The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 2021

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Investigating cognition in midlife, Jan S. Novotný, Juan P. Gonzalez-Rivas, Jose R. Medina-Inojosa, Francisco Lopez-Jimenez, Yonas E. Geda, and Gorazd B. Stokin

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Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group, Alexander Olsen, Talin Babikian, Erin D. Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O'Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta K. Håberg, Ingrid Heggland, Torgeir Hellstrøm, Cooper B. Hodges, Andrei Irimia, Ruchira M. Jha, Paula K. Johnson, Vassilis E. Koliatsos, Harvey Levin, Lucia M. Li, Hannah M. Lindsey, Abigail Livny, Marianne Løvstad, John Medaglia, David K. Menon, Stefania Mondello, Martin M. Monti, Virginia F. Newcombe, Agustin Petroni, Jennie Ponsford, David Sharp, Gershon Spitz, and Lars T. Westlye

Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis, Sabrina Paganoni, Suzanne Hendrix, Samuel P. Dickson, Newman Knowlton, Eric A. Macklin, James D. Berry, Michael A. Elliott, Samuel Maiser, Chafic Karam, James B. Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A. Goutman, Daragh Heitzman, Terry D. Heiman-Patterson, Carlayne E. Jackson, Colin Quinn, Jeffrey D. Rothstein, Edward J. Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq Ladha, Timothy M. Miller, Stephen N. Scelsa, Tuan H. Vu, Christina N. Fournier, Jonathan D. Glass, Kristin M. Johnson, Andrea Swenson, and Namita A. Goyal

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The International Council of Ophthalmology Ophthalmic clinical evaluation exercise, Ana G. Palis, Jesús Barrio-Barrio, Eduardo P. Mayorga, Ilhem Mili-Boussen, Christelle D. Noche, Meenakshi Swaminathan, and Karl C. Golnik

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Polymorphisms and Clopidogrel Efficacy and Safety in Patients With Minor Stroke or TIA, Yuesong Pan, Runqi Wangqin, Hao Li, Yilong Wang, Xia Meng, S Claiborne Johnston, Tabassome Simon, Jinxi Lin, Xingquan Zhao, Liping Liu, David Wang, and Yongjun Wang

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NIA-AA Alzheimer's Disease Framework: Clinical Characterization of Stages, Ronald C. Petersen, Heather J. Wiste, Stephen D. Weigand, Julie A. Fields, Yonas E. Geda, Jonathan Graff-Radford, David S. Knopman, Walter K. Kremers, Val Lowe, Mary M. Machulda, Michelle M. Mielke, Nikki H. Stricker, Terry M. Therneau, Prashanthi Vemuri, and Clifford R. Jack

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A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment, Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, and Yonas E. Geda

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Dementia with Lewy bodies: emerging drug targets and therapeutics, Evans D. Pope, Laura Cordes, Jiong Shi, Zoltan Mari, Boris Decourt, and Marwan Noel Sabbagh

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Diagnosis of Early Alzheimer’s Disease: Clinical Practice in 2021, A. P. Porsteinsson, R. S. Isaacson, Sean Knox, M. N. Sabbagh, and I. Rubino

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Depression and anxiety in a manganese-exposed community, Brad A. Racette, Gill Nelson, Wendy W. Dlamini, Tamara Hershey, Pradeep Prathibha, Jay R. Turner, Harvey Checkoway, Lianne Sheppard, and Susan Searles Nielsen

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Severity of parkinsonism associated with environmental manganese exposure, Brad A. Racette, Gill Nelson, Wendy W. Dlamini, Pradeep Prathibha, Jay R. Turner, Mwiza Ushe, Harvey Checkoway, Lianne Sheppard, and Susan Searles Nielsen

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Foix-Chavany-Marie syndrome due to unilateral anterior opercular infarction with leukoaraiosis, Katherine Rivas, Jie Pan, Angela Chen, Bailey Gutiérrez, and Parunyou Julayanont

