Risk Factors for High Symptom Burden Three Months after Traumatic Brain Injury and Implications for Clinical Trial Design: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.
Document Type
Article
Abstract
More than 75% of patients presenting to level I trauma centers in the United States with suspicion of TBI sufficient to require a clinical computed tomography scan report injury-related symptoms 3 months later. There are currently no approved treatments, and few clinical trials have evaluated possible treatments. Efficient trials will require subject inclusion and exclusion criteria that balance cost-effective recruitment with enrolling individuals with a higher chance of benefiting from the interventions. Using data from the
Medical Subject Headings
Humans; Brain Concussion; Brain Injuries, Traumatic; Risk Factors; Trauma Centers; United States; Clinical Trials as Topic
Publication Date
11-1-2022
Publication Title
Journal of neurotrauma
ISSN
1557-9042
Volume
39
Issue
21-22
First Page
1524
Last Page
1532
PubMed ID
35754333
Digital Object Identifier (DOI)
10.1089/neu.2022.0113
Recommended Citation
Temkin, Nancy; Machamer, Joan; Dikmen, Sureyya; Nelson, Lindsay D; Barber, Jason; Hwang, Phillip H; Boase, Kim; Stein, Murray B; Sun, Xiaoying; Giacino, Joseph; McCrea, Michael A; Taylor, Sabrina R; Jain, Sonia; and Manley, Geoff, "Risk Factors for High Symptom Burden Three Months after Traumatic Brain Injury and Implications for Clinical Trial Design: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study." (2022). Neurology. 1435.
https://scholar.barrowneuro.org/neurology/1435