IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature

Authors

Ellen K. Chang, Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Matthew A. Smith-Cohn, Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.Follow
Benita Tamrazi, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jianling Ji, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Mark Krieger, Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Matthias Holdhoff, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Charles G. Eberhart, Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA.
Ashley S. Margol, Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jennifer A. Cotter, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Document Type

Article

Abstract

Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH-mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.

Medical Subject Headings

Adult; Brain Neoplasms (genetics, pathology); Brain Stem (pathology); Brain Stem Neoplasms (diagnosis, genetics, pathology); Glioma (diagnosis, genetics, pathology); Humans; Isocitrate Dehydrogenase (genetics); Male; Mutation (genetics); Young Adult

Publication Date

7-1-2021

Publication Title

Brain pathology (Zurich, Switzerland)

E-ISSN

1750-3639

Volume

31

Issue

4

First Page

e12959

PubMed ID

33960568

Digital Object Identifier (DOI)

10.1111/bpa.12959

Recommended Citation

Chang, Ellen K.; Smith-Cohn, Matthew A.; Tamrazi, Benita; Ji, Jianling; Krieger, Mark; Holdhoff, Matthias; Eberhart, Charles G.; Margol, Ashley S.; and Cotter, Jennifer A., "IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature" (2021). Neurology. 1747.
https://scholar.barrowneuro.org/neurology/1747