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Does Informant-Based Reporting of Cognitive Decline Correlate with Age-Adjusted Hippocampal Volume in Mild Cognitive Impairment and Alzheimer's Disease?, Marwan Sabbagh, Justin Miller, Stephen Jones, Aaron Ritter, Jiong Shi, Boris Decourt, and Dylan Wint

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Open Peer Commentary to “Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE Trials as reported by Biogen December 2019”, Marwan Noel Sabbagh and Jeffrey Cummings

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Therapeutic considerations for APOE and TOMM40 in Alzheimers disease: A tribute to Allen Roses MD, Marwan Noel Sabbagh, Evans Pope, Laura Cordes, Jiong Shi, and Boris DeCourt

Is diabetes associated with increased pathological burden in Alzheimer's disease?, Kaviyon Sadrolashrafi, Suzanne Craft, Boris Decourt, Abdu Adem, Jeffrey R. Wilson, Justin Miller, and Marwan N. Sabbagh

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Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium, Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, and Lawrence S. Honig

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Hospital Characteristics and Mortality in Aneurysmal Subarachnoid Hemorrhage, Tiffany O. Sheehan, Nicolle W. Davis, Brian C. Peach, Margaret Ansell, Jeannie P. Cimiotti, Yi Guo, Debra Lynch Kelly, Saunjoo L. Yoon, and Ann L. Horgas

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Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status, Xue Ning Shen, Yu Yuan Huang, Shi Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, and Ozioma Okonkwo

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Molecular clarification of brainstem astroblastoma with EWSR1-BEND2 fusion in a 38-year-old man, Matthew A. Smith-Cohn, Zied Abdullaev, Kenneth D. Aldape, Martha Quezado, Marc K. Rosenblum, Chad M. Vanderbilt, Fausto J. Rodriguez, John Laterra, and Charles G. Eberhart

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Molecularly Targeted Clinical Trials, Matthew A. Smith-Cohn, Orieta Celiku, and Mark R. Gilbert

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Effect of age on clinical trial outcome in participants with probable alzheimer's disease, Steven D. Targum, Lisa Fosdick, Kristen E. Drake, Paul B. Rosenberg, Anna D. Burke, David A. Wolk, Kelly D. Foote, Wael F. Asaad, Marwan Sabbagh, Gwenn S. Smith, Andres M. Lozano, and Constantine G. Lyketsos

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(Sulfonylurea Receptor-1) Impact on Brain Atrophy after Traumatic Brain Injury Varies by Sex, Swathi Tata, Benjamin E. Zusman, Patrick M. Kochanek, Volodymyr Gerzanich, Min Seong Kwon, Seung Kyoon Woo, Robert S. Clark, Keri Janesko-Feldman, Vincent A. Vagni, J Marc Simard, and Ruchira M. Jha

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Pneumocephalus: a radiological presentation of intracranial hypotension secondary to spinal anaesthesia, Thanita Thongtan, Parunyou Julayanont, and Victor Test

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Editorial: A Time of Transition of Alzheimer's Disease in the Advent of Anti-Amyloid Monoclonal Antibodies, Babak Tousi and Marwan Noel Sabbagh

Intravenous immunoglobulin treatment for mild Guillain-Barré syndrome: an international observational study., Christine Verboon, Thomas Harbo, David R Cornblath, Richard A C Hughes, Pieter A van Doorn, Michael P Lunn, Kenneth C Gorson, Fabio Barroso, Satoshi Kuwabara, Giuliana Galassi, Helmar C Lehmann, Susumu Kusunoki, Ricardo C Reisin, Davide Binda, Guido Cavaletti, Bart C Jacobs, and Shafeeq S. Ladha

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Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease (Nature Communications, (2020), 11, 1, (2612), 10.1038/s41467-020-15701-2), Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Michael Donohue, Matthew Bernstein, Nick Fox, and Paul Thompson

