrew A. Wolff, Fady I. Malik, and Jeremy M. Shefner

Association Between Decline in Slow Vital Capacity and Respiratory Insufficiency Use of Assisted Ventilation Tracheostomy Or Death in Patients With Amyotrophic Lateral Sclerosis, Jinsy A. Andrews, Lisa Meng, Sarah F. Kulke, Stacy A. Rudnicki, Andrew A. Wolff, Michael E. Bozik, Fady I. Malik, and Jeremy M. Shefner

5HT6 Antagonists in the Treatment of Alzheimer's Dementia: Current Progress, Megan Andrews, Babak Tousi, and Marwan N. Sabbagh

What Promises the CJD Diagnosis in a Case of Rapidly Progressive Dementia?, Sana Aslam, Mason A. Fritz, Laura Cordes, and Marwan N. Sabbagh

Protective Effects of the Angiotensin II At 2 Receptor Agonist Compound 21 in Ischemic Stroke: A Nose-To-Brain Delivery Approach, Douglas M. Bennion, Chad H. Jones, Alex N. Dang, Jacob Isenberg, Justin T. Graham, Lena Lindblad, Oliver Domenig, Michael F. Waters, Marko Poglitsch, Colin Sumners, and Ulrike Muscha Steckelings

The Road Less Traveled, Anna D. Burke and William J. Burke

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Inflammatory bowel disease and risk of Parkinson's disease in Medicare beneficiaries, Alejandra Camacho-Soto, Anat Gross, Susan Searles Nielsen, Neelendu Dey, and Brad A. Racette

Association Between Pathology and Electroencephalographic Activity in Parkinson's Disease, John N. Caviness, Thomas G. Beach, Joseph G. Hentz, Holly A. Shill, Erika D. Driver-Dunckley, and Charles H. Adler

Intraoperative Test Stimulation Versus Stereotactic Accuracy as a Surgical End Point: A Comparison of Essential Tremor Outcomes After Ventral Intermediate Nucleus Deep Brain Stimulation, Tsinsue Chen, Zaman Mirzadeh, Kristina M. Chapple, Margaret Lambert, Virgilio G. Evidente, Guillermo Moguel-Cobos, Srivadee Oravivattanakul, Padma R. Mahant, and Francisco A. Ponce

A Randomized Phase II Study of Everolimus in Combination With Chemoradiation in Newly Diagnosed Glioblastoma: Results of NRG Oncology RTOG 0913, Prakash Chinnaiyan, Minhee Won, Patrick Y. Wen, Amyn M. Rojiani, Maria Werner-Wasik, Helen A. Shih, Lynn S. Ashby, Hsiang Hsuan Michael Yu, Volker W. Stieber, Shawn C. Malone, John B. Fiveash, Nimish A. Mohile, Manmeet S. Ahluwalia, Merideth M. Wendland, Philip J. Stella, Andrew Y. Kee, and Minesh P. Mehta

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[F]FDOPA positron emission tomography in manganese-exposed workers, Susan R. Criswell, Susan Searles Nielsen, Mark Warden, Joel S. Perlmutter, Stephen M. Moerlein, Hubert P. Flores, John Huang, Lianne Sheppard, Noah Seixas, Harvey Checkoway, and Brad A. Racette

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Selective D2 receptor PET in manganese-exposed workers, Susan R. Criswell, Mark N. Warden, Susan Searles Nielsen, Joel S. Perlmutter, Stephen M. Moerlein, Lianne Sheppard, Jason Lenox-Krug, Harvey Checkoway, and Brad A. Racette

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Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1109 Neurosciences, Jana Crum, Jeffrey Wilson, and Marwan Sabbagh

Regional variation of Guillain-Barré syndrome, Alex Y. Doets, Christine Verboon, Bianca van den Berg, Thomas Harbo, David R. Cornblath, Hugh J. Willison, Zhahirul Islam, Shahram Attarian, Fabio A. Barroso, Kathleen Bateman, Luana Benedetti, Peter van den Bergh, Carlos Casasnovas, Guido Cavaletti, Govindsinh Chavada, Kristl G. Claeys, Efthimios Dardiotis, Amy Davidson, Pieter A. van Doorn, Tom E. Feasby, Giuliana Galassi, Kenneth C. Gorson, Hans Peter Hartung, Sung Tsang Hsieh, Richard A.C. Hughes, Isabel Illa, Badrul Islam, Susumu Kusunoki, Satoshi Kuwabara, Helmar C. Lehmann, and James A.L. Miller

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The network of Shanghai Stroke Service System (4S): A public health-care web-based database using automatic extraction of electronic medical records, Yi Dong, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, Jianren Liu, Jianhua Zhuang, Panshi Wang, Xin Chen, Haipeng Shen, David Z. Wang, Ying Xian, Wuwei Feng, Bruce Cv Campbell, Mark Parsons, and Qiang Dong

