Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging
Document Type
Article
Abstract
INTRODUCTION: We examined the association between cerebrospinal fluid (CSF)-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non-demented adults. METHODS: We included 784 persons (699 cognitively unimpaired, 85 with mild cognitive impairment) aged ≥ 50 years who underwent CSF amyloid beta (Aβ42), hyperphosphorylated tau 181 (p-tau), and total tau (t-tau) as well as NPS assessment using Beck Depression and Anxiety Inventories (BDI-II, BAI), and Neuropsychiatric Inventory Questionnaire (NPI-Q). RESULTS: Lower CSF Aβ42, and higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II ≥ 13), and clinical anxiety (BAI ≥ 10), as well as NPI-Q-assessed anxiety, apathy, and nighttime behavior. DISCUSSION: CSF Aβ42, t-tau/Aβ42, and p-tau/Aβ42 ratios were associated with NPS in community-dwelling individuals free of dementia. If confirmed by a longitudinal cohort study, the findings have clinical relevance of taking into account the NPS status of individuals with abnormal CSF biomarkers.
Publication Date
2-9-2022
Publication Title
Alzheimer's & dementia : the journal of the Alzheimer's Association
E-ISSN
1552-5279
PubMed ID
35142047
Digital Object Identifier (DOI)
10.1002/alz.12557
Recommended Citation
Krell-Roesch, Janina; Rakusa, Martin; Syrjanen, Jeremy A.; van Harten, Argonde C.; Lowe, Val J.; Jack, Clifford R.; Kremers, Walter K.; Knopman, David S.; Stokin, Gorazd B.; Petersen, Ronald C.; Vassilaki, Maria; and Geda, Yonas E., "Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging" (2022). Neurology. 1219.
https://scholar.barrowneuro.org/neurology/1219