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Four distinct trajectories of tau deposition identified in Alzheimer’s disease, Jacob W. Vogel, Alexandra L. Young, Neil P. Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T. Strandberg, Renaud La Joie, Leon M. Aksman, Michel J. Grothe, Yasser Iturria-Medina, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, and Matthew Bernstein

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial, Brian J. Wainger, Eric A. Macklin, Steve Vucic, Courtney E. McIlduff, Sabrina Paganoni, Nicholas J. Maragakis, Richard Bedlack, Namita A. Goyal, Seward B. Rutkove, Dale J. Lange, Michael H. Rivner, Stephen A. Goutman, Shafeeq S. Ladha, Elizabeth A. Mauricio, Robert H. Baloh, Zachary Simmons, Lindsay Pothier, Sylvia Baedorf Kassis, Thuong La, Meghan Hall, Armineuza Evora, David Klements, Aura Hurtado, Joao D. Pereira, Joan Koh, Pablo A. Celnik, Vinay Chaudhry, Karissa Gable, Vern C. Juel, Nicolas Phielipp, and Adel Marei

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Predictors of indirect neural decompression in minimally invasive transpsoas lateral lumbar interbody fusion, Corey T. Walker, David S. Xu, Tyler S. Cole, Lea M. Alhilali, Jakub Godzik, Santiago Angel Estrada, Juan Pedro Giraldo, Joshua T. Wewel, Clinton D. Morgan, James J. Zhou, Alexander C. Whiting, S Harrison Farber, Nikolay L. Martirosyan, Jay D. Turner, and Juan S. Uribe

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Treating supratentorial intracerebral haemorrhage: hopeless? Or rethink our strategy, David Z. Wang, Liping Liu, Guohua Xi, and Yongjun Wang

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Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial, Guangyao Wang, Jing Jing, Jiejie Li, Yuesong Pan, Hongyi Yan, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, David Z. Wang, Yongjun Wang, and Yilong Wang

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Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial, Guangyao Wang, Jing Jing, Jiejie Li, Yuesong Pan, Hongyi Yan, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, David Z. Wang, Yongjun Wang, and Yilong Wang

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Clopidogrel Plus Aspirin in Patients With Different Types of Single Small Subcortical Infarction, Guangyao Wang, Xiaomeng Yang, Jing Jing, Xingquan Zhao, Liping Liu, Chunxue Wang, David Wang, Anxin Wang, Xia Meng, Yongjun Wang, and Yilong Wang

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A comparison of prediction approaches for identifying prodromal Parkinson disease, Mark N. Warden, Susan Searles Nielsen, Alejandra Camacho-Soto, Roman Garnett, and Brad A. Racette

Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial, Michael D. Weiss, Eric A. Macklin, Courtney E. McIlduff, Steve Vucic, Brian J. Wainger, Matthew C. Kiernan, Stephen A. Goutman, Namita A. Goyal, Seward B. Rutkove, Shafeeq S. Ladha, I. Hweii Amy Chen, Matthew B. Harms, Thomas H. Brannagan, David Lacomis, Sasha Zivkovic, Maxwell Ma, Leo H. Wang, Zachary Simmons, Michael H. Rivner, Jeremy M. Shefner, Merit E. Cudkowicz, and Nazem Atassi

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Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome, Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, and Bradley T. Christian

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Intravenous thrombolysis for acute ischaemic stroke during COVID-19 pandemic in Wuhan, China: a multicentre, retrospective cohort study, Yifan Zhou, Candong Hong, Jiang Chang, Yuanpeng Xia, Huijuan Jin, Yanan Li, Ling Mao, Yong Wang, Lei Zhang, Chunlian Pan, Jichuan Hu, Ming Huang, David Wang, Shengcai Chen, and Bo Hu