Reliability of the Sway Balance Mobile Application: A Retrospective Analysis, Kristina L. Dunn, R. Curtis Bay, Javier F. Cardenas, Matthew Anastasi, Tamara C. Valovich McLeod, and Richelle M. Williams

National Football League Head Neck and Spine Committee's Concussion Diagnosis and Management Protocol: 2017-18 Season, Richard G. Ellenbogen, Hunt Batjer, Javier F. Cardenas, Mitchel Berger, Julian Bailes, Elizabeth Pieroth, Robert Heyer, Nicholas Theodore, Wellington Hsu, Elizabeth Nabel, Joe Maroon, Robert Cantu, Ronnie Barnes, James Collins, Margot Putukian, Russell Lonser, Gary Solomon, and Allen Sills

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Author Correction to: Pooled Analyses of Phase III Studies of ADS-5102 (Amantadine) Extended-Release Capsules for Dyskinesia in Parkinson's Disease, Lawrence W. Elmer, Jorge L. Juncos, Carlos Singer, Daniel D. Truong, Susan R. Criswell, Sotirios Parashos, Larissa Felt, Reed Johnson, and Rajiv Patni

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Pooled Analyses of Phase III Studies of ADS-5102 (Amantadine) Extended-Release Capsules for Dyskinesia in Parkinson's Disease, Lawrence W. Elmer, Jorge L. Juncos, Carlos Singer, Daniel D. Truong, Susan R. Criswell, Sotirios Parashos, Larissa Felt, Reed Johnson, and Rajiv Patni

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Bilateral Vestibular Dysfunction Associated With Chronic Exposure to Military Jet Propellant Type-Eight Jet Fuel., Terry D. Fife, Michael J A Robb, Kristen K Steenerson, and Kamala C Saha

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Vestibular Evoked Myogenic Potential Testing Payment Policy Review for Clinicians and Payers, Terry D. Fife, Saty Satya-Murti, Robert F. Burkard, and John P. Carey

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CPD? What happened to CME? CME and beyond, Helena P. Filipe, Karl C. Golnik, and Heather G. Mack

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Dynamical Properties of Postural Control in Obese Community-Dwelling Older Adults, Christopher W. Frames, Rahul Soangra, Thurmon E. Lockhart, John Lach, Dong Sam Ha, Karen A. Roberto, and Abraham N. Lieberman

Biomarkers of Cognitive Impairment, Ladan Ghazi-Saidi, Ryan R. Walsh, Guogen Shan, and Sarah J. Banks

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Neuropsychiatric Factors Linked to Adherence and Short-Term Outcome in a U.S. Functional Neurological Disorders Clinic: A Retrospective Cohort Study, Sean P. Glass, Nassim Matin, Benjamin Williams, Julie Mello, Christopher D. Stephen, Sigrid S. Young, Janet Callahan, W Curt LaFrance, and David L. Perez

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Use of medical care biases associations between Parkinson disease and other medical conditions, Anat Gross, Brad A. Racette, Alejandra Camacho-Soto, Umber Dube, and Susan Searles Nielsen

Are Clinical Certainty Ratings Helpful in the Diagnosis of Parkinson's Disease?, Harsh V. Gupta, Shyamal H. Mehta, Nan Zhang, Joseph G. Hentz, Holly A. Shill, Erika Driver-Dunckley, Marwan N. Sabbagh, Christine M. Belden, Brittany N. Dugger, Thomas G. Beach, Geidy E. Serrano, Lucia I. Sue, Kathryn Davis, and Charles H. Adler

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Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema, Pramod K. Guru, Anjali Agarwal, Mario Pimentel, Diane C. McLaughlin, and Vikas Bansal

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Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema, Pramod K. Guru, Anjali Agarwal, Mario Pimentel, Diane C. McLaughlin, and Vikas Bansal

Occipital and Cingulate Hypometabolism are Significantly Under-Reported on 18-Fluorodeoxyglucose Positron Emission Tomography Scans of Patients with Lewy Body Dementia, Moath Hamed, Frank Schraml, Jeffrey Wilson, James Galvin, and Marwan N. Sabbagh

Neuropsychological comparison of incident MCI and prevalent MCI, Allison Hansen, Richard J. Caselli, Gretchen Schlosser-Covell, Michael A. Golafshar, Amylou C. Dueck, Bryan K. Woodruff, Cynthia M. Stonnington, Yonas E. Geda, and Dona E.C. Locke

