The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2023
Treatment patterns for patients initiating novel acute migraine specific medications (nAMSMs) in the context of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway., Zifan Zhou, Robert Urman, Karminder Gill, Andrew S Park, Fiston Vuvu, Leah B Patel, Jingsong Lu, Rolin L Wade, Lindsay Frerichs, and Mark E Bensink
Benchmarking Hospital Practices and Policies on Intrahospital Neurocritical Care Transport: The Safe-Neuro-Transport Study, Kapil G. Zirpe, Bhunyawee Alunpipatthanachai, Nassim Matin, Bernice G. Gulek, Patricia A. Blissitt, Katherine Palmieri, Kathryn Rosenblatt, Umeshkumar Athiraman, Suneeta Gollapudy, Marie Angele Theard, Sarah Wahlster, Monica S. Vavilala, Abhijit V. Lele, and Safe-Neuro-Transport Collaborators
Submissions from 2022
Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values., Samuel Arends, Judith Drenthen, Peter van den Bergh, Hessel Franssen, Robert D M Hadden, Badrul Islam, Satoshi Kuwabara, Ricardo C Reisin, Nortina Shahrizaila, Hiroshi Amino, Giovanni Antonini, Shahram Attarian, Claudia Balducci, Fabio Barroso, Tulio Bertorini, Davide Binda, Thomas H Brannagan, Jan Buermann, Carlos Casasnovas, Guido Cavaletti, Chi-Chao Chao, Mazen M Dimachkie, Ernesto A Fulgenzi, Giuliana Galassi, Gerardo Gutiérrez Gutiérrez, Thomas Harbo, Hans-Peter Hartung, Sung-Tsang Hsieh, Lynette Kiers, Helmar C Lehmann, Fiore Manganelli, Girolama A Marfia, Giorgia Mataluni, Julio Pardo, Yann Péréon, Yusuf A Rajabally, Lucio Santoro, Yukari Sekiguchi, Beth Stein, Mark Stettner, Antonino Uncini, Christine Verboon, Camiel Verhamme, Michal Vytopil, Waqar Waheed, Min Wang, Sasha Zivkovic, Bart C Jacobs, David R Cornblath, and Shafeeq S. Ladha
Increased serum uric acid level is associated with better outcome after endovascular treatment for acute ischemic stroke-a prospective cohort study, Haiwei Bai, Ximing Nie, Xinyi Leng, David Wang, Yuesong Pan, Hongyi Yan, Zhonghua Yang, Miao Wen, Yuehua Pu, Zhe Zhang, Wanying Duan, Ning Ma, Zhongrong Miao, Xiran Liu, Qixuan Lu, Yufei Wei, Liping Liu, and Junyan Liu
Sex-specific lesion pattern of functional outcomes after stroke, Anna K. Bonkhoff, Martin Bretzner, Sungmin Hong, Markus D. Schirmer, Alexander Cohen, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, Stephen Bevan, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, and Arndt Rolfs
Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome, Anna K. Bonkhoff, Sungmin Hong, Martin Bretzner, Markus D. Schirmer, Robert W. Regenhardt, E Murat Arsava, Kathleen Donahue, Marco Nardin, Adrian Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa McIntosh, John Attia, Oscar Benavente, John W. Cole, Amanda Donatti, Christoph Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven Kittner, Robin Lemmens, Christopher Levi, Caitrin W. McDonough, James Meschia, Chia-Ling Phuah, Arndt Rolfs, and Stefan Ropele
Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics, Anna K. Bonkhoff, Teresa Ullberg, Martin Bretzner, Sungmin Hong, Markus D. Schirmer, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa C. McIntosh, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, and Jaume Roquer
Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury., Lanya T Cai, Benjamin L Brett, Eva M Palacios, Esther L Yuh, Ioanna Bourla, Jamie Wren-Jarvis, Yang Wang, Christine Mac Donald, Ramon Diaz-Arrastia, Joseph T Giacino, David O Okonkwo, Harvey S Levin, Claudia S Robertson, Nancy Temkin, Amy J Markowitz, Geoffrey T Manley, Murray B Stein, Michael A McCrea, Ross D Zafonte, Lindsay D Nelson, and Pratik Mukherjee
Incidence of Amyotrophic Lateral Sclerosis in Older Adults., Alejandra Camacho-Soto, Susan Searles Nielsen, Irene M Faust, Robert C Bucelli, Timothy M Miller, and Brad A Racette