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Choice of Whole Blood versus Lactated Ringer's Resuscitation Modifies the Relationship between Blood Pressure Target and Functional Outcome after Traumatic Brain Injury plus Hemorrhagic Shock in Mice, Benjamin E. Zusman, C Edward Dixon, Ruchira M. Jha, Vincent A. Vagni, Jeremy J. Henchir, Shaun W. Carlson, Keri L. Janesko-Feldman, Zachary S. Bailey, Deborah A. Shear, Janice S. Gilsdorf, and Patrick M. Kochanek

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Multifaceted Benefit of Whole Blood Versus Lactated Ringer's Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice, Benjamin E. Zusman, Patrick M. Kochanek, Zachary S. Bailey, Lai Yee Leung, Vincent A. Vagni, David O. Okonkwo, Ava M. Puccio, Lori A. Shutter, Keri L. Janesko-Feldman, Janice S. Gilsdorf, Deborah A. Shear, and Ruchira M. Jha

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Cerebrospinal Fluid Sulfonylurea Receptor-1 is Associated with Intracranial Pressure and Outcome after Pediatric TBI: An Exploratory Analysis of the Cool Kids Trial, Benjamin E. Zusman, Patrick M. Kochanek, Michael J. Bell, P David Adelson, Stephen R. Wisniewski, Alicia K. Au, Robert S. Clark, Hülya Bayır, Keri Janesko-Feldman, and Ruchira M. Jha

Submissions from 2020

C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke., Saif Ahmad, Chirayu Pandya, Adam Kindelin, Kanchan Bhatia, Rafay Chaudhary, Alok Kumar Dwivedi, Jennifer M Eschbacher, Qiang Liu, Michael F Waters, Md Nasrul Hoda, and Andrew F. Ducruet

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Long-Term Safety Evaluation of Ubrogepant for the Acute Treatment of Migraine: Phase 3, Randomized, 52-Week Extension Trial., Jessica Ailani, Richard B Lipton, Susan Hutchinson, Kerry Knievel, Kaifeng Lu, Matthew Butler, Sung Yun Yu, Michelle Finnegan, Lawrence Severt, and Joel M Trugman

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Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry, Rahul Anil, Aditya Kumar, Sneha Alaparthi, Aditi Sharma, Joan L. Nye, Bhaskar Roy, Kevin C. O'Connor, and Richard J. Nowak

Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults, Eider M. Arenaza-Urquijo, Scott A. Przybelski, Mary M. MacHulda, David S. Knopman, Val J. Lowe, Michelle M. Mielke, Ashritha L. Reddy, Yonas E. Geda, Clifford R. Jack, Ronald C. Petersen, and Prashanthi Vemuri

Rare but life-threatening aspiration pneumonia related to initiation of clobazam therapy, Thandar Aung and Vladimir Shvarts

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Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer’s disease dementia, Thomas G. Beach, Charles H. Adler, Nan Zhang, Geidy E. Serrano, Lucia I. Sue, Erika Driver-Dunckley, Shayamal H. Mehta, Edouard E. Zamrini, Marwan N. Sabbagh, Holly A. Shill, Christine M. Belden, David R. Shprecher, Richard J. Caselli, Eric M. Reiman, Kathryn J. Davis, Kathy E. Long, Lisa R. Nicholson, Anthony J. Intorcia, Michael J. Glass, Jessica E. Walker, Michael M. Callan, Javon C. Oliver, Richard Arce, and Richard C. Gerkin

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Preliminary Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI (IVIM-DWI) Metrics in Alzheimer's Disease, Maurizio Bergamino, Ashley Nespodzany, Leslie C. Baxter, Anna Burke, Richard J. Caselli, Marwan N. Sabbagh, Ryan R. Walsh, and Ashley M. Stokes

Radicava / edaravone findings in biomarkers from ALS (REFINE ALS): Protocol and study design, James Berry, Benjamin Brooks, Angela Genge, Terry Heiman-Patterson, Stanley Appel, Michael Benatar, Robert Bowser, Merit Cudkowicz, Clifton Gooch, Jeremy Shefner, Jurjen Westra, Wendy Agnese, Charlotte Merrill, Sally Nelson, and Stephen Apple

