ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

Authors

• Cecilia Lagging, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden. cecilia.lagging@gu.se.
• Erik Lorentzen, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Tara M. Stanne, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Annie Pedersen, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Martin Söderholm, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• John W. Cole, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Katarina Jood, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Robin Lemmens, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Chia-Ling Phuah, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Natalia S. Rost, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Vincent Thijs, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Daniel Woo, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Jane M. Maguire, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Arne Lindgren, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.
• Christina Jern, From the Department of Laboratory Medicine (C.L., T.M.S., A.P., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics (C.L., A.P., C.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Bioinformatics Core Facility (E.L.), University of Gothenburg, Sweden; Department of Clinical Sciences Lund (M.S., A.L.), Neurology, Lund University, Sweden; Department of Neurology and Rehabilitation Medicine (M.S.), Neurology, Skåne University Hospital, Malmö, Sweden; Department of Neurology (J.W.C.), Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience (K.J.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg, Sweden; Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB-Center for Brain & Disease Research (R.L.); Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurology (C.-L.P.), Washington University School of Medicine in St. Louis; J. Philip Kistler Stroke Research Center (N.S.R.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia; Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Faculty of Health (J.M.M.), University of Technology Sydney, Sydney, Australia; Hunter Medical Research Centre (J.M.M.), Newcastle, Australia; and Department of Neurology and Rehabilitation Medicine (A.L.), Neurology, Skåne University Hospital, Lund, Sweden.

Document Type

Article

Medical Subject Headings

Age of Onset; Alleles; Apolipoprotein E2 (genetics); Apolipoprotein E3 (genetics); Apolipoprotein E4 (genetics); Brain Ischemia (epidemiology, genetics, physiopathology); Genome-Wide Association Study; Genotype; Humans; Polymorphism, Single Nucleotide; Prognosis; Severity of Illness Index; Sex Factors; Stroke (epidemiology, genetics, physiopathology)

Publication Date

11-5-2019

Publication Title

Neurology

E-ISSN

1526-632X

Volume

93

Issue

19

First Page

849

Last Page

853

PubMed ID

31619479

Digital Object Identifier (DOI)

10.1212/WNL.0000000000008459

Recommended Citation

Lagging, Cecilia; Lorentzen, Erik; Stanne, Tara M.; Pedersen, Annie; Söderholm, Martin; Cole, John W.; Jood, Katarina; Lemmens, Robin; Phuah, Chia-Ling; Rost, Natalia S.; Thijs, Vincent; Woo, Daniel; Maguire, Jane M.; Lindgren, Arne; and Jern, Christina, "ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome" (2019). Neurology. 1739.
https://scholar.barrowneuro.org/neurology/1739