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No evidence of neurocognitive adverse events associated with alirocumab treatment in 3340 patients from 14 randomized Phase 2 and 3 controlled trials: A meta-analysis of individual patient data, Philip D. Harvey, Marwan N. Sabbagh, John E. Harrison, Henry N. Ginsberg, M. John Chapman, Garen Manvelian, Angele Moryusef, Jonas Mandel, and Michel Farnier

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Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease, Sheng Yao Huang, Jung Lung Hsu, Kun Ju Lin, Ho Ling Liu, Shiaw Pying Wey, Ing Tsung Hsiao, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, and Charles DeCarli

Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures, Aatif M. Husain, Jong W. Lee, Bradley J. Kolls, Lawrence J. Hirsch, Jonathan J. Halford, Puneet K. Gupta, Yafa Minazad, Jennifer M. Jones, Suzette M. LaRoche, Susan T. Herman, Christa B. Swisher, Saurabh R. Sinha, Adriana Palade, Keith E. Dombrowski, William B. Gallentine, Cecil D. Hahn, Elizabeth E. Gerard, Manjushri Bhapkar, Yuliya Lokhnygina, and M. Brandon Westover

Relationships Between Slow Vital Capacity and Measures of Respiratory Function on the ALSFRS-R, Carlayne Jackson, Mamede De Carvalho, Angela Genge, Terry Heiman-Patterson, Jeremy M. Shefner, Jenny Wei, and Andrew A. Wolff

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Ophthalmologic Findings in Patients with Neuro-metabolic Disorders, Narjes Jafari, Karl Golnik, Mansoor Shahriari, Parvaneh Karimzadeh, and Sayena Jabbehdari

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Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes, Ruchira M. Jha, Jonathan Elmer, Benjamin E. Zusman, Shashvat Desai, Ava M. Puccio, David O. Okonkwo, Seo Young Park, Lori A. Shutter, Jessica S. Wallisch, Yvette P. Conley, and Patrick M. Kochanek

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Regionally clustered polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury, Ruchira Menka Jha, Theresa A. Koleck, Ava M. Puccio, David O. Okonkwo, Seo-Young Park, Benjamin E. Zusman, Robert S. Clark, Lori A. Shutter, Jessica S. Wallisch, Philip E. Empey, Patrick M. Kochanek, and Yvette P. Conley

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A Precision Medicine Approach to Cerebral Edema and Intracranial Hypertension after Severe Traumatic Brain Injury: Quo Vadis?, Ruchira M. Jha and Patrick M. Kochanek

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Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice, Ruchira M. Jha, Bradley J. Molyneaux, Travis C. Jackson, Jessica S. Wallisch, Seo-Young Park, Samuel Poloyac, Vincent A. Vagni, Keri L. Janesko-Feldman, Keito Hoshitsuki, M Beth Minnigh, and Patrick M. Kochanek

Activation of JAK/STAT3 Restores NK-Cell Function and Improves Immune Defense After Brain Ischemia, Wei Na Jin, Andrew F. Ducruet, Qiang Liu, Samuel Xiang Yu Shi, Michael F. Waters, Ming Zou, Kevin N. Sheth, Rayna Gonzales, and Fu-Dong Shi

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Growth Hormone Research Society perspective on biomarkers of GH action in children and adults., Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, and Jens O L Jorgensen

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Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1, Jenny U. Johansson, William D. Brubaker, Harold Javitz, Andrew W. Bergen, Denise Nishita, Abhishek Trigunaite, Andrés Crane, Justine Ceballos, Diego Mastroeni, Andrea J. Tenner, Marwan Sabbagh, and Joseph Rogers

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA., S Claiborne Johnston, J Donald Easton, Mary Farrant, William Barsan, Robin A Conwit, Jordan J Elm, Anthony S Kim, Anne S Lindblad, and Yuko Y Palesch

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The illiterate brain and the neuropsychological assessment: From the past knowledge to the future new instruments, Parunyou Julayanont and Doungporn Ruthirago

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The Ophthalmology Surgical Competency Assessment Rubric (OSCAR) for anterior approach ptosis surgery, Valerie Juniat, Karl C. Golnik, Francesco P. Bernardini, Altug Cetinkaya, Aaron Fay, Bipasha Mukherjee, Farzad Pakdel, Brent Skippen, and George M. Saleh

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension, Raju Kapoor, Pei Ran Ho, Nolan Campbell, Ih Chang, Aaron Deykin, Fiona Forrestal, Nisha Lucas, Bei Yu, Douglas L. Arnold, Mark S. Freedman, Myla D. Goldman, Hans Peter Hartung, Eva Kubala Havrdová, Douglas Jeffery, Aaron Miller, Finn Sellebjerg, Diego Cadavid, Dan Mikol, Deborah Steiner, Emmanuel Bartholomé, Marie D'Hooghe, Massimo Pandolfo, Bart Van Wijmeersch, Virender Bhan, Gregg Blevins, Donald Brunet, Virginia Devonshire, Pierre Duquette, Mark Freedman, François Grand'Maison, and François Jacques