Neuromuscular Electrical Stimulation for Venous Thromboembolism Prophylaxis and Its Effects on Somatosensory-Evoked Potentials: A Pretrial Study of a New, U.S. Food and Drug Administration-Approved Device, Michael A. Bohl, Christina A. Newell, Vladimir Shvarts, and Asim Haque

Cost-Effectiveness and Efficacy of a Novel Combination Regimen in Acromegaly: A Prospective, Randomized Trial., Vivien Bonert, James Mirocha, John Carmichael, Kevin C J Yuen, Takako Araki, and Shlomo Melmed

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Herpesvirus Infections and Risk of Parkinson's Disease, Alejandra Camacho-Soto, Irene Faust, Brad A. Racette, David B. Clifford, Harvey Checkoway, and Susan Searles Nielsen

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Fractures in the prodromal period of Parkinson disease, Alejandra Camacho-Soto, Anat Gross, Susan Searles Nielsen, Anna N. Miller, Mark N. Warden, Amber Salter, and Brad A. Racette

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[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers, Susan R. Criswell, Susan Searles Nielsen, Mark N. Warden, Joel S. Perlmutter, Stephen M. Moerlein, Lianne Sheppard, Jason Lenox-Krug, Harvey Checkoway, and Brad A. Racette

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Alzheimer's disease drug development pipeline: 2020, Jeffrey Cummings, Garam Lee, Aaron Ritter, Marwan Sabbagh, and Kate Zhong

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Emergency Department Length of Stay and Other Factors Contributing to Intracerebral Hemorrhage Patient Outcomes: An Executive Summary, Nicolle W. Davis, Tiffany O. Sheehan, Brian C. Peach, Margaret Ansell, Jeannie P. Cimiotti, Yi Guo, Debra Lynch Kelly, Ann L. Horgas, and Saunjoo L. Yoon

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MCLENA-1: A phase ii clinical trial for the assessment of safety, tolerability, and efficacy of lenalidomide in patients with mild cognitive impairment due to alzheimer’s disease, Boris Decourt, Jeffrey Wilson, Aaron Ritter, Christopher Dardis, Frank P. Difilippo, Xiaowei Zhuang, Dietmar Cordes, Garam Lee, Nadia D. Fulkerson, Tessa St Rose, Katurah Hartley, and Marwan N. Sabbagh

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Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage, Rajat Dhar, Guido J. Falcone, Yasheng Chen, Ali Hamzehloo, Elayna P. Kirsch, Rommell B. Noche, Kilian Roth, Julian Acosta, Andres Ruiz, Chia-Ling Phuah, Daniel Woo, Thomas M. Gill, Kevin N. Sheth, and Jin-Moo Lee

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Manganese exposure, parkinsonian signs, and quality of life in South African mine workers, Wendy W. Dlamini, Gill Nelson, Susan Searles Nielsen, and Brad A. Racette

Heterogeneity in Outcome Reporting in Endoscopic Endonasal Skull Base Reconstruction: A Systematic Review, Christina Dorismond, Griffin D. Santarelli, Brian D. Thorp, Adam J. Kimple, Charles S. Ebert, and Adam M. Zanation

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Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage, Guido J. Falcone, Elayna Kirsch, Julian N. Acosta, Rommell B. Noche, Audrey Leasure, Sandro Marini, Jaeyoon Chung, Magdy Selim, James F. Meschia, Devin L. Brown, Bradford B. Worrall, David L. Tirschwell, Jeremiasz M. Jagiella, Helena Schmidt, Jordi Jimenez-Conde, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Dipender Gill, Michael Holmes, Chia-Ling Phuah, Nils H. Petersen, Charles N. Matouk Md, Murat Gunel, Lauren Sansing, Derrick Bennett, Zhengming Chen, Luan L. Sun, Robert Clarke, Robin G. Walters, and Thomas M. Gill