Liver Cirrhosis and Inpatient Mortality in Aneurysmal Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis, Joshua S. Catapano, Katriel E. Lee, Kavelin Rumalla, Visish M. Srinivasan, Tyler S. Cole, Jacob F. Baranoski, Ethan A. Winkler, Christopher S. Graffeo, Muhaiman Alabdly, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia, Boris Decourt, Keith Noorda, Kevin Noorda, Jiong Shi, and Marwan N. Sabbagh
The importance of genomics in advancing the diagnosis and treatment of dementia, Boris Decourt and Marwan N. Sabbagh
Long-term Safety and Efficacy of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease, Mazen M. Dimachkie, Richard J. Barohn, Barry Byrne, Ozlem Goker-Alpan, Priya S. Kishnani, Shafeeq Ladha, Pascal Laforêt, Karl Eugen Mengel, Loren D. Peña, Sabrina Sacconi, Volker Straub, Jaya Trivedi, Philip Van Damme, Ans T. van der Ploeg, John Vissing, Peter Young, Kristina An Haack, Meredith Foster, Jane M. Gilbert, Patrick Miossec, Olivier Vitse, Tianyue Zhou, and Benedikt Schoser
Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score., Alex Y Doets, Hester F Lingsma, Christa Walgaard, Badrul Islam, Nowshin Papri, Amy Davidson, Yuko Yamagishi, Susumu Kusunoki, Mazen M Dimachkie, Waqar Waheed, Noah Kolb, Zhahirul Islam, Quazi Deen Mohammad, Thomas Harbo, Soren H Sindrup, Govindsinh Chavada, Hugh J Willison, Carlos Casasnovas, Kathleen Bateman, James A L Miller, Bianca van den Berg, Christine Verboon, Joyce Roodbol, Sonja E Leonhard, Luana Benedetti, Satoshi Kuwabara, Peter Van den Bergh, Soledad Monges, Girolama A Marfia, Nortina Shahrizaila, Giuliana Galassi, Yann Péréon, Jan Bürmann, Krista Kuitwaard, Ruud P Kleyweg, Cintia Marchesoni, María J Sedano Tous, Luis Querol, Isabel Illa, Yuzhong Wang, Eduardo Nobile-Orazio, Simon Rinaldi, Angelo Schenone, Julio Pardo, Frederique H Vermeij, Helmar C Lehmann, Volkan Granit, Guido Cavaletti, Gerardo Gutiérrez-Gutiérrez, Fabio A Barroso, Leo H Visser, Hans D Katzberg, Efthimios Dardiotis, Shahram Attarian, Anneke J van der Kooi, Filip Eftimov, Paul W Wirtz, Johnny P A Samijn, H Jacobus Gilhuis, Robert D M Hadden, James K L Holt, Kazim A Sheikh, Summer Karafiath, Michal Vytopil, Giovanni Antonini, Thomas E Feasby, Catharina G Faber, Cees J Gijsbers, Mark Busby, Rhys C Roberts, Nicholas J Silvestri, Raffaella Fazio, Gert W van Dijk, Marcel P J Garssen, Chiara S M Straathof, Kenneth C Gorson, Bart C Jacobs, and Shafeeq S. Ladha
International Validation of the Erasmus Guillain-Barré Syndrome Respiratory Insufficiency Score., Alex Y Doets, Christa Walgaard, Hester F Lingsma, Badrul Islam, Nowshin Papri, Yuko Yamagishi, Susumu Kusunoki, Mazen M Dimachkie, Waqar Waheed, Noah Kolb, Kenneth C Gorson, Bart C Jacobs, and Shafeeq S. Ladha
Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns, Yi Dong, Yi Sui, Xin Cheng, and David Z. Wang
Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation., Stefania Galimberti, Francesca Graziano, Andrew I R Maas, Giulia Isernia, Fiona Lecky, Sonia Jain, Xiaoying Sun, Raquel C Gardner, Sabrina R Taylor, Amy J Markowitz, Geoffrey T Manley, Maria Grazia Valsecchi, Giuseppe Bellelli, and Giuseppe Citerio
Anatomical positional changes in the lateral lumbar interbody fusion, Shashank V. Gandhi, Robert Dugan, Samuel H. Farber, Jakub Godzik, Lea Alhilali, and Juan S. Uribe
Employment and Economic Outcomes of Participants With Mild Traumatic Brain Injury in the TRACK-TBI Study., Étienne Gaudette, Seth A Seabury, Nancy Temkin, Jason Barber, Anthony M DiGiorgio, Amy J Markowitz, and Geoffrey T Manley
Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke, Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H. Farias, Jorge L. Del Aguila, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia Ling Phuah, Robin Lemmens, Alessandro A. Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, and Tomas Segura
