Recommendations for clinical implementation of blood-based biomarkers for Alzheimer's disease.
Document Type
Article
Abstract
Blood-based biomarkers (BBM) for Alzheimer's disease (AD) are being increasingly used in clinical practice to support an AD diagnosis. In contrast to traditional diagnostic modalities, such as amyloid positron emission tomography and cerebrospinal fluid biomarkers, BBMs offer a more accessible and lower cost alternative for AD biomarker testing. Their unique scalability addresses the anticipated surge in demand for biomarker testing with the emergence of disease-modifying treatments (DMTs) that require confirmation of amyloid pathology. To facilitate the uptake of BBMs in clinical practice, The Global CEO Initiative on Alzheimer's Disease convened a BBM Workgroup to provide recommendations for two clinical implementational pathways for BBMs: one for current use for triaging and another for future use to confirm amyloid pathology. These pathways provide a standardized diagnostic approach with guidance on interpreting BBM test results. Integrating BBMs into clinical practice will simplify the diagnostic process and facilitate timely access to DMTs for eligible patients.
Medical Subject Headings
Alzheimer Disease; Humans; Biomarkers; Positron-Emission Tomography
Publication Date
11-1-2024
Publication Title
Alzheimers Dement
ISSN
1552-5279
Volume
20
Issue
11
First Page
8216
Last Page
8224
PubMed ID
39351838
Digital Object Identifier (DOI)
10.1002/alz.14184
Recommended Citation
Mielke, Michelle M; Anderson, Matthew; Ashford, J Wesson; Jeromin, Andreas; Lin, Pei-Jung; Rosen, Allyson; Tyrone, Jamie; Vandevrede, Lawren; Willis, Deanna R; Hansson, Oskar; Khachaturian, Ara S; Schindler, Suzanne E; Weiss, Joan; Batrla, Richard; Bozeat, Sasha; Dwyer, John R; Holzapfel, Drew; Jones, Daryl Rhys; Murray, James F; Partrick, Katherine A; Scholler, Emily; Vradenburg, George; Young, Dylan; Braunstein, Joel B; Burnham, Samantha C; de Oliveira, Fabricio Ferreira; Hu, Yan Helen; Mattke, Soeren; Merali, Zul; Monane, Mark; Sabbagh, Marwan Noel; Shobin, Eli; Weiner, Michael; and Udeh-Momoh, Chinedu T, "Recommendations for clinical implementation of blood-based biomarkers for Alzheimer's disease." (2024). Neurology. 1910.
https://scholar.barrowneuro.org/neurology/1910