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Validation of a Parkinson Disease Predictive Model in a Population-Based Study, Irene M. Faust, Brad A. Racette, and Susan Searles Nielsen

Neuro-Otology., Terry D. Fife

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A Rare Mutation Associated With Probable Late-Onset Leber's Hereditary Optic Neuropathy, Jacob J. Fondriest and Karl C. Golnik

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Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, and Nick Fox

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Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration, Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, Michael Weiner, Paul Aisen, Gerald Novak, Robert C. Green, Tom Montine, Ronald Petersen, Anthony Gamst, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Laurel Beckett, Danielle Harvey, John Kornak, Clifford R. Jack, Anders Dale, Matthew Bernstein, and Joel Felmlee

Gender Disparity and Potential Strategies for Improvement in Neurology and Clinical Neurophysiology, Gloria Galloway, Sarah Schmitt, Susan T. Herman, and Suzette La Roche

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Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report, Serge Gauthier, P. S. Aisen, J. Cummings, M. J. Detke, F. M. Longo, R. Raman, M. Sabbagh, L. Schneider, R. Tanzi, P. Tariot, M. Weiner, J. Touchon, and B. Vellas

The Pursuit of Training Meritorious Learners of Diverse Backgrounds: Mayo Clinic College of Medicine and Science, Yonas E. Geda and Fredric B. Meyer

Multidisciplinary management of acromegaly: A consensus., Andrea Giustina, Garni Barkhoudarian, Albert Beckers, Anat Ben-Shlomo, Nienke Biermasz, Beverly Biller, Cesar Boguszewski, Marek Bolanowski, Jens Bollerslev, Vivien Bonert, Marcello D Bronstein, Michael Buchfelder, Felipe Casanueva, Philippe Chanson, David Clemmons, Maria Fleseriu, Anna Maria Formenti, Pamela Freda, Monica Gadelha, Eliza Geer, Mark Gurnell, Anthony P Heaney, Ken K Y Ho, Adriana G Ioachimescu, Steven Lamberts, Edward Laws, Marco Losa, Pietro Maffei, Adam Mamelak, Moises Mercado, Mark Molitch, Pietro Mortini, Alberto M Pereira, Stephan Petersenn, Kalmon Post, Manuel Puig-Domingo, Roberto Salvatori, Susan L Samson, Ilan Shimon, Christian Strasburger, Brooke Swearingen, Peter Trainer, Mary L Vance, John Wass, Margaret E Wierman, Kevin C J Yuen, Maria Chiara Zatelli, and Shlomo Melmed

High-Density Adaptive Ten Ten: Proposal for Electrode Nomenclature for High-Density EEG, Walter Heine, Mary Ann Dobrota, Donald Schomer, Rebekah Wigton, and Susan Herman

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Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/s41598-019-49970-9), Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, and M. Marcel Mesulam

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Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke, Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H. Farias, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia-Ling Phuah, Robin Lemmens, Alessandro A. Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, Tomas Segura, and Gemma Serrano-Heras

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Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence, Ruchira M. Jha, Josh Bell, Giuseppe Citerio, J Claude Hemphill, W Taylor Kimberly, Raj K. Narayan, Juan Sahuquillo, Kevin N. Sheth, and J Marc Simard

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Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists, Huijuan Jin, Candong Hong, Shengcai Chen, Yifan Zhou, Yong Wang, Ling Mao, Yanan Li, Quanwei He, Man Li, Ying Su, David Wang, Longde Wang, and Bo Hu

A feasibility assessment of functioning and quality-of-life patient-reported outcome measures in adult epilepsy clinics: A systematic review, Felipe J.S. Jones, Farrah L. Ezzeddine, Susan T. Herman, Jeffrey Buchhalter, Brandy Fureman, and Lidia M.V.R. Moura