The Montreal Cognitive Assessment (MoCA) in neuro-oncology: A pilot study of feasibility and utility in telehealth and in-person clinical assessments, Varna Jammula, James L. Rogers, Elizabeth Vera, Alexa Christ, Heather E. Leeper, Alvina Acquaye, Nicole Briceno, Anna Choi, Ewa Grajkowska, Jason E. Levine, Matthew Lindsley, Jennifer Reyes, Kayla N. Roche, Michael Timmer, Lisa Boris, Eric Burton, Nicole Lollo, Marissa Panzer, Matthew A. Smith-Cohn, Marta Penas-Prado, Valentina Pillai, Brett J. Theeler, Jing Wu, Mark R. Gilbert, and Terri S. Armstrong
Monogenic Stroke-Can We Overcome Nature With Nurture?, Ruchira M. Jha
Do We Need an ICU for All Elective Postcraniotomy Patients? A Critical Appraisal, Ruchira Menka Jha
Validity of the Clinical Dementia Rating Scale Sum of Boxes in Staging and Detection of Cognitive Impairment in Mexican Americans, Parunyou Julayanont and John C. DeToledo
Frontotemporal Dementia and the Sagging Brain, Parunyou Julayanont and Meredith Wicklund
The Ophthalmology Surgical Competency Assessment Rubric (OSCAR) for Open Globe Surgical Management, Grant A. Justin, Mohammed Soleimani, Sidra Zafar, Kasra Cheraqpour, Catherine Green, Mohammad Moin, N Venkatesh Prajna, Karl C. Golnik, and Fasika A. Woreta
Pharmacologic Mydriasis Secondary to Topical Glycopyrronium Tosylate Cloths: Clinical Characterization From a Multicenter Analysis, Aaron R. Kaufman, Shawn Gulati, John H. Pula, Timothy M. Janetos, Neena R. Cherayil, Eric Chiu, Emily Anne Shepherd, Karl C. Golnik, Enrique Garcia-Valenzuela, Peter W. MacIntosh, Brooke T. Johnson, and Kimberlee M. Curnyn
Health Care Expenditures Associated with Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis, Stefan W. Koester, Joshua S. Catapano, Kavelin Rumalla, Stephen J. Dabrowski, Dimitri Benner, Ethan A. Winkler, Tyler S. Cole, Jacob F. Baranoski, Visish M. Srinivasan, Christopher S. Graffeo, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton
CD11b B Cells Increase after Stroke and Regulate Microglia, Janelle M. Korf, Pedram Honarpisheh, Eric C. Mohan, Anik Banerjee, Maria P. Blasco-Conesa, Parisa Honarpisheh, Gary U. Guzman, Romeesa Khan, Bhanu P. Ganesh, Amy L. Hazen, Juneyoung Lee, Aditya Kumar, Louise D. McCullough, and Anjali Chauhan
Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging, Janina Krell-Roesch, Martin Rakusa, Jeremy A. Syrjanen, Argonde C. van Harten, Val J. Lowe, Clifford R. Jack, Walter K. Kremers, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda
Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD, Gopinath Krishnan, Denitza Raitcheva, Daniel Bartlett, Mercedes Prudencio, Diane M. McKenna-Yasek, Catherine Douthwright, Björn E. Oskarsson, Shafeeq Ladha, Oliver D. King, Sami J. Barmada, Timothy M. Miller, Robert Bowser, Jonathan K. Watts, Leonard Petrucelli, Robert H. Brown, Mark W. Kankel, and Fen-Biao Gao
Twenty Years of the Health Insurance Portability and Accountability Act Safe Harbor Provision: Unsolved Challenges and Ways Forward, Brittany Krzyzanowski and Steven M. Manson
Dynamic susceptibility contrast and diffusion-weighted MRI in posterior fossa pilocytic astrocytoma and medulloblastoma, Ryo Kurokawa, Yoshie Umemura, Aristides Capizzano, Mariko Kurokawa, Akira Baba, Adam Holmes, John Kim, Yoshiaki Ota, Ashok Srinivasan, and Toshio Moritani
Efficacy and toxicity with radiation field designs and concurrent temozolomide for CNS lymphoma, Anna M. Laucis, Katherine Selwa, Yilun Sun, Michelle M. Kim, Kyle C. Cuneo, Theodore S. Lawrence, Daniel R. Wahl, Larry Junck, and Yoshie Umemura
Decreased DNA Methylation of RGMA is Associated with Intracranial Hypertension After Severe Traumatic Brain Injury: An Exploratory Epigenome-Wide Association Study, Dongjing Liu, Benjamin E. Zusman, John R. Shaffer, Yunqi Li, Annie I. Arockiaraj, Shuwei Liu, Daniel E. Weeks, Shashvat M. Desai, Patrick M. Kochanek, Ava M. Puccio, David O. Okonkwo, Yvette P. Conley, and Ruchira M. Jha