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Herpes Zoster Optic Neuropathy, Aaron R. Kaufman, Eileen M. Myers, Mark L. Moster, Jordan Stanley, Lanning B. Kline, and Karl C. Golnik

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Development, application, and results from a precision-medicine platform that personalizes multi-modal treatment plans for mild alzheimer’s disease and at-risk individuals, Dorothy Keine, John Q. Walker, Brian K. Kennedy, and Marwan N. Sabbagh

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Impact of Stroke Call on the Stroke Neurology Workforce in the United States: Possible Challenges and Opportunities, Edgar J. Kenton, Antonio Culebras, Pierre B. Fayad, Larry B. Goldstein, Brian Kaskie, Enrique C. Leira, Helmi L. Lutsep, Lawrence R. Wechsler, José Biller, Irene L. Katzan, James C. Stevens, David Z. Wang, Nellie Adams, and Carolyn Cahill

C-Terminal Proline Deletions in KCNC3 Cause Delayed Channel Inactivation and an Adult-Onset Progressive SCA13 With Spasticity, Swati Khare, Kira Galeano, Yalan Zhang, Jerelyn A. Nick, Harry S. Nick, S. H. Subramony, Jacinda Sampson, Leonard K. Kaczmarek, and Michael F. Waters

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Bevacizumab and Glioblastoma: Past, Present, and Future Directions, Michelle M. Kim, Yoshie Umemura, and Denise Leung

Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging, Janina Krell-Roesch, Nathanael T. Feder, Rosebud O. Roberts, Michelle M. Mielke, Teresa J. Christianson, David S. Knopman, Ronald C. Petersen, and Yonas E. Geda

Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: The Mayo Clinic Study of Aging, Janina Krell-Roesch, Val J. Lowe, Jennifer Neureiter, Anna Pink, Rosebud O. Roberts, Michelle M. Mielke, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Clifford R. Jack, David S. Knopman, Bradley F. Boeve, Walter K. Kremers, Ronald C. Petersen, and Yonas E. Geda

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The Ophthalmology Surgical Competency Assessment Rubric for Panretinal Photocoagulation, Janice C. Law, Karl C. Golnik, Edward F. Cherney, J Fernando Arevalo, Xiaoxin Li, and Kim Ramasamy

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Respiratory Measures in Amyotrophic Lateral Sclerosis, Noah Lechtzin, Merit E. Cudkowicz, Mamede de Carvalho, Angela Genge, Orla Hardiman, Hiroshi Mitsumoto, Jesus S. Mora, Jeremy M. Shefner, Leonard H. Van, and Jinsy A. Andrews

Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (The Advance Trial): A two Year Follow-Up Including Results of Delayed Activation, Jeannie Marie S. Leoutsakos, Haijuan Yan, William S. Anderson, Wael F. Asaad, Gordon Baltuch, Anna D. Burke, M. Mallar Chakravarty, Kristen E. Drake, Kelly D. Foote, Lisa Fosdick, Peter Giacobbe, Zoltan Mari, Mary Pat McAndrews, Cynthia A. Munro, Esther S. Oh, Michael S. Okun, Jo Cara Pendergrass, Francisco A. Ponce, Paul B. Rosenberg, and et al.

Identification of Therapeutic Targets in Chordoma Through Comprehensive Genomic and Transcriptomic Analyses, Winnie S. Liang, Christopher Dardis, Adrienne Helland, Shobana Sekar, Jonathan Adkins, Lori Cuyugan, Daniel Enriquez, Sara Byron, and Andrew S. Little

Downward Finger Displacement Distinguishes Parkinson Disease Dementia From Alzheimer Disease, Abraham N. Lieberman, Aman Deep, Jiong Shi, Rohit Dhall, Saulena Shafer, Guillermo Moguel-Cobos, Ravneet Dhillon, Christopher W. Frames, and Margaret McCauley

Anticholinergic Medications and Cognitive Function in Late Midlife, Martin M. Limback-Stokin, Janina Krell-Roesch, Kimberly Roesler, Allison Hansen, Cynthia M. Stonnington, M'Hamed Temkit, Richard J. Caselli, and Yonas E. Geda

Low- versus Standard-Dose Intravenous Tissue-Type Plasminogen Activator for Acute Ischemic Stroke: An Updated Meta-Analysis., Huihui Liu, Huaguang Zheng, Yongjun Cao, Yuesong Pan, David Z. Wang, Runhua Zhang, Shoujiang You, Xinmiao Zhang, Shuya Li, Xu Tong, Chun-Feng Liu, and Yilong Wang