Implementing standardized provider documentation in a tertiary epilepsy clinic, Felipe J.S. Jones, Jason R. Smith, Neishay Ayub, Susan T. Herman, Jeffrey R. Buchhalter, Brandy E. Fureman, Sydney S. Cash, Daniel B. Hoch, and Lidia M.V.R. Moura

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Proactive interference apraxic agraphia: a writing and drawing disorder associated with corticobasal syndrome, Parunyou Julayanont, David W. Burks, and Kenneth M. Heilman

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Early-Motor Phenotype Relates to Neuropsychiatric and Cognitive Disorders in Huntington's Disease, Parunyou Julayanont, Kenneth M. Heilman, and Nikolaus R. McFarland

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Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence, Parunyou Julayanont, Nikolaus R. McFarland, and Kenneth M. Heilman

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Lasmiditan for the acute treatment of migraine: Subgroup analyses by prior response to triptans., Kerry Knievel, Andrew S Buchanan, Louise Lombard, Simin Baygani, Joel Raskin, John H Krege, Li Shen Loo, Mika Komori, and Joshua Tobin

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Neuropathological Findings in Parkinson's Disease With Mild Cognitive Impairment, Molly G. Knox, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal A. Mehta, Christine Belden, Edward Zamrini, Geidy Serrano, Marwan N. Sabbagh, John N. Caviness, Lucia I. Sue, Kathryn J. Davis, Brittany N. Dugger, and Thomas G. Beach

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Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision, Patrick M. Kochanek, Travis C. Jackson, Ruchira M. Jha, Robert S. Clark, David O. Okonkwo, Hülya Bayır, Samuel M. Poloyac, Amy K. Wagner, Philip E. Empey, Yvette P. Conley, Michael J. Bell, Anthony E. Kline, Corina O. Bondi, Dennis W. Simon, Shaun W. Carlson, Ava M. Puccio, Christopher M. Horvat, Alicia K. Au, Jonathan Elmer, Amery Treble-Barna, Milos D. Ikonomovic, Lori A. Shutter, D Lansing Taylor, Andrew M. Stern, Steven H. Graham, Valerian E. Kagan, Edwin K. Jackson, Stephen R. Wisniewski, and C Edward Dixon

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"Take a Number"-Precision Monitoring Directs Precision Therapy, Patrick M. Kochanek, Ruchira M. Jha, and Robert S. Clark

Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging, Janina Krell-Roesch, Jeremy A. Syrjanen, Michelle M. Mielke, Teresa J. Christianson, Walter K. Kremers, Mary M. MacHulda, David S. Knopman, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda

Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Michelle M. Mielke, Mary M. Machulda, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, and Yonas E. Geda

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Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions, Enrique C. Leira, Andrew N. Russman, José Biller, Devin L. Brown, Cheryl D. Bushnell, Valeria Caso, Angel Chamorro, Claire J. Creutzfeldt, Salvador Cruz-Flores, Mitchell S. Elkind, Pierre Fayad, Michael T. Froehler, Larry B. Goldstein, Nicole R. Gonzales, Brian Kaskie, Pooja Khatri, Sarah Livesay, David S. Liebeskind, Jennifer J. Majersik, Asma M. Moheet, Jose G. Romano, Nerses Sanossian, Lauren H. Sansing, Brian Silver, Alexis N. Simpkins, Wade Smith, David L. Tirschwell, David Z. Wang, Dileep R. Yavagal, and Bradford B. Worrall

Placebo effect in chronic inflammatory demyelinating polyneuropathy: The PATH study and a systematic review, Richard A. Lewis, David R. Cornblath, Hans Peter Hartung, Gens Sobue, John Philip Lawo, Orell Mielke, Billie L. Durn, Vera Bril, Ingemar S.J. Merkies, Paul Bassett, Alexa Cleasby, Ivo N. van Schaik, A. Sabet, K. George, L. Roberts, R. Carne, S. Blum, R. Henderson, P. Van Damme, J. Demeestere, S. Larue, C. D’Amour, P. Kunc, M. Valis, J. Sussova, T. Kalous, R. Talab, M. Bednar, T. Toomsoo, I. Rubanovits, and K. Gross-Paju

