Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management

Yifan Zhou, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wei Li, Department of Neurology, Army Medical Center of PLA, Chongqing 400042, China.
David Wang, Neurovascular Division, Barrow Neurological Institute, Saint Joseph Hospital Medical Center, Phoenix, Arizona 85013, USA.Follow
Ling Mao, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Huijuan Jin, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yanan Li, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Candong Hong, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Shengcai Chen, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jiang Chang, Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430030, China.
Quanwei He, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Mengdie Wang, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Bo Hu, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China hubo@mail.hust.edu.cn.

Document Type

Article

Abstract

Coronavirus disease-2019 (COVID-19) has become a global pandemic. COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1-2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. The key is to prevent a patient from progressing to this severe infection from mild infection. We are sharing our experience on prevention and management of COVID-19.

Medical Subject Headings

Betacoronavirus (pathogenicity); COVID-19; COVID-19 Testing; Central Nervous System (physiopathology, virology); Central Nervous System Infections (diagnosis, physiopathology, therapy, virology); Clinical Laboratory Techniques; Coronavirus Infections (diagnosis, physiopathology, therapy, virology); Disease Progression; Early Diagnosis; Host-Pathogen Interactions; Humans; Pandemics; Pneumonia, Viral (diagnosis, physiopathology, therapy, virology); Predictive Value of Tests; Prognosis; SARS-CoV-2; Time Factors

Publication Date

6-1-2020

Publication Title

Stroke and vascular neurology

E-ISSN

2059-8696

Volume

5

Issue

2

First Page

177

Last Page

179

PubMed ID

32366614

Digital Object Identifier (DOI)

10.1136/svn-2020-000398

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