Outcomes in Patients With Mild Traumatic Brain Injury Without Acute Intracranial Traumatic Injury., Debbie Y Madhok, Robert M Rodriguez, Jason Barber, Nancy R Temkin, Amy J Markowitz, Natalie Kreitzer, and Geoffrey T Manley
Poststroke motor, cognitive and speech rehabilitation with brain-computer interface: a perspective review, Ravikiran Mane, Zhenzhou Wu, and David Wang
Brain-Lung Crosstalk: Management of Concomitant Severe Acute Brain Injury and Acute Respiratory Distress Syndrome, Nassim Matin, Kasra Sarhadi, C Patrick Crooks, Abhijit V. Lele, Vasisht Srinivasan, Nicholas J. Johnson, Chiara Robba, James A. Town, and Sarah Wahlster
Neuropathologic validation of the Alzheimer's Questionnaire, Ida Mohebpour, Michael Malek-Ahmadi, Thomas Virden, Angela Breitmeyer, Marwan N. Sabbagh, Briana Auman, Christine M. Belden, Parichita Choudhury, Autumn Arch, Kathryn Davis, Carol Cline, Naudia Moorley, Alireza Atri, Geidy Serrano, and Thomas G. Beach
Ophthalmology foundation Ophthalmic Surgical Competency Assessment Rubric (OSCAR) for pterygium surgery, Muhammad Moin, Karl C. Golnik, Sepehr Feizi, Agvaandorj Buyandelger, and Rosa E. Adrianzen
Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials, Moyra E. Mortby, Lawrence Adler, Luis Agüera-Ortiz, Daniel R. Bateman, Henry Brodaty, Marc Cantillon, Yonas E. Geda, Zahinoor Ismail, Krista L. Lanctôt, Gad A. Marshall, Prasad R. Padala, Antonios Politis, Paul B. Rosenberg, Kostas Siarkos, David L. Sultzer, and Christos Theleritis
Between Scylla and Charybdis: risks of early therapeutic anticoagulation for venous thromboembolism after acute intracranial hemorrhage., Thuhien Nguyen, Monisha Sharma, Patrick Crooks, Pratik V Patel, Robert H Bonow, Claire J Creutzfeldt, and Sarah Wahlster
Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion, Ximing Nie, David Wang, Yuehua Pu, Yufei Wei, Qixuan Lu, Hongyi Yan, Xin Liu, Lina Zheng, Jingyi Liu, Xinxuan Yang, Yarong Ding, Dacheng Liu, Wanying Duan, Zhe Zhang, Zhonghua Yang, Miao Wen, Weibin Gu, Xinyi Hou, Xinyi Leng, Yuesong Pan, Zhongrong Miao, and Liping Liu
Natural Pattern of Cognitive Aging, Jan S. Novotný, Juan P. Gonzalez-Rivas, Maria Vassilaki, Janina Krell-Roesch, Yonas E. Geda, and Gorazd B. Stokin
Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development., Sabrina Paganoni, James D Berry, Melanie Quintana, Eric Macklin, Benjamin R Saville, Michelle A Detry, Marianne Chase, Alexander V Sherman, Hong Yu, Kristin Drake, Jinsy Andrews, Jeremy Shefner, Lori B Chibnik, Matteo Vestrucci, Merit E Cudkowicz, and Shafeeq S. Ladha
Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial, Sabrina Paganoni, Suzanne Hendrix, Samuel P. Dickson, Newman Knowlton, James D. Berry, Michael A. Elliott, Samuel Maiser, Chafic Karam, James B. Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A. Goutman, Daragh Heitzman, Terry D. Heiman-Patterson, Carlayne Jackson, Colin Quinn, Jeffrey D. Rothstein, Edward J. Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq S. Ladha, Timothy M. Miller, Stephen N. Scelsa, Tuan H. Vu, Christina Fournier, Kristin M. Johnson, Andrea Swenson, Namita Goyal, Gary L. Pattee, Suma Babu, and Marianne Chase
Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies, Chia-Ling Phuah, Yasheng Chen, Jeremy F. Strain, Nirupama Yechoor, Osvaldo J. Laurido-Soto, Beau M. Ances, and Jin-Moo Lee
Environmental manganese exposure and cognitive control in a South African population, Brad A. Racette, Gill Nelson, Wendy W. Dlamini, Tamara Hershey, Pradeep Prathibha, Jay R. Turner, Harvey Checkoway, Lianne Sheppard, and Susan Searles Nielsen
Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial, Michael S. Rafii, Olivier Sol, William C. Mobley, Saskia Delpretti, Brian G. Skotko, Anna D. Burke, Marwan N. Sabbagh, Shauna H. Yuan, Robert A. Rissman, Margaret Pulsifer, Casey Evans, A Carol Evans, Gregory Beth, Nicolas Fournier, Julian A. Gray, Antonio Melo Dos Santos, Valerie Hliva, Marija Vukicevic, Marie Kosco-Vilbois, Johannes Streffer, Andrea Pfeifer, and Howard H. Feldman
Pearls & Oy-sters: Pivoting Treatment Regimens of Pediatric Atypical Teratoid Rhabdoid Tumors to Optimize Care in Adult ATRT: A Case Report, Rohan Rao, Abigail Koehler, Yehudit Rothman, Brandi Turner, Jamie Denlinger, Melissa Erickson, Matthew Hagen, Timothy S. Braverman, Abdelkader Mahammedi, Karl Golnik, Mario Zuccarello, Yair M. Gozal, E Randolph Broun, Susan N. Chi, and Soma Sengupta
Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease, Ana Sofía Ríos, Simón Oxenford, Clemens Neudorfer, Konstantin Butenko, Ningfei Li, Nanditha Rajamani, Alexandre Boutet, Gavin J. Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Fuyixue Wang, Kawin Setsompop, Bryan Salvato, Leonardo Brito Almeida, Kelly D. Foote, Robert Amaral, Paul B. Rosenberg, David F. Tang-Wai, David A. Wolk, Anna D. Burke, Stephen Salloway, Marwan N. Sabbagh, M Mallar Chakravarty, Gwenn S. Smith, Constantine G. Lyketsos, Michael S. Okun, William S. Anderson, Zoltan Mari, Francisco A. Ponce, Andres M. Lozano, and Andreas Horn
COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease, Marwan N. Sabbagh and Boris Decourt
Primary prevention recommendations to reduce the risk of cognitive decline, Marwan N. Sabbagh, Adriana Perez, Thomas M. Holland, Malaz Boustani, Stephanie R. Peabody, Kristine Yaffe, Michelle Bruno, Russell Paulsen, Kelly O'Brien, Naila Wahid, and Rudolph E. Tanzi
Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report, Sanjit Shah, Saima Manzoor, Yehudit Rothman, Matthew Hagen, Luke Pater, Karl Golnik, Abdelkader Mahammedi, Andrew L. Lin, Ruchi Bhabhra, Jonathan A. Forbes, and Soma Sengupta
Predictors of Time to Aneurysm Repair and Mortality in Aneurysmal Subarachnoid Hemorrhage, Tiffany O. Sheehan, Nicolle W. Davis, Yi Guo, Debra Lynch Kelly, Saunjoo L. Yoon, and Ann L. Horgas
Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?, Matthew A. Smith-Cohn, Nicholas B. Burley, and Stuart A. Grossman
Liquid biopsy in gliomas: A RANO review and proposals for clinical applications, Riccardo Soffietti, Chetan Bettegowda, Ingo K. Mellinghoff, Katherine E. Warren, Manmeet S. Ahluwalia, John F. De Groot, Evanthia Galanis, Mark R. Gilbert, Kurt A. Jaeckle, Emilie Le Rhun, Roberta Rudà, Joan Seoane, Niklas Thon, Yoshie Umemura, Michael Weller, Martin J. van den Bent, Michael A. Vogelbaum, Susan M. Chang, and Patrick Y. Wen
Vascular endothelial-cadherin as a marker of endothelial injury in preclinical Alzheimer disease, Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia-Ling Phuah, Jason Hassenstab, and Carlos Cruchaga
Risk Factors for High Symptom Burden Three Months after Traumatic Brain Injury and Implications for Clinical Trial Design: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study., Nancy Temkin, Joan Machamer, Sureyya Dikmen, Lindsay D Nelson, Jason Barber, Phillip H Hwang, Kim Boase, Murray B Stein, Xiaoying Sun, Joseph Giacino, Michael A McCrea, Sabrina R Taylor, Sonia Jain, and Geoff Manley
Inpatient long-term video-electroencephalographic monitoring event capture audiovisual diagnostic quality, Samuel Waller Terman, Susanna S. O'Kula, Melissa Marie Asmar, Kathryn A. Davis, Deana M. Gazzola, Rodica Lesanu, Laura George, Linda M. Selwa, Simon M. Glynn, and Chloe E. Hill
Increased creativity associated with dopamine agonist therapy: A case report and short review of the literature, Smathorn Thakolwiboon, Amputch Karukote, Parunyou Julayanont, and Henrik Wilms
Discordance Between Perceptions and Experience of Lumbar Puncture: A Prospective Study, Yoshie Umemura, Baber Khan, Benjamin J. Weill, Justin J. Buthorn, Anna Skakodub, Andrew J. Ridder, Kathryn S. Nevel, Yilun Sun, and Adrienne Boire