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Differential response to rituximab in anti-AChR and anti-MuSK positive myasthenia gravis patients: a single-center retrospective study, Tess Litchman, Bhaskar Roy, Aditya Kumar, Aditi Sharma, Valentine Njike, and Richard J. Nowak

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Approaches to global stroke care during the COVID-19 pandemic, Liping Liu, David Wang, Michael Brainin, Mitchell S. Elkind, Enrique Leira, and Yongjun Wang

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Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study, Yanan Li, Man Li, Mengdie Wang, Yifan Zhou, Jiang Chang, Ying Xian, David Wang, Ling Mao, Huijuan Jin, and Bo Hu

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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China, Ling Mao, Huijuan Jin, Mengdie Wang, Yu Hu, Shengcai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Xiaoping Miao, Yanan Li, and Bo Hu

Prevalence of ideal cardiovascular health in a Central European community: results from the Kardiovize Brno 2030 Project, Jose R. Medina-Inojosa, Manlio Vinciguerra, Andrea Maugeri, Sarka Kunzova, Ondřej Sochor, Narine Movsisyan, Yonas E. Geda, Gorazd B. Stokin, and Francisco Lopez-Jimenez

Long-Acting Growth Hormone Preparations - Current Status and Future Considerations., Bradley S Miller, Eric Velazquez, and Kevin C J Yuen

Phase 1-2 Trial of antisense oligonucleotide tofersen for SOD1 ALS, T. Miller, M. Cudkowicz, P. J. Shaw, P. M. Andersen, N. Atassi, R. C. Bucelli, A. Genge, J. Glass, S. Ladha, A. L. Ludolph, N. J. Maragakis, C. J. McDermott, A. Pestronk, J. Ravits, F. Salachas, R. Trudell, P. Van Damme, L. Zinman, C. F. Bennett, R. Lane, A. Sandrock, H. Runz, D. Graham, H. Houshyar, A. McCampbell, I. Nestorov, I. Chang, M. McNeill, L. Fanning, S. Fradette, and T. A. Ferguson

Rituximab in refractory chronic inflammatory demyelinating polyneuropathy, Suraj A. Muley, Bill Jacobsen, Gareth Parry, Uzma Usman, Erik Ortega, David Walk, Jeff Allen, Mamatha Pasnoor, Matthew Varon, and Mazen M. Dimachkie

Autoimmune Vestibulocerebellar Syndromes., Ram N Narayan, Andrew McKeon, and Terry D. Fife

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Validation of Parkinson's Disease-Related Questionnaires in South Africa, Gill Nelson, Ntombizodwa Ndlovu, Nicola Christofides, Tintswalo M. Hlungwani, Irene Faust, and Brad A. Racette

Risk Factors Underlying COVID-19 Lockdown-Induced Mental Distress, Jan Sebastian Novotný, Juan Pablo Gonzalez-Rivas, Šárka Kunzová, Mária Skladaná, Anna Pospíšilová, Anna Polcrová, Jose Ramon Medina-Inojosa, Francisco Lopez-Jimenez, Yonas Endale Geda, and Gorazd Bernard Stokin

Depressive symptoms and myeloproliferative neoplasms: Understanding the confounding factor in a complex condition, Leslie Padrnos, Robyn Scherber, Holly Geyer, Blake T. Langlais, Amylou C. Dueck, Heidi E. Kosiorek, Zhenya Senyak, Matthew Clark, Michael Boxer, Mary Cotter, Claire Harrison, Cynthia Stonnington, Yonas Geda, and Ruben Mesa