Association of neighborhood socioeconomic disadvantage and cognitive impairment, Maria Vassilaki, Jeremiah A. Aakre, Anna Castillo, Alanna M. Chamberlain, Patrick M. Wilson, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, Rabe E. Alhurani, Jonathan Graff-Radford, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack, David S. Knopman, and Ronald C. Petersen
Association of Performance on the Financial Capacity Instrument-Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults, Maria Vassilaki, Jeremiah A. Aakre, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, David S. Knopman, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack, Erik D. Roberson, Adam Gerstenecker, Roy C. Martin, Richard E. Kennedy, Daniel C. Marson, and Ronald C. Petersen
Precision antiplatelet therapy for the prevention of ischaemic stroke, David Wang
Association Between Preonset Anti-hypertensive Treatment and Intracerebral Hemorrhage Mortality: A Cohort Study From CHEERY, Yan Wan, Hongxiu Guo, Jing Shen, Shaoli Chen, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, Jiang Chang, David Wang, Quanwei He, and Bo Hu
Feasibility and preliminary effects of exercise interventions on plasma biomarkers of Alzheimer's disease in the FIT-AD trial: a randomized pilot study in older adults with Alzheimer's dementia, Fang Yu, Seung Yong Han, Dereck Salisbury, Jeremy J. Pruzin, Yonas Geda, Richard J. Caselli, and Danni Li
No rebound effect after a course of clopidogrel in patients with acute TIA or minor stroke, Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Anxin Wang, Yuesong Pan, David Wang, S Claiborne Johnston, Yilong Wang, Yongjun Wang, and Xia Meng
Albumin-Corrected Fructosamine Predicts All-Cause and Non-CVD Mortality Among the Very Elderly Aged 80 Years or Older Without Diabetes., Jinhui Zhou, Yuebin Lv, Feng Zhao, Yuan Wei, Xiang Gao, Chen Chen, Feng Lu, Yingchun Liu, Chengcheng Li, Jiaonan Wang, Xiaochang Zhang, Heng Gu, Zhaoxue Yin, Zhaojin Cao, Virginia B Kraus, Chen Mao, and Xiaoming Shi
Submissions from 2021
Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project, Michael L. Alosco, Megan L. Mariani, Charles H. Adler, Laura J. Balcer, Charles Bernick, Rhoda Au, Sarah J. Banks, William B. Barr, Sylvain Bouix, Robert C. Cantu, Michael J. Coleman, David W. Dodick, Lindsay A. Farrer, Yonas E. Geda, Douglas I. Katz, Inga K. Koerte, Neil W. Kowall, Alexander P. Lin, Daniel S. Marcus, Kenneth L. Marek, Michael D. McClean, Ann C. McKee, Jesse Mez, Joseph N. Palmisano, Elaine R. Peskind, Yorghos Tripodis, Robert W. Turner, Jennifer V. Wethe, Jeffrey L. Cummings, Eric M. Reiman, Martha E. Shenton, and Robert A. Stern
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial, Richard J. Barohn, Byron Gajewski, Mamatha Pasnoor, Alexandra Brown, Laura L. Herbelin, Kim S. Kimminau, Dinesh Pal Mudaranthakam, Omar Jawdat, Mazen M. Dimachkie, Stanley Iyadurai, Amro Stino, John Kissel, Robert Pascuzzi, Thomas Brannagan, Matthew Wicklund, Aiesha Ahmed, David Walk, Gordon Smith, Dianna Quan, Darryl Heitzman, Alejandro Tobon, Shafeeq Ladha, Gil Wolfe, Michael Pulley, Ghazala Hayat, Yuebing Li, Pariwat Thaisetthawatkul, Richard Lewis, Suur Biliciler, Khema Sharma, and Kian Salajegheh
Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review, Barry S. Baumel, P. Murali Doraiswamy, Marwan Sabbagh, and Richard Wurtman
Outcome after acute ischemic stroke is linked to sex-specific lesion patterns, Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sungmin Hong, Robert W. Regenhardt, Mikael Brudfors, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, Stephen Bevan, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, and Arndt Rolfs
MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes, Martin Bretzner, Anna K. Bonkhoff, Markus D. Schirmer, Sungmin Hong, Adrian V. Dalca, Kathleen L. Donahue, Anne-Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Razvan Marinescu, Clinton Wang, Robert W. Regenhardt, Xavier Leclerc, Renaud Lopes, Oscar R. Benavente, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Patrick F. McArdle, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, and Arndt Rolfs
Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial, Daniel K. Burns, Robert C. Alexander, Kathleen A. Welsh-Bohmer, Meredith Culp, Carl Chiang, Janet O'Neil, Rebecca M. Evans, Patrick Harrigan, Brenda L. Plassman, James R. Burke, Jingtao Wu, Michael W. Lutz, Stephen Haneline, Adam J. Schwarz, Lon S. Schneider, Kristine Yaffe, Ann M. Saunders, Emiliangelo Ratti, Dag Aarsland, Oda Ackermann, Joscelyn Agron-Figueroa, Thomas Arnold, Peter Bailey, Clive Ballard, Scott Barton, Christine Belden, James Bergthold, Wendy Bond, Ronald Bradley, Walter Braude, Mark Brody, and Richard Brown
IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature, Ellen K. Chang, Matthew A. Smith-Cohn, Benita Tamrazi, Jianling Ji, Mark Krieger, Matthias Holdhoff, Charles G. Eberhart, Ashley S. Margol, and Jennifer A. Cotter
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study, Shi Dong Chen, Jia Ying Lu, Hong Qi Li, Yu Xiang Yang, Jie Hui Jiang, Mei Cui, Chuan Tao Zuo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, and Eliezer Masliah
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization, Yeonwoo Chung, Hyunju Lee, Michael W. Weiner, Paul Aisen, Ronald Petersen, Cliford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, and Tamie Sather
Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications, Andrea Comba, Syed M. Faisal, Maria Luisa Varela, Todd Hollon, Wajd N. Al-Holou, Yoshie Umemura, Felipe J. Nunez, Sebastien Motsch, Maria G. Castro, and Pedro R. Lowenstein
Pharmacoresistant seizures and IDH mutation in low-grade gliomas, Carlos Eduardo Correia, Yoshie Umemura, Jessica R. Flynn, Anne S. Reiner, and Edward K. Avila
Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers, Susan R. Criswell, Susan Searles Nielsen, Wendy W. Dlamini, Mark N. Warden, Joel S. Perlmutter, Lianne Sheppard, Stephen M. Moerlein, Jason Lenox-Krug, Harvey Checkoway, and Brad A. Racette
Aducanumab produced a clinically meaningful benefit in association with amyloid lowering, Jeffrey Cummings, Paul Aisen, Cynthia Lemere, Alireza Atri, Marwan Sabbagh, and Stephen Salloway
Methohexital - Induced lateralized periodic discharges during Wada test., Omar A Danoun, Nicholas Beimer, Henry Buchtel, Simon Glynn, and David Harris
Outcomes of seizures, status epilepticus, and EEG findings in critically ill patient with COVID-19., Omar A Danoun, Andrew Zillgitt, Chloe Hill, Deepti Zutshi, David Harris, Gamaleldin Osman, Rohit Marawar, Subhendu Rath, Maryam J Syed, Muhammad Affan, Lonni Schultz, and Vibhangini S Wasade
Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease, Sandhitsu R. Das, Xueying Lyu, Michael Tran Duong, Long Xie, Lauren McCollum, Robin de Flores, Michael DiCalogero, David J. Irwin, Bradford C. Dickerson, Ilya M. Nasrallah, Paul A. Yushkevich, David A. Wolk, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, and Gus Jiminez
Factors Associated With Emergency Department Length of Stay and In-hospital Mortality in Intracerebral Hemorrhage Patients, Nicolle W. Davis, Tiffany O. Sheehan, Yi Guo, Debra Lynch Kelly, Ann L. Horgas, and Saunjoo L. Yoon
Critical Appraisal of Amyloid Lowering Agents in AD, Boris Decourt, Fadel Boumelhem, Evans D. Pope, Jiong Shi, Zoltan Mari, and Marwan Noel Sabbagh
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients, Steven T. DeKosky, Patrick M. Kochanek, Alex B. Valadka, Robert S. Clark, Sherry H-Y Chou, Alicia K. Au, Christopher Horvat, Ruchira M. Jha, Rebekah Mannix, Stephen R. Wisniewski, Max Wintermark, Susan E. Rowell, Robert D. Welch, Lawrence Lewis, Stacey House, Rudolph E. Tanzi, Darci R. Smith, Amy Y. Vittor, Nancy D. Denslow, Michael D. Davis, Olena Y. Glushakova, and Ronald L. Hayes
Collateral Circulation Augmentation and Neuroprotection as Adjuvant to Mechanical Thrombectomy in Acute Ischemic Stroke, Shashvat M. Desai, Ruchira M. Jha, and Italo Linfante
Acute Cerebrovascular Events With COVID-19 Infection, Mandip S. Dhamoon, Alison Thaler, Kapil Gururangan, Amit Kohli, Daniella Sisniega, Danielle Wheelwright, Connor Mensching, Johanna T. Fifi, Michael G. Fara, Nathalie Jette, Ella Cohen, Priya Dave, Aislyn C. DiRisio, Jonathan Goldstein, Emma M. Loebel, Naomi A. Mayman, Akarsh Sharma, Daniel S. Thomas, Ruben D. Vega Perez, Mark R. Weingarten, Huei Hsun Wen, Stanley Tuhrim, and Laura K. Stein
Safety and efficacy of avalglucosidase alfa versus alglucosidase alfa in patients with late-onset Pompe disease (COMET): a phase 3, randomised, multicentre trial, Jordi Diaz-Manera, Priya S. Kishnani, Hani Kushlaf, Shafeeq Ladha, Tahseen Mozaffar, Volker Straub, Antonio Toscano, Ans T. van der Ploeg, Kenneth I. Berger, Paula R. Clemens, Yin-Hsiu Chien, John W. Day, Sergey Illarioshkin, Mark Roberts, Shahram Attarian, Joao Lindolfo Borges, Francoise Bouhour, Young Chul Choi, Sevim Erdem-Ozdamar, Ozlem Goker-Alpan, Anna Kostera-Pruszczyk, Kristina An Haack, Christopher Hug, Olivier Huynh-Ba, Judith Johnson, Nathan Thibault, Tianyue Zhou, Mazen M. Dimachkie, and Benedikt Schoser
A Rapid Motor Task-Based Screening Tool for Parkinsonism in Community-Based Studies, Wendy W. Dlamini, Searles Nielsen, Mwiza Ushe, Gill Nelson, and Brad A. Racette
Establishing a learning healthcare system to improve health outcomes for people with epilepsy, Maria A. Donahue, Susan T. Herman, Deepika Dass, Kathleen Farrell, Alison Kukla, Nicholas S. Abend, Lidia M.V.R. Moura, Jeffrey R. Buchhalter, and Brandy E. Fureman
Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group, Bruno Dubois, Nicolas Villain, Giovanni B. Frisoni, Gil D. Rabinovici, Marwan Sabbagh, Stefano Cappa, Alexandre Bejanin, Stéphanie Bombois, Stéphane Epelbaum, Marc Teichmann, Marie Odile Habert, Agneta Nordberg, Kaj Blennow, Douglas Galasko, Yaakov Stern, Christopher C. Rowe, Stephen Salloway, Lon S. Schneider, Jeffrey L. Cummings, and Howard H. Feldman
Online Faculty Development: An African Lusophone Ophthalmic Society Experience During the COVID-19 Pandemic, Helena P. Filipe, Karl C. Golnik, Amelia Geary, Amelia Buque, and Heather G. Mack
Galcanezumab for the prevention of migraine., Lindsay M Frerichs and Deborah I Friedman
Early Stages of Alzheimer's Disease: Evolving the Care Team for Optimal Patient Management, James E. Galvin, Paul Aisen, Jessica B. Langbaum, Eric Rodriguez, Marwan Sabbagh, Richard Stefanacci, Robert A. Stern, Elizabeth A. Vassey, Arno de Wilde, Neva West, and Ivana Rubino
Acceptance and Commitment Therapy in a Low-Income Country in Sub-Saharan Africa: A Call for Further Research, Yonas E. Geda, Janina Krell-Roesch, Yaphet Fisseha, Aida Tefera, Teferra Beyero, Deborah Rosenbaum, Thomas G. Szabo, Mesfin Araya, and Steven C. Hayes
Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer's disease, Jürgen Germann, Gavin J.B. Elias, Alexandre Boutet, Keshav Narang, Clemens Neudorfer, Andreas Horn, Aaron Loh, Wissam Deeb, Bryan Salvato, Leonardo Almeida, Kelly D. Foote, Paul B. Rosenberg, David F. Tang-Wai, David A. Wolk, Anna D. Burke, Stephen Salloway, Marwan N. Sabbagh, M. Mallar Chakravarty, Gwenn S. Smith, Constantine G. Lyketsos, Michael S. Okun, and Andres M. Lozano
Examining the Role of Microbiota in Emotional Behavior: Antibiotic Treatment Exacerbates Anxiety in High Anxiety-Prone Male Rats, M E. Glover, J L. Cohen, J R. Singer, M N. Sabbagh, J R. Rainville, M T. Hyland, C D. Morrow, C T. Weaver, G E. Hodes, Ilan A. Kerman, and S M. Clinton